dbPTM

RMXL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RMXL1_HUMAN
UniProt AC	Q96E39
Protein Name	RNA binding motif protein, X-linked-like-1
Gene Name	RBMXL1
Organism	Homo sapiens (Human).
Sequence Length	390
Subcellular Localization	Nucleus.
Protein Description	RNA-binding protein which may be involved in pre-mRNA splicing..
Protein Sequence	MVEADRPGKLFIGGLNTETNEKALETVFGKYGRIVEVLLIKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFERGRHGPPPPPRSRGPPRGFGAGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPSPKRSAPSGLVRSSSGMGGRAPLSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRSAPLTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSCDRVGRQERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVEADRPG -------CCCCCCCC	5.77	-
2	Acetylation	------MVEADRPGK ------CCCCCCCCC	9.26	-
9	Acetylation	VEADRPGKLFIGGLN CCCCCCCCEEECCCC	42.79	-
9	Ubiquitination	VEADRPGKLFIGGLN CCCCCCCCEEECCCC	42.79	23000965
17	Phosphorylation	LFIGGLNTETNEKAL EEECCCCCCCCHHHH	49.59	23186163
19	Phosphorylation	IGGLNTETNEKALET ECCCCCCCCHHHHHH	46.79	30576142
22	Acetylation	LNTETNEKALETVFG CCCCCCHHHHHHHHH	61.41	26051181
22	Ubiquitination	LNTETNEKALETVFG CCCCCCHHHHHHHHH	61.41	21906983
30	Acetylation	ALETVFGKYGRIVEV HHHHHHHHHCCEEEE	32.82	-
30	Ubiquitination	ALETVFGKYGRIVEV HHHHHHHHHCCEEEE	32.82	21890473
48	Phosphorylation	KDRETNKSRGFAFVT EECCCCCCCCEEEEE	39.44	23882029
49	Methylation	DRETNKSRGFAFVTF ECCCCCCCCEEEEEE	45.95	-
55	Phosphorylation	SRGFAFVTFESPADA CCCEEEEEECCCCHH	18.41	30266825
58	Phosphorylation	FAFVTFESPADAKDA EEEEEECCCCHHHHH	22.61	29255136
63	Acetylation	FESPADAKDAARDMN ECCCCHHHHHHHHHC	48.74	30792461
63	Sumoylation	FESPADAKDAARDMN ECCCCHHHHHHHHHC	48.74	-
63	Ubiquitination	FESPADAKDAARDMN ECCCCHHHHHHHHHC	48.74	21906983
72	Acetylation	AARDMNGKSLDGKAI HHHHHCCCCCCCCEE	42.72	7427439
73	Phosphorylation	ARDMNGKSLDGKAIK HHHHCCCCCCCCEEE	32.84	25849741
77	Ubiquitination	NGKSLDGKAIKVEQA CCCCCCCCEEEEEEC	46.75	32015554
80	Sumoylation	SLDGKAIKVEQATKP CCCCCEEEEEECCCC	44.58	-
80	Sumoylation	SLDGKAIKVEQATKP CCCCCEEEEEECCCC	44.58	28112733
85	Phosphorylation	AIKVEQATKPSFERG EEEEEECCCCCCCCC	43.09	23401153
86	Acetylation	IKVEQATKPSFERGR EEEEECCCCCCCCCC	41.50	26051181
86	Methylation	IKVEQATKPSFERGR EEEEECCCCCCCCCC	41.50	115490919
88	Phosphorylation	VEQATKPSFERGRHG EEECCCCCCCCCCCC	41.10	25159151
91	Methylation	ATKPSFERGRHGPPP CCCCCCCCCCCCCCC	45.49	81453641
93	Methylation	KPSFERGRHGPPPPP CCCCCCCCCCCCCCC	37.50	115490923
101	Methylation	HGPPPPPRSRGPPRG CCCCCCCCCCCCCCC	44.77	-
102	Phosphorylation	GPPPPPRSRGPPRGF CCCCCCCCCCCCCCC	47.57	24719451
103	Methylation	PPPPPRSRGPPRGFG CCCCCCCCCCCCCCC	64.02	-
107	Methylation	PRSRGPPRGFGAGRG CCCCCCCCCCCCCCC	57.09	83108253
113	Dimethylation	PRGFGAGRGGSGGTR CCCCCCCCCCCCCCC	45.85	-
113	Methylation	PRGFGAGRGGSGGTR CCCCCCCCCCCCCCC	45.85	80700839
116	Phosphorylation	FGAGRGGSGGTRGPP CCCCCCCCCCCCCCC	36.55	28450419
119	Phosphorylation	GRGGSGGTRGPPSRG CCCCCCCCCCCCCCC	35.66	22496350
120	Methylation	RGGSGGTRGPPSRGG CCCCCCCCCCCCCCC	59.92	83108257
124	Phosphorylation	GGTRGPPSRGGHMDD CCCCCCCCCCCCCCC	46.84	23401153
125	Asymmetric dimethylarginine	GTRGPPSRGGHMDDG CCCCCCCCCCCCCCC	61.97	-
125	Methylation	GTRGPPSRGGHMDDG CCCCCCCCCCCCCCC	61.97	12020041
134	Phosphorylation	GHMDDGGYSMNFNMS CCCCCCCEECCCCCC	15.41	21945579
135	Phosphorylation	HMDDGGYSMNFNMSS CCCCCCEECCCCCCC	15.55	21945579
141	Phosphorylation	YSMNFNMSSSRGPLP EECCCCCCCCCCCCC	26.68	23401153
142	Phosphorylation	SMNFNMSSSRGPLPV ECCCCCCCCCCCCCC	17.18	21945579
143	Phosphorylation	MNFNMSSSRGPLPVK CCCCCCCCCCCCCCC	33.67	21945579
144	Methylation	NFNMSSSRGPLPVKR CCCCCCCCCCCCCCC	53.34	30760825
150	Acetylation	SRGPLPVKRGPPPRS CCCCCCCCCCCCCCC	50.09	7296941
150	Methylation	SRGPLPVKRGPPPRS CCCCCCCCCCCCCCC	50.09	7296941
150	Ubiquitination	SRGPLPVKRGPPPRS CCCCCCCCCCCCCCC	50.09	27667366
151	Methylation	RGPLPVKRGPPPRSG CCCCCCCCCCCCCCC	64.18	-
157	Phosphorylation	KRGPPPRSGGPSPKR CCCCCCCCCCCCCCC	54.60	30266825
161	Phosphorylation	PPRSGGPSPKRSAPS CCCCCCCCCCCCCCC	46.45	30266825
164	Methylation	SGGPSPKRSAPSGLV CCCCCCCCCCCCCCC	41.24	81121013
165	Phosphorylation	GGPSPKRSAPSGLVR CCCCCCCCCCCCCCC	51.13	24247654
172	Methylation	SAPSGLVRSSSGMGG CCCCCCCCCCCCCCC	35.54	80700843
173	Phosphorylation	APSGLVRSSSGMGGR CCCCCCCCCCCCCCC	22.75	21406692
174	Phosphorylation	PSGLVRSSSGMGGRA CCCCCCCCCCCCCCC	21.98	22210691
175	Phosphorylation	SGLVRSSSGMGGRAP CCCCCCCCCCCCCCC	33.76	21406692
180	Methylation	SSSGMGGRAPLSRGR CCCCCCCCCCCCCCC	27.57	80700831
184	Phosphorylation	MGGRAPLSRGRDSYG CCCCCCCCCCCCCCC	31.46	22210691
185	Methylation	GGRAPLSRGRDSYGG CCCCCCCCCCCCCCC	52.42	58854927
187	Methylation	RAPLSRGRDSYGGPP CCCCCCCCCCCCCCC	28.70	58854935
189	Phosphorylation	PLSRGRDSYGGPPRR CCCCCCCCCCCCCCC	25.07	23401153
190	Phosphorylation	LSRGRDSYGGPPRRE CCCCCCCCCCCCCCC	30.32	24732914
195	Methylation	DSYGGPPRREPLPSR CCCCCCCCCCCCCCC	59.74	115490895
201	Phosphorylation	PRREPLPSRRDVYLS CCCCCCCCCCCCEEC	47.86	26074081
206	Phosphorylation	LPSRRDVYLSPRDDG CCCCCCCEECCCCCC	13.02	23927012
208	Phosphorylation	SRRDVYLSPRDDGYS CCCCCEECCCCCCCC	10.53	19664994
214	Phosphorylation	LSPRDDGYSTKDSYS ECCCCCCCCCCCCCC	21.84	23927012
215	Phosphorylation	SPRDDGYSTKDSYSS CCCCCCCCCCCCCCC	34.21	23401153
216	Phosphorylation	PRDDGYSTKDSYSSR CCCCCCCCCCCCCCC	30.32	23927012
217	Acetylation	RDDGYSTKDSYSSRD CCCCCCCCCCCCCCC	38.44	24510283
217	Ubiquitination	RDDGYSTKDSYSSRD CCCCCCCCCCCCCCC	38.44	23000965
219	Phosphorylation	DGYSTKDSYSSRDYP CCCCCCCCCCCCCCC	28.59	23401153
220	Phosphorylation	GYSTKDSYSSRDYPS CCCCCCCCCCCCCCC	22.31	23927012
221	Phosphorylation	YSTKDSYSSRDYPSS CCCCCCCCCCCCCCC	23.89	23401153
222	Phosphorylation	STKDSYSSRDYPSSR CCCCCCCCCCCCCCC	22.42	23927012
225	Phosphorylation	DSYSSRDYPSSRDTR CCCCCCCCCCCCCCC	12.14	28102081
227	Phosphorylation	YSSRDYPSSRDTRDY CCCCCCCCCCCCCCC	31.60	28152594
228	Phosphorylation	SSRDYPSSRDTRDYA CCCCCCCCCCCCCCC	29.66	28152594
231	Phosphorylation	DYPSSRDTRDYAPPP CCCCCCCCCCCCCCC	25.08	29116813
234	Phosphorylation	SSRDTRDYAPPPRDY CCCCCCCCCCCCCCC	20.09	21945579
241	Phosphorylation	YAPPPRDYTYRDYGH CCCCCCCCCCCCCCC	13.62	21945579
242	Phosphorylation	APPPRDYTYRDYGHS CCCCCCCCCCCCCCC	19.17	21945579
243	Phosphorylation	PPPRDYTYRDYGHSS CCCCCCCCCCCCCCC	8.68	21945579
246	Phosphorylation	RDYTYRDYGHSSSRD CCCCCCCCCCCCCCC	14.03	25463755
249	Phosphorylation	TYRDYGHSSSRDDYP CCCCCCCCCCCCCCC	26.16	22167270
250	Phosphorylation	YRDYGHSSSRDDYPS CCCCCCCCCCCCCCC	24.58	23401153
251	Phosphorylation	RDYGHSSSRDDYPSR CCCCCCCCCCCCCCC	42.62	22167270
255	Phosphorylation	HSSSRDDYPSRGYGD CCCCCCCCCCCCCCC	13.85	27273156
257	Phosphorylation	SSRDDYPSRGYGDRD CCCCCCCCCCCCCCC	31.91	21955146
272	Phosphorylation	GYGRDRDYSDHPSGG CCCCCCCCCCCCCCC	19.52	27273156
273	Phosphorylation	YGRDRDYSDHPSGGS CCCCCCCCCCCCCCC	33.46	23927012
277	Phosphorylation	RDYSDHPSGGSYRDS CCCCCCCCCCCCCCC	52.98	22167270
280	Phosphorylation	SDHPSGGSYRDSYES CCCCCCCCCCCCHHH	22.11	23401153
281	Phosphorylation	DHPSGGSYRDSYESY CCCCCCCCCCCHHHH	23.01	22167270
284	Phosphorylation	SGGSYRDSYESYGNS CCCCCCCCHHHHCCC	23.08	23927012
285	Phosphorylation	GGSYRDSYESYGNSR CCCCCCCHHHHCCCC	17.12	23927012
287	Phosphorylation	SYRDSYESYGNSRSA CCCCCHHHHCCCCCC	30.06	20164059
288	Phosphorylation	YRDSYESYGNSRSAP CCCCHHHHCCCCCCC	14.37	27273156
291	Phosphorylation	SYESYGNSRSAPLTR CHHHHCCCCCCCCCC	24.21	23927012
292	Methylation	YESYGNSRSAPLTRG HHHHCCCCCCCCCCC	40.62	30760829
298	Methylation	SRSAPLTRGPPPSYG CCCCCCCCCCCCCCC	64.40	115490911
303	Phosphorylation	LTRGPPPSYGGSSRY CCCCCCCCCCCCCCC	42.03	23403867
304	Phosphorylation	TRGPPPSYGGSSRYD CCCCCCCCCCCCCCC	31.14	23403867
307	Phosphorylation	PPPSYGGSSRYDDYS CCCCCCCCCCCCCCC	13.79	23403867
308	Phosphorylation	PPSYGGSSRYDDYSS CCCCCCCCCCCCCCC	37.83	23403867
310	Phosphorylation	SYGGSSRYDDYSSSR CCCCCCCCCCCCCCC	18.34	20007894
313	Phosphorylation	GSSRYDDYSSSRDGY CCCCCCCCCCCCCCC	13.93	21955146
314	Phosphorylation	SSRYDDYSSSRDGYG CCCCCCCCCCCCCCC	28.91	23401153
315	Phosphorylation	SRYDDYSSSRDGYGG CCCCCCCCCCCCCCC	24.14	23401153
316	Phosphorylation	RYDDYSSSRDGYGGS CCCCCCCCCCCCCCC	28.57	23401153
317	Methylation	YDDYSSSRDGYGGSR CCCCCCCCCCCCCCC	43.23	-
320	Phosphorylation	YSSSRDGYGGSRDSY CCCCCCCCCCCCCCC	23.70	22167270
323	Phosphorylation	SRDGYGGSRDSYSSS CCCCCCCCCCCCCCC	28.66	22167270
326	Phosphorylation	GYGGSRDSYSSSRSD CCCCCCCCCCCCHHH	26.29	22167270
327	Phosphorylation	YGGSRDSYSSSRSDL CCCCCCCCCCCHHHH	19.50	22167270
328	Phosphorylation	GGSRDSYSSSRSDLY CCCCCCCCCCHHHHH	26.28	22167270
329	Phosphorylation	GSRDSYSSSRSDLYS CCCCCCCCCHHHHHH	22.87	22167270
330	Phosphorylation	SRDSYSSSRSDLYSS CCCCCCCCHHHHHHH	29.84	23401153
332	Phosphorylation	DSYSSSRSDLYSSCD CCCCCCHHHHHHHHC	33.64	28450419
335	Phosphorylation	SSSRSDLYSSCDRVG CCCHHHHHHHHCHHC	11.97	27732954
336	Phosphorylation	SSRSDLYSSCDRVGR CCHHHHHHHHCHHCC	31.61	30576142
337	Phosphorylation	SRSDLYSSCDRVGRQ CHHHHHHHHCHHCCC	13.38	26055452
343	Methylation	SSCDRVGRQERGLPP HHHCHHCCCCCCCCC	32.12	24384629
346	Methylation	DRVGRQERGLPPSVE CHHCCCCCCCCCCHH	43.54	24384635
351	Phosphorylation	QERGLPPSVERGYPS CCCCCCCCHHCCCCC	34.37	23401153
354	Methylation	GLPPSVERGYPSSRD CCCCCHHCCCCCCCC	48.03	24384641
359	Phosphorylation	VERGYPSSRDSYSSS HHCCCCCCCCCCCCC	35.29	27067055
362	Phosphorylation	GYPSSRDSYSSSSRG CCCCCCCCCCCCCCC	26.29	27251275
363	Phosphorylation	YPSSRDSYSSSSRGA CCCCCCCCCCCCCCC	19.50	-
368	Dimethylation	DSYSSSSRGAPRGAG CCCCCCCCCCCCCCC	47.44	-
368	Methylation	DSYSSSSRGAPRGAG CCCCCCCCCCCCCCC	47.44	24395781
372	Dimethylation	SSSRGAPRGAGPGGS CCCCCCCCCCCCCCC	47.24	-
372	Methylation	SSSRGAPRGAGPGGS CCCCCCCCCCCCCCC	47.24	80700835
380	Methylation	GAGPGGSRSDRGGGR CCCCCCCCCCCCCCC	45.94	81453639

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
326	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RMXL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RMXL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RMXL1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RMXL1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88, AND MASSSPECTROMETRY.	18669648 [Abstract]