| UniProt ID | PAK5_HUMAN | |
|---|---|---|
| UniProt AC | Q9P286 | |
| Protein Name | Serine/threonine-protein kinase PAK 5 {ECO:0000305} | |
| Gene Name | PAK5 {ECO:0000312|HGNC:HGNC:15916} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 719 | |
| Subcellular Localization | Mitochondrion. Cytoplasm. Nucleus. Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival. | |
| Protein Description | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.. | |
| Protein Sequence | MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEAYYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTAGTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 104 | Phosphorylation | SNSLRKESPPTPDQG CCCCCCCCCCCCCCC | - | ||
| 107 | Phosphorylation | LRKESPPTPDQGASS CCCCCCCCCCCCCCC | - | ||
| 113 | Phosphorylation | PTPDQGASSHGPGHA CCCCCCCCCCCCCCC | 30576142 | ||
| 127 | Phosphorylation | AEENGFITFSQYSSE CHHCCEEEEEECCCC | 30576142 | ||
| 141 | Phosphorylation | ESDTTADYTTEKYRE CCCCCCCCCCHHHHH | 30576142 | ||
| 150 | Phosphorylation | TEKYREKSLYGDDLD CHHHHHHHCCCCCCC | 27732954 | ||
| 152 | Phosphorylation | KYREKSLYGDDLDPY HHHHHHCCCCCCCHH | 27732954 | ||
| 159 | Phosphorylation | YGDDLDPYYRGSHAA CCCCCCHHHCCHHHH | 25884760 | ||
| 160 | Phosphorylation | GDDLDPYYRGSHAAK CCCCCHHHCCHHHHH | 22817900 | ||
| 167 | Acetylation | YRGSHAAKQNGHVMK HCCHHHHHHCCEEEE | 11794157 | ||
| 182 | Phosphorylation | MKHGEAYYSEVKPLK CCCCCEECCCCCCCC | 25884760 | ||
| 183 | Phosphorylation | KHGEAYYSEVKPLKS CCCCEECCCCCCCCC | 25884760 | ||
| 223 | Phosphorylation | KWEYQRASSSSPLDY CCEEECCCCCCCCCE | 27732954 | ||
| 224 | Phosphorylation | WEYQRASSSSPLDYS CEEECCCCCCCCCEE | 22617229 | ||
| 225 | Phosphorylation | EYQRASSSSPLDYSF EEECCCCCCCCCEEE | 27732954 | ||
| 226 | Phosphorylation | YQRASSSSPLDYSFQ EECCCCCCCCCEEEE | 22617229 | ||
| 230 | Phosphorylation | SSSSPLDYSFQFTPS CCCCCCCEEEEECCC | 27732954 | ||
| 231 | Phosphorylation | SSSPLDYSFQFTPSR CCCCCCEEEEECCCC | 27732954 | ||
| 235 | Phosphorylation | LDYSFQFTPSRTAGT CCEEEEECCCCCCCC | 27732954 | ||
| 237 | Phosphorylation | YSFQFTPSRTAGTSG EEEEECCCCCCCCCC | 27732954 | ||
| 249 | Phosphorylation | TSGCSKESLAYSESE CCCCCHHHHCCCCCC | 27732954 | ||
| 252 | Phosphorylation | CSKESLAYSESEWGP CCHHHHCCCCCCCCC | 27732954 | ||
| 253 | Phosphorylation | SKESLAYSESEWGPS CHHHHCCCCCCCCCC | 27732954 | ||
| 255 | Phosphorylation | ESLAYSESEWGPSLD HHHCCCCCCCCCCHH | 27732954 | ||
| 270 | Phosphorylation | DYDRRPKSSYLNQTS HCCCCCCCHHCCCCC | 27732954 | ||
| 271 | Phosphorylation | YDRRPKSSYLNQTSP CCCCCCCHHCCCCCC | 27732954 | ||
| 272 | Phosphorylation | DRRPKSSYLNQTSPQ CCCCCCHHCCCCCCC | 22817900 | ||
| 276 | Phosphorylation | KSSYLNQTSPQPTMR CCHHCCCCCCCCCCC | 27732954 | ||
| 277 | Phosphorylation | SSYLNQTSPQPTMRQ CHHCCCCCCCCCCCC | 27732954 | ||
| 281 | Phosphorylation | NQTSPQPTMRQRSRS CCCCCCCCCCCCCCC | 29083192 | ||
| 285 | Methylation | PQPTMRQRSRSGSGL CCCCCCCCCCCCCCC | 24161617 | ||
| 285 | Dimethylation | PQPTMRQRSRSGSGL CCCCCCCCCCCCCCC | - | ||
| 286 | Phosphorylation | QPTMRQRSRSGSGLQ CCCCCCCCCCCCCCC | 25884760 | ||
| 288 | Phosphorylation | TMRQRSRSGSGLQEP CCCCCCCCCCCCCCC | 27732954 | ||
| 290 | Phosphorylation | RQRSRSGSGLQEPMM CCCCCCCCCCCCCCC | 25884760 | ||
| 345 | Phosphorylation | MVLSPPLSGSDTYPR EEECCCCCCCCCCCC | - | ||
| 347 | Phosphorylation | LSPPLSGSDTYPRGP ECCCCCCCCCCCCCC | - | ||
| 349 | Phosphorylation | PPLSGSDTYPRGPAK CCCCCCCCCCCCCCC | - | ||
| 350 | Phosphorylation | PLSGSDTYPRGPAKL CCCCCCCCCCCCCCC | - | ||
| 551 | Phosphorylation | QIATVCLSVLRALSY HHHHHHHHHHHHHHH | 24719451 | ||
| 573 | Phosphorylation | HRDIKSDSILLTSDG CCCCCCCEEEEECCC | 22817900 | ||
| 602 | Phosphorylation | KEVPKRKSLVGTPYW CCCCCCCCCCCCCCC | 22322096 | ||
| 606 | Phosphorylation | KRKSLVGTPYWMAPE CCCCCCCCCCCCCHH | 25106551 | ||
| 608 | Phosphorylation | KSLVGTPYWMAPEVI CCCCCCCCCCCHHHH | 28176443 | ||
| 616 | Phosphorylation | WMAPEVISRLPYGTE CCCHHHHHCCCCCCC | 28176443 | ||
| 658 | Phosphorylation | AMRRIRDSLPPRVKD HHHHHHHCCCCCHHH | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 573 | S | Phosphorylation | Kinase | PAK5 | Q9P286 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PAK5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PAK5_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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