dbPTM

INKA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	INKA1_HUMAN
UniProt AC	Q96EL1
Protein Name	PAK4-inhibitor INKA1 {ECO:0000305}
Gene Name	FAM212A {ECO:0000312\|HGNC:HGNC:32480}
Organism	Homo sapiens (Human).
Sequence Length	285
Subcellular Localization	Nucleus . Cytoplasm . Mainly nuclear (PubMed:26607847). Relocalizes to the cytoplasm following interaction with PAK4 (PubMed:26607847).
Protein Description	Inhibitor of the serine/threonine-protein kinase PAK4. [PubMed: 26607847 Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity]
Protein Sequence	MHSARLDSFLSQLRWELLCGRDTGSPSMPGPLQPTSQTGPDVQPSHQLRASGALEEDSVCCVEEEEEEEEEAVVTEDRDAALGGPREHALDWDSGFSEVSGSTWREEELPVSQRPAPSAQPLRRQCLSVSGLPMPSRAPVASVPPVHHPRPKSTPDACLEHWQGLEAEDWTAALLNRGRSRQPLVLGDNCFADLVHNWMELPETGSEGGDGGGHRARARPPQFLLGLSEQLRRRLARARRTAMAGKRLSCPPRPEPELPADVSRFAALMSCRSRQPIICNDVSYL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
128	Phosphorylation	PLRRQCLSVSGLPMP CHHHHHHCCCCCCCC	26074081
130	Phosphorylation	RRQCLSVSGLPMPSR HHHHHCCCCCCCCCC	26074081
153	Phosphorylation	VHHPRPKSTPDACLE CCCCCCCCCHHHHHH	28348404
154	Phosphorylation	HHPRPKSTPDACLEH CCCCCCCCHHHHHHH	28122231
228	Phosphorylation	PQFLLGLSEQLRRRL CCHHHHHHHHHHHHH	-
241	Phosphorylation	RLARARRTAMAGKRL HHHHHHHHHHCCCCC	24719451
249	Phosphorylation	AMAGKRLSCPPRPEP HHCCCCCCCCCCCCC	27794612
263	Phosphorylation	PELPADVSRFAALMS CCCCCCHHHHHHHHH	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of INKA1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of INKA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of INKA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of INKA1_HUMAN

Related Literatures of Post-Translational Modification