COA7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COA7_HUMAN
• UniProt AC: Q96BR5
• Protein Name: Cytochrome c oxidase assembly factor 7
• Gene Name: COA7
• Organism: Homo sapiens (Human).
• Sequence Length: 231
• Subcellular Localization: Mitochondrion intermembrane space .
• Protein Description: Required for assembly of mitochondrial respiratory chain complex I and complex IV..
• Protein Sequence: MAGMVDFQDEEQVKSFLENMEVECNYHCYHEKDPDGCYRLVDYLEGIRKNFDEAAKVLKFNCEENQHSDSCYKLGAYYVTGKGGLTQDLKAAARCFLMACEKPGKKSIAACHNVGLLAHDGQVNEDGQPDLGKARDYYTRACDGGYTSSCFNLSAMFLQGAPGFPKDMDLACKYSMKACDLGHIWACANASRMYKLGDGVDKDEAKAEVLKNRAQQLHKEQQKGVQPLTFG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGMVDFQD ------CCCCCCCCC		19413330
32	Acetylation	NYHCYHEKDPDGCYR EEEEEECCCCCCHHH		26051181
56	Ubiquitination	KNFDEAAKVLKFNCE HCHHHHHHHHCCCCC		27667366
59	Ubiquitination	DEAAKVLKFNCEENQ HHHHHHHCCCCCCCC		22817900
59	Acetylation	DEAAKVLKFNCEENQ HHHHHHHCCCCCCCC		26051181
68	Phosphorylation	NCEENQHSDSCYKLG CCCCCCCCCCCEEEE		-
70	Phosphorylation	EENQHSDSCYKLGAY CCCCCCCCCEEEECE		-
73	Acetylation	QHSDSCYKLGAYYVT CCCCCCEEEECEEEE		26051181
73	Ubiquitination	QHSDSCYKLGAYYVT CCCCCCEEEECEEEE		29967540
77	Phosphorylation	SCYKLGAYYVTGKGG CCEEEECEEEECCCC		20068231
78	Phosphorylation	CYKLGAYYVTGKGGL CEEEECEEEECCCCC		20068231
80	Phosphorylation	KLGAYYVTGKGGLTQ EEECEEEECCCCCHH		20068231
82	Acetylation	GAYYVTGKGGLTQDL ECEEEECCCCCHHHH		26051181
82	Ubiquitination	GAYYVTGKGGLTQDL ECEEEECCCCCHHHH		21906983
86	Phosphorylation	VTGKGGLTQDLKAAA EECCCCCHHHHHHHH		21406692
90	Ubiquitination	GGLTQDLKAAARCFL CCCHHHHHHHHHHHH		22817900
106	Ubiquitination	ACEKPGKKSIAACHN HCCCCCCCCHHHHCC		29967540
107	Phosphorylation	CEKPGKKSIAACHNV CCCCCCCCHHHHCCC		28555341
133	Ubiquitination	DGQPDLGKARDYYTR CCCCCCHHHHCHHHH		-
139	Phosphorylation	GKARDYYTRACDGGY HHHHCHHHHHCCCCC		30576142
148	Phosphorylation	ACDGGYTSSCFNLSA HCCCCCCHHHHHHHH		30576142
154	Phosphorylation	TSSCFNLSAMFLQGA CHHHHHHHHHHHHCC		30576142
173	Ubiquitination	KDMDLACKYSMKACD CCHHHHHHHHCCCCC		29967540
191	Phosphorylation	IWACANASRMYKLGD HHHHHCCHHHHCCCC		-
195	Ubiquitination	ANASRMYKLGDGVDK HCCHHHHCCCCCCCH		22817900
206	Ubiquitination	GVDKDEAKAEVLKNR CCCHHHHHHHHHHHH		24816145
211	Ubiquitination	EAKAEVLKNRAQQLH HHHHHHHHHHHHHHH		29967540
223	Ubiquitination	QLHKEQQKGVQPLTF HHHHHHHCCCCCCCC		27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COA7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COA7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COA7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TXD17_HUMAN	TXNDC17	physical	22939629
SDHF2_HUMAN	SDHAF2	physical	22939629
FKB10_HUMAN	FKBP10	physical	22939629
MPRI_HUMAN	IGF2R	physical	22939629
WDHD1_HUMAN	WDHD1	physical	22939629
SFR15_HUMAN	SCAF4	physical	22939629
SVIL_HUMAN	SVIL	physical	22939629
VMA21_HUMAN	VMA21	physical	22939629
FBP1L_HUMAN	FNBP1L	physical	22939629
SBP1_HUMAN	SELENBP1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.