SDHF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDHF2_HUMAN
• UniProt AC: Q9NX18
• Protein Name: Succinate dehydrogenase assembly factor 2, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03057}
• Gene Name: SDHAF2 {ECO:0000255|HAMAP-Rule:MF_03057}
• Organism: Homo sapiens (Human).
• Sequence Length: 166
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer..
• Protein Sequence: MAVSTVFSTSSLMLALSRHSLLSPLLSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVMALLRDFAKNKNKEQRLRAPDLEYLFEKPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAVSTVFSTSS ----CCCHHCCCHHH	14.87	24043423
5	Phosphorylation	---MAVSTVFSTSSL ---CCCHHCCCHHHH	20.97	24043423
8	Phosphorylation	MAVSTVFSTSSLMLA CCCHHCCCHHHHHHH	24.04	24043423
9	Phosphorylation	AVSTVFSTSSLMLAL CCHHCCCHHHHHHHH	15.75	22210691
10	Phosphorylation	VSTVFSTSSLMLALS CHHCCCHHHHHHHHH	21.92	24043423
11	Phosphorylation	STVFSTSSLMLALSR HHCCCHHHHHHHHHH	20.20	24043423
17	Phosphorylation	SSLMLALSRHSLLSP HHHHHHHHHHCCHHH	23.49	24719451
20	Phosphorylation	MLALSRHSLLSPLLS HHHHHHHCCHHHHCH	29.87	24043423
23	Phosphorylation	LSRHSLLSPLLSVTS HHHHCCHHHHCHHHH	20.85	22210691
27	Phosphorylation	SLLSPLLSVTSFRRF CCHHHHCHHHHCHHH	30.91	24043423
29	Phosphorylation	LSPLLSVTSFRRFYR HHHHCHHHHCHHHHC	20.83	22210691
30	Phosphorylation	SPLLSVTSFRRFYRG HHHCHHHHCHHHHCC	18.01	24043423
66	Ubiquitination	TDESIETKRARLLYE CCCCHHHHHHHHHHH	31.13	21906983
100	Ubiquitination	HLQHMTEKQLNLYDR HHHHHCHHHHHHHHH	51.42	22817900
145	Ubiquitination	ALLRDFAKNKNKEQR HHHHHHHHCCCHHHH	69.33	23503661
147	Ubiquitination	LRDFAKNKNKEQRLR HHHHHHCCCHHHHHC	69.55	24816145
149	Ubiquitination	DFAKNKNKEQRLRAP HHHHCCCHHHHHCCC	57.76	23503661
164	Ubiquitination	DLEYLFEKPR----- CHHHHHCCCC-----	38.46	21906983
164	Acetylation	DLEYLFEKPR----- CHHHHHCCCC-----	38.46	27452117

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDHF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDHF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDHF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIC60_HUMAN	IMMT	physical	16169070
CC90B_HUMAN	CCDC90B	physical	16169070
EF1A1_HUMAN	EEF1A1	physical	16169070
ELP1_HUMAN	IKBKAP	physical	16169070
SRC8_HUMAN	CTTN	physical	22939629
VINC_HUMAN	VCL	physical	22939629
UCRI_HUMAN	UQCRFS1	physical	22939629
UBXN7_HUMAN	UBXN7	physical	22939629
UPAR_HUMAN	PLAUR	physical	22939629
SH3L1_HUMAN	SH3BGRL	physical	22939629
SUMO2_HUMAN	SUMO2	physical	22939629
SUCB2_HUMAN	SUCLG2	physical	22939629
ABCA2_HUMAN	ABCA2	physical	26496610
CTNA2_HUMAN	CTNNA2	physical	26496610
HSP7C_HUMAN	HSPA8	physical	26496610
GRP75_HUMAN	HSPA9	physical	26496610
RIR2_HUMAN	RRM2	physical	26496610
SDHA_HUMAN	SDHA	physical	26496610
AAAT_HUMAN	SLC1A5	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
KLDC2_HUMAN	KLHDC2	physical	26496610
NOL8_HUMAN	NOL8	physical	26496610
ADIP_HUMAN	SSX2IP	physical	26496610
C19L2_HUMAN	CWF19L2	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 601650: Paragangliomas 2 (PGL2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.