dbPTM

ABCA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ABCA2_HUMAN
UniProt AC	Q9BZC7
Protein Name	ATP-binding cassette sub-family A member 2
Gene Name	ABCA2
Organism	Homo sapiens (Human).
Sequence Length	2435
Subcellular Localization	Endosome membrane Multi-pass membrane protein . Lysosome membrane Multi-pass membrane protein . Forms discrete, punctate intracellular vesicles.
Protein Description	Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development..
Protein Sequence	MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEAFYTAAPLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLDRVVEEGNLFDPARPSLGSELEALRQHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQNLSLPNSTAQALLAARVDPPEVYHLLFGPSSALDSQSGLHKGQEPWSRLGGNPLFRMEELLLAPALLEQLTCTPGSGELGRILTVPESQKGALQGYRDAVCSGQAAARARRFSGLSAELRNQLDVAKVSQQLGLDAPNGSDSSPQAPPPRRLQALLGDLLDAQKVLQDVDVLSALALLLPQGACTGRTPGPPASGAGGAANGTGAGAVMGPNATAEEGAPSAAALATPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSKEQRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAACGWIQFMSKVSVDIFKGFHDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDTEDEGLISFEEERAQLSFNTDTLC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	N-linked_Glycosylation	LQLLLWKNVTLKRRS HHHHHHCCCCCCCCC	22.03	UniProtKB CARBOHYD
50	Phosphorylation	RQKKPTISVKEAFYT HCCCCCEEHHHHHHH	29.61	22798277
55 (in isoform 3)	Phosphorylation	-	6.13	-
57 (in isoform 3)	Phosphorylation	-	15.19	-
58 (in isoform 3)	Phosphorylation	-	8.83	-
89	N-linked_Glycosylation	FGFLQYANSTVTQLL CCHHHHCCHHHHHHH	33.02	UniProtKB CARBOHYD
118	Phosphorylation	PARPSLGSELEALRQ CCCCCCHHHHHHHHH	44.28	24300666
137	Phosphorylation	LSAGPGTSGSHLDRS HHCCCCCCCCCCCHH	44.18	46156381
168	N-linked_Glycosylation	LWRFLTQNLSLPNST HHHHHHHCCCCCCCH	26.76	UniProtKB CARBOHYD
173	N-linked_Glycosylation	TQNLSLPNSTAQALL HHCCCCCCCHHHHHH	58.23	UniProtKB CARBOHYD
251	Phosphorylation	GELGRILTVPESQKG CCCCCEEECCHHHCC	31.48	20068231
255	Phosphorylation	RILTVPESQKGALQG CEEECCHHHCCCCCC	30.99	20068231
271	Methylation	RDAVCSGQAAARARR HHHHHHHHHHHHHHH	16.13	26797129
280	Phosphorylation	AARARRFSGLSAELR HHHHHHHHCCCHHHH	36.69	28152594
282	Phosphorylation	RARRFSGLSAELRNQ HHHHHHCCCHHHHHH	4.20	20068231
283	Phosphorylation	ARRFSGLSAELRNQL HHHHHCCCHHHHHHH	24.19	28152594
305	N-linked_Glycosylation	QLGLDAPNGSDSSPQ HHCCCCCCCCCCCCC	65.41	UniProtKB CARBOHYD
368	N-linked_Glycosylation	SGAGGAANGTGAGAV CCCCCCCCCCCCCCC	48.28	UniProtKB CARBOHYD
379	N-linked_Glycosylation	AGAVMGPNATAEEGA CCCCCCCCCCCCCCC	44.16	UniProtKB CARBOHYD
420	N-linked_Glycosylation	QPILCGNNRTIEPEA CEEECCCCCCCCHHH	27.96	UniProtKB CARBOHYD
422	Phosphorylation	ILCGNNRTIEPEALR EECCCCCCCCHHHHH	31.64	30108239
432	N-linked_Glycosylation	PEALRRGNMSSLGFT HHHHHCCCCHHCCCC	25.92	UniProtKB CARBOHYD
476	N-linked_Glycosylation	DRVILKANETFAFVG CEEEECCCCCEEEEC	47.45	UniProtKB CARBOHYD
484	N-linked_Glycosylation	ETFAFVGNVTHYAQV CCEEEECCCHHEEEH	30.16	UniProtKB CARBOHYD
494	N-linked_Glycosylation	HYAQVWLNISAEIRS HEEEHHHHHHHHHHH	15.51	UniProtKB CARBOHYD
530	N-linked_Glycosylation	RLHPEALNLSLDELP CCCHHHHCCCHHHCC	34.33	UniProtKB CARBOHYD
544	N-linked_Glycosylation	PPALRQDNFSLPSGM CHHHCCCCCCCCHHH	21.77	UniProtKB CARBOHYD
590	N-linked_Glycosylation	HDEESIVNYTLNQAY CCHHHHHHHCCCHHH	23.54	UniProtKB CARBOHYD
600	N-linked_Glycosylation	LNQAYQDNVTVFASV CCHHHHCCCEEEEEE	18.81	UniProtKB CARBOHYD
628	N-linked_Glycosylation	VHYKIRQNSSFTEKT EEEEECCCCCCCHHC	29.76	UniProtKB CARBOHYD
958	Phosphorylation	WARTPRLSVMEEDQA CCCCCCCCCHHHHHH	22.24	113334045
989	Phosphorylation	EPTHLPLVVCVDKLT CCCCCCEEEEHHHHH	2.71	27251275
1045	Phosphorylation	TGLFPPTSGSATIYG CCCCCCCCCCCEECC	36.20	27660413
1047	Phosphorylation	LFPPTSGSATIYGHD CCCCCCCCCEECCCC	23.23	19835603
1049	Phosphorylation	PPTSGSATIYGHDIR CCCCCCCEECCCCHH	19.21	27660419
1051	Phosphorylation	TSGSATIYGHDIRTE CCCCCEECCCCHHHH	12.21	19835603
1057	Phosphorylation	IYGHDIRTEMDEIRK ECCCCHHHHHHHHHH	35.68	19835603
1076	Phosphorylation	CPQHNVLFDRLTVEE CCCCCCHHCCCCHHH	4.47	-
1078	Phosphorylation	QHNVLFDRLTVEEHL CCCCHHCCCCHHHHH	25.56	-
1080	Phosphorylation	NVLFDRLTVEEHLWF CCHHCCCCHHHHHHH	27.11	-
1082	Phosphorylation	LFDRLTVEEHLWFYS HHCCCCHHHHHHHHH	34.17	-
1088	Phosphorylation	VEEHLWFYSRLKSMA HHHHHHHHHHHHHHH	4.94	-
1093	Phosphorylation	WFYSRLKSMAQEEIR HHHHHHHHHHHHHHH	24.76	20068231
1105	Ubiquitination	EIRREMDKMIEDLEL HHHHHHHHHHHHHHH	40.23	-
1113	Phosphorylation	MIEDLELSNKRHSLV HHHHHHHHHHHHHHH	30.81	28555341
1115	Ubiquitination	EDLELSNKRHSLVQT HHHHHHHHHHHHHHH	48.38	23503661
1115 (in isoform 2)	Ubiquitination	-	48.38	-
1116	Ubiquitination	DLELSNKRHSLVQTL HHHHHHHHHHHHHHH	28.95	23503661
1118	Phosphorylation	ELSNKRHSLVQTLSG HHHHHHHHHHHHHHH	33.98	50558411
1124	Phosphorylation	HSLVQTLSGGMKRKL HHHHHHHHHHHHHHE	36.37	50558419
1128	Methylation	QTLSGGMKRKLSVAI HHHHHHHHHHEEEEE	50.05	-
1128	Ubiquitination	QTLSGGMKRKLSVAI HHHHHHHHHHEEEEE	50.05	23503661
1128 (in isoform 2)	Ubiquitination	-	50.05	-
1129	Ubiquitination	TLSGGMKRKLSVAIA HHHHHHHHHEEEEEE	35.93	23503661
1130	Ubiquitination	LSGGMKRKLSVAIAF HHHHHHHHEEEEEEE	39.33	23503661
1131	Ubiquitination	SGGMKRKLSVAIAFV HHHHHHHEEEEEEEE	6.05	23503661
1132	Phosphorylation	GGMKRKLSVAIAFVG HHHHHHEEEEEEEEC	16.73	46156375
1141	O-linked_Glycosylation	AIAFVGGSRAIILDE EEEEECCCEEEEECC	16.77	28510447
1146	Ubiquitination	GGSRAIILDEPTAGV CCCEEEEECCCCCCC	5.08	23503661
1159	Methylation	GVDPYARRAIWDLIL CCCHHHHHHHHHHHH	23.42	-
1159	Ubiquitination	GVDPYARRAIWDLIL CCCHHHHHHHHHHHH	23.42	23503661
1161	Ubiquitination	DPYARRAIWDLILKY CHHHHHHHHHHHHHC	2.52	23503661
1167	Acetylation	AIWDLILKYKPGRTI HHHHHHHHCCCCCEE	44.21	7306317
1216	Phosphorylation	KGTYGDGYRLTLVKR EECCCCCEEEEEEEC	13.74	24719451
1219	Phosphorylation	YGDGYRLTLVKRPAE CCCCEEEEEEECCCC	22.10	24719451
1222	Ubiquitination	GYRLTLVKRPAEPGG CEEEEEEECCCCCCC	56.64	21906983
1222 (in isoform 2)	Ubiquitination	-	56.64	21906983
1223 (in isoform 1)	Ubiquitination	-	28.34	21906983
1237	Phosphorylation	PQEPGLASSPPGRAP CCCCCCCCCCCCCCC	48.71	30266825
1238	Phosphorylation	QEPGLASSPPGRAPL CCCCCCCCCCCCCCC	29.52	30266825
1247	Phosphorylation	PGRAPLSSCSELQVS CCCCCCCCCCHHHHH	29.37	24719451
1250	Phosphorylation	APLSSCSELQVSQFI CCCCCCCHHHHHHHH	47.77	24719451
1253	Ubiquitination	SSCSELQVSQFIRKH CCCCHHHHHHHHHHH	8.31	-
1268	Phosphorylation	VASCLLVSDTSTELS HHHHEEEECCCCCHH	34.83	32142685
1269	Phosphorylation	ASCLLVSDTSTELSY HHHEEEECCCCCHHH	36.88	-
1322	Phosphorylation	EEVFLKVSEEDQSLE HHHHHHHCHHHHHHC	33.41	22167270
1327	Phosphorylation	KVSEEDQSLENSEAD HHCHHHHHHCCCCCH	50.39	22167270
1331	Phosphorylation	EDQSLENSEADVKES HHHHHCCCCCHHHHH	25.45	22167270
1336	Ubiquitination	ENSEADVKESRKDVL CCCCCHHHHHHHCCC	50.98	21906983
1336 (in isoform 2)	Ubiquitination	-	50.98	21906983
1337	Ubiquitination	NSEADVKESRKDVLP CCCCHHHHHHHCCCC	56.47	21963094
1337 (in isoform 1)	Ubiquitination	-	56.47	21906983
1338	Phosphorylation	SEADVKESRKDVLPG CCCHHHHHHHCCCCC	38.62	28450419
1341	Ubiquitination	DVKESRKDVLPGAEG HHHHHHHCCCCCCCC	46.18	29967540
1351	Phosphorylation	PGAEGPASGEGHAGN CCCCCCCCCCCCCHH	40.28	25159151
1358	Phosphorylation	SGEGHAGNLARCSEL CCCCCCHHHHHHHHH	31.17	24719451
1362	Phosphorylation	HAGNLARCSELTQSQ CCHHHHHHHHHHHHH	2.85	24719451
1367	Ubiquitination	ARCSELTQSQASLQS HHHHHHHHHHHHHHH	46.28	21963094
1371	Phosphorylation	ELTQSQASLQSASSV HHHHHHHHHHHCHHC	21.21	24275569
1371	Ubiquitination	ELTQSQASLQSASSV HHHHHHHHHHHCHHC	21.21	29967540
1374	Phosphorylation	QSQASLQSASSVGSA HHHHHHHHCHHCCCC	35.10	24275569
1376	Phosphorylation	QASLQSASSVGSARG HHHHHHCHHCCCCCC	30.70	24275569
1377	Phosphorylation	ASLQSASSVGSARGD HHHHHCHHCCCCCCC	30.16	24275569
1382	Phosphorylation	ASSVGSARGDEGAGY CHHCCCCCCCCCCCC	55.59	-
1389	Phosphorylation	RGDEGAGYTDVYGDY CCCCCCCCCCCCCCC	10.15	23663014
1390	Phosphorylation	GDEGAGYTDVYGDYR CCCCCCCCCCCCCCC	20.33	23663014
1393	Phosphorylation	GAGYTDVYGDYRPLF CCCCCCCCCCCCCCC	13.69	23663014
1396	Phosphorylation	YTDVYGDYRPLFDNP CCCCCCCCCCCCCCC	15.12	23663014
1408	N-linked_Glycosylation	DNPQDPDNVSLQEVE CCCCCCCCCCHHHHH	30.57	UniProtKB CARBOHYD
1410	Phosphorylation	PQDPDNVSLQEVEAE CCCCCCCCHHHHHHH	30.50	23663014
1424	Phosphorylation	EALSRVGQGSRKLDG HHHHHCCCCCCCCCC	43.78	-
1441	Phosphorylation	LKVRQFHGLLVKRFH EEEEEHHHHHHHHHH	23.22	27251275
1496	N-linked_Glycosylation	LSPSQYHNYTQPRGN CCHHHCCCCCCCCCC	36.29	UniProtKB CARBOHYD
1530	Phosphorylation	ASPQQLVSTFRLPSG CCHHHHHEEEECCCC	30.35	46156387
1531	Phosphorylation	SPQQLVSTFRLPSGV CHHHHHEEEECCCCC	12.80	46156405
1549	N-linked_Glycosylation	CVLKSPANGSLGPTL EEEECCCCCCCCCEE	43.93	UniProtKB CARBOHYD
1551	Phosphorylation	LKSPANGSLGPTLNL EECCCCCCCCCEEEC	29.93	28348404
1555	Phosphorylation	ANGSLGPTLNLSSGE CCCCCCCEEECCCHH	26.87	24719451
1557	N-linked_Glycosylation	GSLGPTLNLSSGESR CCCCCEEECCCHHHH	40.11	UniProtKB CARBOHYD
1559	Phosphorylation	LGPTLNLSSGESRLL CCCEEECCCHHHHHH	34.91	24719451
1560	Phosphorylation	GPTLNLSSGESRLLA CCEEECCCHHHHHHH	50.15	28348404
1563	Phosphorylation	LNLSSGESRLLAARF EECCCHHHHHHHHHH	31.58	27251275
1582	Phosphorylation	CLESFTQGLPLSNFV HHHHHCCCCCHHHCC	26.63	27251275
1586	Phosphorylation	FTQGLPLSNFVPPPP HCCCCCHHHCCCCCC	26.70	24719451
1590	Phosphorylation	LPLSNFVPPPPSPAP CCHHHCCCCCCCCCC	31.38	24719451
1591	Phosphorylation	PLSNFVPPPPSPAPS CHHHCCCCCCCCCCC	48.40	27251275
1594	Phosphorylation	NFVPPPPSPAPSDSP HCCCCCCCCCCCCCC	39.19	24719451
1612	N-linked_Glycosylation	DEDLQAWNVSLPPTA CCCHHHCCCCCCCCC	19.26	UniProtKB CARBOHYD
1677	N-linked_Glycosylation	LTDITGHNVSEYLLF HHHCCCCCHHHEEEE	40.11	UniProtKB CARBOHYD
1694	Phosphorylation	DRFRLHRYGAITFGN CCCEEEECCCEEECH	10.52	18083107
1704	Ubiquitination	ITFGNVLKSIPASFG EEECHHHHHCCCCCC	41.90	-
1705	Phosphorylation	TFGNVLKSIPASFGT EECHHHHHCCCCCCC	29.64	21712546
1712	Phosphorylation	SIPASFGTRAPPMVR HCCCCCCCCCCHHHH	22.96	21712546
1731	Phosphorylation	RRAAQVFYNNKGYHS HHHHHHHHCCCCCCC	20.97	68736307
1735	Ubiquitination	QVFYNNKGYHSMPTY HHHHCCCCCCCCCHH	27.75	-
1736	Phosphorylation	VFYNNKGYHSMPTYL HHHCCCCCCCCCHHH	7.73	27732954
1738	Phosphorylation	YNNKGYHSMPTYLNS HCCCCCCCCCHHHHH	20.27	27732954
1741	Phosphorylation	KGYHSMPTYLNSLNN CCCCCCCHHHHHHHH	31.81	27732954
1742	Phosphorylation	GYHSMPTYLNSLNNA CCCCCCHHHHHHHHH	9.67	27732954
1743	Phosphorylation	YHSMPTYLNSLNNAI CCCCCHHHHHHHHHH	3.74	-
1745	Phosphorylation	SMPTYLNSLNNAILR CCCHHHHHHHHHHHH	29.85	27732954
1775	N-linked_Glycosylation	TVTNHPMNKTSASLS EECCCCCCCCCCHHC	49.24	UniProtKB CARBOHYD
1981	Phosphorylation	GQFDKMKSPFEWDIV CCCCCCCCCCCHHHH	31.18	29083192
2025	Ubiquitination	QRMPVSTKPVEDDVD CCCCCCCCCCCCCCC	39.29	2190698
2025 (in isoform 2)	Ubiquitination	-	39.29	21906983
2026	Ubiquitination	RMPVSTKPVEDDVDV CCCCCCCCCCCCCCH	34.51	29901268
2026 (in isoform 1)	Ubiquitination	-	34.51	21906983
2035	Phosphorylation	EDDVDVASERQRVLR CCCCCHHHHHHHHHC	32.91	24043423
2054	N-linked_Glycosylation	NDMVKIENLTKVYKS CCCEEEHHHHHHHHH	57.39	UniProtKB CARBOHYD
2056	Phosphorylation	MVKIENLTKVYKSRK CEEEHHHHHHHHHCC	30.00	29405407
2056	Ubiquitination	MVKIENLTKVYKSRK CEEEHHHHHHHHHCC	30.00	29901268
2087	Phosphorylation	GECFGLLGVNGAGKT CCEEEEEECCCCCCC	18.84	-
2101	Phosphorylation	TSTFKMLTGDESTTG CEEEEECCCCCCCCC	38.80	10081147
2117	Phosphorylation	EAFVNGHSVLKELLQ CCCCCHHHHHHHHHH	30.46	10081157
2178	Phosphorylation	EKLELTKYADKPAGT HHHCCCCCCCCCCCC	18.13	18083107
2186	Phosphorylation	ADKPAGTYSGGNKRK CCCCCCCCCCCCCCH	12.37	18083107
2242	Phosphorylation	GRSVVLTSHSMEECE CCCEEEECCCHHHHH	14.92	-
2322	Phosphorylation	KVQYQLKSEHISLAQ HHHHHHHHHCCCHHH	42.89	68714267
2326	Phosphorylation	QLKSEHISLAQVFSK HHHHHCCCHHHHHHH	21.40	68714273
2332	Phosphorylation	ISLAQVFSKMEQVSG CCHHHHHHHHHHHCC	32.03	68714279
2381	Phosphorylation	EPPSALQSPLGCLLS CCCCHHHCHHHHHHH	23.96	25159151
2397	Phosphorylation	LRPRSAPTELRALVA HCCCCCCHHHHHHHC	47.57	24719451
2412	Phosphorylation	DEPEDLDTEDEGLIS CCCCCCCCCCCCCCC	53.27	10470851
2413	Phosphorylation	EPEDLDTEDEGLISF CCCCCCCCCCCCCCH	54.45	32142685
2419	Phosphorylation	TEDEGLISFEEERAQ CCCCCCCCHHHHHHH	31.48	25849741
2428	Phosphorylation	EEERAQLSFNTDTLC HHHHHHHHCCCCCCC	12.36	20873877
2431	Phosphorylation	RAQLSFNTDTLC--- HHHHHCCCCCCC---	28.49	20873877
2433	Phosphorylation	QLSFNTDTLC----- HHHCCCCCCC-----	28.17	27134283
2443	Phosphorylation	--------------- ---------------		24719451
2450	Phosphorylation	---------------------- ----------------------		-
2459	Phosphorylation	------------------------------- -------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ABCA2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
271	Q	Methylation		26797129
Methylated at Gln-271 by N6AMT1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ABCA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CK5P2_HUMAN	CDK5RAP2	physical	12421765

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ABCA2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1327 AND SER-1331, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2412, AND MASSSPECTROMETRY.	18669648 [Abstract]

show