| UniProt ID | SDHA_HUMAN | |
|---|---|---|
| UniProt AC | P31040 | |
| Protein Name | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | |
| Gene Name | SDHA | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 664 | |
| Subcellular Localization |
Mitochondrion inner membrane Peripheral membrane protein Matrix side . |
|
| Protein Description | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). [PubMed: 24781757 Can act as a tumor suppressor] | |
| Protein Sequence | MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEADCATVPPAIRSY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | RGLSRLLSARRLALA HHHHHHHHHHHHHHH | 24719451 | ||
| 24 | Phosphorylation | ALAKAWPTVLQTGTR HHHHHHCCEECCCCC | 20068231 | ||
| 28 | Phosphorylation | AWPTVLQTGTRGFHF HHCCEECCCCCEEEE | 20068231 | ||
| 30 | Phosphorylation | PTVLQTGTRGFHFTV CCEECCCCCEEEEEE | 20068231 | ||
| 41 | Ubiquitination | HFTVDGNKRASAKVS EEEECCCCCCCEEEC | - | ||
| 91 | Phosphorylation | GFNTACVTKLFPTRS CCCCEEEEECCCCCC | 21601212 | ||
| 92 | Ubiquitination | FNTACVTKLFPTRSH CCCEEEEECCCCCCH | 21890473 | ||
| 92 | Ubiquitination | FNTACVTKLFPTRSH CCCEEEEECCCCCCH | - | ||
| 92 | Ubiquitination | FNTACVTKLFPTRSH CCCEEEEECCCCCCH | 21890473 | ||
| 98 | Phosphorylation | TKLFPTRSHTVAAQG EECCCCCCHHHHHCC | 26437602 | ||
| 98 | Ubiquitination | TKLFPTRSHTVAAQG EECCCCCCHHHHHCC | 21890473 | ||
| 99 | Tele-8alpha-FAD histidine | KLFPTRSHTVAAQGG ECCCCCCHHHHHCCC | - | ||
| 99 | Other | KLFPTRSHTVAAQGG ECCCCCCHHHHHCCC | - | ||
| 100 | Phosphorylation | LFPTRSHTVAAQGGI CCCCCCHHHHHCCCH | 26437602 | ||
| 124 | Phosphorylation | DNWRWHFYDTVKGSD CCCEEEEEECCCCCC | 29496907 | ||
| 131 | Acetylation | YDTVKGSDWLGDQDA EECCCCCCCCCCCCH | 19608861 | ||
| 131 | Ubiquitination | YDTVKGSDWLGDQDA EECCCCCCCCCCCCH | 19608861 | ||
| 167 | 2-Hydroxyisobutyrylation | FSRTEDGKIYQRAFG CCCCCCCCEEEEECC | - | ||
| 167 | Acetylation | FSRTEDGKIYQRAFG CCCCCCCCEEEEECC | 25953088 | ||
| 167 | Ubiquitination | FSRTEDGKIYQRAFG CCCCCCCCEEEEECC | - | ||
| 169 | Phosphorylation | RTEDGKIYQRAFGGQ CCCCCCEEEEECCCC | 29496907 | ||
| 177 | Phosphorylation | QRAFGGQSLKFGKGG EEECCCCCCEECCCC | - | ||
| 179 | Ubiquitination | AFGGQSLKFGKGGQA ECCCCCCEECCCCCC | 21890473 | ||
| 179 | 2-Hydroxyisobutyrylation | AFGGQSLKFGKGGQA ECCCCCCEECCCCCC | - | ||
| 179 | Acetylation | AFGGQSLKFGKGGQA ECCCCCCEECCCCCC | 19608861 | ||
| 179 | Malonylation | AFGGQSLKFGKGGQA ECCCCCCEECCCCCC | 26320211 | ||
| 179 | Succinylation | AFGGQSLKFGKGGQA ECCCCCCEECCCCCC | - | ||
| 179 | Succinylation | AFGGQSLKFGKGGQA ECCCCCCEECCCCCC | - | ||
| 179 | Ubiquitination | AFGGQSLKFGKGGQA ECCCCCCEECCCCCC | 21890473 | ||
| 182 | Acetylation | GQSLKFGKGGQAHRC CCCCEECCCCCCEEE | - | ||
| 182 | Succinylation | GQSLKFGKGGQAHRC CCCCEECCCCCCEEE | 27452117 | ||
| 196 | Phosphorylation | CCCVADRTGHSLLHT EEEECCCCCCHHHHH | 28152594 | ||
| 199 | Phosphorylation | VADRTGHSLLHTLYG ECCCCCCHHHHHHHC | 28152594 | ||
| 203 | Phosphorylation | TGHSLLHTLYGRSLR CCCHHHHHHHCCCCC | 28152594 | ||
| 205 | Phosphorylation | HSLLHTLYGRSLRYD CHHHHHHHCCCCCCC | 28152594 | ||
| 215 | Phosphorylation | SLRYDTSYFVEYFAL CCCCCCHHHHHHHHH | 22823520 | ||
| 243 | Phosphorylation | ALCIEDGSIHRIRAK EEEECCCCEEEEEEC | 26437602 | ||
| 250 | 2-Hydroxyisobutyrylation | SIHRIRAKNTVVATG CEEEEEECCEEEEEC | - | ||
| 250 | Acetylation | SIHRIRAKNTVVATG CEEEEEECCEEEEEC | - | ||
| 250 | Malonylation | SIHRIRAKNTVVATG CEEEEEECCEEEEEC | 26320211 | ||
| 250 | Succinylation | SIHRIRAKNTVVATG CEEEEEECCEEEEEC | - | ||
| 250 | Succinylation | SIHRIRAKNTVVATG CEEEEEECCEEEEEC | - | ||
| 250 | Ubiquitination | SIHRIRAKNTVVATG CEEEEEECCEEEEEC | 21906983 | ||
| 252 | Phosphorylation | HRIRAKNTVVATGGY EEEEECCEEEEECCC | 21082442 | ||
| 256 | Phosphorylation | AKNTVVATGGYGRTY ECCEEEEECCCCCEE | 28152594 | ||
| 259 | Phosphorylation | TVVATGGYGRTYFSC EEEEECCCCCEEEEE | 28152594 | ||
| 287 | Ubiquitination | ITRAGLPCQDLEFVQ EEECCCCCCCCEEEE | - | ||
| 287 | Acetylation | ITRAGLPCQDLEFVQ EEECCCCCCCCEEEE | 19608861 | ||
| 287 | Ubiquitination | ITRAGLPCQDLEFVQ EEECCCCCCCCEEEE | 19608861 | ||
| 321 | Phosphorylation | EGGILINSQGERFME CCCEEECCCCHHHHH | 21712546 | ||
| 335 | Ubiquitination | ERYAPVAKDLASRDV HHHHHHHHHHHCCCC | 21890473 | ||
| 335 | 2-Hydroxyisobutyrylation | ERYAPVAKDLASRDV HHHHHHHHHHHCCCC | - | ||
| 335 | Acetylation | ERYAPVAKDLASRDV HHHHHHHHHHHCCCC | 19608861 | ||
| 335 | Succinylation | ERYAPVAKDLASRDV HHHHHHHHHHHCCCC | - | ||
| 335 | Succinylation | ERYAPVAKDLASRDV HHHHHHHHHHHCCCC | 27452117 | ||
| 335 | Ubiquitination | ERYAPVAKDLASRDV HHHHHHHHHHHCCCC | 19608861 | ||
| 341 | Ubiquitination | AKDLASRDVVSRSMT HHHHHCCCCCCHHEE | 21890473 | ||
| 344 | Phosphorylation | LASRDVVSRSMTLEI HHCCCCCCHHEEEEE | 23403867 | ||
| 346 | Phosphorylation | SRDVVSRSMTLEIRE CCCCCCHHEEEEEEC | 21601212 | ||
| 347 | Sulfoxidation | RDVVSRSMTLEIREG CCCCCHHEEEEEECC | 28183972 | ||
| 348 | Phosphorylation | DVVSRSMTLEIREGR CCCCHHEEEEEECCC | 21601212 | ||
| 361 | Acetylation | GRGCGPEKDHVYLQL CCCCCCCCCCEEEEE | 25825284 | ||
| 365 | Phosphorylation | GPEKDHVYLQLHHLP CCCCCCEEEEECCCC | 22817900 | ||
| 372 | Ubiquitination | YLQLHHLPPEQLATR EEEECCCCHHHHHHC | 21890473 | ||
| 397 | Acetylation | FAGVDVTKEPIPVLP EECCCCCCCCCCCCC | 25038526 | ||
| 418 | Ubiquitination | GGIPTNYKGQVLRHV CCCCCCCCCCEEEEC | - | ||
| 436 | Phosphorylation | DQIVPGLYACGEAAC CCCCCCEEHHHHHHH | - | ||
| 456 | Phosphorylation | ANRLGANSLLDLVVF CCCCCCCHHHHHHHH | 28450419 | ||
| 469 | Ubiquitination | VFGRACALSIEESCR HHCHHHHHCHHHHCC | - | ||
| 480 | Acetylation | ESCRPGDKVPPIKPN HHCCCCCCCCCCCCC | - | ||
| 485 | Acetylation | GDKVPPIKPNAGEES CCCCCCCCCCCCCCC | - | ||
| 485 | Succinylation | GDKVPPIKPNAGEES CCCCCCCCCCCCCCC | - | ||
| 485 | Succinylation | GDKVPPIKPNAGEES CCCCCCCCCCCCCCC | 27452117 | ||
| 485 | Ubiquitination | GDKVPPIKPNAGEES CCCCCCCCCCCCCCC | - | ||
| 490 | Ubiquitination | PIKPNAGEESVMNLD CCCCCCCCCCCCCHH | - | ||
| 493 | Acetylation | PNAGEESVMNLDKLR CCCCCCCCCCHHHCE | - | ||
| 493 | Ubiquitination | PNAGEESVMNLDKLR CCCCCCCCCCHHHCE | - | ||
| 493 | Acetylation | PNAGEESVMNLDKLR CCCCCCCCCCHHHCE | 19608861 | ||
| 498 | 2-Hydroxyisobutyrylation | ESVMNLDKLRFADGS CCCCCHHHCEECCCC | - | ||
| 498 | Acetylation | ESVMNLDKLRFADGS CCCCCHHHCEECCCC | 20167786 | ||
| 498 | Succinylation | ESVMNLDKLRFADGS CCCCCHHHCEECCCC | - | ||
| 498 | Succinylation | ESVMNLDKLRFADGS CCCCCHHHCEECCCC | - | ||
| 498 | Ubiquitination | ESVMNLDKLRFADGS CCCCCHHHCEECCCC | - | ||
| 499 | Acetylation | SVMNLDKLRFADGSI CCCCHHHCEECCCCC | - | ||
| 499 | Ubiquitination | SVMNLDKLRFADGSI CCCCHHHCEECCCCC | - | ||
| 499 | Acetylation | SVMNLDKLRFADGSI CCCCHHHCEECCCCC | 19608861 | ||
| 500 | Methylation | VMNLDKLRFADGSIR CCCHHHCEECCCCCH | 115493475 | ||
| 502 | Ubiquitination | NLDKLRFADGSIRTS CHHHCEECCCCCHHH | - | ||
| 507 | Methylation | RFADGSIRTSELRLS EECCCCCHHHHHHHH | 115493485 | ||
| 508 | Phosphorylation | FADGSIRTSELRLSM ECCCCCHHHHHHHHH | 26437602 | ||
| 509 | Phosphorylation | ADGSIRTSELRLSMQ CCCCCHHHHHHHHHH | 26437602 | ||
| 512 | Methylation | SIRTSELRLSMQKSM CCHHHHHHHHHHHHH | 115493495 | ||
| 514 | Phosphorylation | RTSELRLSMQKSMQN HHHHHHHHHHHHHHC | 26437602 | ||
| 517 | Acetylation | ELRLSMQKSMQNHAA HHHHHHHHHHHCCCH | 25953088 | ||
| 517 | Malonylation | ELRLSMQKSMQNHAA HHHHHHHHHHHCCCH | 26320211 | ||
| 517 | Ubiquitination | ELRLSMQKSMQNHAA HHHHHHHHHHHCCCH | - | ||
| 518 | Phosphorylation | LRLSMQKSMQNHAAV HHHHHHHHHHCCCHH | 29978859 | ||
| 519 | Sulfoxidation | RLSMQKSMQNHAAVF HHHHHHHHHCCCHHH | 28183972 | ||
| 530 | Phosphorylation | AAVFRVGSVLQEGCG CHHHHHHHHHHHCCH | 30108239 | ||
| 536 | S-nitrosylation | GSVLQEGCGKISKLY HHHHHHCCHHHHHHH | 25040305 | ||
| 538 | 2-Hydroxyisobutyrylation | VLQEGCGKISKLYGD HHHHCCHHHHHHHHC | - | ||
| 538 | Acetylation | VLQEGCGKISKLYGD HHHHCCHHHHHHHHC | 25953088 | ||
| 538 | Malonylation | VLQEGCGKISKLYGD HHHHCCHHHHHHHHC | 26320211 | ||
| 538 | Succinylation | VLQEGCGKISKLYGD HHHHCCHHHHHHHHC | - | ||
| 538 | Succinylation | VLQEGCGKISKLYGD HHHHCCHHHHHHHHC | 27452117 | ||
| 538 | Ubiquitination | VLQEGCGKISKLYGD HHHHCCHHHHHHHHC | - | ||
| 541 | 2-Hydroxyisobutyrylation | EGCGKISKLYGDLKH HCCHHHHHHHHCHHH | - | ||
| 541 | Acetylation | EGCGKISKLYGDLKH HCCHHHHHHHHCHHH | 19608861 | ||
| 541 | Malonylation | EGCGKISKLYGDLKH HCCHHHHHHHHCHHH | 26320211 | ||
| 541 | Succinylation | EGCGKISKLYGDLKH HCCHHHHHHHHCHHH | 27452117 | ||
| 541 | Ubiquitination | EGCGKISKLYGDLKH HCCHHHHHHHHCHHH | 19608861 | ||
| 543 | Phosphorylation | CGKISKLYGDLKHLK CHHHHHHHHCHHHCC | 29496907 | ||
| 547 | Acetylation | SKLYGDLKHLKTFDR HHHHHCHHHCCCCCC | 25825284 | ||
| 547 | Methylation | SKLYGDLKHLKTFDR HHHHHCHHHCCCCCC | 92565 | ||
| 547 | Succinylation | SKLYGDLKHLKTFDR HHHHHCHHHCCCCCC | - | ||
| 547 | Succinylation | SKLYGDLKHLKTFDR HHHHHCHHHCCCCCC | - | ||
| 547 | Ubiquitination | SKLYGDLKHLKTFDR HHHHHCHHHCCCCCC | 19608861 | ||
| 550 | Acetylation | YGDLKHLKTFDRGMV HHCHHHCCCCCCCCC | 27452117 | ||
| 550 | Succinylation | YGDLKHLKTFDRGMV HHCHHHCCCCCCCCC | 23954790 | ||
| 550 | Ubiquitination | YGDLKHLKTFDRGMV HHCHHHCCCCCCCCC | - | ||
| 560 | Ubiquitination | DRGMVWNTDLVETLE CCCCCCCCCHHHHHH | - | ||
| 560 | Acetylation | DRGMVWNTDLVETLE CCCCCCCCCHHHHHH | 19608861 | ||
| 560 | Phosphorylation | DRGMVWNTDLVETLE CCCCCCCCCHHHHHH | 30257219 | ||
| 560 | Ubiquitination | DRGMVWNTDLVETLE CCCCCCCCCHHHHHH | 19608861 | ||
| 565 | Phosphorylation | WNTDLVETLELQNLM CCCCHHHHHHHHHHH | 30257219 | ||
| 585 | Methylation | TIYGAEARKESRGAH HHHCHHHHHHHCCCC | 115385205 | ||
| 589 | Methylation | AEARKESRGAHARED HHHHHHHCCCCCCCC | 115385215 | ||
| 594 | Methylation | ESRGAHAREDYKVRI HHCCCCCCCCCEEEE | 115385225 | ||
| 598 | Acetylation | AHAREDYKVRIDEYD CCCCCCCEEEEEECC | 2402329 | ||
| 604 | Phosphorylation | YKVRIDEYDYSKPIQ CEEEEEECCCCCCCC | 28152594 | ||
| 606 | Phosphorylation | VRIDEYDYSKPIQGQ EEEEECCCCCCCCCC | 28152594 | ||
| 607 | Phosphorylation | RIDEYDYSKPIQGQQ EEEECCCCCCCCCCC | 28152594 | ||
| 608 | 2-Hydroxyisobutyrylation | IDEYDYSKPIQGQQK EEECCCCCCCCCCCC | - | ||
| 608 | Acetylation | IDEYDYSKPIQGQQK EEECCCCCCCCCCCC | 19608861 | ||
| 608 | Malonylation | IDEYDYSKPIQGQQK EEECCCCCCCCCCCC | 26320211 | ||
| 608 | Succinylation | IDEYDYSKPIQGQQK EEECCCCCCCCCCCC | 27452117 | ||
| 608 | Ubiquitination | IDEYDYSKPIQGQQK EEECCCCCCCCCCCC | 19608861 | ||
| 615 | Succinylation | KPIQGQQKKPFEEHW CCCCCCCCCCHHHHH | - | ||
| 615 | Succinylation | KPIQGQQKKPFEEHW CCCCCCCCCCHHHHH | 23954790 | ||
| 616 | Malonylation | PIQGQQKKPFEEHWR CCCCCCCCCHHHHHH | 26320211 | ||
| 616 | Ubiquitination | PIQGQQKKPFEEHWR CCCCCCCCCHHHHHH | - | ||
| 624 | 2-Hydroxyisobutyrylation | PFEEHWRKHTLSYVD CHHHHHHHCEEEEEE | - | ||
| 624 | Acetylation | PFEEHWRKHTLSYVD CHHHHHHHCEEEEEE | 25825284 | ||
| 624 | Ubiquitination | PFEEHWRKHTLSYVD CHHHHHHHCEEEEEE | - | ||
| 626 | Phosphorylation | EEHWRKHTLSYVDVG HHHHHHCEEEEEECC | 28152594 | ||
| 628 | Phosphorylation | HWRKHTLSYVDVGTG HHHHCEEEEEECCCC | 28152594 | ||
| 629 | Phosphorylation | WRKHTLSYVDVGTGK HHHCEEEEEECCCCE | 28152594 | ||
| 634 | Phosphorylation | LSYVDVGTGKVTLEY EEEEECCCCEEEEEE | 24905233 | ||
| 636 | Acetylation | YVDVGTGKVTLEYRP EEECCCCEEEEEEEE | - | ||
| 641 | Phosphorylation | TGKVTLEYRPVIDKT CCEEEEEEEECCCCC | 28152594 | ||
| 647 | Acetylation | EYRPVIDKTLNEADC EEEECCCCCCCHHHH | 25038526 | ||
| 647 | Ubiquitination | EYRPVIDKTLNEADC EEEECCCCCCCHHHH | - | ||
| 662 | Methylation | ATVPPAIRSY----- CCCCHHHHCC----- | 115367833 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 215 | Y | Phosphorylation | Kinase | SRC | P12931 | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SDHA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SDHA_HUMAN !! | ||||||
| Kegg Disease | |
|---|---|
| H00294 | Dilated cardiomyopathy (DCM) |
| H00473 | Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency ( |
| H01022 | Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogena |
| OMIM Disease | |
| 252011 | Mitochondrial complex II deficiency (MT-C2D) |
| 256000 | Leigh syndrome (LS) |
| 613642 | Cardiomyopathy, dilated 1GG (CMD1GG) |
| 614165 | Paragangliomas 5 (PGL5) |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB00139 | Succinic acid |
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