dbPTM

SDHF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SDHF4_HUMAN
UniProt AC	Q5VUM1
Protein Name	Succinate dehydrogenase assembly factor 4, mitochondrial {ECO:0000303\|PubMed:24954416, ECO:0000312\|HGNC:HGNC:20957}
Gene Name	SDHAF4 {ECO:0000303\|PubMed:24954416, ECO:0000312\|HGNC:HGNC:20957}
Organism	Homo sapiens (Human).
Sequence Length	108
Subcellular Localization	Mitochondrion matrix .
Protein Description	Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. [PubMed: 24954416 Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity]
Protein Sequence	MTPSRLPWLLSWVSATAWRAARSPLLCHSLRKTSSSQGGKSELVKQSLKKPKLPEGRFDAPEDSHLEKEPLEKFPDDVNPVTKEKGGPRGPEPTRYGDWERKGRCIDF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
47	Phosphorylation	KSELVKQSLKKPKLP HHHHHHHHHCCCCCC		23186163
64	Phosphorylation	RFDAPEDSHLEKEPL CCCCCCCCCCCCCCH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SDHF4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SDHF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
47	Phosphorylation	46 (1)	Q ⇒ R	rs1048886	Type 2 diabetes	21490949

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLRX5_HUMAN	GLRX5	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
PREP_HUMAN	PITRM1	physical	27499296
TMLH_HUMAN	TMLHE	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SDHF4_HUMAN

Related Literatures of Post-Translational Modification