GLRX5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLRX5_HUMAN
• UniProt AC: Q86SX6
• Protein Name: Glutaredoxin-related protein 5, mitochondrial
• Gene Name: GLRX5
• Organism: Homo sapiens (Human).
• Sequence Length: 157
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. [PubMed: 20364084 Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase]
• Protein Sequence: MSGSLGRAAAALLRWGRGAGGGGLWGPGVRAAGSGAGGGGSAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIHSALLDEKKDQDSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	SGAGGGGSAEQLDAL CCCCCCCCHHHHHHH	31.72	-
53	2-Hydroxyisobutyrylation	DALVKKDKVVVFLKG HHHHCCCEEEEEECC	45.89	-
53	Acetylation	DALVKKDKVVVFLKG HHHHCCCEEEEEECC	45.89	25953088
59	Succinylation	DKVVVFLKGTPEQPQ CEEEEEECCCCCCCC	49.64	-
59	Succinylation	DKVVVFLKGTPEQPQ CEEEEEECCCCCCCC	49.64	-
85	Phosphorylation	RLHGVRDYAAYNVLD HHCCCCCCHHHHCCC	5.20	-
145	Phosphorylation	LKKLGIHSALLDEKK HHHHCCCHHHHHHHC	20.77	20068231
151	2-Hydroxyisobutyrylation	HSALLDEKKDQDSK- CHHHHHHHCCCCCC-	62.41	-
156	Phosphorylation	DEKKDQDSK------ HHHCCCCCC------	34.33	24719451
157	Acetylation	EKKDQDSK------- HHCCCCCC-------	73.06	2380821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLRX5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLRX5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLRX5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KEAP1_HUMAN	KEAP1	physical	21988832
BOLA1_HUMAN	BOLA1	physical	26344197
BOLA3_HUMAN	BOLA3	physical	26344197
GLOD4_HUMAN	GLOD4	physical	26344197
THIO_HUMAN	TXN	physical	26344197
BOLA1_HUMAN	BOLA1	physical	27532772
BOLA3_HUMAN	BOLA3	physical	27532772

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 205950: Anemia, sideroblastic, pyridoxine-refractory, autosomal recessive (PRARSA)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.