RAB21_HUMAN - dbPTM
RAB21_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAB21_HUMAN
UniProt AC Q9UL25
Protein Name Ras-related protein Rab-21
Gene Name RAB21
Organism Homo sapiens (Human).
Sequence Length 225
Subcellular Localization Endoplasmic reticulum membrane
Lipid-anchor . Golgi apparatus, trans-Golgi network . Golgi apparatus membrane . Early endosome membrane . Cytoplasmic vesicle membrane . Cleavage furrow . Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity
Protein Description Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity)..
Protein Sequence MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQPGTARRGVQIIDDEPQAQTSGGGCCSSG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAAGGGGG
------CCCCCCCCC		13.1525944712
16MethylationGGAAAAGRAYSFKVV
CHHHHCCCCCEEEEE		26.14115389263
19PhosphorylationAAAGRAYSFKVVLLG
HHCCCCCEEEEEEEC		20.0129514088
43AcetylationVLRYCENKFNDKHIT
HHHHHHHCCCCCCEE		24.2125953088
47AcetylationCENKFNDKHITTLQA
HHHCCCCCCEEHHHH		37.7025953088
50PhosphorylationKFNDKHITTLQASFL
CCCCCCEEHHHHHHH		22.6023312004
51PhosphorylationFNDKHITTLQASFLT
CCCCCEEHHHHHHHH		19.1023312004
55PhosphorylationHITTLQASFLTKKLN
CEEHHHHHHHHHCCC		14.0825159151
58PhosphorylationTLQASFLTKKLNIGG
HHHHHHHHHCCCCCC		24.9123312004
592-HydroxyisobutyrylationLQASFLTKKLNIGGK
HHHHHHHHCCCCCCE		58.36-
60MalonylationQASFLTKKLNIGGKR
HHHHHHHCCCCCCEE		41.3426320211
60UbiquitinationQASFLTKKLNIGGKR
HHHHHHHCCCCCCEE		41.34-
66AcetylationKKLNIGGKRVNLAIW
HCCCCCCEEEEEEEE		48.2125953088
66UbiquitinationKKLNIGGKRVNLAIW
HCCCCCCEEEEEEEE		48.21-
88PhosphorylationFHALGPIYYRDSNGA
HEEECCEEEECCCCC		8.7928152594
89PhosphorylationHALGPIYYRDSNGAI
EEECCEEEECCCCCE		14.5228152594
109UbiquitinationTDEDSFQKVKNWVKE
CCHHHHHHHHHHHHH		53.8422053931
115UbiquitinationQKVKNWVKELRKMLG
HHHHHHHHHHHHHHC		42.5219608861
115AcetylationQKVKNWVKELRKMLG
HHHHHHHHHHHHHHC		42.5219608861
115MalonylationQKVKNWVKELRKMLG
HHHHHHHHHHHHHHC		42.5226320211
138UbiquitinationGNKIDLEKERHVSIQ
CCCCCCCHHHCCCHH		68.31-
143PhosphorylationLEKERHVSIQEAESY
CCHHHCCCHHHHHHH		16.6630108239
149PhosphorylationVSIQEAESYAESVGA
CCHHHHHHHHHHHCC		36.3730108239
150PhosphorylationSIQEAESYAESVGAK
CHHHHHHHHHHHCCC		13.09-
157UbiquitinationYAESVGAKHYHTSAK
HHHHHCCCHHCCCHH		38.4722053931
1642-HydroxyisobutyrylationKHYHTSAKQNKGIEE
CHHCCCHHHCCCHHH		54.92-
164UbiquitinationKHYHTSAKQNKGIEE
CHHCCCHHHCCCHHH		54.92-
167UbiquitinationHTSAKQNKGIEELFL
CCCHHHCCCHHHHHH		59.79-
178UbiquitinationELFLDLCKRMIETAQ
HHHHHHHHHHHHHHC		52.91-
1782-HydroxyisobutyrylationELFLDLCKRMIETAQ
HHHHHHHHHHHHHHC		52.91-
179MethylationLFLDLCKRMIETAQV
HHHHHHHHHHHHHCC		30.25115389271
195PhosphorylationERAKGNGSSQPGTAR
HHHCCCCCCCCCCCC		29.7826699800
196PhosphorylationRAKGNGSSQPGTARR
HHCCCCCCCCCCCCC		41.6226699800
200PhosphorylationNGSSQPGTARRGVQI
CCCCCCCCCCCCEEE		24.5523403867
221GeranylgeranylationAQTSGGGCCSSG---
CCCCCCCCCCCC---		1.99-
222GeranylgeranylationQTSGGGCCSSG----
CCCCCCCCCCC----		4.03-
222MethylationQTSGGGCCSSG----
CCCCCCCCCCC----		4.03-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAB21_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAB21_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAB21_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DP13A_HUMANAPPL1physical
17581628
CCHL_HUMANHCCSphysical
27173435
GLCM_HUMANGBAphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAB21_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.

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