dbPTM

C560_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	C560_HUMAN
UniProt AC	Q99643
Protein Name	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Gene Name	SDHC
Organism	Homo sapiens (Human).
Sequence Length	169
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein.
Protein Description	Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)..
Protein Sequence	MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYSWSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFALVFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7 (in isoform 5)	Phosphorylation	-	23.55	23663014
35	Ubiquitination	VPLGTTAKEEMERFW CCCCCCCHHHHHHHH	52.71	21906983
35 (in isoform 2)	Ubiquitination	-	52.71	-
44 (in isoform 2)	Ubiquitination	-	40.30	-
60	Phosphorylation	SPHITIYSWSLPMAM CCCEEEEEECHHHHH	13.31	-
141	Ubiquitination	HLMWDLGKGLKIPQL HHHHHCCCCCCHHHH	69.26	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of C560_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of C560_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of C560_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
XRCC6_HUMAN	XRCC6	physical	21900206
GDIR1_HUMAN	ARHGDIA	physical	21900206

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
605373	Paragangliomas 3 (PGL3)
606864	Paraganglioma and gastric stromal sarcoma (PGGSS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00139	Succinic acid

Regulatory Network of C560_HUMAN

Related Literatures of Post-Translational Modification