IMPA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMPA3_HUMAN
• UniProt AC: Q9NX62
• Protein Name: Inositol monophosphatase 3
• Gene Name: IMPAD1
• Organism: Homo sapiens (Human).
• Sequence Length: 359
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein .
• Protein Description: May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation..
• Protein Sequence: MAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGEPGGGAAGPAAAADGGTVDLREMLAVSVLAAVRGGDEVRRVRESNVLHEKSKGKTREGAEDKMTSGDVLSNRKMFYLLKTAFPSVQINTEEHVDAADQEVILWDHKIPEDILKEVTTPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPMLGVIHKPFSEYTAWAMVDGGSNVKARSSYNEKTPRIVVSRSHSGMVKQVALQTFGNQTTIIPAGGAGYKVLALLDVPDKSQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLSGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKTGHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAPMGIRL -------CCCCCCCC	9.48	25732826
93	2-Hydroxyisobutyrylation	ESNVLHEKSKGKTRE HHCCCCCCCCCCCCC	46.88	-
98	Phosphorylation	HEKSKGKTREGAEDK CCCCCCCCCCCCCCC	42.49	24888630
98	O-linked_Glycosylation	HEKSKGKTREGAEDK CCCCCCCCCCCCCCC	42.49	55834449
106	Sulfoxidation	REGAEDKMTSGDVLS CCCCCCCCCCCCHHH	5.80	21406390
107	Phosphorylation	EGAEDKMTSGDVLSN CCCCCCCCCCCHHHC	34.99	24275569
107	O-linked_Glycosylation	EGAEDKMTSGDVLSN CCCCCCCCCCCHHHC	34.99	55833101
108	Phosphorylation	GAEDKMTSGDVLSNR CCCCCCCCCCHHHCH	29.51	23312004
108	O-linked_Glycosylation	GAEDKMTSGDVLSNR CCCCCCCCCCHHHCH	29.51	55833107
113	Phosphorylation	MTSGDVLSNRKMFYL CCCCCHHHCHHHHHH	34.14	23312004
116	2-Hydroxyisobutyrylation	GDVLSNRKMFYLLKT CCHHHCHHHHHHHHH	37.30	-
116	Ubiquitination	GDVLSNRKMFYLLKT CCHHHCHHHHHHHHH	37.30	21890473
156	Ubiquitination	KIPEDILKEVTTPKE CCCHHHHHHCCCCCC	50.93	21906983
162	Ubiquitination	LKEVTTPKEVPAESV HHHCCCCCCCCCCEE	70.07	-
224	Phosphorylation	WAMVDGGSNVKARSS EEEEECCCCCEECCC	43.93	22210691
230	Phosphorylation	GSNVKARSSYNEKTP CCCCEECCCCCCCCC	41.87	22210691
242	Phosphorylation	KTPRIVVSRSHSGMV CCCCEEEECCCCCCE	19.71	24719451
259	N-linked_Glycosylation	VALQTFGNQTTIIPA EEEEECCCEEEEEEC	31.66	12754519
259	N-linked_Glycosylation	VALQTFGNQTTIIPA EEEEECCCEEEEEEC	31.66	18695242
282	Ubiquitination	ALLDVPDKSQEKADL EEEECCCCCHHHCCE	48.22	21906983
282	2-Hydroxyisobutyrylation	ALLDVPDKSQEKADL EEEECCCCCHHHCCE	48.22	-
283	Phosphorylation	LLDVPDKSQEKADLY EEECCCCCHHHCCEE	51.45	27251275
338	Phosphorylation	IEGGLLASIRMNHQA CCCCCHHHHHHHHHH	15.65	24719451
349	Ubiquitination	NHQALVRKLPDLEKT HHHHHHHCCCCHHHH	57.82	-
355	Acetylation	RKLPDLEKTGHK--- HCCCCHHHHCCC---	68.08	7380193
356	Phosphorylation	KLPDLEKTGHK---- CCCCHHHHCCC----	34.83	24260401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMPA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMPA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMPA3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of IMPA3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614078: Chondrodysplasia with joint dislocations, GPAPP type (CDP-GPAPP)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.