LDH6A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LDH6A_HUMAN
• UniProt AC: Q6ZMR3
• Protein Name: L-lactate dehydrogenase A-like 6A
• Gene Name: LDHAL6A
• Organism: Homo sapiens (Human).
• Sequence Length: 332
• Subcellular Localization: Cytoplasm .
• Protein Description: Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed..
• Protein Sequence: MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLKGETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLMIPNITQYSPHCKLLIVTNPVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQRLGIHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYEMVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENGITDLIKVKLTLEEEACLQKSAETLWEIQKELKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATIKSELI ------CCCHHHHHH	20.31	-
5	Succinylation	---MATIKSELIKNF ---CCCHHHHHHHHH	33.26	-
5	Acetylation	---MATIKSELIKNF ---CCCHHHHHHHHH	33.26	-
57	Acetylation	LVDVDEGKLKGETMD EEECCCCCEEECEEE	45.00	-
81	Acetylation	MPNIVSSKDYLVTAN CCCCCCCCCEEEECC	42.77	-
95	Phosphorylation	NSNLVIITAGARQKK CCCEEEEECCCCCCC	14.12	28857561
115	Phosphorylation	DLVQRNVSIFKLMIP HHHHHCHHHHHHHCC	26.34	24719451
118	Succinylation	QRNVSIFKLMIPNIT HHCHHHHHHHCCCHH	35.16	-
118	Acetylation	QRNVSIFKLMIPNIT HHCHHHHHHHCCCHH	35.16	-
155	Ubiquitination	WKLSGFPKNRVIGSG HHHHCCCCCCEECCC	55.94	-
155	Malonylation	WKLSGFPKNRVIGSG HHHHCCCCCCEECCC	55.94	26320211
157	Methylation	LSGFPKNRVIGSGCN HHCCCCCCEECCCCC	27.79	-
161	Phosphorylation	PKNRVIGSGCNLDSA CCCCEECCCCCCCHH	29.11	24114839
163	S-palmitoylation	NRVIGSGCNLDSARF CCEECCCCCCCHHHH	4.97	29575903
167	Phosphorylation	GSGCNLDSARFRYFI CCCCCCCHHHHHHHH	25.22	21712546
169	Methylation	GCNLDSARFRYFIGQ CCCCCHHHHHHHHHH	22.11	-
232	Acetylation	EQWENVHKKVISSGY HHHHHHHHHHHHCCC	44.44	-
236	Phosphorylation	NVHKKVISSGYEMVK HHHHHHHHCCCEEEE	22.24	-
239	Phosphorylation	KKVISSGYEMVKMKG HHHHHCCCEEEEECC	11.64	-
243	Acetylation	SSGYEMVKMKGYTSW HCCCEEEEECCCCCC	33.32	-
260	Phosphorylation	SLSVADLTESILKNL EEEHHHHHHHHHHHH	28.38	-
262	Phosphorylation	SVADLTESILKNLRR EHHHHHHHHHHHHHC	28.17	24719451
309	Phosphorylation	DLIKVKLTLEEEACL HHEEEEEECCHHHHH	26.80	-
318	Succinylation	EEEACLQKSAETLWE CHHHHHHHHHHHHHH	38.39	-
318	Acetylation	EEEACLQKSAETLWE CHHHHHHHHHHHHHH	38.39	-
322	Phosphorylation	CLQKSAETLWEIQKE HHHHHHHHHHHHHHH	36.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LDH6A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LDH6A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LDH6A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDHM_HUMAN	MDH2	physical	22939629
ALDH2_HUMAN	ALDH2	physical	26344197
AL4A1_HUMAN	ALDH4A1	physical	26344197
ARF4_HUMAN	ARF4	physical	26344197
ARF5_HUMAN	ARF5	physical	26344197
CATD_HUMAN	CTSD	physical	26344197
ETFA_HUMAN	ETFA	physical	26344197
MDHC_HUMAN	MDH1	physical	26344197
PEBP1_HUMAN	PEBP1	physical	26344197
PGK2_HUMAN	PGK2	physical	26344197
KPYM_HUMAN	PKM	physical	26344197
DHSO_HUMAN	SORD	physical	26344197
TALDO_HUMAN	TALDO1	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
UBE2N_HUMAN	UBE2N	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.