CPT1A_HUMAN - dbPTM
CPT1A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CPT1A_HUMAN
UniProt AC P50416
Protein Name Carnitine O-palmitoyltransferase 1, liver isoform
Gene Name CPT1A
Organism Homo sapiens (Human).
Sequence Length 773
Subcellular Localization Mitochondrion outer membrane
Multi-pass membrane protein .
Protein Description Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism..
Protein Sequence MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILPTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHDGRLLKPREMEQQMQRILDNTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTLDETEEGYRSEDPDTSMDSYAKSLLHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETSLNTANLLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMVDPAQTVEQRLKLFKLASEKHQHMYRLAMTGSGIDRHLFCLYVVSKYLAVESPFLKEVLSEPWRLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGYGVSYILVGENLINFHISSKFSCPETDSHRFGRHLKEAMTDIITLFGLSSNSKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAEAHQAVA
------CCCCCCEEE		23.76-
40UbiquitinationLSGLHSWKKKFIRFK
HHCHHHHHHHEEEEE		49.4521890473
86UbiquitinationPSLGIIAKINRTLET
CCCCHHHHHHCHHHH		30.0621890473
86 (in isoform 2)Ubiquitination-30.0621890473
86 (in isoform 1)Ubiquitination-30.0621890473
862-HydroxyisobutyrylationPSLGIIAKINRTLET
CCCCHHHHHHCHHHH		30.06-
106PhosphorylationSQTKNVVSGVLFGTG
CCCCCCCCHHHHCCH		20.92-
125PhosphorylationLIVTMRYSLKVLLSY
HHHHHHHHHHHHHHH		16.0224719451
131PhosphorylationYSLKVLLSYHGWMFT
HHHHHHHHHCCCEEE		15.7829759185
132PhosphorylationSLKVLLSYHGWMFTE
HHHHHHHHCCCEEEC		12.3429759185
158PhosphorylationMGMVKIFSGRKPMLY
HEEHHHHCCCCCEEE		40.9624719451
161 (in isoform 2)Ubiquitination-38.0021890473
161 (in isoform 1)Ubiquitination-38.0021890473
161UbiquitinationVKIFSGRKPMLYSFQ
HHHHCCCCCEEEEEC		38.0021890473
165PhosphorylationSGRKPMLYSFQTSLP
CCCCCEEEEECCCCC		10.9427732954
166PhosphorylationGRKPMLYSFQTSLPR
CCCCEEEEECCCCCC		13.6027732954
169PhosphorylationPMLYSFQTSLPRLPV
CEEEEECCCCCCCCC		30.1627732954
170PhosphorylationMLYSFQTSLPRLPVP
EEEEECCCCCCCCCC		26.1227732954
180UbiquitinationRLPVPAVKDTVNRYL
CCCCCCHHHHHHHHH		50.1921890473
1802-HydroxyisobutyrylationRLPVPAVKDTVNRYL
CCCCCCHHHHHHHHH		50.19-
180MalonylationRLPVPAVKDTVNRYL
CCCCCCHHHHHHHHH		50.1926320211
180 (in isoform 1)Ubiquitination-50.1921890473
180 (in isoform 2)Ubiquitination-50.1921890473
189PhosphorylationTVNRYLQSVRPLMKE
HHHHHHHHHHHHCCH		19.9424532841
195 (in isoform 1)Ubiquitination-66.6821890473
195 (in isoform 2)Ubiquitination-66.6821890473
195UbiquitinationQSVRPLMKEEDFKRM
HHHHHHCCHHHHHHH		66.6821890473
200UbiquitinationLMKEEDFKRMTALAQ
HCCHHHHHHHHHHHH		54.29-
282NitrationAIHAILLYRRKLDRE
HHHHHHHHHCCCCHH		12.62-
282Nitrated tyrosineAIHAILLYRRKLDRE
HHHHHHHHHCCCCHH		12.62-
2922-HydroxyisobutyrylationKLDREEIKPIRLLGS
CCCHHHCCCCEECCC		37.36-
292UbiquitinationKLDREEIKPIRLLGS
CCCHHHCCCCEECCC		37.36-
322PhosphorylationSRIPGEETDTIQHMR
CCCCCCCCCCCCHHH		33.85-
324PhosphorylationIPGEETDTIQHMRDS
CCCCCCCCCCHHHHC		29.9229759185
328SulfoxidationETDTIQHMRDSKHIV
CCCCCCHHHHCCEEE		2.6721406390
331PhosphorylationTIQHMRDSKHIVVYH
CCCHHHHCCEEEEEE		18.7729759185
371PhosphorylationQRILDNTSEPQPGEA
HHHHHCCCCCCCCHH		54.2421712546
384PhosphorylationEARLAALTAGDRVPW
HHHHHHHHCCCCCCH		24.7023532336
405 (in isoform 2)Ubiquitination-44.7621890473
405 (in isoform 1)Ubiquitination-44.7621890473
405UbiquitinationYFGRGKNKQSLDAVE
HCCCCCCHHHHHHHH		44.7621906983
441UbiquitinationTSMDSYAKSLLHGRC
CCHHHHHHHHHCCCH		33.14-
466UbiquitinationFVVFKNGKMGLNAEH
EEEEECCEEEECCCC		38.91-
514PhosphorylationDINPNIPYPTRLQWD
CCCCCCCCCCCEECC		17.2828152594
516PhosphorylationNPNIPYPTRLQWDIP
CCCCCCCCCEECCCC		37.8628152594
588PhosphorylationDMGKFCLTYEASMTR
HHCHHHHEHHHHHHH		22.09-
589NitrationMGKFCLTYEASMTRL
HCHHHHEHHHHHHHH		9.13-
589Nitrated tyrosineMGKFCLTYEASMTRL
HCHHHHEHHHHHHHH		9.13-
604PhosphorylationFREGRTETVRSCTTE
HHCCCCCCHHHCCCC		22.17-
619SulfoxidationSCDFVRAMVDPAQTV
CCHHHHHHCCHHHHH		2.1721406390
634AcetylationEQRLKLFKLASEKHQ
HHHHHHHHHHHHHHH		54.2925953088
634UbiquitinationEQRLKLFKLASEKHQ
HHHHHHHHHHHHHHH		54.29-
648SulfoxidationQHMYRLAMTGSGIDR
HHHHHHHHCCCCHHH		5.3021406390
649PhosphorylationHMYRLAMTGSGIDRH
HHHHHHHCCCCHHHH		23.6920860994
651PhosphorylationYRLAMTGSGIDRHLF
HHHHHCCCCHHHHHH		24.3320860994
666PhosphorylationCLYVVSKYLAVESPF
HHHHHHHHHHHCCHH		7.7421406692
671PhosphorylationSKYLAVESPFLKEVL
HHHHHHCCHHHHHHH		17.8524719451
675 (in isoform 1)Ubiquitination-46.2721890473
675 (in isoform 2)Ubiquitination-46.2721890473
675UbiquitinationAVESPFLKEVLSEPW
HHCCHHHHHHHCCCC		46.272190698
741PhosphorylationFHISSKFSCPETDSH
EEECCCCCCCCCCCH		32.2821082442
747PhosphorylationFSCPETDSHRFGRHL
CCCCCCCCHHHHHHH		24.7921082442
755UbiquitinationHRFGRHLKEAMTDII
HHHHHHHHHHHHHHH		36.98-
768PhosphorylationIITLFGLSSNSKK--
HHHHHCCCCCCCC--		28.0528348404
769PhosphorylationITLFGLSSNSKK---
HHHHCCCCCCCC---		50.6028348404
771PhosphorylationLFGLSSNSKK-----
HHCCCCCCCC-----		43.7129457462
772 (in isoform 1)Ubiquitination-67.7521890473
772UbiquitinationFGLSSNSKK------
HCCCCCCCC------		67.75-
773UbiquitinationGLSSNSKK-------
CCCCCCCC-------		66.45-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CPT1A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CPT1A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CPT1A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EIF3C_HUMANEIF3Cphysical
22939629
LPP_HUMANLPPphysical
22939629
TOM40_HUMANTOMM40physical
22939629
VATC1_HUMANATP6V1C1physical
22939629
RHOA_HUMANRHOAphysical
22939629
NDUA2_HUMANNDUFA2physical
22939629
ERLN1_HUMANERLIN1physical
22939629
NDUV1_HUMANNDUFV1physical
22939629
NDUS1_HUMANNDUFS1physical
22939629
PCBP1_HUMANPCBP1physical
22939629
U520_HUMANSNRNP200physical
22939629
NPDC1_HUMANNPDC1physical
21988832
CY24A_HUMANCYBAphysical
21988832
NR4A1_HUMANNR4A1physical
21988832
GRP78_HUMANHSPA5physical
21988832
KBTB7_HUMANKBTBD7physical
21988832
Drug and Disease Associations
Kegg Disease
H00525 Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficien
OMIM Disease
255120Carnitine palmitoyltransferase 1A deficiency (CPT1AD)
Kegg Drug
D05292 Oxfenicine (USAN/INN)
D05442 Perhexiline maleate (USAN)
D08340 Perhexiline (INN)
DrugBank
DB01016Glyburide
DB00583L-Carnitine
DB01074Perhexiline
Regulatory Network of CPT1A_HUMAN

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Related Literatures of Post-Translational Modification

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