NPDC1_HUMAN - dbPTM
NPDC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NPDC1_HUMAN
UniProt AC Q9NQX5
Protein Name Neural proliferation differentiation and control protein 1
Gene Name NPDC1
Organism Homo sapiens (Human).
Sequence Length 325
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity)..
Protein Sequence MATPLPPPSPRHLRLLRLLLSGLVLGAALRGAAAGHPDVAACPGSLDCALKRRARCPPGAHACGPCLQPFQEDQQGLCVPRMRRPPGGGRPQPRLEDEIDFLAQELARKESGHSTPPLPKDRQRLPEPATLGFSARGQGLELGLPSTPGTPTPTPHTSLGSPVSSDPVHMSPLEPRGGQGDGLALVLILAFCVAGAAALSVASLCWCRLQREIRLTQKADYATAKAPGSPAAPRISPGDQRLAQSAEMYHYQHQRQQMLCLERHKEPPKELDTASSDEENEDGDFTVYECPGLAPTGEMEVRNPLFDHAALSAPLPAPSSPPALP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MATPLPPPSP
-----CCCCCCCCCH		24.8628111955
9PhosphorylationATPLPPPSPRHLRLL
CCCCCCCCHHHHHHH		40.1028111955
114O-linked_GlycosylationARKESGHSTPPLPKD
HHHHCCCCCCCCCCC		46.2455827631
114PhosphorylationARKESGHSTPPLPKD
HHHHCCCCCCCCCCC		46.24-
115PhosphorylationRKESGHSTPPLPKDR
HHHCCCCCCCCCCCH		24.21-
115O-linked_GlycosylationRKESGHSTPPLPKDR
HHHCCCCCCCCCCCH		24.2146511133
130O-linked_GlycosylationQRLPEPATLGFSARG
HCCCCCCCCCCEECC		37.8255412979
134O-linked_GlycosylationEPATLGFSARGQGLE
CCCCCCCEECCCCCC		18.4355830651
161O-linked_GlycosylationTPHTSLGSPVSSDPV
CCCCCCCCCCCCCCC		27.67OGP
164O-linked_GlycosylationTSLGSPVSSDPVHMS
CCCCCCCCCCCCCCC		32.20OGP
216PhosphorylationLQREIRLTQKADYAT
HHHHHHHHHHCCHHC		20.4129978859
218UbiquitinationREIRLTQKADYATAK
HHHHHHHHCCHHCCC		37.6821906983
221PhosphorylationRLTQKADYATAKAPG
HHHHHCCHHCCCCCC		15.6528152594
223PhosphorylationTQKADYATAKAPGSP
HHHCCHHCCCCCCCC		23.5929978859
225UbiquitinationKADYATAKAPGSPAA
HCCHHCCCCCCCCCC		51.2432142685
229PhosphorylationATAKAPGSPAAPRIS
HCCCCCCCCCCCCCC		15.4223401153
236PhosphorylationSPAAPRISPGDQRLA
CCCCCCCCHHCHHHH		24.9025159151
245PhosphorylationGDQRLAQSAEMYHYQ
HCHHHHHHHHHHHHH		22.1626356563
249PhosphorylationLAQSAEMYHYQHQRQ
HHHHHHHHHHHHHHH		6.7325884760
251PhosphorylationQSAEMYHYQHQRQQM
HHHHHHHHHHHHHHH		7.1025884760
275PhosphorylationPKELDTASSDEENED
CCCCCCCCCCCCCCC		40.1828348404
276PhosphorylationKELDTASSDEENEDG
CCCCCCCCCCCCCCC		46.7228348404
286PhosphorylationENEDGDFTVYECPGL
CCCCCCCEEEECCCC		27.2428348404
319PhosphorylationSAPLPAPSSPPALP-
CCCCCCCCCCCCCC-		58.5530278072
320PhosphorylationAPLPAPSSPPALP--
CCCCCCCCCCCCC--		33.5730278072
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NPDC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NPDC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NPDC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KR412_HUMANKRTAP4-12physical
16189514
E2F1_HUMANE2F1physical
11042687
TFDP1_HUMANTFDP1physical
11042687
CCND1_HUMANCCND1physical
11042687
CCND2_HUMANCCND2physical
11042687
CCND3_HUMANCCND3physical
11042687
CDK2_HUMANCDK2physical
11042687
KHDR2_HUMANKHDRBS2physical
25416956
KR107_HUMANKRTAP10-7physical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR101_HUMANKRTAP10-1physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
H1T_HUMANHIST1H1Tphysical
26186194
PTER_HUMANPTERphysical
26186194
PMGT2_HUMANPOMGNT2physical
26186194
AT11A_HUMANATP11Aphysical
26186194
CCD94_HUMANCCDC94physical
26186194
TCAF2_HUMANFAM115Cphysical
26186194
PRAF3_HUMANARL6IP5physical
26186194
SNX17_HUMANSNX17physical
26186194
TBC23_HUMANTBC1D23physical
26186194
AT11A_HUMANATP11Aphysical
28514442
PTER_HUMANPTERphysical
28514442
TBC23_HUMANTBC1D23physical
28514442
TCAF2_HUMANFAM115Cphysical
28514442
CCD94_HUMANCCDC94physical
28514442
SNX17_HUMANSNX17physical
28514442
H1T_HUMANHIST1H1Tphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NPDC1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, AND MASSSPECTROMETRY.

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