TCAF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCAF2_HUMAN
• UniProt AC: A6NFQ2
• Protein Name: TRPM8 channel-associated factor 2 {ECO:0000303|PubMed:25559186}
• Gene Name: TCAF2 {ECO:0000312|HGNC:HGNC:26878}
• Organism: Homo sapiens (Human).
• Sequence Length: 919
• Subcellular Localization: Isoform 2: Cell membrane . Colocalizes with TRPM8 on the plasma membrane.
• Protein Description: Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner..
• Protein Sequence: MATIAAAAFEALMDGVTCWDVPRGPIPSELLLIGEAAFPVMVNDKGQVLIAASSYGRGRLVVVSHEGYLSHTGLAPFLLNAVSWLCPCPGAPVGVHPSLAPLVNILQDAGLEAQVKPEPGEPLGVYCINAYNDTLTATLIQFVKHGGGLLIGGQAWYWASQHGPDKVLSRFPGNKVTSVAGVYFTDTYGDRDRFKVSKKVPKIPLHVRYGEDVRQDQQQLLEGISELDIRTGGVPSQLLVHGALAFPLGLDASLNCFLAAAHYGRGRVVLAAHECLLCAPKMGPFLLNAVRWLARGQTGKVGVNTNLKDLCPLLSEHGLQCSLEPHLNSDLCVYCCKAYSDKEAKQLQEFVAEGGGLLIGGQAWWWASQNPGHCPLAGFPGNIILNCFGLSILPQTLKAGCFPVPTPEMRSYHFRKALSQFQAILNHENGNLEKSCLAKLRVDGAAFLQIPAEGVPAYISLHRLLRKMLRGSGLPAVSRENPVASDSYEAAVLSLATGLAHSGTDCSQLAQGLGTWTCSSSLYPSKHPITVEINGINPGNNDCWVSTGLYLLEGQNAEVSLSEAAASAGLRVQIGCHTDDLTKARKLSRAPVVTHQCWMDRTERSVSCLWGGLLYVIVPKGSQLGPVPVTIRGAVPAPYYKLGKTSLEEWKRQMQENLAPWGELATDNIILTVPTTNLQALKDPEPVLRLWDEMMQAVARLAAEPFPFRRPERIVADVQISAGWMHSGYPIMCHLESVKEIINEMDMRSRGVWGPIHELGHNQQRHGWEFPPHTTEATCNLWSVYVHETVLGIPRAQAHEALSPPERERRIKAHLGKGAPLCDWNVWTALETYLQLQEAFGWEPFTQLFAEYQTLSHLPKDNTGRMNLWVKKFSEKVKKNLVPFFEAWGWPIQKEVADSLASLPEWQENPMQVYLRARK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
185	Phosphorylation	SVAGVYFTDTYGDRD EEEEEEEECCCCCCC		19845377
195	Ubiquitination	YGDRDRFKVSKKVPK CCCCCCEEECCCCCC		32015554
472	Phosphorylation	LRKMLRGSGLPAVSR HHHHHCCCCCCCCCC		-
478	Phosphorylation	GSGLPAVSRENPVAS CCCCCCCCCCCCCCC		-
530	Phosphorylation	YPSKHPITVEINGIN CCCCCCEEEEECCCC		-
615	Phosphorylation	CLWGGLLYVIVPKGS HHHCCEEEEEEECCC		29214152
871	Acetylation	GRMNLWVKKFSEKVK CCCCHHHHHHHHHHH		25825284
874	Phosphorylation	NLWVKKFSEKVKKNL CHHHHHHHHHHHHHC		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCAF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCAF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCAF2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TCAF2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.