dbPTM

H1T_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	H1T_HUMAN
UniProt AC	P22492
Protein Name	Histone H1t
Gene Name	HIST1H1T
Organism	Homo sapiens (Human).
Sequence Length	207
Subcellular Localization	Nucleus . Chromosome .
Protein Description	Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. [PubMed: 26757249 Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination]
Protein Sequence	MSETVPAASASAGVAAMEKLPTKKRGRKPAGLISASRKVPNLSVSKLITEALSVSQERVGMSLVALKKALAAAGYDVEKNNSRIKLSLKSLVNKGILVQTRGTGASGSFKLSKKVIPKSTRSKAKKSVSAKTKKLVLSRDSKSPKTAKTNKRAKKPRATTPKTVRSGRKAKGAKGKQQQKSPVKARASKSKLTQHHEVNVRKATSKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSETVPAAS ------CCCCCCHHH	41.81	25693802
4	Phosphorylation	----MSETVPAASAS ----CCCCCCHHHHH	25.20	25693802
9	Phosphorylation	SETVPAASASAGVAA CCCCCHHHHHHCHHH	25.51	30387612
11	Phosphorylation	TVPAASASAGVAAME CCCHHHHHHCHHHHH	24.06	25693802
22	Phosphorylation	AAMEKLPTKKRGRKP HHHHHCCCCCCCCCC	60.68	22964224
43	Phosphorylation	SRKVPNLSVSKLITE CCCCCCCCHHHHHHH	30.87	24719451
45	Phosphorylation	KVPNLSVSKLITEAL CCCCCCHHHHHHHHH	20.54	27282143
53	Phosphorylation	KLITEALSVSQERVG HHHHHHHHCCHHHHH	27.11	26699800
55	Phosphorylation	ITEALSVSQERVGMS HHHHHHCCHHHHHHH	23.97	26699800
58	Citrullination	ALSVSQERVGMSLVA HHHCCHHHHHHHHHH	23.74	-
58	Citrullination	ALSVSQERVGMSLVA HHHCCHHHHHHHHHH	23.74	-
62	Phosphorylation	SQERVGMSLVALKKA CHHHHHHHHHHHHHH	17.48	26074081
67	Ubiquitination	GMSLVALKKALAAAG HHHHHHHHHHHHHCC	26.68	22817900
68	Sumoylation	MSLVALKKALAAAGY HHHHHHHHHHHHCCC	49.86	-
68	Sumoylation	MSLVALKKALAAAGY HHHHHHHHHHHHCCC	49.86	-
68	Ubiquitination	MSLVALKKALAAAGY HHHHHHHHHHHHCCC	49.86	22053931
75	Phosphorylation	KALAAAGYDVEKNNS HHHHHCCCCCHHCCC	16.46	28152594
79	Acetylation	AAGYDVEKNNSRIKL HCCCCCHHCCCEEEE	62.37	158563
79	Ubiquitination	AAGYDVEKNNSRIKL HCCCCCHHCCCEEEE	62.37	23000965
82	Phosphorylation	YDVEKNNSRIKLSLK CCCHHCCCEEEEEHH	44.79	23401153
82	Ubiquitination	YDVEKNNSRIKLSLK CCCHHCCCEEEEEHH	44.79	21890473
85	Ubiquitination	EKNNSRIKLSLKSLV HHCCCEEEEEHHHHH	30.80	23000965
87	Phosphorylation	NNSRIKLSLKSLVNK CCCEEEEEHHHHHHC	28.84	22210691
93	Ubiquitination	LSLKSLVNKGILVQT EEHHHHHHCCEEEEE	41.97	21890473
103	Phosphorylation	ILVQTRGTGASGSFK EEEEECCCCCCCCCC	26.70	26657352
106	Phosphorylation	QTRGTGASGSFKLSK EECCCCCCCCCCCCC	35.99	25849741
108	Phosphorylation	RGTGASGSFKLSKKV CCCCCCCCCCCCCCC	19.40	30266825
110	Acetylation	TGASGSFKLSKKVIP CCCCCCCCCCCCCCC	54.25	7428721
113	Acetylation	SGSFKLSKKVIPKST CCCCCCCCCCCCCCC	62.59	7428731
138	Phosphorylation	KTKKLVLSRDSKSPK HHHHHHCCCCCCCCC	26.94	24719451
141	Phosphorylation	KLVLSRDSKSPKTAK HHHCCCCCCCCCHHH	33.64	25159151
143	Phosphorylation	VLSRDSKSPKTAKTN HCCCCCCCCCHHHCC	35.26	-
148	Ubiquitination	SKSPKTAKTNKRAKK CCCCCHHHCCCCCCC	58.84	24816145
149	Phosphorylation	KSPKTAKTNKRAKKP CCCCHHHCCCCCCCC	43.43	-
159	Phosphorylation	RAKKPRATTPKTVRS CCCCCCCCCCCCHHC	44.93	20068231
160	Phosphorylation	AKKPRATTPKTVRSG CCCCCCCCCCCHHCC	23.08	20068231
162	Acetylation	KPRATTPKTVRSGRK CCCCCCCCCHHCCCC	58.52	30585545
166	Phosphorylation	TTPKTVRSGRKAKGA CCCCCHHCCCCCCCC	38.32	-
171	Acetylation	VRSGRKAKGAKGKQQ HHCCCCCCCCCCCCC	63.54	12634851
181	Phosphorylation	KGKQQQKSPVKARAS CCCCCCCCCHHHHHC	30.50	-
190	Phosphorylation	VKARASKSKLTQHHE HHHHHCCCHHHHHHH	30.33	-
191	Acetylation	KARASKSKLTQHHEV HHHHCCCHHHHHHHH	60.33	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of H1T_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
58	R	Citrullination		-
Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of H1T_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
H14_HUMAN	HIST1H1E	physical	28514442
YBOX2_HUMAN	YBX2	physical	28514442
RL30_HUMAN	RPL30	physical	28514442
ELAV2_HUMAN	ELAVL2	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
SRS12_HUMAN	SRSF12	physical	28514442
DHX57_HUMAN	DHX57	physical	28514442
BUD13_HUMAN	BUD13	physical	28514442
ZNF92_HUMAN	ZNF92	physical	28514442
DHX8_HUMAN	DHX8	physical	28514442
ZC3H8_HUMAN	ZC3H8	physical	28514442
RBM19_HUMAN	RBM19	physical	28514442
CMS1_HUMAN	CMSS1	physical	28514442
ZCRB1_HUMAN	ZCRB1	physical	28514442
PURB_HUMAN	PURB	physical	28514442
NO40_HUMAN	ZCCHC17	physical	28514442
TPM2_HUMAN	TPM2	physical	28514442
KRR1_HUMAN	KRR1	physical	28514442
GPT11_HUMAN	GPATCH11	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
SREK1_HUMAN	SREK1	physical	28514442
SFR19_HUMAN	SCAF1	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
NAT10_HUMAN	NAT10	physical	28514442
DDX52_HUMAN	DDX52	physical	28514442
UTP23_HUMAN	UTP23	physical	28514442
RSBN1_HUMAN	RSBN1	physical	28514442
NGDN_HUMAN	NGDN	physical	28514442
RRP12_HUMAN	RRP12	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442
ZCHC7_HUMAN	ZCCHC7	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442
SR140_HUMAN	U2SURP	physical	28514442
TOE1_HUMAN	TOE1	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
SRRM1_HUMAN	SRRM1	physical	28514442
PRP4B_HUMAN	PRPF4B	physical	28514442
TTF1_HUMAN	TTF1	physical	28514442
RS15_HUMAN	RPS15	physical	28514442
ZN771_HUMAN	ZNF771	physical	28514442
KRI1_HUMAN	KRI1	physical	28514442
ZCHC9_HUMAN	ZCCHC9	physical	28514442
MPP10_HUMAN	MPHOSPH10	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442
SYFM_HUMAN	FARS2	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
CHERP_HUMAN	CHERP	physical	28514442
ZN668_HUMAN	ZNF668	physical	28514442
DDX21_HUMAN	DDX21	physical	28514442
H2A2B_HUMAN	HIST2H2AB	physical	28514442
DDX10_HUMAN	DDX10	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
RRS1_HUMAN	RRS1	physical	28514442
NOL12_HUMAN	NOL12	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
RS5_HUMAN	RPS5	physical	28514442
PRD10_HUMAN	PRDM10	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
NOC4L_HUMAN	NOC4L	physical	28514442
DDX56_HUMAN	DDX56	physical	28514442
CI114_HUMAN	C9orf114	physical	28514442
RS3_HUMAN	RPS3	physical	28514442
NKAP_HUMAN	NKAP	physical	28514442
YTDC1_HUMAN	YTHDC1	physical	28514442
RL10A_HUMAN	RPL10A	physical	28514442
RS10_HUMAN	RPS10	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of H1T_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-159 AND THR-160, ANDMASS SPECTROMETRY.	17081983 [Abstract]

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