SRRM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRRM1_HUMAN
• UniProt AC: Q8IYB3
• Protein Name: Serine/arginine repetitive matrix protein 1
• Gene Name: SRRM1
• Organism: Homo sapiens (Human).
• Sequence Length: 904
• Subcellular Localization: Nucleus matrix. Nucleus speckle.
• Protein Description: Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates..
• Protein Sequence: MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRKAQVSPQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDAGFFRG -------CCCCCCCC	7.81	22814378
7	Citrullination	-MDAGFFRGTSAEQD -CCCCCCCCCCHHHC	45.26	-
7	Citrullination	-MDAGFFRGTSAEQD -CCCCCCCCCCHHHC	45.26	-
7	Methylation	-MDAGFFRGTSAEQD -CCCCCCCCCCHHHC	45.26	115917753
9	Phosphorylation	DAGFFRGTSAEQDNR CCCCCCCCCHHHCCC	22.10	23927012
9 (in isoform 2)	Phosphorylation	-	22.10	21406692
10	Phosphorylation	AGFFRGTSAEQDNRF CCCCCCCCHHHCCCC	32.41	28355574
10 (in isoform 2)	Phosphorylation	-	32.41	21406692
16	Methylation	TSAEQDNRFSNKQKK CCHHHCCCCCHHHHH	44.66	97804657
18	Phosphorylation	AEQDNRFSNKQKKLL HHHCCCCCHHHHHHH	39.62	23403867
29	Acetylation	KKLLKQLKFAECLEK HHHHHHHHHHHHHHH	39.78	25953088
29	Ubiquitination	KKLLKQLKFAECLEK HHHHHHHHHHHHHHH	39.78	-
36	2-Hydroxyisobutyrylation	KFAECLEKKVDMSKV HHHHHHHHHCCHHHC	45.19	-
36	Acetylation	KFAECLEKKVDMSKV HHHHHHHHHCCHHHC	45.19	23749302
36	Malonylation	KFAECLEKKVDMSKV HHHHHHHHHCCHHHC	45.19	26320211
36	Ubiquitination	KFAECLEKKVDMSKV HHHHHHHHHCCHHHC	45.19	-
42	2-Hydroxyisobutyrylation	EKKVDMSKVNLEVIK HHHCCHHHCCHHHHH	28.62	-
49	Acetylation	KVNLEVIKPWITKRV HCCHHHHHHHHHHHH	39.20	26051181
49	Ubiquitination	KVNLEVIKPWITKRV HCCHHHHHHHHHHHH	39.20	21890473
49 (in isoform 1)	Ubiquitination	-	39.20	21890473
49 (in isoform 2)	Ubiquitination	-	39.20	21890473
54	2-Hydroxyisobutyrylation	VIKPWITKRVTEILG HHHHHHHHHHHHHHC	35.42	-
54	Acetylation	VIKPWITKRVTEILG HHHHHHHHHHHHHHC	35.42	25953088
54	Ubiquitination	VIKPWITKRVTEILG HHHHHHHHHHHHHHC	35.42	2189047
54 (in isoform 1)	Ubiquitination	-	35.42	21890473
54 (in isoform 2)	Ubiquitination	-	35.42	21890473
121	Phosphorylation	ENIAGIPSAFLELKK HHHCCCCHHHHHHCH	29.72	22210691
127	Sumoylation	PSAFLELKKEEIKQR CHHHHHHCHHHHHHH	49.08	28112733
140	Acetylation	QRQIEQEKLASMKKQ HHHHHHHHHHHHHHH	49.39	19608861
140	Ubiquitination	QRQIEQEKLASMKKQ HHHHHHHHHHHHHHH	49.39	19608861
161	Phosphorylation	RDKEEKESSREKRER HHHHHHHHHHHHHHH	45.85	24300666
162	Phosphorylation	DKEEKESSREKRERS HHHHHHHHHHHHHHH	45.62	24719451
169	Phosphorylation	SREKRERSRSPRRRK HHHHHHHHHCHHHHH	32.15	29743597
171	Phosphorylation	EKRERSRSPRRRKSR HHHHHHHCHHHHHCC	24.81	29743597
177	Phosphorylation	RSPRRRKSRSPSPRR HCHHHHHCCCCCCCC	35.86	28102081
177 (in isoform 2)	Phosphorylation	-	35.86	21406692
179	Phosphorylation	PRRRKSRSPSPRRRS HHHHHCCCCCCCCCC	36.50	28102081
179 (in isoform 2)	Phosphorylation	-	36.50	21406692
181	Phosphorylation	RRKSRSPSPRRRSSP HHHCCCCCCCCCCCH	32.08	28102081
181 (in isoform 2)	Phosphorylation	-	32.08	21406692
186	Phosphorylation	SPSPRRRSSPVRRER CCCCCCCCCHHHHHH	36.86	21955146
186 (in isoform 2)	Phosphorylation	-	36.86	21406692
187	Phosphorylation	PSPRRRSSPVRRERK CCCCCCCCHHHHHHH	26.13	21955146
187 (in isoform 2)	Phosphorylation	-	26.13	21406692
196	Phosphorylation	VRRERKRSHSRSPRH HHHHHHHHHCCCCCC	28.93	27273156
198	Phosphorylation	RERKRSHSRSPRHRT HHHHHHHCCCCCCCC	35.38	27273156
200	Phosphorylation	RKRSHSRSPRHRTKS HHHHHCCCCCCCCCC	29.33	27273156
205	Phosphorylation	SRSPRHRTKSRSPSP CCCCCCCCCCCCCCC	27.52	24144214
207	Phosphorylation	SPRHRTKSRSPSPAP CCCCCCCCCCCCCCC	37.06	20164059
207 (in isoform 2)	Phosphorylation	-	37.06	21406692
209	Phosphorylation	RHRTKSRSPSPAPEK CCCCCCCCCCCCCCC	36.50	20164059
209 (in isoform 2)	Phosphorylation	-	36.50	21406692
211	Phosphorylation	RTKSRSPSPAPEKKE CCCCCCCCCCCCCCC	34.63	20164059
211 (in isoform 2)	Phosphorylation	-	34.63	21406692
220	Phosphorylation	APEKKEKTPELPEPS CCCCCCCCCCCCCCC	24.08	19664994
220 (in isoform 2)	Phosphorylation	-	24.08	21406692
227	Phosphorylation	TPELPEPSVKVKEPS CCCCCCCCCCCCCCC	32.67	30266825
227 (in isoform 2)	Phosphorylation	-	32.67	21406692
231	Sumoylation	PEPSVKVKEPSVQEA CCCCCCCCCCCHHCC	59.18	-
231	Sumoylation	PEPSVKVKEPSVQEA CCCCCCCCCCCHHCC	59.18	25114211
234	Phosphorylation	SVKVKEPSVQEATST CCCCCCCCHHCCCCC	37.21	29255136
234 (in isoform 2)	Phosphorylation	-	37.21	21406692
239	Phosphorylation	EPSVQEATSTSDILK CCCHHCCCCCCHHCC	31.61	30266825
240	Phosphorylation	PSVQEATSTSDILKV CCHHCCCCCCHHCCC	32.72	30266825
241	Phosphorylation	SVQEATSTSDILKVP CHHCCCCCCHHCCCC	26.51	30266825
242	Phosphorylation	VQEATSTSDILKVPK HHCCCCCCHHCCCCC	23.56	30266825
249	Sumoylation	SDILKVPKPEPIPEP CHHCCCCCCCCCCCC	66.07	-
249	Sumoylation	SDILKVPKPEPIPEP CHHCCCCCCCCCCCC	66.07	28112733
260	Phosphorylation	IPEPKEPSPEKNSKK CCCCCCCCCCCCCHH	46.94	29255136
260 (in isoform 2)	Phosphorylation	-	46.94	21406692
265	Phosphorylation	EPSPEKNSKKEKEKE CCCCCCCCHHHHHHH	57.06	23927012
282	Phosphorylation	RPRSRSRSKSRSRTR CCCHHHHHHHCCCCC	35.91	24144214
284	Phosphorylation	RSRSRSKSRSRTRSR CHHHHHHHCCCCCCC	36.41	24144214
286	Phosphorylation	RSRSKSRSRTRSRSP HHHHHHCCCCCCCCC	45.13	24144214
288	Phosphorylation	RSKSRSRTRSRSPSH HHHHCCCCCCCCCCC	33.95	24144214
290	Phosphorylation	KSRSRTRSRSPSHTR HHCCCCCCCCCCCCC	36.18	27362937
292	Phosphorylation	RSRTRSRSPSHTRPR CCCCCCCCCCCCCCC	31.81	30266825
292 (in isoform 2)	Phosphorylation	-	31.81	21406692
294	Phosphorylation	RTRSRSPSHTRPRRR CCCCCCCCCCCCCHH	38.44	30266825
294 (in isoform 2)	Phosphorylation	-	38.44	21406692
296	Phosphorylation	RSRSPSHTRPRRRHR CCCCCCCCCCCHHHH	46.86	30266825
304	Phosphorylation	RPRRRHRSRSRSYSP CCCHHHHHCCCCCCC	28.60	26846344
306	Phosphorylation	RRRHRSRSRSYSPRR CHHHHHCCCCCCCCC	27.16	26846344
308	Phosphorylation	RHRSRSRSYSPRRRP HHHHCCCCCCCCCCC	31.07	26846344
309	Phosphorylation	HRSRSRSYSPRRRPS HHHCCCCCCCCCCCC	22.91	26846344
310	Phosphorylation	RSRSRSYSPRRRPSP HHCCCCCCCCCCCCC	17.12	28355574
316	Phosphorylation	YSPRRRPSPRRRPSP CCCCCCCCCCCCCCC	29.27	20068231
322	Phosphorylation	PSPRRRPSPRRRTPP CCCCCCCCCCCCCCC	29.27	20068231
327	Phosphorylation	RPSPRRRTPPRRMPP CCCCCCCCCCCCCCC	35.51	22798277
341	Phosphorylation	PPPRHRRSRSPVRRR CCCCCCCCCCHHHHH	36.75	30576142
343	Phosphorylation	PRHRRSRSPVRRRRR CCCCCCCCHHHHHHH	29.06	30576142
351	Phosphorylation	PVRRRRRSSASLSGS HHHHHHHHCCCCCCC	28.57	23927012
352	Phosphorylation	VRRRRRSSASLSGSS HHHHHHHCCCCCCCC	21.77	25849741
354	Phosphorylation	RRRRSSASLSGSSSS HHHHHCCCCCCCCCC	25.64	23927012
356	Phosphorylation	RRSSASLSGSSSSSS HHHCCCCCCCCCCCC	33.85	24275569
359	Phosphorylation	SASLSGSSSSSSSSR CCCCCCCCCCCCCCC	37.45	28674151
360	Phosphorylation	ASLSGSSSSSSSSRS CCCCCCCCCCCCCCC	35.62	25849741
361	Phosphorylation	SLSGSSSSSSSSRSR CCCCCCCCCCCCCCC	35.87	25849741
363	Phosphorylation	SGSSSSSSSSRSRSP CCCCCCCCCCCCCCC	33.99	24275569
364	Phosphorylation	GSSSSSSSSRSRSPP CCCCCCCCCCCCCCC	31.55	24260401
365	Phosphorylation	SSSSSSSSRSRSPPK CCCCCCCCCCCCCCC	35.90	19845377
367	Phosphorylation	SSSSSSRSRSPPKKP CCCCCCCCCCCCCCC	38.77	21601212
369	Phosphorylation	SSSSRSRSPPKKPPK CCCCCCCCCCCCCCC	46.96	26657352
378	Phosphorylation	PKKPPKRTSSPPRKT CCCCCCCCCCCCCCC	39.42	30266825
378 (in isoform 2)	Phosphorylation	-	39.42	21406692
379	Phosphorylation	KKPPKRTSSPPRKTR CCCCCCCCCCCCCCC	44.90	30266825
379 (in isoform 2)	Phosphorylation	-	44.90	21406692
380	Phosphorylation	KPPKRTSSPPRKTRR CCCCCCCCCCCCCCC	38.01	30266825
384 (in isoform 2)	Phosphorylation	-	52.75	21406692
385	Phosphorylation	TSSPPRKTRRLSPSA CCCCCCCCCCCCCCC	23.46	22115753
388 (in isoform 2)	Phosphorylation	-	8.77	21406692
389	Phosphorylation	PRKTRRLSPSASPPR CCCCCCCCCCCCCCC	18.26	25159151
390 (in isoform 2)	Phosphorylation	-	38.21	21406692
391	Phosphorylation	KTRRLSPSASPPRRR CCCCCCCCCCCCCCC	37.69	29255136
392 (in isoform 2)	Phosphorylation	-	29.46	21406692
393	Phosphorylation	RRLSPSASPPRRRHR CCCCCCCCCCCCCCC	39.51	29255136
402	Phosphorylation	PRRRHRPSPPATPPP CCCCCCCCCCCCCCC	43.39	25159151
406	Phosphorylation	HRPSPPATPPPKTRH CCCCCCCCCCCCCCC	41.94	25159151
409 (in isoform 2)	Phosphorylation	-	52.43	21406692
411	Phosphorylation	PATPPPKTRHSPTPQ CCCCCCCCCCCCCCC	39.11	22167270
412 (in isoform 2)	Phosphorylation	-	34.12	21406692
414	Phosphorylation	PPPKTRHSPTPQQSN CCCCCCCCCCCCCCC	27.46	22167270
414 (in isoform 2)	Phosphorylation	-	27.46	21406692
416	Phosphorylation	PKTRHSPTPQQSNRT CCCCCCCCCCCCCCC	36.42	22167270
418 (in isoform 2)	Phosphorylation	-	62.91	21406692
420	Phosphorylation	HSPTPQQSNRTRKSR CCCCCCCCCCCCCCC	24.03	22167270
423	Phosphorylation	TPQQSNRTRKSRVSV CCCCCCCCCCCCEEE	46.85	-
424 (in isoform 2)	Phosphorylation	-	31.54	21406692
425	Methylation	QQSNRTRKSRVSVSP CCCCCCCCCCEEECC	41.84	23748837
426	Phosphorylation	QSNRTRKSRVSVSPG CCCCCCCCCEEECCC	34.32	26846344
427 (in isoform 2)	Phosphorylation	-	27.97	21406692
429	Phosphorylation	RTRKSRVSVSPGRTS CCCCCCEEECCCCCC	18.77	26846344
429 (in isoform 2)	Phosphorylation	-	18.77	21406692
431	Phosphorylation	RKSRVSVSPGRTSGK CCCCEEECCCCCCCC	17.71	29255136
433 (in isoform 2)	Phosphorylation	-	37.68	21406692
434 (in isoform 2)	Phosphorylation	-	29.15	21406692
435	Phosphorylation	VSVSPGRTSGKVTKH EEECCCCCCCCEEEC	47.98	26846344
436	Phosphorylation	SVSPGRTSGKVTKHK EECCCCCCCCEEECC	34.94	26846344
438	Acetylation	SPGRTSGKVTKHKGT CCCCCCCCEEECCCC	46.64	7709759
440	Phosphorylation	GRTSGKVTKHKGTEK CCCCCCEEECCCCCC	30.80	26074081
445	Phosphorylation	KVTKHKGTEKRESPS CEEECCCCCCCCCCC	43.04	23927012
447	Sumoylation	TKHKGTEKRESPSPA EECCCCCCCCCCCCC	62.39	28112733
448 (in isoform 2)	Phosphorylation	-	43.31	21406692
450	Phosphorylation	KGTEKRESPSPAPKP CCCCCCCCCCCCCCC	34.41	29255136
450 (in isoform 2)	Phosphorylation	-	34.41	21406692
452	O-linked_Glycosylation	TEKRESPSPAPKPRK CCCCCCCCCCCCCCE	42.86	23301498
452	Phosphorylation	TEKRESPSPAPKPRK CCCCCCCCCCCCCCE	42.86	29255136
459	Sumoylation	SPAPKPRKVELSESE CCCCCCCEEECCCCC	48.89	28112733
461 (in isoform 2)	Phosphorylation	-	50.00	21406692
463	Phosphorylation	KPRKVELSESEEDKG CCCEEECCCCCCCCC	26.10	29255136
463 (in isoform 2)	Phosphorylation	-	26.10	21406692
465	Phosphorylation	RKVELSESEEDKGGK CEEECCCCCCCCCCC	42.80	29255136
472	Sumoylation	SEEDKGGKMAAADSV CCCCCCCCCCHHHHH	33.75	28112733
478	Phosphorylation	GKMAAADSVQQRRQY CCCCHHHHHHHHHHH	19.66	29255136
492	Phosphorylation	YRRQNQQSSSDSGSS HHHHHHHCCCCCCCC	23.26	20873877
493	Phosphorylation	RRQNQQSSSDSGSSS HHHHHHCCCCCCCCC	33.55	25849741
494	Phosphorylation	RQNQQSSSDSGSSSS HHHHHCCCCCCCCCC	40.83	25849741
496	Phosphorylation	NQQSSSDSGSSSSSE HHHCCCCCCCCCCCC	42.39	20363803
498	Phosphorylation	QSSSDSGSSSSSEDE HCCCCCCCCCCCCCC	30.88	20363803
499	Phosphorylation	SSSDSGSSSSSEDER CCCCCCCCCCCCCCC	37.45	20363803
500	Phosphorylation	SSDSGSSSSSEDERP CCCCCCCCCCCCCCC	39.31	20363803
501	Phosphorylation	SDSGSSSSSEDERPK CCCCCCCCCCCCCCC	39.43	20363803
502	Phosphorylation	DSGSSSSSEDERPKR CCCCCCCCCCCCCCC	51.52	20363803
510	Phosphorylation	EDERPKRSHVKNGEV CCCCCCCHHCCCCHH	38.46	30576142
522 (in isoform 2)	Phosphorylation	-	32.59	21406692
524	Phosphorylation	VGRRRRHSPSRSASP HHCCCCCCCCCCCCC	23.82	21955146
524 (in isoform 2)	Phosphorylation	-	23.82	21406692
526	Phosphorylation	RRRRHSPSRSASPSP CCCCCCCCCCCCCCC	41.71	21955146
526 (in isoform 2)	Phosphorylation	-	41.71	21406692
528	Phosphorylation	RRHSPSRSASPSPRK CCCCCCCCCCCCCCC	37.12	21955146
528 (in isoform 2)	Phosphorylation	-	37.12	21406692
530	Phosphorylation	HSPSRSASPSPRKRQ CCCCCCCCCCCCCCC	27.45	21955146
532	Phosphorylation	PSRSASPSPRKRQKE CCCCCCCCCCCCCCC	34.54	24260401
540	Phosphorylation	PRKRQKETSPRGRRR CCCCCCCCCCCCCCC	51.58	30266825
541	Phosphorylation	RKRQKETSPRGRRRR CCCCCCCCCCCCCCC	17.43	30266825
547 (in isoform 2)	Phosphorylation	-	41.91	21406692
549	Phosphorylation	PRGRRRRSPSPPPTR CCCCCCCCCCCCCCC	28.11	29255136
549 (in isoform 2)	Phosphorylation	-	28.11	21406692
551	O-linked_Glycosylation	GRRRRSPSPPPTRRR CCCCCCCCCCCCCCC	51.81	23301498
551	Phosphorylation	GRRRRSPSPPPTRRR CCCCCCCCCCCCCCC	51.81	29255136
553 (in isoform 2)	Phosphorylation	-	47.43	21406692
555	O-linked_Glycosylation	RSPSPPPTRRRRSPS CCCCCCCCCCCCCCC	42.45	23301498
555	Phosphorylation	RSPSPPPTRRRRSPS CCCCCCCCCCCCCCC	42.45	20164059
558 (in isoform 2)	Phosphorylation	-	39.89	21406692
560	Phosphorylation	PPTRRRRSPSPAPPP CCCCCCCCCCCCCCC	28.11	29255136
560 (in isoform 2)	Phosphorylation	-	28.11	21406692
562	Phosphorylation	TRRRRSPSPAPPPRR CCCCCCCCCCCCCCC	34.63	29255136
570 (in isoform 2)	Phosphorylation	-	48.37	21406692
572	Phosphorylation	PPPRRRRTPTPPPRR CCCCCCCCCCCCCCC	29.69	29255136
572 (in isoform 2)	Phosphorylation	-	29.69	21406692
574	Phosphorylation	PRRRRTPTPPPRRRT CCCCCCCCCCCCCCC	48.06	29255136
579 (in isoform 2)	Phosphorylation	-	53.23	21406692
581	Phosphorylation	TPPPRRRTPSPPPRR CCCCCCCCCCCCCCC	26.72	22167270
581 (in isoform 2)	Phosphorylation	-	26.72	21406692
583	Phosphorylation	PPRRRTPSPPPRRRS CCCCCCCCCCCCCCC	49.80	22167270
588 (in isoform 2)	Phosphorylation	-	49.56	21406692
590	Phosphorylation	SPPPRRRSPSPRRYS CCCCCCCCCCCCCCC	28.11	27273156
590 (in isoform 2)	Phosphorylation	-	28.11	21406692
592	Phosphorylation	PPRRRSPSPRRYSPP CCCCCCCCCCCCCCC	32.08	27273156
595 (in isoform 2)	Phosphorylation	-	39.40	21406692
596	Phosphorylation	RSPSPRRYSPPIQRR CCCCCCCCCCCCCCC	27.15	25463755
597	Phosphorylation	SPSPRRYSPPIQRRY CCCCCCCCCCCCCCC	23.53	25159151
603 (in isoform 2)	Phosphorylation	-	21.65	21406692
604	Phosphorylation	SPPIQRRYSPSPPPK CCCCCCCCCCCCCCC	27.42	23927012
605	Phosphorylation	PPIQRRYSPSPPPKR CCCCCCCCCCCCCCC	19.65	29255136
605 (in isoform 2)	Phosphorylation	-	19.65	21406692
607	Phosphorylation	IQRRYSPSPPPKRRT CCCCCCCCCCCCCCC	44.06	29255136
612 (in isoform 2)	Phosphorylation	-	47.13	21406692
614	Phosphorylation	SPPPKRRTASPPPPP CCCCCCCCCCCCCCC	35.20	22167270
614 (in isoform 2)	Phosphorylation	-	35.20	21406692
616	Phosphorylation	PPKRRTASPPPPPKR CCCCCCCCCCCCCCC	37.01	19664994
624 (in isoform 2)	Phosphorylation	-	45.61	21406692
626	Phosphorylation	PPPKRRASPSPPPKR CCCCCCCCCCCCCCC	24.89	22167270
626 (in isoform 2)	Phosphorylation	-	24.89	21406692
628	Phosphorylation	PKRRASPSPPPKRRV CCCCCCCCCCCCCCC	47.76	22167270
634 (in isoform 2)	Phosphorylation	-	40.18	21406692
636	Phosphorylation	PPPKRRVSHSPPPKQ CCCCCCCCCCCCCCC	19.21	22167270
636 (in isoform 2)	Phosphorylation	-	19.21	21406692
638	Phosphorylation	PKRRVSHSPPPKQRS CCCCCCCCCCCCCCC	31.43	22167270
643 (in isoform 2)	Phosphorylation	-	57.15	21406692
644 (in isoform 2)	Phosphorylation	-	45.27	21406692
645	Phosphorylation	SPPPKQRSSPVTKRR CCCCCCCCCCCCCCC	36.18	30266825
646	Phosphorylation	PPPKQRSSPVTKRRS CCCCCCCCCCCCCCC	26.11	30266825
649	Phosphorylation	KQRSSPVTKRRSPSL CCCCCCCCCCCCCCC	23.40	30266825
651 (in isoform 2)	Phosphorylation	-	34.64	21406692
653	Phosphorylation	SPVTKRRSPSLSSKH CCCCCCCCCCCCHHC	23.91	22167270
653 (in isoform 2)	Phosphorylation	-	23.91	21406692
655	Phosphorylation	VTKRRSPSLSSKHRK CCCCCCCCCCHHCCC	41.97	26846344
655 (in isoform 2)	Phosphorylation	-	41.97	21406692
657	Phosphorylation	KRRSPSLSSKHRKGS CCCCCCCCHHCCCCC	41.50	30266825
658	Phosphorylation	RRSPSLSSKHRKGSS CCCCCCCHHCCCCCC	37.46	30266825
662 (in isoform 2)	Phosphorylation	-	63.96	21406692
664	Phosphorylation	SSKHRKGSSPSRSTR CHHCCCCCCCCHHHC	41.95	30576142
665	Phosphorylation	SKHRKGSSPSRSTRE HHCCCCCCCCHHHCH	35.25	30278072
665 (in isoform 2)	Phosphorylation	-	35.25	21406692
667	Phosphorylation	HRKGSSPSRSTREAR CCCCCCCCHHHCHHC	40.59	30576142
669	Phosphorylation	KGSSPSRSTREARSP CCCCCCHHHCHHCCC	35.83	30576142
670	O-linked_Glycosylation	GSSPSRSTREARSPQ CCCCCHHHCHHCCCC	31.27	23301498
670	Phosphorylation	GSSPSRSTREARSPQ CCCCCHHHCHHCCCC	31.27	30576142
673 (in isoform 2)	Phosphorylation	-	17.60	21406692
675	Phosphorylation	RSTREARSPQPNKRH HHHCHHCCCCCCCCC	34.63	22167270
681 (in isoform 2)	Phosphorylation	-	42.00	21406692
683	Phosphorylation	PQPNKRHSPSPRPRA CCCCCCCCCCCCCCC	30.98	22167270
683 (in isoform 2)	Phosphorylation	-	30.98	21406692
685	Phosphorylation	PNKRHSPSPRPRAPQ CCCCCCCCCCCCCCC	36.23	22167270
691 (in isoform 2)	Phosphorylation	-	38.98	21406692
692 (in isoform 2)	Phosphorylation	-	53.69	21406692
693	Phosphorylation	PRPRAPQTSSSPPPV CCCCCCCCCCCCCCC	29.53	29255136
693 (in isoform 2)	Phosphorylation	-	29.53	21406692
694	Phosphorylation	RPRAPQTSSSPPPVR CCCCCCCCCCCCCCC	24.46	29255136
694 (in isoform 2)	Phosphorylation	-	24.46	21406692
695	Phosphorylation	PRAPQTSSSPPPVRR CCCCCCCCCCCCCCC	50.69	29255136
696	Phosphorylation	RAPQTSSSPPPVRRG CCCCCCCCCCCCCCC	40.99	22167270
703 (in isoform 2)	Phosphorylation	-	21.17	21406692
704 (in isoform 2)	Phosphorylation	-	12.39	21406692
705	Phosphorylation	PPVRRGASSSPQRRQ CCCCCCCCCCCCCCC	33.89	27273156
705 (in isoform 2)	Phosphorylation	-	33.89	21406692
706	Phosphorylation	PVRRGASSSPQRRQS CCCCCCCCCCCCCCC	45.57	27273156
707	Phosphorylation	VRRGASSSPQRRQSP CCCCCCCCCCCCCCC	23.66	27273156
711 (in isoform 2)	Phosphorylation	-	35.76	21406692
713	O-linked_Glycosylation	SSPQRRQSPSPSTRP CCCCCCCCCCCCCCC	26.07	23301498
713	Phosphorylation	SSPQRRQSPSPSTRP CCCCCCCCCCCCCCC	26.07	29255136
713 (in isoform 2)	Phosphorylation	-	26.07	21406692
715	Phosphorylation	PQRRQSPSPSTRPIR CCCCCCCCCCCCCCC	36.41	29255136
715 (in isoform 2)	Phosphorylation	-	36.41	21406692
716 (in isoform 2)	Phosphorylation	-	43.00	21406692
717	O-linked_Glycosylation	RRQSPSPSTRPIRRV CCCCCCCCCCCCCCC	41.19	23301498
717	Phosphorylation	RRQSPSPSTRPIRRV CCCCCCCCCCCCCCC	41.19	29255136
718	Phosphorylation	RQSPSPSTRPIRRVS CCCCCCCCCCCCCCC	43.80	29255136
723 (in isoform 2)	Phosphorylation	-	31.33	21406692
725	Phosphorylation	TRPIRRVSRTPEPKK CCCCCCCCCCCCCHH	28.73	22167270
725 (in isoform 2)	Phosphorylation	-	28.73	21406692
727	Phosphorylation	PIRRVSRTPEPKKIK CCCCCCCCCCCHHHC	25.21	22167270
736 (in isoform 2)	Phosphorylation	-	14.26	21406692
738	Phosphorylation	KKIKKAASPSPQSVR HHHCCCCCCCHHHHH	30.67	29255136
738 (in isoform 2)	Phosphorylation	-	30.67	21406692
740	Phosphorylation	IKKAASPSPQSVRRV HCCCCCCCHHHHHHH	32.83	29255136
741 (in isoform 2)	Phosphorylation	-	33.57	21406692
743	Phosphorylation	AASPSPQSVRRVSSS CCCCCHHHHHHHHCC	22.45	29255136
746 (in isoform 2)	Phosphorylation	-	30.43	21406692
747 (in isoform 2)	Phosphorylation	-	4.57	21406692
748	Phosphorylation	PQSVRRVSSSRSVSG HHHHHHHHCCCCCCC	22.30	26846344
748 (in isoform 2)	Phosphorylation	-	22.30	21406692
749	Phosphorylation	QSVRRVSSSRSVSGS HHHHHHHCCCCCCCC	27.24	26846344
750	Phosphorylation	SVRRVSSSRSVSGSP HHHHHHCCCCCCCCC	22.52	26846344
750 (in isoform 2)	Phosphorylation	-	22.52	21406692
752	Phosphorylation	RRVSSSRSVSGSPEP HHHHCCCCCCCCCCC	23.68	29255136
752 (in isoform 2)	Phosphorylation	-	23.68	21406692
754	Phosphorylation	VSSSRSVSGSPEPAA HHCCCCCCCCCCCHH	34.50	29255136
754 (in isoform 2)	Phosphorylation	-	34.50	21406692
756	Phosphorylation	SSRSVSGSPEPAAKK CCCCCCCCCCCHHCC	20.70	29255136
767 (in isoform 2)	Phosphorylation	-	35.36	21406692
769	Phosphorylation	KKPPAPPSPVQSQSP CCCCCCCCCCCCCCC	36.32	19664994
771 (in isoform 2)	Phosphorylation	-	11.39	21406692
773	Phosphorylation	APPSPVQSQSPSTNW CCCCCCCCCCCCCCC	32.62	22167270
773 (in isoform 2)	Phosphorylation	-	32.62	21406692
775	Phosphorylation	PSPVQSQSPSTNWSP CCCCCCCCCCCCCCC	26.51	19664994
775 (in isoform 2)	Phosphorylation	-	26.51	21406692
776 (in isoform 2)	Phosphorylation	-	37.22	21406692
777	Phosphorylation	PVQSQSPSTNWSPAV CCCCCCCCCCCCCCC	39.35	22167270
778	Phosphorylation	VQSQSPSTNWSPAVP CCCCCCCCCCCCCCC	44.05	22167270
779 (in isoform 2)	Phosphorylation	-	41.38	21406692
781	Phosphorylation	QSPSTNWSPAVPVKK CCCCCCCCCCCCCCC	12.68	22167270
787	Acetylation	WSPAVPVKKAKSPTP CCCCCCCCCCCCCCC	40.73	25953088
789 (in isoform 2)	Phosphorylation	-	16.31	21406692
791	Phosphorylation	VPVKKAKSPTPSPSP CCCCCCCCCCCCCCC	38.58	23927012
791 (in isoform 2)	Phosphorylation	-	38.58	21406692
793	Phosphorylation	VKKAKSPTPSPSPPR CCCCCCCCCCCCCCC	43.41	23927012
793 (in isoform 2)	Phosphorylation	-	43.41	21406692
795	Phosphorylation	KAKSPTPSPSPPRNS CCCCCCCCCCCCCCC	40.25	23927012
795 (in isoform 2)	Phosphorylation	-	40.25	21406692
797	Phosphorylation	KSPTPSPSPPRNSDQ CCCCCCCCCCCCCCC	52.45	23927012
800 (in isoform 2)	Phosphorylation	-	59.68	21406692
802	Phosphorylation	SPSPPRNSDQEGGGK CCCCCCCCCCCCCCC	41.78	25159151
811	Ubiquitination	QEGGGKKKKKKKDKK CCCCCCCCCCHHCHH	73.62	-
812	Ubiquitination	EGGGKKKKKKKDKKH CCCCCCCCCHHCHHH	77.90	-
846	Phosphorylation	AAAAAAVTPAAIAAA HHHHHHHCHHHHHHH	11.50	25159151
854	Phosphorylation	PAAIAAATTTLAQEE HHHHHHHHHHHHHCC	18.65	28464451
855	Phosphorylation	AAIAAATTTLAQEEP HHHHHHHHHHHHCCC	18.32	28464451
856	Phosphorylation	AIAAATTTLAQEEPV HHHHHHHHHHHCCCC	18.75	25159151
869	Sumoylation	PVAAPEPKKETESEA CCCCCCCCCCCHHHH	62.67	28112733
870 (in isoform 2)	Phosphorylation	-	79.27	21406692
872	Phosphorylation	APEPKKETESEAEDN CCCCCCCCHHHHHHC	54.41	19664994
872 (in isoform 2)	Phosphorylation	-	54.41	21406692
874	Phosphorylation	EPKKETESEAEDNLD CCCCCCHHHHHHCHH	49.91	19664994
894	Phosphorylation	LREKALRSMRKAQVS HHHHHHHHHHHHHCC	24.64	26074081
899 (in isoform 2)	Phosphorylation	-	38.98	21406692
901	Phosphorylation	SMRKAQVSPQS---- HHHHHHCCCCC----	12.73	30266825
904	Phosphorylation	KAQVSPQS------- HHHCCCCC-------	45.64	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
572	T	Phosphorylation	Kinase	MTOR	P42345	PSP
574	T	Phosphorylation	Kinase	MTOR	P42345	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRRM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRRM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FUS_HUMAN	FUS	physical	12581738
DEK_HUMAN	DEK	physical	10908574
SRRM2_HUMAN	SRRM2	physical	9531537
SRSF4_HUMAN	SRSF4	physical	9531537
SRSF5_HUMAN	SRSF5	physical	9531537
SMC1A_HUMAN	SMC1A	physical	16159877
RAD21_HUMAN	RAD21	physical	16159877
SMC3_HUMAN	SMC3	physical	16159877
SRRM2_HUMAN	SRRM2	physical	16159877
SRSF4_HUMAN	SRSF4	physical	16159877
SRSF6_HUMAN	SRSF6	physical	16159877
T2FA_HUMAN	GTF2F1	physical	16159877
RSMB_HUMAN	SNRPB	physical	16159877
RBMX_HUMAN	RBMX	physical	16159877
PTBP1_HUMAN	PTBP1	physical	16159877
HNRPM_HUMAN	HNRNPM	physical	16159877
SMD2_HUMAN	SNRPD2	physical	16159877
SMD3_HUMAN	SNRPD3	physical	16159877
RUXE_HUMAN	SNRPE	physical	16159877
RUXF_HUMAN	SNRPF	physical	16159877
RU1C_HUMAN	SNRPC	physical	16159877
RBM25_HUMAN	RBM25	physical	16159877
SF3B2_HUMAN	SF3B2	physical	16159877
RU2A_HUMAN	SNRPA1	physical	16159877
RU2B_HUMAN	SNRPB2	physical	16159877
SF3B3_HUMAN	SF3B3	physical	16159877
SF3B4_HUMAN	SF3B4	physical	16159877
U5S1_HUMAN	EFTUD2	physical	16159877
PRP8_HUMAN	PRPF8	physical	16159877
U520_HUMAN	SNRNP200	physical	16159877
SNR40_HUMAN	SNRNP40	physical	16159877
PRPF3_HUMAN	PRPF3	physical	16159877
CDC5L_HUMAN	CDC5L	physical	16159877
PININ_HUMAN	PNN	physical	16159877
PRP19_HUMAN	PRPF19	physical	16159877
RBM8A_HUMAN	RBM8A	physical	16159877
PLRG1_HUMAN	PLRG1	physical	16159877
SRSF3_HUMAN	SRSF3	physical	16159877
RBM23_HUMAN	RBM23	physical	16159877
SRSF2_HUMAN	SRSF2	physical	16159877
SRSF7_HUMAN	SRSF7	physical	16159877
DDX5_HUMAN	DDX5	physical	16159877
DHX16_HUMAN	DHX16	physical	16159877
NONO_HUMAN	NONO	physical	16159877
SFPQ_HUMAN	SFPQ	physical	16159877
DNJC8_HUMAN	DNAJC8	physical	16159877
SNW1_HUMAN	SNW1	physical	16159877
KHDR1_HUMAN	KHDRBS1	physical	16159877
PR40A_HUMAN	PRPF40A	physical	16159877
PCF11_HUMAN	PCF11	physical	16159877
CSTF2_HUMAN	CSTF2	physical	16159877
ZC3HE_HUMAN	ZC3H14	physical	16159877
FUBP1_HUMAN	FUBP1	physical	16159877
PUF60_HUMAN	PUF60	physical	16159877
BCLF1_HUMAN	BCLAF1	physical	16159877
PAXI1_HUMAN	PAXIP1	physical	16159877
GTF2I_HUMAN	GTF2I	physical	16159877
OLIG2_HUMAN	OLIG2	physical	16159877
KMT2D_HUMAN	KMT2D	physical	16159877
ASH2L_HUMAN	ASH2L	physical	16159877
NCOA5_HUMAN	NCOA5	physical	16159877
CNOT3_HUMAN	CNOT3	physical	16159877
RBM39_HUMAN	RBM39	physical	16159877
STAG2_HUMAN	STAG2	physical	16159877
WAPL_HUMAN	WAPAL	physical	16159877
SAP18_HUMAN	SAP18	physical	16159877
H2A2A_HUMAN	HIST2H2AA3	physical	16159877
SMRC2_HUMAN	SMARCC2	physical	16159877
CHD4_HUMAN	CHD4	physical	16159877
CBX3_HUMAN	CBX3	physical	16159877
SAFB1_HUMAN	SAFB	physical	16159877
EIF3H_HUMAN	EIF3H	physical	16159877
IF4A3_HUMAN	EIF4A3	physical	16159877
EF1A1_HUMAN	EEF1A1	physical	16159877
RS5_HUMAN	RPS5	physical	16159877
RS7_HUMAN	RPS7	physical	16159877
RS19_HUMAN	RPS19	physical	16159877
DDX21_HUMAN	DDX21	physical	16159877
YBOX3_HUMAN	YBX3	physical	16159877
ACINU_HUMAN	ACIN1	physical	16159877
NRP1_HUMAN	NRP1	physical	16159877
OGFR_HUMAN	OGFR	physical	16159877
LMNA_HUMAN	LMNA	physical	16159877
DNJA1_HUMAN	DNAJA1	physical	16159877
CSK2B_HUMAN	CSNK2B	physical	16159877
CRBB3_HUMAN	CRYBB3	physical	16159877
TCPE_HUMAN	CCT5	physical	16159877
NEST_HUMAN	NES	physical	16159877
TOP2B_HUMAN	TOP2B	physical	16159877
SOS1_HUMAN	SOS1	physical	16159877
CNGB1_HUMAN	CNGB1	physical	16159877
DPY30_HUMAN	DPY30	physical	16159877
ASB7_HUMAN	ASB7	physical	16159877
ISY1_HUMAN	ISY1	physical	16159877
PPIL1_HUMAN	PPIL1	physical	16159877
PDS5A_HUMAN	PDS5A	physical	16159877
ZN638_HUMAN	ZNF638	physical	16159877
SRSF3_HUMAN	SRSF3	physical	10809668
SRSF6_HUMAN	SRSF6	physical	10809668
PRP8_HUMAN	PRPF8	physical	10809668
REN3A_HUMAN	UPF3A	physical	11546874
SRRM2_HUMAN	SRRM2	physical	22939629
DHX15_HUMAN	DHX15	physical	26344197
T2EA_HUMAN	GTF2E1	physical	26344197
NOLC1_HUMAN	NOLC1	physical	26344197
NUMA1_HUMAN	NUMA1	physical	26344197
RBP2_HUMAN	RANBP2	physical	26344197
SRRM2_HUMAN	SRRM2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-10; THR-220; SER-260; SER-389; SER-391;SER-393; SER-429; SER-431; SER-463; SER-465; SER-560; SER-562;TYR-604; SER-605; SER-607; THR-614; SER-616; THR-693; SER-694;SER-695; SER-696; SER-738; SER-740; SER-769; SER-773; SER-775;SER-777; THR-778; SER-781; THR-872 AND SER-874, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-140, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-220; SER-260; SER-402;THR-406; SER-429; SER-431; SER-616; SER-694; SER-696; SER-738;SER-740; SER-769; SER-775; THR-778; SER-781; THR-872 AND SER-874, ANDMASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-10; THR-220; SER-260; SER-389; SER-391;SER-393; SER-429; SER-431; SER-463; SER-465; SER-560; SER-562;TYR-604; SER-605; SER-607; THR-614; SER-616; THR-693; SER-694;SER-695; SER-696; SER-738; SER-740; SER-769; SER-773; SER-775;SER-777; THR-778; SER-781; THR-872 AND SER-874, AND MASS SPECTROMETRY.
PubMed: 19413330

"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-872 AND SER-874, ANDMASS SPECTROMETRY.
PubMed: 18318008

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-220; SER-260; SER-389;SER-391; SER-393; SER-402; THR-406; SER-429; SER-431; SER-436;SER-463; SER-465; SER-560; SER-562; SER-597; SER-605; SER-607;THR-614; SER-616; SER-694; SER-696; SER-713; SER-715; THR-718;SER-738; SER-740; SER-743; SER-748; SER-752; SER-754; SER-756;SER-769; SER-773; SER-775; SER-777; SER-781; SER-791; THR-793;SER-795; SER-797; SER-802; THR-872 AND SER-874, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429 AND SER-431, ANDMASS SPECTROMETRY.
PubMed: 18691976

"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-738, AND MASSSPECTROMETRY.
PubMed: 19367720

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-220; SER-260; SER-389;SER-393; SER-597; SER-696; SER-713 AND THR-718, AND MASS SPECTROMETRY.
PubMed: 18187866

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-478; SER-597; SER-616;SER-696; SER-738; SER-740 AND SER-756, AND MASS SPECTROMETRY.
PubMed: 19007248

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-220; SER-260; SER-389;SER-391; SER-393; SER-402; THR-406; SER-429; SER-431; SER-463;SER-465; THR-614; SER-616; SER-665; SER-675; SER-695; SER-740;SER-750; SER-756; SER-769; SER-773; SER-775; THR-872; SER-874 ANDSER-894, AND MASS SPECTROMETRY.
PubMed: 17287340

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260; SER-389; SER-393;SER-402; THR-406; SER-450; SER-452; SER-597; SER-696; SER-713; THR-718AND SER-874, AND MASS SPECTROMETRY.
PubMed: 17924679

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-478; SER-560; SER-562;THR-614; SER-616; SER-738; SER-740; SER-743; SER-752; SER-754;SER-756; THR-872 AND SER-874, AND MASS SPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186; SER-187; SER-196;SER-198; SER-200; THR-220; SER-260; SER-292; SER-389; SER-391;SER-393; SER-402; THR-406; SER-429; SER-431; SER-450; SER-452;SER-463; SER-465; SER-524; SER-526; SER-528; SER-530; SER-532;SER-549; SER-551; SER-560; SER-562; THR-572; THR-574; THR-581;SER-583; SER-597; SER-605; SER-607; THR-614; SER-616; SER-626;SER-628; SER-636; SER-638; SER-675; SER-683; SER-685; SER-725;THR-727; SER-738; SER-740; THR-872 AND SER-874, AND MASS SPECTROMETRY.
PubMed: 17081983

"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402; THR-406; SER-463;SER-465; SER-541; SER-605; SER-607; SER-738; SER-740 AND SER-769, ANDMASS SPECTROMETRY.
PubMed: 16083285

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-211; THR-220;SER-389; SER-391; SER-393; SER-429; SER-431; THR-435; SER-478;SER-532; SER-549; SER-551; SER-560; SER-562; THR-572; THR-574;THR-581; SER-583; SER-605; SER-607; THR-614; SER-616; SER-626;SER-628; SER-675; SER-696; SER-738; SER-740; SER-754; SER-756;SER-769; SER-775 AND SER-781, AND MASS SPECTROMETRY.
PubMed: 15302935

"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry.";
Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.;
Anal. Chem. 76:2763-2772(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402 AND THR-406, ANDMASS SPECTROMETRY.
PubMed: 15144186