ASB7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASB7_HUMAN
• UniProt AC: Q9H672
• Protein Name: Ankyrin repeat and SOCS box protein 7
• Gene Name: ASB7
• Organism: Homo sapiens (Human).
• Sequence Length: 318
• Protein Description: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	Phosphorylation	IARLMLESEYRSDII HHHHHHHHHHHHHCC	35.65	-
105	Phosphorylation	RLMLESEYRSDIINA HHHHHHHHHHHCCCC	25.38	-
149	Ubiquitination	EVDPLSDKGTTPLQL CCCCCCCCCCCCHHH	55.57	-
234	Phosphorylation	VLCARMLYNYGADTN HHHHHHHHHCCCCCC	9.30	-
245	Phosphorylation	ADTNTRNYEGQTPLA CCCCCCCCCCCCCEE	20.39	22210691
305	Ubiquitination	LDELPIAKVMKDYLK CHHCHHHHHHHHHHH	43.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASB7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASB7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASB7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL5_HUMAN	CUL5	physical	16325183
RBX2_HUMAN	RNF7	physical	16325183
ATF4_HUMAN	ATF4	physical	21988832
CUL5_HUMAN	CUL5	physical	24337577
RBX2_HUMAN	RNF7	physical	24337577
ELOC_HUMAN	TCEB1	physical	24337577
ELOB_HUMAN	TCEB2	physical	24337577
HIF1N_HUMAN	HIF1AN	physical	24337577
ASB4_HUMAN	ASB4	physical	24337577
VINC_HUMAN	VCL	physical	24337577
FIBG_HUMAN	FGG	physical	24337577
FIBB_HUMAN	FGB	physical	24337577
FIBA_HUMAN	FGA	physical	24337577
GANAB_HUMAN	GANAB	physical	24337577
TCPH_HUMAN	CCT7	physical	24337577
PSRC1_HUMAN	PSRC1	physical	27697924
CUL5_HUMAN	CUL5	physical	27697924
CH034_HUMAN	C8orf34	physical	28514442
TRIPB_HUMAN	TRIP11	physical	28514442
CUL5_HUMAN	CUL5	physical	28514442
NPAT_HUMAN	NPAT	physical	28514442
HMBX1_HUMAN	HMBOX1	physical	28514442
KI13B_HUMAN	KIF13B	physical	28514442
ZFN2B_HUMAN	ZFAND2B	physical	28514442
KI13A_HUMAN	KIF13A	physical	28514442
HIF1N_HUMAN	HIF1AN	physical	28514442
SALL2_HUMAN	SALL2	physical	28514442
RMP_HUMAN	URI1	physical	28514442
RPC1_HUMAN	POLR3A	physical	28514442
CC136_HUMAN	CCDC136	physical	28514442
KMT2A_HUMAN	KMT2A	physical	28514442
RABE2_HUMAN	RABEP2	physical	28514442
RPAP3_HUMAN	RPAP3	physical	28514442
RPA1_HUMAN	POLR1A	physical	28514442
MD1L1_HUMAN	MAD1L1	physical	28514442
WDR75_HUMAN	WDR75	physical	28514442
PDRG1_HUMAN	PDRG1	physical	28514442
PIHD1_HUMAN	PIH1D1	physical	28514442
UXT_HUMAN	UXT	physical	28514442
WDR92_HUMAN	WDR92	physical	28514442
AN13A_HUMAN	ANKRD13A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.