ZFN2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZFN2B_HUMAN
• UniProt AC: Q8WV99
• Protein Name: AN1-type zinc finger protein 2B {ECO:0000305}
• Gene Name: ZFAND2B {ECO:0000312|HGNC:HGNC:25206}
• Organism: Homo sapiens (Human).
• Sequence Length: 257
• Subcellular Localization: Endoplasmic reticulum membrane ; Lipid-anchor .
• Protein Description: Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. [PubMed: 26692333]
• Protein Sequence: MEFPDLGAHCSEPSCQRLDFLPLKCDACSGIFCADHVAYAQHHCGSAYQKDIQVPVCPLCNVPVPVARGEPPDRAVGEHIDRDCRSDPAQQKRKIFTNKCERAGCRQREMMKLTCERCSRNFCIKHRHPLDHDCSGEGHPTSRAGLAAISRAQAVASTSTVPSPSQTMPSCTSPSRATTRSPSWTAPPVIALQNGLSEDEALQRALEMSLAETKPQVPSCQEEEDLALAQALSASEAEYQRQQAQSRSSKPSNCSLC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Ubiquitination	RLDFLPLKCDACSGI CCCCCCCCCCCCCCE	28.29	-
92	Ubiquitination	RSDPAQQKRKIFTNK CCCHHHHHHHHHHHH	43.51	2190698
92 (in isoform 2)	Ubiquitination	-	43.51	21906983
92 (in isoform 1)	Ubiquitination	-	43.51	21906983
94	Ubiquitination	DPAQQKRKIFTNKCE CHHHHHHHHHHHHHH	49.56	-
99	Ubiquitination	KRKIFTNKCERAGCR HHHHHHHHHHHHCCC	34.12	-
112	Ubiquitination	CRQREMMKLTCERCS CCHHHHHHHHHHHHC	39.06	-
125	Ubiquitination	CSRNFCIKHRHPLDH HCCCCCCCCCCCCCC	35.45	-
150	O-linked_Glycosylation	RAGLAAISRAQAVAS HHHHHHHHHHHHHHC	19.48	23301498
157	Phosphorylation	SRAQAVASTSTVPSP HHHHHHHCCCCCCCH	19.11	28450419
158	Phosphorylation	RAQAVASTSTVPSPS HHHHHHCCCCCCCHH	20.76	28450419
159	Phosphorylation	AQAVASTSTVPSPSQ HHHHHCCCCCCCHHH	25.55	28450419
160	Phosphorylation	QAVASTSTVPSPSQT HHHHCCCCCCCHHHC	36.20	28450419
163	Phosphorylation	ASTSTVPSPSQTMPS HCCCCCCCHHHCCCC	32.61	28450419
165	Phosphorylation	TSTVPSPSQTMPSCT CCCCCCHHHCCCCCC	42.49	28450419
167	Phosphorylation	TVPSPSQTMPSCTSP CCCCHHHCCCCCCCC	35.07	21712546
170	Phosphorylation	SPSQTMPSCTSPSRA CHHHCCCCCCCCCCC	21.14	21712546
172	Phosphorylation	SQTMPSCTSPSRATT HHCCCCCCCCCCCCC	48.27	21712546
173	Phosphorylation	QTMPSCTSPSRATTR HCCCCCCCCCCCCCC	25.79	21712546
175	Phosphorylation	MPSCTSPSRATTRSP CCCCCCCCCCCCCCC	34.02	21712546
178	Phosphorylation	CTSPSRATTRSPSWT CCCCCCCCCCCCCCC	22.95	28450419
179	Phosphorylation	TSPSRATTRSPSWTA CCCCCCCCCCCCCCC	28.32	28450419
181	Phosphorylation	PSRATTRSPSWTAPP CCCCCCCCCCCCCCC	22.61	21712546
183	Phosphorylation	RATTRSPSWTAPPVI CCCCCCCCCCCCCEE	38.00	23401153
185	Phosphorylation	TTRSPSWTAPPVIAL CCCCCCCCCCCEEEC	33.36	21712546
197	Phosphorylation	IALQNGLSEDEALQR EECCCCCCHHHHHHH	44.38	26074081
209	Phosphorylation	LQRALEMSLAETKPQ HHHHHHHHHHHCCCC	18.30	30631047
214	Ubiquitination	EMSLAETKPQVPSCQ HHHHHHCCCCCCCCC	25.59	-
239	Phosphorylation	LSASEAEYQRQQAQS HHHHHHHHHHHHHHH	18.95	27642862
250	Ubiquitination	QAQSRSSKPSNCSLC HHHHHCCCCCCCCCC	54.43	-
254	Geranylgeranylation	RSSKPSNCSLC---- HCCCCCCCCCC----	3.74	-
254	Methylation	RSSKPSNCSLC---- HCCCCCCCCCC----	3.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZFN2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZFN2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZFN2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAZP2_HUMAN	DAZAP2	physical	19060904
TERA_HUMAN	VCP	physical	24160817
NPL4_HUMAN	NPLOC4	physical	24160817
FAF2_HUMAN	FAF2	physical	24160817
DERL1_HUMAN	DERL1	physical	24160817
BAG6_HUMAN	BAG6	physical	24160817
UBB_HUMAN	UBB	physical	26186194
H11_HUMAN	HIST1H1A	physical	26186194
PRS10_HUMAN	PSMC6	physical	26186194
PRS6A_HUMAN	PSMC3	physical	26186194
PRS8_HUMAN	PSMC5	physical	26186194
PSD10_HUMAN	PSMD10	physical	26186194
PSMD6_HUMAN	PSMD6	physical	26186194
RAD50_HUMAN	RAD50	physical	26186194
PAAF1_HUMAN	PAAF1	physical	26186194
GLNA_HUMAN	GLUL	physical	26186194
VCAM1_HUMAN	VCAM1	physical	26337389
TERA_HUMAN	VCP	physical	26337389
BAG6_HUMAN	BAG6	physical	26337389
UBC_HUMAN	UBC	physical	26337389
UBB_HUMAN	UBB	physical	28514442
PRS8_HUMAN	PSMC5	physical	28514442
PRS10_HUMAN	PSMC6	physical	28514442
RAD50_HUMAN	RAD50	physical	28514442
GLNA_HUMAN	GLUL	physical	28514442
PAAF1_HUMAN	PAAF1	physical	28514442
H11_HUMAN	HIST1H1A	physical	28514442
PSMD6_HUMAN	PSMD6	physical	28514442
PRS6B_HUMAN	PSMC4	physical	28514442
PRS6A_HUMAN	PSMC3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.