UniProt ID | VCAM1_HUMAN | |
---|---|---|
UniProt AC | P19320 | |
Protein Name | Vascular cell adhesion protein 1 | |
Gene Name | VCAM1 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 739 | |
Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
Protein Description | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.. | |
Protein Sequence | MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
81 | O-linked_Glycosylation | EGTTSTLTMNPVSFG CCCCCEEEECCCCCC | 18.26 | OGP | |
177 | Phosphorylation | RKSLETKSLEVTFTP HHHCCCCCEEEEECC | 36.86 | 27251275 | |
181 | Phosphorylation | ETKSLEVTFTPVIED CCCCEEEEECCCHHH | 16.65 | 27251275 | |
183 | Phosphorylation | KSLEVTFTPVIEDIG CCEEEEECCCHHHHH | 13.79 | 27251275 | |
222 | Phosphorylation | KELQVYISPKNTVIS HHCEEEECCCCEEEE | 16.48 | 24719451 | |
273 | N-linked_Glycosylation | NLQHLSGNATLTLIA CCCCCCCCCEEEEEE | 26.78 | UniProtKB CARBOHYD | |
365 | N-linked_Glycosylation | KVRSEGTNSTLTLSP CCCCCCCCCEEEEEC | 43.80 | UniProtKB CARBOHYD | |
369 | O-linked_Glycosylation | EGTNSTLTLSPVSFE CCCCCEEEEECCCCC | 25.86 | OGP | |
401 | Phosphorylation | KGIQVELYSFPRDPE CCEEEEEEECCCCCC | 8.51 | 22210691 | |
402 | Phosphorylation | GIQVELYSFPRDPEI CEEEEEEECCCCCCE | 41.20 | 22210691 | |
417 | N-linked_Glycosylation | EMSGGLVNGSSVTVS EEECCEECCCEEEEE | 50.07 | UniProtKB CARBOHYD | |
445 | Phosphorylation | IELLKGETILENIEF EEEECCCCHHHHHHH | 39.26 | 28122231 | |
460 | Phosphorylation | LEDTDMKSLENKSLE HHCCCCHHHCCCCEE | 33.99 | 28857561 | |
463 | N-linked_Glycosylation | TDMKSLENKSLEMTF CCCHHHCCCCEEEEE | 44.50 | UniProtKB CARBOHYD | |
465 | Phosphorylation | MKSLENKSLEMTFIP CHHHCCCCEEEEEEC | 40.94 | 28857561 | |
504 | O-linked_Glycosylation | KQRQSTQTLYVNVAP CCCCCCEEEEEEECC | 21.83 | OGP | |
531 | N-linked_Glycosylation | LEEGSSVNMTCLSQG HCCCCCCCCEECCCC | 23.22 | UniProtKB CARBOHYD | |
561 | N-linked_Glycosylation | ELQPLSENATLTLIS CCCCCCCCCEEEEEE | 34.54 | 16335952 | |
568 | Phosphorylation | NATLTLISTKMEDSG CCEEEEEEECCCCCC | 25.70 | 24719451 | |
653 | Phosphorylation | LKSIDGAYTIRKAQL EHHCCCCEEEEEHHH | 14.29 | - | |
654 | Phosphorylation | KSIDGAYTIRKAQLK HHCCCCEEEEEHHHH | 17.48 | 24719451 | |
703 | Phosphorylation | SPELLVLYFASSLII CHHHHHHHHHHHCHH | 6.93 | 19835603 | |
706 | Phosphorylation | LLVLYFASSLIIPAI HHHHHHHHHCHHHHH | 18.77 | 19835603 | |
707 | Phosphorylation | LVLYFASSLIIPAIG HHHHHHHHCHHHHHH | 21.84 | 19835603 | |
718 | Phosphorylation | PAIGMIIYFARKANM HHHHHHHHHHHHCCC | 4.73 | 22817900 | |
728 | Phosphorylation | RKANMKGSYSLVEAQ HHCCCCCCCCHHHHH | 13.16 | 29083192 | |
730 | Phosphorylation | ANMKGSYSLVEAQKS CCCCCCCCHHHHHHC | 27.86 | 24275569 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VCAM1_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VCAM1_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VCAM1_HUMAN !! |
Kegg Disease | ||||||
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H00080 | Systemic lupus erythematosus | |||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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N-linked Glycosylation | |
Reference | PubMed |
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-561, AND MASSSPECTROMETRY. |