| UniProt ID | VCAM1_HUMAN | |
|---|---|---|
| UniProt AC | P19320 | |
| Protein Name | Vascular cell adhesion protein 1 | |
| Gene Name | VCAM1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 739 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.. | |
| Protein Sequence | MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 81 | O-linked_Glycosylation | EGTTSTLTMNPVSFG CCCCCEEEECCCCCC | 18.26 | OGP | |
| 177 | Phosphorylation | RKSLETKSLEVTFTP HHHCCCCCEEEEECC | 36.86 | 27251275 | |
| 181 | Phosphorylation | ETKSLEVTFTPVIED CCCCEEEEECCCHHH | 16.65 | 27251275 | |
| 183 | Phosphorylation | KSLEVTFTPVIEDIG CCEEEEECCCHHHHH | 13.79 | 27251275 | |
| 222 | Phosphorylation | KELQVYISPKNTVIS HHCEEEECCCCEEEE | 16.48 | 24719451 | |
| 273 | N-linked_Glycosylation | NLQHLSGNATLTLIA CCCCCCCCCEEEEEE | 26.78 | UniProtKB CARBOHYD | |
| 365 | N-linked_Glycosylation | KVRSEGTNSTLTLSP CCCCCCCCCEEEEEC | 43.80 | UniProtKB CARBOHYD | |
| 369 | O-linked_Glycosylation | EGTNSTLTLSPVSFE CCCCCEEEEECCCCC | 25.86 | OGP | |
| 401 | Phosphorylation | KGIQVELYSFPRDPE CCEEEEEEECCCCCC | 8.51 | 22210691 | |
| 402 | Phosphorylation | GIQVELYSFPRDPEI CEEEEEEECCCCCCE | 41.20 | 22210691 | |
| 417 | N-linked_Glycosylation | EMSGGLVNGSSVTVS EEECCEECCCEEEEE | 50.07 | UniProtKB CARBOHYD | |
| 445 | Phosphorylation | IELLKGETILENIEF EEEECCCCHHHHHHH | 39.26 | 28122231 | |
| 460 | Phosphorylation | LEDTDMKSLENKSLE HHCCCCHHHCCCCEE | 33.99 | 28857561 | |
| 463 | N-linked_Glycosylation | TDMKSLENKSLEMTF CCCHHHCCCCEEEEE | 44.50 | UniProtKB CARBOHYD | |
| 465 | Phosphorylation | MKSLENKSLEMTFIP CHHHCCCCEEEEEEC | 40.94 | 28857561 | |
| 504 | O-linked_Glycosylation | KQRQSTQTLYVNVAP CCCCCCEEEEEEECC | 21.83 | OGP | |
| 531 | N-linked_Glycosylation | LEEGSSVNMTCLSQG HCCCCCCCCEECCCC | 23.22 | UniProtKB CARBOHYD | |
| 561 | N-linked_Glycosylation | ELQPLSENATLTLIS CCCCCCCCCEEEEEE | 34.54 | 16335952 | |
| 568 | Phosphorylation | NATLTLISTKMEDSG CCEEEEEEECCCCCC | 25.70 | 24719451 | |
| 653 | Phosphorylation | LKSIDGAYTIRKAQL EHHCCCCEEEEEHHH | 14.29 | - | |
| 654 | Phosphorylation | KSIDGAYTIRKAQLK HHCCCCEEEEEHHHH | 17.48 | 24719451 | |
| 703 | Phosphorylation | SPELLVLYFASSLII CHHHHHHHHHHHCHH | 6.93 | 19835603 | |
| 706 | Phosphorylation | LLVLYFASSLIIPAI HHHHHHHHHCHHHHH | 18.77 | 19835603 | |
| 707 | Phosphorylation | LVLYFASSLIIPAIG HHHHHHHHCHHHHHH | 21.84 | 19835603 | |
| 718 | Phosphorylation | PAIGMIIYFARKANM HHHHHHHHHHHHCCC | 4.73 | 22817900 | |
| 728 | Phosphorylation | RKANMKGSYSLVEAQ HHCCCCCCCCHHHHH | 13.16 | 29083192 | |
| 730 | Phosphorylation | ANMKGSYSLVEAQKS CCCCCCCCHHHHHHC | 27.86 | 24275569 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VCAM1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VCAM1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VCAM1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00080 | Systemic lupus erythematosus | |||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-561, AND MASSSPECTROMETRY. | |