dbPTM

ITA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ITA4_HUMAN
UniProt AC	P13612
Protein Name	Integrin alpha-4
Gene Name	ITGA4
Organism	Homo sapiens (Human).
Sequence Length	1032
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. [PubMed: 23125415 ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1]
Protein Sequence	MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	N-linked_Glycosylation	PTANWLANASVINPG CCCHHHCCCCCCCCC	30.49	19349973
79	N-linked_Glycosylation	PTANWLANASVINPG CCCHHHCCCCCCCCC	30.49	19349973
95	Ubiquitination	IYRCRIGKNPGQTCE EEEEECCCCCCCCCE	58.56	22505724
116	Ubiquitination	PNGEPCGKTCLEERD CCCCCCCCCCCCCCC	42.66	22505724
117	Phosphorylation	NGEPCGKTCLEERDN CCCCCCCCCCCCCCC	13.96	29978859
130	Phosphorylation	DNQWLGVTLSRQPGE CCCEEEEEEECCCCC	19.74	29978859
132	Phosphorylation	QWLGVTLSRQPGENG CEEEEEEECCCCCCC	21.36	29978859
138	N-linked_Glycosylation	LSRQPGENGSIVTCG EECCCCCCCCEEECC	56.26	UniProtKB CARBOHYD
140	Phosphorylation	RQPGENGSIVTCGHR CCCCCCCCEEECCCC	26.01	29978859
143	Phosphorylation	GENGSIVTCGHRWKN CCCCCEEECCCCCEE	15.88	29978859
149	Ubiquitination	VTCGHRWKNIFYIKN EECCCCCEEEEEEEC	39.87	29967540
155	Ubiquitination	WKNIFYIKNENKLPT CEEEEEEECCCCCCC	46.99	29967540
159	Ubiquitination	FYIKNENKLPTGGCY EEEECCCCCCCCCCC	50.06	29967540
162	Phosphorylation	KNENKLPTGGCYGVP ECCCCCCCCCCCCCC	57.55	29083192
166	Phosphorylation	KLPTGGCYGVPPDLR CCCCCCCCCCCHHHH	25.16	29083192
189	Ubiquitination	PCYQDYVKKFGENFA HHHHHHHHHHHHCHH	35.83	22505724
190	Ubiquitination	CYQDYVKKFGENFAS HHHHHHHHHHHCHHH	48.86	29967540
229	N-linked_Glycosylation	TGSLFVYNITTNKYK CCEEEEEEECCCEEE	21.59	UniProtKB CARBOHYD
236	Ubiquitination	NITTNKYKAFLDKQN EECCCEEEHHHCCCC	33.98	29967540
241	Ubiquitination	KYKAFLDKQNQVKFG EEEHHHCCCCCCCCC	53.98	29967540
280	Ubiquitination	PQHEQIGKAYIFSID CCHHHCCCEEEEECC	39.38	29967540
289	Ubiquitination	YIFSIDEKELNILHE EEEECCHHHHHHHHH	64.85	29967540
298	Ubiquitination	LNILHEMKGKKLGSY HHHHHHHCCCCCHHH	65.67	29967540
300	Ubiquitination	ILHEMKGKKLGSYFG HHHHHCCCCCHHHCC	39.03	-
331	Phosphorylation	LVGAPMQSTIREEGR CCCCCCCCEECCCCC	21.39	27174698
332	Phosphorylation	VGAPMQSTIREEGRV CCCCCCCEECCCCCE	13.73	27174698
363	Ubiquitination	TNLVGSDKYAARFGE HCCCCCHHHHHHHCC	38.19	-
412	Phosphorylation	GRADGISSTFSQRIE CCCCCCCHHHHHHHH	31.39	-
480	N-linked_Glycosylation	LSHPESVNRTKFDCV CCCHHHCCCCCCCHH	56.00	19349973
480	N-linked_Glycosylation	LSHPESVNRTKFDCV CCCHHHCCCCCCCHH	56.00	19349973
499	Phosphorylation	PSVCIDLTLCFSYKG CCEEEEEEEEEECCC	20.10	30576142
503	Phosphorylation	IDLTLCFSYKGKEVP EEEEEEEECCCCCCC	25.57	30576142
512	Phosphorylation	KGKEVPGYIVLFYNM CCCCCCEEEEEEEEE	5.04	26074081
517	Phosphorylation	PGYIVLFYNMSLDVN CEEEEEEEEEECCCC	13.04	26074081
518	N-linked_Glycosylation	GYIVLFYNMSLDVNR EEEEEEEEEECCCCC	13.26	19349973
518	N-linked_Glycosylation	GYIVLFYNMSLDVNR EEEEEEEEEECCCCC	13.26	19349973
520	Phosphorylation	IVLFYNMSLDVNRKA EEEEEEEECCCCCCC	20.13	26074081
538	N-linked_Glycosylation	PRFYFSSNGTSDVIT CCEEECCCCCCCEEE	57.47	19349973
538	N-linked_Glycosylation	PRFYFSSNGTSDVIT CCEEECCCCCCCEEE	57.47	19349973
590	Ubiquitination	LGPHVISKRSTEEFP CCCCEECCCCCCCCC	38.96	29967540
606	Ubiquitination	LQPILQQKKEKDIMK CHHHHHHHHHHHHHH	50.36	22505724
607	Ubiquitination	QPILQQKKEKDIMKK HHHHHHHHHHHHHHH	66.70	-
614	Ubiquitination	KEKDIMKKTINFARF HHHHHHHHHHCHHHH	36.94	29967540
626	N-linked_Glycosylation	ARFCAHENCSADLQV HHHHCCCCCCCCEEE	18.38	UniProtKB CARBOHYD
634	Phosphorylation	CSADLQVSAKIGFLK CCCCEEEEEEEEEEC	15.75	-
641	Ubiquitination	SAKIGFLKPHENKTY EEEEEEECCCCCCEE	41.91	29967540
645	N-linked_Glycosylation	GFLKPHENKTYLAVG EEECCCCCCEEEEEC	38.65	19349973
645	N-linked_Glycosylation	GFLKPHENKTYLAVG EEECCCCCCEEEEEC	38.65	19349973
646	Ubiquitination	FLKPHENKTYLAVGS EECCCCCCEEEEECC	35.25	-
656	Phosphorylation	LAVGSMKTLMLNVSL EEECCCEEEEEEEEE	14.57	28348404
660	N-linked_Glycosylation	SMKTLMLNVSLFNAG CCEEEEEEEEEEECC	13.84	19349973
660	N-linked_Glycosylation	SMKTLMLNVSLFNAG CCEEEEEEEEEEECC	13.84	19349973
662	Phosphorylation	KTLMLNVSLFNAGDD EEEEEEEEEEECCCC	26.60	28348404
734	Phosphorylation	SFLLDVSSLSRAEED EEEECHHHHCCCCCC	30.16	-
760	Ubiquitination	EEEMDNLKHSRVTVA HHHHHHCCCCEEEEE	45.87	-
771	Ubiquitination	VTVAIPLKYEVKLTV EEEEEEEEEEEEEEE	33.73	29967540
806	N-linked_Glycosylation	TCMVEKMNLTFHVIN EEEEEECEEEEEEEE	47.17	19349973
806	N-linked_Glycosylation	TCMVEKMNLTFHVIN EEEEEECEEEEEEEE	47.17	UniProtKB CARBOHYD
813	N-linked_Glycosylation	NLTFHVINTGNSMAP EEEEEEEECCCCCCC	40.62	19349973
813	N-linked_Glycosylation	NLTFHVINTGNSMAP EEEEEEEECCCCCCC	40.62	19349973
821	N-linked_Glycosylation	TGNSMAPNVSVEIMV CCCCCCCCEEEEEEC	29.20	UniProtKB CARBOHYD
867	Ubiquitination	VCALEQQKSAMQTLK HHHHHHHHHHHHHHH	39.62	29967540
873	Ubiquitination	QKSAMQTLKGIVRFL HHHHHHHHHHHHHHH	2.42	21906983
906	Ubiquitination	NFLCNFGKMESGKEA HHHHHCCCCCCCCEE	35.04	29967540
924	Phosphorylation	IQLEGRPSILEMDET EEECCCCCEEEECCC	38.14	-
1010	Ubiquitination	GFFKRQYKSILQEEN CHHHHHHHHHHCHHH	23.76	-
1011	Phosphorylation	FFKRQYKSILQEENR HHHHHHHHHHCHHHC	24.48	29255136
1021	Phosphorylation	QEENRRDSWSYINSK CHHHCHHCCHHHHCC	18.99	18707149
1023	Phosphorylation	ENRRDSWSYINSKSN HHCHHCCHHHHCCCC	21.78	23401153
1024	Phosphorylation	NRRDSWSYINSKSND HCHHCCHHHHCCCCC	9.62	23927012
1027	Phosphorylation	DSWSYINSKSNDD-- HCCHHHHCCCCCC--	28.09	23927012
1028	Ubiquitination	SWSYINSKSNDD--- CCHHHHCCCCCC---	49.11	22505724
1029	Phosphorylation	WSYINSKSNDD---- CHHHHCCCCCC----	45.36	-
1034	Ubiquitination	SKSNDD--------- CCCCCC---------		21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1021	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1021	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
1027	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1027	S	Phosphorylation		11533025
Phosphorylation on Ser-1027 inhibits PXN binding.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ITA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EED_HUMAN	EED	physical	9765275
CLH1_HUMAN	CLTC	physical	22623428
PRKDC_HUMAN	PRKDC	physical	22623428
FLNA_HUMAN	FLNA	physical	22623428
HNRPM_HUMAN	HNRNPM	physical	22623428
HSP7C_HUMAN	HSPA8	physical	22623428
TBB4B_HUMAN	TUBB4B	physical	22623428
DDX5_HUMAN	DDX5	physical	22623428
ACTB_HUMAN	ACTB	physical	22623428
ACTG_HUMAN	ACTG1	physical	22623428
HS90B_HUMAN	HSP90AB1	physical	22623428
FUBP2_HUMAN	KHSRP	physical	22623428
VCAM1_HUMAN	VCAM1	physical	22623428
TLN1_HUMAN	TLN1	physical	22623428
PDC6I_HUMAN	PDCD6IP	physical	22623428
CLIC1_HUMAN	CLIC1	physical	22623428
ROA2_HUMAN	HNRNPA2B1	physical	22623428
VIME_HUMAN	VIM	physical	22623428
CH60_HUMAN	HSPD1	physical	22623428
RS3_HUMAN	RPS3	physical	22623428
BUB3_HUMAN	BUB3	physical	22623428
PRDX1_HUMAN	PRDX1	physical	22623428
AP2A1_HUMAN	AP2A1	physical	22623428
SYVC_HUMAN	VARS	physical	22623428
EF2_HUMAN	EEF2	physical	22623428
PABP1_HUMAN	PABPC1	physical	22623428
TBA1C_HUMAN	TUBA1C	physical	22623428
K1C16_HUMAN	KRT16	physical	22623428
FUBP3_HUMAN	FUBP3	physical	22623428
EF1A1_HUMAN	EEF1A1	physical	22623428
HBG1_HUMAN	HBG1	physical	22623428
HNRH3_HUMAN	HNRNPH3	physical	22623428
K2C1_HUMAN	KRT1	physical	22623428
UBP2L_HUMAN	UBAP2L	physical	22623428
CDK1_HUMAN	CDK1	physical	22623428
RS18_HUMAN	RPS18	physical	22623428
PICAL_HUMAN	PICALM	physical	22623428
HSPB1_HUMAN	HSPB1	physical	22623428
NSUN2_HUMAN	NSUN2	physical	22623428
G3P_HUMAN	GAPDH	physical	22623428
HNRPK_HUMAN	HNRNPK	physical	22623428
H4_HUMAN	HIST1H4I	physical	22623428
IF4G1_HUMAN	EIF4G1	physical	22623428
PTBP1_HUMAN	PTBP1	physical	22623428
HNRPL_HUMAN	HNRNPL	physical	22623428
RS4X_HUMAN	RPS4X	physical	22623428
RS14_HUMAN	RPS14	physical	22623428
TAGL2_HUMAN	TAGLN2	physical	22623428
IF2B1_HUMAN	IGF2BP1	physical	22623428
DDX3X_HUMAN	DDX3X	physical	22623428
K2C6A_HUMAN	KRT6A	physical	22623428
CAN1_HUMAN	CAPN1	physical	22623428
RBM4_HUMAN	RBM4	physical	22623428
RAN_HUMAN	RAN	physical	22623428
PRP8_HUMAN	PRPF8	physical	22623428
IF4G2_HUMAN	EIF4G2	physical	22623428
PARP1_HUMAN	PARP1	physical	22623428
NTPCR_HUMAN	NTPCR	physical	22623428
RS27A_HUMAN	RPS27A	physical	22623428
RL40_HUMAN	UBA52	physical	22623428
UBB_HUMAN	UBB	physical	22623428
UBC_HUMAN	UBC	physical	22623428
H2B1L_HUMAN	HIST1H2BL	physical	22623428
H2B1D_HUMAN	HIST1H2BD	physical	22623428
H2B1C_HUMAN	HIST1H2BD	physical	22623428
H2B1H_HUMAN	HIST1H2BH	physical	22623428
H2B2F_HUMAN	HIST2H2BF	physical	22623428
H2B1M_HUMAN	HIST1H2BM	physical	22623428
H2B1N_HUMAN	HIST1H2BN	physical	22623428
H13_HUMAN	HIST1H1D	physical	22623428
SHIP2_HUMAN	INPPL1	physical	22623428
TCRG1_HUMAN	TCERG1	physical	22623428
PIMT_HUMAN	PCMT1	physical	22623428
PCBP1_HUMAN	PCBP1	physical	22623428
GCN1_HUMAN	GCN1L1	physical	22623428
GRB2_HUMAN	GRB2	physical	22623428
HNRPU_HUMAN	HNRNPU	physical	22623428
SMD2_HUMAN	SNRPD2	physical	22623428
CPSF5_HUMAN	NUDT21	physical	22623428
U520_HUMAN	SNRNP200	physical	22623428
RS19_HUMAN	RPS19	physical	22623428
NU214_HUMAN	NUP214	physical	22623428
ANXA1_HUMAN	ANXA1	physical	22623428
RBM14_HUMAN	RBM14	physical	22623428
1433Z_HUMAN	YWHAZ	physical	22623428
PTN23_HUMAN	PTPN23	physical	22623428
HBA_HUMAN	HBA1	physical	22623428
PPIA_HUMAN	PPIA	physical	22623428
HNRH1_HUMAN	HNRNPH1	physical	22623428
HBE_HUMAN	HBE1	physical	22623428
ROA1_HUMAN	HNRNPA1	physical	22623428
H32_HUMAN	HIST2H3C	physical	22623428
H33_HUMAN	H3F3A	physical	22623428
H31_HUMAN	HIST1H3A	physical	22623428
H31T_HUMAN	HIST3H3	physical	22623428
RS3A_HUMAN	RPS3A	physical	22623428
HNRPC_HUMAN	HNRNPC	physical	22623428
IST1_HUMAN	IST1	physical	22623428
SYEP_HUMAN	EPRS	physical	22623428
DDX21_HUMAN	DDX21	physical	22623428
HNRPD_HUMAN	HNRNPD	physical	22623428
SDCB1_HUMAN	SDCBP	physical	22623428
PROF1_HUMAN	PFN1	physical	22623428
IF2B2_HUMAN	IGF2BP2	physical	22623428
ARK72_HUMAN	AKR7A2	physical	22623428
SFPQ_HUMAN	SFPQ	physical	22623428
AP2B1_HUMAN	AP2B1	physical	22623428
CLCA_HUMAN	CLTA	physical	22623428
PHB2_HUMAN	PHB2	physical	22623428
DYN2_HUMAN	DNM2	physical	22623428
PYR1_HUMAN	CAD	physical	22623428
NQO1_HUMAN	NQO1	physical	22623428
ACTN4_HUMAN	ACTN4	physical	22623428
MCM5_HUMAN	MCM5	physical	22623428
RS9_HUMAN	RPS9	physical	22623428
DYHC1_HUMAN	DYNC1H1	physical	22623428
RL11_HUMAN	RPL11	physical	22623428
CHM4B_HUMAN	CHMP4B	physical	22623428
SYLC_HUMAN	LARS	physical	22623428
RSSA_HUMAN	RPSA	physical	22623428
LMNA_HUMAN	LMNA	physical	22623428
H2A1B_HUMAN	HIST1H2AE	physical	22623428
H2A3_HUMAN	HIST3H2A	physical	22623428
H2A1C_HUMAN	HIST1H2AC	physical	22623428
RAC2_HUMAN	RAC2	physical	22623428
K1C19_HUMAN	KRT19	physical	22623428
LPPRC_HUMAN	LRPPRC	physical	22623428
RL22_HUMAN	RPL22	physical	22623428
PPIL1_HUMAN	PPIL1	physical	22623428
RL23_HUMAN	RPL23	physical	22623428
CH10_HUMAN	HSPE1	physical	22623428
RL30_HUMAN	RPL30	physical	22623428
RS5_HUMAN	RPS5	physical	22623428
APT_HUMAN	APRT	physical	22623428
RL18_HUMAN	RPL18	physical	22623428
HNRPQ_HUMAN	SYNCRIP	physical	22623428
TCPH_HUMAN	CCT7	physical	22623428
EF1D_HUMAN	EEF1D	physical	22623428
RS11_HUMAN	RPS11	physical	22623428
URP2_HUMAN	FERMT3	physical	22623428
RS21_HUMAN	RPS21	physical	22623428
PRDX2_HUMAN	PRDX2	physical	22623428
HNRPR_HUMAN	HNRNPR	physical	22623428
TCPZ_HUMAN	CCT6A	physical	22623428
ATX2L_HUMAN	ATXN2L	physical	22623428
PRDX6_HUMAN	PRDX6	physical	22623428
RS8_HUMAN	RPS8	physical	22623428
K2C8_HUMAN	KRT8	physical	22623428
RS13_HUMAN	RPS13	physical	22623428
XPO5_HUMAN	XPO5	physical	22623428
SF01_HUMAN	SF1	physical	22623428
EWS_HUMAN	EWSR1	physical	22623428
CSK2B_HUMAN	CSNK2B	physical	22623428
NUCL_HUMAN	NCL	physical	22623428
TCPD_HUMAN	CCT4	physical	22623428
FUBP1_HUMAN	FUBP1	physical	22623428
CHM2A_HUMAN	CHMP2A	physical	22623428
ROA0_HUMAN	HNRNPA0	physical	22623428
RL12_HUMAN	RPL12	physical	22623428
CPNS1_HUMAN	CAPNS1	physical	22623428
SRP09_HUMAN	SRP9	physical	22623428
RS20_HUMAN	RPS20	physical	22623428
RS16_HUMAN	RPS16	physical	22623428
CBL_HUMAN	CBL	physical	22623428
SNX3_HUMAN	SNX3	physical	22623428
RENT1_HUMAN	UPF1	physical	22623428
RS6_HUMAN	RPS6	physical	22623428
HBAZ_HUMAN	HBZ	physical	22623428
K1C9_HUMAN	KRT9	physical	22623428
PCBP2_HUMAN	PCBP2	physical	22623428
LYPA1_HUMAN	LYPLA1	physical	22623428
TCPQ_HUMAN	CCT8	physical	22623428
HIP1R_HUMAN	HIP1R	physical	22623428
RL13_HUMAN	RPL13	physical	22623428
PDCD6_HUMAN	PDCD6	physical	22623428
FUS_HUMAN	FUS	physical	22623428
ROAA_HUMAN	HNRNPAB	physical	22623428
RLA0_HUMAN	RPLP0	physical	22623428
ESYT1_HUMAN	ESYT1	physical	22623428
RL9_HUMAN	RPL9	physical	22623428
ADT2_HUMAN	SLC25A5	physical	22623428
XRCC6_HUMAN	XRCC6	physical	22623428
LRC59_HUMAN	LRRC59	physical	22623428
TIAR_HUMAN	TIAL1	physical	22623428
SYIC_HUMAN	IARS	physical	22623428
KSYK_HUMAN	SYK	physical	22623428
SYMC_HUMAN	MARS	physical	22623428
RL38_HUMAN	RPL38	physical	22623428
1433E_HUMAN	YWHAE	physical	22623428
ILF2_HUMAN	ILF2	physical	22623428
HBG2_HUMAN	HBG2	physical	22623428
MBNL1_HUMAN	MBNL1	physical	22623428
TOP2A_HUMAN	TOP2A	physical	22623428
TADBP_HUMAN	TARDBP	physical	22623428
RS15A_HUMAN	RPS15A	physical	22623428
MIF_HUMAN	MIF	physical	22623428
TOM34_HUMAN	TOMM34	physical	22623428
TTC9C_HUMAN	TTC9C	physical	22623428
DAZP1_HUMAN	DAZAP1	physical	22623428
RS28_HUMAN	RPS28	physical	22623428
COF1_HUMAN	CFL1	physical	22623428
MCM7_HUMAN	MCM7	physical	22623428
PPIH_HUMAN	PPIH	physical	22623428
ACTC_HUMAN	ACTC1	physical	22623428
PSB1_HUMAN	PSMB1	physical	22623428
TERA_HUMAN	VCP	physical	22623428
ATP5I_HUMAN	ATP5I	physical	22623428
PIN1_HUMAN	PIN1	physical	22623428
SRSF9_HUMAN	SRSF9	physical	22623428
PUM1_HUMAN	PUM1	physical	22623428
RAB10_HUMAN	RAB10	physical	22623428
RL23A_HUMAN	RPL23A	physical	22623428
RL26_HUMAN	RPL26	physical	22623428
TCPB_HUMAN	CCT2	physical	22623428
RL35_HUMAN	RPL35	physical	22623428
STMN1_HUMAN	STMN1	physical	22623428
YBOX1_HUMAN	YBX1	physical	22623428
CPSF7_HUMAN	CPSF7	physical	22623428
PSA7_HUMAN	PSMA7	physical	22623428
LSM3_HUMAN	LSM3	physical	22623428
HCD2_HUMAN	HSD17B10	physical	22623428
STOM_HUMAN	STOM	physical	22623428
RS25_HUMAN	RPS25	physical	22623428
PSME3_HUMAN	PSME3	physical	22623428
XPO2_HUMAN	CSE1L	physical	22623428
DNJC7_HUMAN	DNAJC7	physical	22623428
SMD1_HUMAN	SNRPD1	physical	22623428
IF2A_HUMAN	EIF2S1	physical	22623428
RUXF_HUMAN	SNRPF	physical	22623428
NDUA2_HUMAN	NDUFA2	physical	22623428
RL14_HUMAN	RPL14	physical	22623428
SDHB_HUMAN	SDHB	physical	22623428
RL17_HUMAN	RPL17	physical	22623428
U5S1_HUMAN	EFTUD2	physical	22623428
DDX1_HUMAN	DDX1	physical	22623428
SND1_HUMAN	SND1	physical	22623428
DDX17_HUMAN	DDX17	physical	22623428
PHB_HUMAN	PHB	physical	22623428
HEAT1_HUMAN	HEATR1	physical	22623428
IF4E_HUMAN	EIF4E	physical	22623428
FCG2C_HUMAN	FCGR2C	physical	22623428
FCG2A_HUMAN	FCGR2A	physical	22623428
RL1D1_HUMAN	RSL1D1	physical	22623428
LDHA_HUMAN	LDHA	physical	22623428
PABP4_HUMAN	PABPC4	physical	22623428
DECR_HUMAN	DECR1	physical	22623428
PFKAP_HUMAN	PFKP	physical	22623428
ANR17_HUMAN	ANKRD17	physical	22623428
DRG1_HUMAN	DRG1	physical	22623428
RS2_HUMAN	RPS2	physical	22623428
XRCC5_HUMAN	XRCC5	physical	22623428
TCPA_HUMAN	TCP1	physical	22623428
SC24C_HUMAN	SEC24C	physical	22623428
EIF3K_HUMAN	EIF3K	physical	22623428
PPAC_HUMAN	ACP1	physical	22623428
CCAR2_HUMAN	CCAR2	physical	22623428
SDHA_HUMAN	SDHA	physical	22623428
VAPA_HUMAN	VAPA	physical	22623428
TTL12_HUMAN	TTLL12	physical	22623428
VAMP8_HUMAN	VAMP8	physical	22623428
RL10_HUMAN	RPL10	physical	22623428
MEMO1_HUMAN	MEMO1	physical	22623428
G3BP1_HUMAN	G3BP1	physical	22623428
PRC2C_HUMAN	PRRC2C	physical	22623428
P5CR1_HUMAN	PYCR1	physical	22623428
IMB1_HUMAN	KPNB1	physical	22623428
RL10A_HUMAN	RPL10A	physical	22623428
EIF3A_HUMAN	EIF3A	physical	22623428
CD2AP_HUMAN	CD2AP	physical	22623428
RL27A_HUMAN	RPL27A	physical	22623428
EF1B_HUMAN	EEF1B2	physical	22623428
RBM3_HUMAN	RBM3	physical	22623428
ROA3_HUMAN	HNRNPA3	physical	22623428
AP2S1_HUMAN	AP2S1	physical	22623428
GSTK1_HUMAN	GSTK1	physical	22623428
TCPG_HUMAN	CCT3	physical	22623428
TIF1B_HUMAN	TRIM28	physical	22623428
H12_HUMAN	HIST1H1C	physical	22623428
RL5_HUMAN	RPL5	physical	22623428
IQGA1_HUMAN	IQGAP1	physical	22623428
PLEC_HUMAN	PLEC	physical	22623428
DX39B_HUMAN	DDX39B	physical	22623428
ATD3A_HUMAN	ATAD3A	physical	22623428
K1C10_HUMAN	KRT10	physical	22623428
SPEE_HUMAN	SRM	physical	22623428
MYH10_HUMAN	MYH10	physical	22623428
RL4_HUMAN	RPL4	physical	22623428
IF4A3_HUMAN	EIF4A3	physical	22623428
DIM1_HUMAN	DIMT1	physical	22623428
PSA6_HUMAN	PSMA6	physical	22623428
ITA4_HUMAN	ITGA4	physical	22623428
2AAA_HUMAN	PPP2R1A	physical	22623428
SYFB_HUMAN	FARSB	physical	22623428
TCPE_HUMAN	CCT5	physical	22623428
ANXA2_HUMAN	ANXA2	physical	22623428
RU2A_HUMAN	SNRPA1	physical	22623428
K1C18_HUMAN	KRT18	physical	22623428
NONO_HUMAN	NONO	physical	22623428
EPS15_HUMAN	EPS15	physical	22623428
ARF5_HUMAN	ARF5	physical	22623428
MOES_HUMAN	MSN	physical	22623428
NU205_HUMAN	NUP205	physical	22623428
IF4A1_HUMAN	EIF4A1	physical	22623428
NPM_HUMAN	NPM1	physical	22623428
AP2M1_HUMAN	AP2M1	physical	22623428
DHX15_HUMAN	DHX15	physical	22623428
ILF3_HUMAN	ILF3	physical	22623428
GSTP1_HUMAN	GSTP1	physical	22623428
NUP93_HUMAN	NUP93	physical	22623428
RL36_HUMAN	RPL36	physical	22623428
EIF3L_HUMAN	EIF3L	physical	22623428
RBMX_HUMAN	RBMX	physical	22623428
PSMD2_HUMAN	PSMD2	physical	22623428
PP1A_HUMAN	PPP1CA	physical	22623428
SYDC_HUMAN	DARS	physical	22623428
TFR1_HUMAN	TFRC	physical	22623428
TPR_HUMAN	TPR	physical	22623428
PDC10_HUMAN	PDCD10	physical	22623428
XPO1_HUMAN	XPO1	physical	22623428
PSB6_HUMAN	PSMB6	physical	22623428
NH2L1_HUMAN	NHP2L1	physical	22623428
VPS35_HUMAN	VPS35	physical	22623428
RAB5C_HUMAN	RAB5C	physical	22623428
MCM6_HUMAN	MCM6	physical	22623428
RAC1_HUMAN	RAC1	physical	22623428
VDAC2_HUMAN	VDAC2	physical	22623428
PSA3_HUMAN	PSMA3	physical	22623428
NAT10_HUMAN	NAT10	physical	22623428
HNRDL_HUMAN	HNRNPDL	physical	22623428
RT23_HUMAN	MRPS23	physical	22623428
MYH9_HUMAN	MYH9	physical	22623428
RL13A_HUMAN	RPL13A	physical	22623428
SMHD1_HUMAN	SMCHD1	physical	22623428
LMNB1_HUMAN	LMNB1	physical	22623428
SYTC_HUMAN	TARS	physical	22623428
PRDX3_HUMAN	PRDX3	physical	22623428
EIF3E_HUMAN	EIF3E	physical	22623428
MIC60_HUMAN	IMMT	physical	22623428
RL7A_HUMAN	RPL7A	physical	22623428
CHD4_HUMAN	CHD4	physical	22623428
STIP1_HUMAN	STIP1	physical	22623428
SMD3_HUMAN	SNRPD3	physical	22623428
MYL6_HUMAN	MYL6	physical	22623428
P85B_HUMAN	PIK3R2	physical	22623428
ENOA_HUMAN	ENO1	physical	22623428
COPD_HUMAN	ARCN1	physical	22623428
COPA_HUMAN	COPA	physical	22623428
SYYC_HUMAN	YARS	physical	22623428
RL28_HUMAN	RPL28	physical	22623428
CAPZB_HUMAN	CAPZB	physical	22623428
ATPO_HUMAN	ATP5O	physical	22623428
ASNS_HUMAN	ASNS	physical	22623428
MCM4_HUMAN	MCM4	physical	22623428
NU188_HUMAN	NUP188	physical	22623428
RS7_HUMAN	RPS7	physical	22623428
RS17_HUMAN	RPS17	physical	22623428
RS24_HUMAN	RPS24	physical	22623428
CAZA1_HUMAN	CAPZA1	physical	22623428
PSMD3_HUMAN	PSMD3	physical	22623428
ML12B_HUMAN	MYL12B	physical	22623428
ML12A_HUMAN	MYL12A	physical	22623428
TYSY_HUMAN	TYMS	physical	22623428
HXK2_HUMAN	HK2	physical	22623428
SCRIB_HUMAN	SCRIB	physical	22623428
RL21_HUMAN	RPL21	physical	22623428
PP2AA_HUMAN	PPP2CA	physical	22623428
PP2AB_HUMAN	PPP2CB	physical	22623428
NUDC_HUMAN	NUDC	physical	22623428
CYBP_HUMAN	CACYBP	physical	22623428
ACON_HUMAN	ACO2	physical	22623428
RCC1_HUMAN	RCC1	physical	22623428
SNAA_HUMAN	NAPA	physical	22623428
HP1B3_HUMAN	HP1BP3	physical	22623428
CNBP_HUMAN	CNBP	physical	22623428
CYC_HUMAN	CYCS	physical	22623428
NAA15_HUMAN	NAA15	physical	22623428
TIA1_HUMAN	TIA1	physical	22623428
UBR4_HUMAN	UBR4	physical	22623428
RU17_HUMAN	SNRNP70	physical	22623428
NDUS3_HUMAN	NDUFS3	physical	22623428
MYL4_HUMAN	MYL4	physical	22623428
THOC4_HUMAN	ALYREF	physical	22623428
PA2G4_HUMAN	PA2G4	physical	22623428
GTR1_HUMAN	SLC2A1	physical	22623428
ATPB_HUMAN	ATP5B	physical	22623428
KC1A_HUMAN	CSNK1A1	physical	22623428
SSRP1_HUMAN	SSRP1	physical	22623428
GLRX3_HUMAN	GLRX3	physical	22623428
SEPT7_HUMAN	SEPT7	physical	22623428
TNPO1_HUMAN	TNPO1	physical	22623428
LONM_HUMAN	LONP1	physical	22623428
STON2_HUMAN	STON2	physical	22623428
PSA1_HUMAN	PSMA1	physical	22623428
THIL_HUMAN	ACAT1	physical	22623428
MCM3_HUMAN	MCM3	physical	22623428
H15_HUMAN	HIST1H1B	physical	22623428
LDHB_HUMAN	LDHB	physical	22623428
TOP1_HUMAN	TOP1	physical	22623428
1433B_HUMAN	YWHAB	physical	22623428
PO210_HUMAN	NUP210	physical	22623428
LARP1_HUMAN	LARP1	physical	22623428
TBB2A_HUMAN	TUBB2A	physical	22623428
TBB2B_HUMAN	TUBB2B	physical	22623428
MDHM_HUMAN	MDH2	physical	22623428
PNPH_HUMAN	PNP	physical	22623428
ODPA_HUMAN	PDHA1	physical	22623428
MCM2_HUMAN	MCM2	physical	22623428
IMA1_HUMAN	KPNA2	physical	22623428
DDX42_HUMAN	DDX42	physical	22623428
MCA3_HUMAN	EEF1E1	physical	22623428
VINC_HUMAN	VCL	physical	22623428
AFAD_HUMAN	MLLT4	physical	22623428
RAP1B_HUMAN	RAP1B	physical	22623428
RAP2B_HUMAN	RAP2B	physical	22623428
AN32B_HUMAN	ANP32B	physical	22623428
SORCN_HUMAN	SRI	physical	22623428
ARF1_HUMAN	ARF1	physical	22623428
ARF3_HUMAN	ARF3	physical	22623428
EPN1_HUMAN	EPN1	physical	22623428
UE2NL_HUMAN	UBE2NL	physical	22623428
PSB2_HUMAN	PSMB2	physical	22623428
FBRL_HUMAN	FBL	physical	22623428
ALDOA_HUMAN	ALDOA	physical	22623428
FLNB_HUMAN	FLNB	physical	22623428
RS10_HUMAN	RPS10	physical	22623428
EIF3B_HUMAN	EIF3B	physical	22623428
EIF3I_HUMAN	EIF3I	physical	22623428
HNRPF_HUMAN	HNRNPF	physical	22623428
ARPC4_HUMAN	ARPC4	physical	22623428
UBC12_HUMAN	UBE2M	physical	22623428
AGFG1_HUMAN	AGFG1	physical	22623428
LEG1_HUMAN	LGALS1	physical	22623428
1433G_HUMAN	YWHAG	physical	22623428
IPO5_HUMAN	IPO5	physical	22623428
PA1B3_HUMAN	PAFAH1B3	physical	22623428
SC31A_HUMAN	SEC31A	physical	22623428
BOLA2_HUMAN	BOLA2	physical	22623428
MARE1_HUMAN	MAPRE1	physical	22623428
KPYM_HUMAN	PKM	physical	22623428
RM43_HUMAN	MRPL43	physical	22623428
UBL5_HUMAN	UBL5	physical	22623428
PFKAL_HUMAN	PFKL	physical	22623428
ARPC3_HUMAN	ARPC3	physical	22623428
RL8_HUMAN	RPL8	physical	22623428
VASP_HUMAN	VASP	physical	22623428
MATR3_HUMAN	MATR3	physical	22623428
ABCE1_HUMAN	ABCE1	physical	22623428
HMGB1_HUMAN	HMGB1	physical	22623428
LYPA2_HUMAN	LYPLA2	physical	22623428
SYAC_HUMAN	AARS	physical	22623428
GUAA_HUMAN	GMPS	physical	22623428
SC61B_HUMAN	SEC61B	physical	22623428
SF3B6_HUMAN	SF3B6	physical	22623428

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D06590	Firategrast (USAN)
D06886	Natalizumab (INN); Tysabri (TN)
D08083	Vedolizumab (USAN)
D09901	Etrolizumab (USAN/INN)
D10028	Valategrast hydrochloride (USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ITA4_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-480; ASN-518; ASN-538 ANDASN-645, AND MASS SPECTROMETRY.	19349973 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1021, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Phosphorylation of the integrin alpha 4 cytoplasmic domain regulatespaxillin binding."; Han J., Liu S., Rose D.M., Schlaepfer D.D., McDonald H.,Ginsberg M.H.; J. Biol. Chem. 276:40903-40909(2001). Cited for: PHOSPHORYLATION AT SER-1021, AND MUTAGENESIS OF SER-1021.	11533025 [Abstract]

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