ARF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARF3_HUMAN
• UniProt AC: P61204
• Protein Name: ADP-ribosylation factor 3
• Gene Name: ARF3
• Organism: Homo sapiens (Human).
• Sequence Length: 181
• Subcellular Localization: Golgi apparatus . Cytoplasm, perinuclear region .
• Protein Description: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus..
• Protein Sequence: MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNIFGNLL ------CCCHHHHHH	35.62	-
15	Ubiquitination	LLKSLIGKKEMRILM HHHHHCCCHHEEEEE	38.27	-
22	Sulfoxidation	KKEMRILMVGLDAAG CHHEEEEEEEECCCC	1.77	28183972
35	Phosphorylation	AGKTTILYKLKLGEI CCCEEEEEEEECCCE	15.49	-
36	Acetylation	GKTTILYKLKLGEIV CCEEEEEEEECCCEE	35.38	22647627
36	Ubiquitination	GKTTILYKLKLGEIV CCEEEEEEEECCCEE	35.38	-
36	Ubiquitination	GKTTILYKLKLGEIV CCEEEEEEEECCCEE	35.38	-
38	Ubiquitination	TTILYKLKLGEIVTT EEEEEEEECCCEEEE	50.74	21890473
38	Ubiquitination	TTILYKLKLGEIVTT EEEEEEEECCCEEEE	50.74	-
44	O-linked_Glycosylation	LKLGEIVTTIPTIGF EECCCEEEECCCCCE	25.35	32119511
45	O-linked_Glycosylation	KLGEIVTTIPTIGFN ECCCEEEECCCCCEE	17.67	32119511
48	O-linked_Glycosylation	EIVTTIPTIGFNVET CEEEECCCCCEEEEE	29.86	32119511
58	Phosphorylation	FNVETVEYKNISFTV EEEEEEEEEEEEEEE	12.66	-
62	Phosphorylation	TVEYKNISFTVWDVG EEEEEEEEEEEEECC	25.02	22199227
64	Phosphorylation	EYKNISFTVWDVGGQ EEEEEEEEEEECCCC	17.56	20068231
73	Sumoylation	WDVGGQDKIRPLWRH EECCCCCCCHHHHHH	32.50	-
73	Ubiquitination	WDVGGQDKIRPLWRH EECCCCCCCHHHHHH	32.50	21890473
81	Phosphorylation	IRPLWRHYFQNTQGL CHHHHHHHHCCCCEE	9.78	29759185
85	Phosphorylation	WRHYFQNTQGLIFVV HHHHHCCCCEEEEEE	17.15	28152594
90	Ubiquitination	QNTQGLIFVVDSNDR CCCCEEEEEECCCCH	5.43	-
105	Acetylation	ERVNEAREELMRMLA HHHHHHHHHHHHHHH	63.63	-
105	Ubiquitination	ERVNEAREELMRMLA HHHHHHHHHHHHHHH	63.63	21890473
108	Sulfoxidation	NEAREELMRMLAEDE HHHHHHHHHHHHHHH	2.40	21406390
110	Sulfoxidation	AREELMRMLAEDELR HHHHHHHHHHHHHHH	2.31	28183972
117	Methylation	MLAEDELRDAVLLVF HHHHHHHHHHHHHHE	28.00	-
127	Ubiquitination	VLLVFANKQDLPNAM HHHHEECCCCCCCCC	41.58	21890473
134	Sulfoxidation	KQDLPNAMNAAEITD CCCCCCCCCHHHHHH	4.45	21406390
140	Phosphorylation	AMNAAEITDKLGLHS CCCHHHHHHHHCCHH	20.70	20860994
141	Acetylation	MNAAEITDKLGLHSL CCHHHHHHHHCCHHC	50.25	-
142	Ubiquitination	NAAEITDKLGLHSLR CHHHHHHHHCCHHCC	35.49	21890473
142	Acetylation	NAAEITDKLGLHSLR CHHHHHHHHCCHHCC	35.49	23954790
147	Phosphorylation	TDKLGLHSLRHRNWY HHHHCCHHCCCCCEE	31.94	23927012
167	Phosphorylation	ATSGDGLYEGLDWLA ECCCCCHHHHHHHHH	17.30	22817900
178	Acetylation	DWLANQLKNKK---- HHHHHHHHCCC----	57.89	21466224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARFP2_HUMAN	ARFIP2	physical	9038142
ARFP1_HUMAN	ARFIP1	physical	9038142
GGA2_HUMAN	GGA2	physical	10749927
GGA1_HUMAN	GGA1	physical	12221117
GGA3_HUMAN	GGA3	physical	12221117
GGA1_HUMAN	GGA1	physical	10749927
GGA3_HUMAN	GGA3	physical	10749927

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.