GGA2_HUMAN - dbPTM
GGA2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GGA2_HUMAN
UniProt AC Q9UJY4
Protein Name ADP-ribosylation factor-binding protein GGA2
Gene Name GGA2
Organism Homo sapiens (Human).
Sequence Length 613
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein . Endosome membrane
Peripheral membrane protein .
Protein Description Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif..
Protein Sequence MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCMNHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSKRVSAVEEVRSHVKVLQEMLSMYRRPGQAPPDQEALQVVYERCEKLRPTLFRLASDTTDDDDALAEILQANDLLTQGVLLYKQVMEGRVTFGNRVTSSLGDIPVSRVFQNPAGCMKTCPLIDLEVDNGPAQMGTVVPSLLHQDLAALGISDAPVTGMVSGQNCCEEKRNPSSSTLPGGGVQNPSADRNLLDLLSAQPAPCPLNYVSQKSVPKEVPPGTKSSPGWSWEAGPLAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLLTMMSTAPQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLAVLGAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25UbiquitinationGPPGPAASLELWLNK
CCCCCCHHHHHHHHH		25.2022817900
30UbiquitinationAASLELWLNKATDPS
CHHHHHHHHHCCCCC		8.0221890473
75UbiquitinationAHKIQSPQEKEALYA
HHHCCCHHHHHHHHH		78.5922817900
80UbiquitinationSPQEKEALYALTVLE
CHHHHHHHHHHHHHH		2.4221890473
103UbiquitinationKFHSEVAKFRFLNEL
HHHHHHHHHHHHHHH		42.1029967540
112UbiquitinationRFLNELIKVLSPKYL
HHHHHHHHHHCHHHC		50.1522817900
113UbiquitinationFLNELIKVLSPKYLG
HHHHHHHHHCHHHCC		5.1924816145
115PhosphorylationNELIKVLSPKYLGSW
HHHHHHHCHHHCCCC		23.49-
117UbiquitinationLIKVLSPKYLGSWAT
HHHHHCHHHCCCCCC		50.1322817900
118PhosphorylationIKVLSPKYLGSWATG
HHHHCHHHCCCCCCC		21.4922817900
126UbiquitinationLGSWATGKVKGRVIE
CCCCCCCCCCCEEEE		36.1029967540
132UbiquitinationGKVKGRVIEILFSWT
CCCCCEEEEEEEEEE		2.3427667366
163UbiquitinationKKQGIIKQDPKLPVD
HHCCCCCCCCCCCCC		62.9324816145
177PhosphorylationDKILPPPSPWPKSSI
CCCCCCCCCCCCHHC		45.4225106551
181UbiquitinationPPPSPWPKSSIFDAD
CCCCCCCCHHCCCCH		53.6329967540
182UbiquitinationPPSPWPKSSIFDADE
CCCCCCCHHCCCCHH		25.2927667366
191UbiquitinationIFDADEEKSKLLTRL
CCCCHHHHHHHHHHH		51.3329967540
200UbiquitinationKLLTRLLKSNHPEDL
HHHHHHHHCCCHHHH		54.5332015554
201PhosphorylationLLTRLLKSNHPEDLQ
HHHHHHHCCCHHHHH		40.1023403867
215UbiquitinationQAANRLIKNLVKEEQ
HHHHHHHHHHHHHHH		49.1529967540
219SumoylationRLIKNLVKEEQEKSE
HHHHHHHHHHHHHHH		59.71-
219SumoylationRLIKNLVKEEQEKSE
HHHHHHHHHHHHHHH		59.71-
219UbiquitinationRLIKNLVKEEQEKSE
HHHHHHHHHHHHHHH		59.7127667366
233PhosphorylationEKVSKRVSAVEEVRS
HHHHHHHHHHHHHHH		30.5430108239
240PhosphorylationSAVEEVRSHVKVLQE
HHHHHHHHHHHHHHH		37.5022817900
250PhosphorylationKVLQEMLSMYRRPGQ
HHHHHHHHHHCCCCC		16.6829978859
252PhosphorylationLQEMLSMYRRPGQAP
HHHHHHHHCCCCCCC		10.4929978859
269PhosphorylationQEALQVVYERCEKLR
HHHHHHHHHHHHHHH		9.9828796482
274UbiquitinationVVYERCEKLRPTLFR
HHHHHHHHHHHHHHH		54.12-
278PhosphorylationRCEKLRPTLFRLASD
HHHHHHHHHHHHHCC		31.90-
284PhosphorylationPTLFRLASDTTDDDD
HHHHHHHCCCCCCHH		39.8328450419
286PhosphorylationLFRLASDTTDDDDAL
HHHHHCCCCCCHHHH		29.6328450419
287PhosphorylationFRLASDTTDDDDALA
HHHHCCCCCCHHHHH		42.2828450419
304PhosphorylationLQANDLLTQGVLLYK
HHHHCHHHHHCHHHH		30.4922210691
325PhosphorylationVTFGNRVTSSLGDIP
CEECCCCHHCCCCCC		14.9026699800
326O-linked_GlycosylationTFGNRVTSSLGDIPV
EECCCCHHCCCCCCH		22.2523301498
326PhosphorylationTFGNRVTSSLGDIPV
EECCCCHHCCCCCCH		22.2528450419
327PhosphorylationFGNRVTSSLGDIPVS
ECCCCHHCCCCCCHH		27.3128450419
400PhosphorylationCEEKRNPSSSTLPGG
CCCCCCCCCCCCCCC		40.2325850435
401PhosphorylationEEKRNPSSSTLPGGG
CCCCCCCCCCCCCCC		28.7128450419
402PhosphorylationEKRNPSSSTLPGGGV
CCCCCCCCCCCCCCC		38.0028450419
403PhosphorylationKRNPSSSTLPGGGVQ
CCCCCCCCCCCCCCC		38.6328450419
433PhosphorylationPAPCPLNYVSQKSVP
CCCCCCCCCCCCCCC		14.7927642862
435PhosphorylationPCPLNYVSQKSVPKE
CCCCCCCCCCCCCCC		22.8728857561
438PhosphorylationLNYVSQKSVPKEVPP
CCCCCCCCCCCCCCC		35.6928450419
447PhosphorylationPKEVPPGTKSSPGWS
CCCCCCCCCCCCCCC		33.26-
458UbiquitinationPGWSWEAGPLAPSPS
CCCCCCCCCCCCCCC		13.2627667366
508UbiquitinationLHFSQTGAPGHPEVQ
EEEECCCCCCCHHHH		15.4127667366
545UbiquitinationVPKSMRVKLQPASSS
CCHHHCEEEECCCCC		30.9227667366
551PhosphorylationVKLQPASSSKLPAFS
EEEECCCCCCCCCCC		33.3318767875
552PhosphorylationKLQPASSSKLPAFSP
EEECCCCCCCCCCCC		35.4018767875
602UbiquitinationFSEVGEVKDFPDLAV
CCEEECCCCCCCCCC		49.7229967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GGA2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GGA2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GGA2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPG21_HUMANSPG21physical
16189514
NECP2_HUMANNECAP2physical
14665628
EPN4_HUMANCLINT1physical
12213833
CLH1_HUMANCLTCphysical
11301005
SORT_HUMANSORT1physical
11331584
RABE1_HUMANRABEP1physical
12505986
BACE2_HUMANBACE2physical
12135764
VPS18_HUMANVPS18physical
16996030
RABE1_HUMANRABEP1physical
14636058
CCD91_HUMANCCDC91physical
12808037
MPRI_HUMANIGF2Rphysical
11387476
CLH1_HUMANCLTCphysical
11387476
RABE1_HUMANRABEP1physical
11387476
CLH1_HUMANCLTCphysical
17344219
RABE1_HUMANRABEP1physical
16473621
GGA1_HUMANGGA1physical
14638859
GGA3_HUMANGGA3physical
14638859
SORT_HUMANSORT1physical
11390366
A4_HUMANAPPphysical
21832049
MAP1A_HUMANMAP1Aphysical
10747088
RABE1_HUMANRABEP1physical
10747088
SYNRG_HUMANSYNRGphysical
10747088
RNF11_HUMANRNF11physical
25195858
ARF1_HUMANARF1physical
11950392
TOLIP_HUMANTOLLIPphysical
15047686
GGA1_HUMANGGA1physical
28514442
RABE1_HUMANRABEP1physical
28514442
EPN4_HUMANCLINT1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GGA2_HUMAN

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Related Literatures of Post-Translational Modification

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