SPG21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPG21_HUMAN
• UniProt AC: Q9NZD8
• Protein Name: Maspardin
• Gene Name: SPG21
• Organism: Homo sapiens (Human).
• Sequence Length: 308
• Subcellular Localization: Cytoplasm, cytosol . Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Partially localized in the cytosol but also accumulated on a
• Protein Description: May play a role as a negative regulatory factor in CD4-dependent T-cell activation..
• Protein Sequence: MGEIKVSPDYNWFRGTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MGEIKVSPDYNW ---CCCEEECCCCCC	32.15	-
21	Ubiquitination	RGTVPLKKIIVDDDD CCCCCCEEEEECCCC	45.40	-
30	Ubiquitination	IVDDDDSKIWSLYDA EECCCCCCCHHHHCC	56.01	21906983
124	Ubiquitination	KFAEYTHKSPRVHSL HHHHHHCCCCCEEEE	55.12	-
170	Phosphorylation	IVLGNFSSGPVDPMM HHHCCCCCCCCCHHH	42.87	24719451
213	Ubiquitination	NSYVEPHKIRDIPVT CCCCCCCCCCCCCEE	50.59	-
235	Ubiquitination	SALSTEAKEEMYKLY CCCCHHHHHHHHHHC	48.23	-
240	Ubiquitination	EAKEEMYKLYPNARR HHHHHHHHHCCCCCH	39.99	-
251	Ubiquitination	NARRAHLKTGGNFPY CCCHHHCCCCCCCCC	34.94	-
252	Phosphorylation	ARRAHLKTGGNFPYL CCHHHCCCCCCCCCE	57.59	23607784
258	Phosphorylation	KTGGNFPYLCRSAEV CCCCCCCCEECCCEE	17.81	23607784
281	Phosphorylation	LQFHGTKYAAIDPSM EEECCCEEEEECHHH	10.91	27642862
290	Phosphorylation	AIDPSMVSAEELEVQ EECHHHCCHHHHHHH	22.71	-
298	Ubiquitination	AEELEVQKGSLGISQ HHHHHHHCCCCCCCC	56.49	-
300	Phosphorylation	ELEVQKGSLGISQEE HHHHHCCCCCCCCCC	30.38	30266825
304	Phosphorylation	QKGSLGISQEEQ--- HCCCCCCCCCCC---	29.73	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPG21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPG21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPG21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKIR2_HUMAN	AKIRIN2	physical	16189514
PYRG2_HUMAN	CTPS2	physical	16189514
MTMR9_HUMAN	MTMR9	physical	16189514
RTN4_HUMAN	RTN4	physical	16189514
YLPM1_HUMAN	YLPM1	physical	22939629
PYRG2_HUMAN	CTPS2	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
C102B_HUMAN	CCDC102B	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
EFHC2_HUMAN	EFHC2	physical	25416956
ATPF2_HUMAN	ATPAF2	physical	25416956
NXP20_HUMAN	FAM114A1	physical	25416956
REEP6_HUMAN	REEP6	physical	25416956
DTX2_HUMAN	DTX2	physical	25416956
TRIM9_HUMAN	TRIM9	physical	25416956
CKLF5_HUMAN	CMTM5	physical	25416956
DTX3L_HUMAN	DTX3L	physical	25416956
SPRE2_HUMAN	SPRED2	physical	25416956
INCA1_HUMAN	INCA1	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	21516116

Drug and Disease Associations

• Kegg Disease
• H00266: Hereditary spastic paraplegia (SPG)
• OMIM Disease
• 248900: Spastic paraplegia 21, autosomal recessive (SPG21)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, AND MASSSPECTROMETRY.
PubMed: 19413330