AKIR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKIR2_HUMAN
• UniProt AC: Q53H80
• Protein Name: Akirin-2
• Gene Name: AKIRIN2
• Organism: Homo sapiens (Human).
• Sequence Length: 203
• Subcellular Localization: Nucleus .
• Protein Description: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity)..
• Protein Sequence: MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPTSAAASPLSAAAATAASFSAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLETSFQQTDPCCTSDAQPHAFLLSGPASPGTSSAASSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Methylation	MACGATLKRTLDFDP CCCCCCCEECCCCCC	38.69	-
10	Phosphorylation	CGATLKRTLDFDPLL CCCCCEECCCCCCCC	29.14	23927012
18	Phosphorylation	LDFDPLLSPASPKRR CCCCCCCCCCCCCCC	26.55	29255136
21	Phosphorylation	DPLLSPASPKRRRCA CCCCCCCCCCCCCCC	34.05	19664994
31	Phosphorylation	RRRCAPLSAPTSAAA CCCCCCCCCCCHHHC	31.01	27080861
34	Phosphorylation	CAPLSAPTSAAASPL CCCCCCCCHHHCCHH	30.62	22199227
35	Phosphorylation	APLSAPTSAAASPLS CCCCCCCHHHCCHHH	18.17	22199227
39	Phosphorylation	APTSAAASPLSAAAA CCCHHHCCHHHHHHH	22.96	22199227
42	Phosphorylation	SAAASPLSAAAATAA HHHCCHHHHHHHHHH	21.17	63766285
47	Phosphorylation	PLSAAAATAASFSAA HHHHHHHHHHHHHHH	20.31	22210691
50	Phosphorylation	AAAATAASFSAAAAS HHHHHHHHHHHHHCC	19.78	29255136
52	Phosphorylation	AATAASFSAAAASPQ HHHHHHHHHHHCCHH	17.95	29255136
57	Phosphorylation	SFSAAAASPQKYLRM HHHHHHCCHHHHCCC	24.12	29255136
61	Phosphorylation	AAASPQKYLRMEPSP HHCCHHHHCCCCCCC	8.35	22210691
67	Phosphorylation	KYLRMEPSPFGDVSS HHCCCCCCCCCCHHH	21.39	21815630
78	Phosphorylation	DVSSRLTTEQILYNI CHHHCCCHHHHHHHH	30.40	46161617
100	Phosphorylation	QKRRHLETSFQQTDP HHHHHHHHHHHHCCC	41.00	23312004
101	Phosphorylation	KRRHLETSFQQTDPC HHHHHHHHHHHCCCC	16.22	23312004
105	Phosphorylation	LETSFQQTDPCCTSD HHHHHHHCCCCCCCC	31.00	23312004
110	Phosphorylation	QQTDPCCTSDAQPHA HHCCCCCCCCCCCCE	36.04	28450419
111	Phosphorylation	QTDPCCTSDAQPHAF HCCCCCCCCCCCCEE	19.62	28450419
121	Phosphorylation	QPHAFLLSGPASPGT CCCEEEECCCCCCCC	44.90	28450419
125	Phosphorylation	FLLSGPASPGTSSAA EEECCCCCCCCCCCC	27.31	25159151
128	Phosphorylation	SGPASPGTSSAASSP CCCCCCCCCCCCCCC	23.92	28464451
129	Phosphorylation	GPASPGTSSAASSPL CCCCCCCCCCCCCCC	24.72	30576142
130	Phosphorylation	PASPGTSSAASSPLK CCCCCCCCCCCCCCC	27.91	28450419
133	Phosphorylation	PGTSSAASSPLKKEQ CCCCCCCCCCCCCCC	32.00	30576142
134	Phosphorylation	GTSSAASSPLKKEQP CCCCCCCCCCCCCCC	29.53	28450419
144	Phosphorylation	KKEQPLFTLRQVGMI CCCCCCHHHHHHHHH	28.81	24719451
174	Ubiquitination	YEEILNTKLAEQYDA HHHHHHHHHHHHHHH	44.63	-
194	Phosphorylation	HDQIMRRYGEQPASY HHHHHHHHCCCCCCC	18.04	22461510
200	Phosphorylation	RYGEQPASYVS---- HHCCCCCCCCC----	32.52	68703755
201	Phosphorylation	YGEQPASYVS----- HCCCCCCCCC-----	13.56	68703761
203	Phosphorylation	EQPASYVS------- CCCCCCCC-------	26.69	59303271

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
18	S	Phosphorylation	Kinase	CDK2	P24941	PSP
21	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKIR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKIR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	16189514
RAN_HUMAN	RAN	physical	28514442
RGPD8_HUMAN	RGPD8	physical	28514442
SPG21_HUMAN	SPG21	physical	28514442
AKIR1_HUMAN	AKIRIN1	physical	28514442
RGPD5_HUMAN	RGPD5	physical	28514442
UBAC1_HUMAN	UBAC1	physical	28514442
IPO9_HUMAN	IPO9	physical	28514442
RN123_HUMAN	RNF123	physical	28514442
TOM34_HUMAN	TOMM34	physical	28514442
BUD31_HUMAN	BUD31	physical	28514442
RGPD3_HUMAN	RGPD3	physical	28514442
PPID_HUMAN	PPID	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-21, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-21, AND MASSSPECTROMETRY.
PubMed: 18691976

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.
PubMed: 17081983