SPRE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPRE2_HUMAN
• UniProt AC: Q7Z698
• Protein Name: Sprouty-related, EVH1 domain-containing protein 2
• Gene Name: SPRED2
• Organism: Homo sapiens (Human).
• Sequence Length: 418
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm . Detected in the cytoplasm of the stratum spinosum cells, where it is assoc
• Protein Description: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases..
• Protein Sequence: MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	RVKAVVMTRDDSSGG EEEEEEEECCCCCCC	21.24	26074081
26	Phosphorylation	VVMTRDDSSGGWFPQ EEEECCCCCCCCCCC	34.86	26074081
27	Phosphorylation	VMTRDDSSGGWFPQE EEECCCCCCCCCCCC	48.60	26074081
104	Phosphorylation	KFGLTFQSPADARAF EEEEEECCHHHHHHH	20.19	21815630
165	Phosphorylation	KREQPTRTISSPTSC CCCCCCCCCCCCCCC	27.91	28152594
167	Phosphorylation	EQPTRTISSPTSCEH CCCCCCCCCCCCCCC	29.65	25849741
168	Phosphorylation	QPTRTISSPTSCEHR CCCCCCCCCCCCCCC	28.48	23898821
170	Phosphorylation	TRTISSPTSCEHRRI CCCCCCCCCCCCCEE	48.21	28152594
171	Phosphorylation	RTISSPTSCEHRRIY CCCCCCCCCCCCEEE	22.38	28152594
178	Phosphorylation	SCEHRRIYTLGHLHD CCCCCEEEEECCCCC	8.29	25884760
192	Phosphorylation	DSYPTDHYHLDQPMP CCCCCCCCCCCCCCC	13.59	25884760
206	Phosphorylation	PRPYRQVSFPDDDEE CCCCCCCCCCCCCCC	23.79	23401153
228	Phosphorylation	EKIWMTGYEDYRHAP CCEEECCCCCCCCCC	9.10	26356563
231	Phosphorylation	WMTGYEDYRHAPVRG EECCCCCCCCCCCCC	7.74	25884760
239	Ubiquitination	RHAPVRGKYPDPSED CCCCCCCCCCCCCCC	42.94	-
249	Phosphorylation	DPSEDADSSYVRFAK CCCCCCCHHCEEECC	25.86	25884760
250	Phosphorylation	PSEDADSSYVRFAKG CCCCCCHHCEEECCC	28.35	25884760
251	Phosphorylation	SEDADSSYVRFAKGE CCCCCHHCEEECCCC	10.29	25884760
256	Ubiquitination	SSYVRFAKGEVPKHD HHCEEECCCCCCCCC	53.55	-
261	Ubiquitination	FAKGEVPKHDYNYPY ECCCCCCCCCCCCCC	55.04	-
264	Phosphorylation	GEVPKHDYNYPYVDS CCCCCCCCCCCCCCH	19.13	25884760
266	Phosphorylation	VPKHDYNYPYVDSSD CCCCCCCCCCCCHHH	6.96	25884760
268	Phosphorylation	KHDYNYPYVDSSDFG CCCCCCCCCCHHHCC	13.41	26356563
271	Phosphorylation	YNYPYVDSSDFGLGE CCCCCCCHHHCCCCC	23.05	23898821
281	Ubiquitination	FGLGEDPKGRGGSVI CCCCCCCCCCCCCEE	73.83	-
286	Phosphorylation	DPKGRGGSVIKTQPS CCCCCCCCEEECCCC	24.40	27470641
289	Ubiquitination	GRGGSVIKTQPSRGK CCCCCEEECCCCCCC	38.66	-
290	Phosphorylation	RGGSVIKTQPSRGKS CCCCEEECCCCCCCC	34.29	27470641
297	Phosphorylation	TQPSRGKSRRRKEDG CCCCCCCCCCCCCCC	33.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CBL	P22681	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPRE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPRE2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TESK1_HUMAN	TESK1	physical	17974561
NBR1_HUMAN	NBR1	physical	19822672
SQSTM_HUMAN	SQSTM1	physical	19822672
PDP1_HUMAN	PDP1	physical	28514442
DPP9_HUMAN	DPP9	physical	28514442
PRDC1_HUMAN	PRTFDC1	physical	28514442
KS6A3_HUMAN	RPS6KA3	physical	28514442
GBG5_HUMAN	GNG5	physical	28514442
KS6A2_HUMAN	RPS6KA2	physical	28514442
STOM_HUMAN	STOM	physical	28514442
GNAQ_HUMAN	GNAQ	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.