NBR1_HUMAN - dbPTM
NBR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NBR1_HUMAN
UniProt AC Q14596
Protein Name Next to BRCA1 gene 1 protein
Gene Name NBR1
Organism Homo sapiens (Human).
Sequence Length 966
Subcellular Localization Cytoplasm . Cytoplasmic vesicle, autophagosome . Lysosome . Cytoplasm, myofibril, sarcomere, M line . In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911).
Protein Description Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets..
Protein Sequence MEPQVTLNVTFKNEIQSFLVSDPENTTWADIEAMVKVSFDLNTIQIKYLDEENEEVSINSQGEYEEALKMAVKQGNQLQMQVHEGHHVVDEAPPPVVGAKRLAARAGKKPLAHYSSLVRVLGSDMKTPEDPAVQSFPLVPCDTDQPQDKPPDWFTSYLETFREQVVNETVEKLEQKLHEKLVLQNPSLGSCPSEVSMPTSEETLFLPENQFSWHIACNNCQRRIVGVRYQCSLCPSYNICEDCEAGPYGHDTNHVLLKLRRPVVGSSEPFCHSKYSTPRLPAALEQVRLQKQVDKNFLKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCTSVMPMLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWSADTKLKFMWGNLTLASTEKKDVLVPCLKAGHVGVVSVEFIAPALEGTYTSHWRLSHKGQQFGPRVWCSIIVDPFPSEESPDNIEKGMISSSKTDDLTCQQEETFLLAKEERQLGEVTEQTEGTAACIPQKAKNVASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPCMSPLPHDSPLIEKPGLGQIEEENEGAGFKALPDSMVSVKRKAENIASVEEAEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQKSLQMTFALPEGPLGNEKEEIIHIAEEEAVMEEEEDEEDEEEEDELKDEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGKPGVEAGQEPAEAGERLPGGENQPQEHSISDILTTSQTLETVPLIPEVVELPPSLPRSSPCVHHHGSPGVDLPVTIPEVSSVPDQIRGEPRGSSGLVNSRQKSYDHSRHHHGSSIAGGLVKGALSVAASAYKALFAGPPVTAQPIISEDQTAALMAHLFEMGFCDRQLNLRLLKKHNYNILQVVTELLQLNNNDWYSQRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
60PhosphorylationNEEVSINSQGEYEEA
CCEEEECCCCHHHHH		37.58-
100UbiquitinationPPPVVGAKRLAARAG
CCCCCCHHHHHHHHC		41.85-
108UbiquitinationRLAARAGKKPLAHYS
HHHHHHCCCCCCCHH		50.67-
109UbiquitinationLAARAGKKPLAHYSS
HHHHHCCCCCCCHHH		44.33-
114PhosphorylationGKKPLAHYSSLVRVL
CCCCCCCHHHHHHHH		8.3721945579
115PhosphorylationKKPLAHYSSLVRVLG
CCCCCCHHHHHHHHC		13.8221945579
116PhosphorylationKPLAHYSSLVRVLGS
CCCCCHHHHHHHHCC		24.5821945579
123PhosphorylationSLVRVLGSDMKTPED
HHHHHHCCCCCCCCC		30.3020068231
126UbiquitinationRVLGSDMKTPEDPAV
HHHCCCCCCCCCCCC		66.95-
149UbiquitinationDTDQPQDKPPDWFTS
CCCCCCCCCCCHHHH		53.88-
149SumoylationDTDQPQDKPPDWFTS
CCCCCCCCCCCHHHH		53.88-
172UbiquitinationVVNETVEKLEQKLHE
HHHHHHHHHHHHHHH		53.65-
176UbiquitinationTVEKLEQKLHEKLVL
HHHHHHHHHHHHHHC		42.30-
193PhosphorylationPSLGSCPSEVSMPTS
CCCCCCCCCCCCCCC		55.7624275569
273PhosphorylationSSEPFCHSKYSTPRL
CCCCCCCCCCCCCCH		34.1728555341
274UbiquitinationSEPFCHSKYSTPRLP
CCCCCCCCCCCCCHH		21.39-
275PhosphorylationEPFCHSKYSTPRLPA
CCCCCCCCCCCCHHH		22.3121712546
276PhosphorylationPFCHSKYSTPRLPAA
CCCCCCCCCCCHHHH		35.3520068231
277PhosphorylationFCHSKYSTPRLPAAL
CCCCCCCCCCHHHHH		14.8820068231
291UbiquitinationLEQVRLQKQVDKNFL
HHHHHHHHHHCHHHH		57.81-
295UbiquitinationRLQKQVDKNFLKAEK
HHHHHHCHHHHHHHH		51.23-
299UbiquitinationQVDKNFLKAEKQRLR
HHCHHHHHHHHHHHH		50.81-
313AcetylationRAEKKQRKAEVKELK
HHHHHHHHHHHHHHH		46.54156467
317UbiquitinationKQRKAEVKELKKQLK
HHHHHHHHHHHHHHH		49.16-
320UbiquitinationKAEVKELKKQLKLHR
HHHHHHHHHHHHHHH		39.29-
328UbiquitinationKQLKLHRKIHLWNSI
HHHHHHHHHHHHHHH		24.59-
334PhosphorylationRKIHLWNSIHGLQSP
HHHHHHHHHCCCCCC		12.3628450419
340PhosphorylationNSIHGLQSPKSPLGR
HHHCCCCCCCCCCCC		39.0620068231
394UbiquitinationQPGTKFIKHWRMKNT
CCCCCEEEEEECCCC		40.00-
399UbiquitinationFIKHWRMKNTGNVKW
EEEEEECCCCCCCCC		42.66-
405UbiquitinationMKNTGNVKWSADTKL
CCCCCCCCCCCCCCE		39.16-
411UbiquitinationVKWSADTKLKFMWGN
CCCCCCCCEEEEEEC		50.67-
426UbiquitinationLTLASTEKKDVLVPC
EEEEECCCCCCCHHC		55.13-
427UbiquitinationTLASTEKKDVLVPCL
EEEECCCCCCCHHCC		47.00-
464 (in isoform 1)Ubiquitination-55.8521906983
464 (in isoform 2)Ubiquitination-55.8521906983
464UbiquitinationSHWRLSHKGQQFGPR
CCEEECCCCCCCCCE		55.8521906983
483PhosphorylationIIVDPFPSEESPDNI
EEEECCCCCCCCCCC		55.1428348404
486PhosphorylationDPFPSEESPDNIEKG
ECCCCCCCCCCCHHC		33.2421712546
492UbiquitinationESPDNIEKGMISSSK
CCCCCCHHCCCCCCC		50.40-
499UbiquitinationKGMISSSKTDDLTCQ
HCCCCCCCCCCCCCC		58.90-
515UbiquitinationEETFLLAKEERQLGE
HHHHHHHHHHHHHCC		61.14-
537 (in isoform 2)Ubiquitination-56.8421906983
537 (in isoform 1)Ubiquitination-56.8421906983
537UbiquitinationTAACIPQKAKNVASE
CCCCCCHHHHCCCCC		56.8421906983
537AcetylationTAACIPQKAKNVASE
CCCCCCHHHHCCCCC		56.8426051181
539UbiquitinationACIPQKAKNVASERE
CCCCHHHHCCCCCCC		60.02-
581PhosphorylationLERVPHNTPVDVTPC
HCCCCCCCCCCCCCC		22.9629255136
586PhosphorylationHNTPVDVTPCMSPLP
CCCCCCCCCCCCCCC		13.3029255136
590PhosphorylationVDVTPCMSPLPHDSP
CCCCCCCCCCCCCCC		29.9625849741
596PhosphorylationMSPLPHDSPLIEKPG
CCCCCCCCCCCCCCC		20.6929255136
601UbiquitinationHDSPLIEKPGLGQIE
CCCCCCCCCCCCCCC		37.07-
617UbiquitinationENEGAGFKALPDSMV
CCCCCCCCCCCHHHH		48.36-
622PhosphorylationGFKALPDSMVSVKRK
CCCCCCHHHHHHHHH		21.1030266825
625PhosphorylationALPDSMVSVKRKAEN
CCCHHHHHHHHHHHH		17.1830266825
627UbiquitinationPDSMVSVKRKAENIA
CHHHHHHHHHHHHCC		40.45-
629UbiquitinationSMVSVKRKAENIASV
HHHHHHHHHHHCCCH		55.10-
656PhosphorylationVCETVIRSLTLDAAP
HHHHHHHHCCCCCCC		18.0030266825
658PhosphorylationETVIRSLTLDAAPDH
HHHHHHCCCCCCCCC		24.6830266825
672UbiquitinationHNPPCRQKSLQMTFA
CCCCCCCCCEEEEEE		33.51-
673PhosphorylationNPPCRQKSLQMTFAL
CCCCCCCCEEEEEEC		18.5928355574
677PhosphorylationRQKSLQMTFALPEGP
CCCCEEEEEECCCCC		7.8722777824
767 (in isoform 1)Ubiquitination-30.0621906983
767 (in isoform 2)Ubiquitination-30.0621906983
767UbiquitinationLERGAEGKPGVEAGQ
CCCCCCCCCCCCCCC		30.0621906983
824PhosphorylationLPPSLPRSSPCVHHH
CCCCCCCCCCCCCCC		36.3725159151
825PhosphorylationPPSLPRSSPCVHHHG
CCCCCCCCCCCCCCC		24.4925159151
833PhosphorylationPCVHHHGSPGVDLPV
CCCCCCCCCCCCCCE		17.7127174698
841PhosphorylationPGVDLPVTIPEVSSV
CCCCCCEECCCCCCC		28.9527174698
846PhosphorylationPVTIPEVSSVPDQIR
CEECCCCCCCCCHHC		24.7727174698
847PhosphorylationVTIPEVSSVPDQIRG
EECCCCCCCCCHHCC		42.7327174698
887UbiquitinationSIAGGLVKGALSVAA
CHHHHHHHHHHHHHH		43.43-
891PhosphorylationGLVKGALSVAASAYK
HHHHHHHHHHHHHHH		14.8028555341
898UbiquitinationSVAASAYKALFAGPP
HHHHHHHHHHHCCCC		38.03-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
586TPhosphorylationKinaseGSK3AP49840
PSP
586TPhosphorylationKinaseGSK3BP49841
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NBR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NBR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VTA1_HUMANVTA1physical
16189514
CIB1_HUMANCIB1physical
11856312
FEZ1_HUMANFEZ1physical
11856312
MLP3A_HUMANMAP1LC3Aphysical
19427866
UBP8_HUMANUSP8physical
19427866
UBC_HUMANUBCphysical
19427866
NBR1_HUMANNBR1physical
15802564
SQSTM_HUMANSQSTM1physical
15802564
TITIN_HUMANTTNphysical
15802564
GBRL2_HUMANGABARAPL2physical
19250911
GBRAP_HUMANGABARAPphysical
19250911
GBRL1_HUMANGABARAPL1physical
19250911
MLP3A_HUMANMAP1LC3Aphysical
19250911
MLP3B_HUMANMAP1LC3Bphysical
19250911
MLP3C_HUMANMAP1LC3Cphysical
19250911
UBC_HUMANUBCphysical
19250911
SQSTM_HUMANSQSTM1physical
12813044
UBC_HUMANUBCphysical
24692539
SQSTM_MOUSESqstm1physical
24879152
MLP3B_MOUSEMap1lc3bphysical
24879152
SQSTM_HUMANSQSTM1physical
25007327
SYT4_HUMANSYT4physical
25416956
SQSTM_HUMANSQSTM1physical
24879152
UBC_HUMANUBCphysical
24879152
MLP3B_HUMANMAP1LC3Bphysical
24879152
GBRAP_HUMANGABARAPphysical
24879152
UBC_HUMANUBCphysical
23649778
MP2K4_HUMANMAP2K4physical
25043814
M3K3_HUMANMAP3K3physical
25043814
UB2D2_HUMANUBE2D2physical
28322253
UB2D3_HUMANUBE2D3physical
28322253
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NBR1_HUMAN

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Related Literatures of Post-Translational Modification

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