MLP3C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLP3C_HUMAN
• UniProt AC: Q9BXW4
• Protein Name: Microtubule-associated proteins 1A/1B light chain 3C
• Gene Name: MAP1LC3C
• Organism: Homo sapiens (Human).
• Sequence Length: 147
• Subcellular Localization: Cytoplasm, cytoskeleton . Endomembrane system ; Lipid-anchor . Cytoplasmic vesicle, autophagosome membrane ; Lipid-anchor . Cytoplasmic vesicle, autophagosome . LC3-II binds to the autophagic membranes.
• Protein Description: Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. [PubMed: 23022382 May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins]
• Protein Sequence: MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	FLVPQELTMTQFLSI CCCCCCCCHHHHHHH	19.88	29083192
67	Phosphorylation	VPQELTMTQFLSIIR CCCCCCHHHHHHHHH	15.78	29083192
71	Phosphorylation	LTMTQFLSIIRSRMV CCHHHHHHHHHHHHH	19.77	29083192
82	Phosphorylation	SRMVLRATEAFYLLV HHHHHHHHHHHHHHH	22.78	27067055
86	Phosphorylation	LRATEAFYLLVNNKS HHHHHHHHHHHCCHH	13.23	27067055
93	Phosphorylation	YLLVNNKSLVSMSAT HHHHCCHHHCCCCCH	35.81	-
96	Phosphorylation	VNNKSLVSMSATMAE HCCHHHCCCCCHHHH	16.59	-
126	Phosphatidylethanolamine amidation	YASQETFGCLESAAP EECHHHCCCHHCCCC	23.63	15187094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
93	S	Phosphorylation	Kinase	TBK1	Q9UHD2	PSP
96	S	Phosphorylation	Kinase	TBK1	Q9UHD2	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MLP3C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLP3C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATG7_HUMAN	ATG7	physical	20562859
PK3C3_HUMAN	PIK3C3	physical	20562859
TFCP2_HUMAN	TFCP2	physical	20562859
A16L1_HUMAN	ATG16L1	physical	20562859
ATG5_HUMAN	ATG5	physical	20562859
RBCC1_HUMAN	RB1CC1	physical	20562859
ATG3_HUMAN	ATG3	physical	20562859
GBRL2_HUMAN	GABARAPL2	physical	20562859
UBP11_HUMAN	USP11	physical	20562859
GBRAP_HUMAN	GABARAP	physical	20562859
SF3A1_HUMAN	SF3A1	physical	20562859
PI3R4_HUMAN	PIK3R4	physical	20562859
ULK1_HUMAN	ULK1	physical	23043107
ATG13_HUMAN	ATG13	physical	23043107
CACO2_HUMAN	CALCOCO2	physical	23022382
TAXB1_HUMAN	TAX1BP1	physical	23209807
ACTA_HUMAN	ACTA2	physical	26186194
WDFY3_HUMAN	WDFY3	physical	24668264
KBTB7_HUMAN	KBTBD7	physical	25684205
KBTB6_HUMAN	KBTBD6	physical	25684205
CUL3_HUMAN	CUL3	physical	25684205
RO52_HUMAN	TRIM21	physical	26347139
CACO2_HUMAN	CALCOCO2	physical	25771791
ACTA_HUMAN	ACTA2	physical	28514442
WDR81_HUMAN	WDR81	physical	28404643
UBC_HUMAN	UBC	physical	28404643
LMNB1_HUMAN	LMNB1	physical	26524528

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.