WDR81_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR81_HUMAN
• UniProt AC: Q562E7
• Protein Name: WD repeat-containing protein 81 {ECO:0000312|HGNC:HGNC:26600}
• Gene Name: WDR81 {ECO:0000312|HGNC:HGNC:26600}
• Organism: Homo sapiens (Human).
• Sequence Length: 1941
• Subcellular Localization: Early endosome membrane ; Peripheral membrane protein . Late endosome membrane . Lysosome membrane . Cytoplasmic vesicle, autophagosome membrane . Mitochondrion . Cytoplasm, cytosol .
• Protein Description: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. [PubMed: 26783301 It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome]
• Protein Sequence: MAQGSGGREGALRTPAGGWHSPPSPDMQELLRSVERDLSIDPRQLAPAPGGTHVVALVPARWLASLRDRRLPLGPCPRAEGLGEAEVRTLLQRSVQRLPAGWTRVEVHGLRKRRLSYPLGGGLPFEDGSCGPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSPAPSAVPALDSVRQALQRVYGCSFLPVGETTQCPSYAREGPCPPRGSPACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVLRAMDACHRQGLACGALSLYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARDEAGIVSQEEQGGQPGQPTGQEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSIHPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLASYGVVQLFDQPHPQRLAGAPALAPEPPLIPKLLVQTIQETTGREDFTENPGQLPNGVGRPVLEATPCEASWTRDRPVAGEDDLEQATEALDSISLAGKAGDQLGSSSQASPGLLSFSVASASRPGRRNKAAGADPGEGEEGRILLPEGFNPMQALEELEKTGNFLAKGLGGLLEVPEQPRVQPAVPLQCLLHRDMQALGVLLAEMVFATRVRTLQPDAPLWVRFQAVRGLCTRHPKEVPVSLQPVLDTLLQMSGPEVPMGAERGKLDQLFEYRPVSQGLPPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQARRVEDEAQGRELVFALWQQLGAVLKDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPCQLHGRFYLYTDCFVAQLMVRLGLQAFLTHLLPHVLQVLAGAEASQEESKDLAGAAEEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTESPQPQEAEAVSLGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEGEQEEVTGASELTLSDTVLSMETVVAGGSGGDGEEEEEALPEQSEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSGESPPLSAGNIYQKRPVLGDIVSGPVLSCLLHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEVLLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSQLHELRQQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAYTIYVPFSCLLGDIIRKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPEWDPHGGGCPQDDGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTVEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVSNKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRLLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	TPAGGWHSPPSPDMQ CCCCCCCCCCCCCHH	22.01	27251275
52	Phosphorylation	LAPAPGGTHVVALVP CCCCCCCCEEEEEEE	3.50	-
65	Phosphorylation	VPARWLASLRDRRLP EEHHHHHHHCCCCCC	42.37	24719451
116	Phosphorylation	GLRKRRLSYPLGGGL CCCCCCCCCCCCCCC	58.13	28348404
217	Phosphorylation	RGSPACPSLLRAEAL CCCCCCHHHHHHHHH	29.57	29449344
294	Ubiquitination	YHIAVDEKLCSELRL HHHHHCHHHHHHHCC	8.52	-
347	Phosphorylation	TGQEELRSLVLDWVH CCHHHHHHHHHHHHH	2.32	24719451
354 (in isoform 2)	Ubiquitination	-	2.04	21906983
362	Phosphorylation	GRISNFHYLMQLNRL HCHHHHHHHHHHHHH	15.80	24719451
417	Phosphorylation	DKQLDFTYEMTRQAF CCCCCEEEEECCHHH	17.52	27642862
454	Ubiquitination	DITYYVYKARRTPRS HHHHHHHHCCCCCCC	39.33	-
496	Phosphorylation	DECIPEFYTDPSIFR CCCCHHHCCCHHHHH	31.34	27642862
552 (in isoform 1)	Ubiquitination	-	39.04	21906983
552	Ubiquitination	IDLTFGYKLQGKEAV HHCCCCEEECCHHHH	39.04	-
668	Phosphorylation	QATEALDSISLAGKA HHHHHHHHHCCCCCC	4.59	30108239
670	Phosphorylation	TEALDSISLAGKAGD HHHHHHHCCCCCCCC	5.08	30108239
681	Phosphorylation	KAGDQLGSSSQASPG CCCCCCCCCCCCCCC	32.13	25627689
682	Phosphorylation	AGDQLGSSSQASPGL CCCCCCCCCCCCCCC	6.03	27251275
683	Phosphorylation	GDQLGSSSQASPGLL CCCCCCCCCCCCCCE	39.26	27251275
686	Phosphorylation	LGSSSQASPGLLSFS CCCCCCCCCCCEEEE	45.15	25159151
691	Phosphorylation	QASPGLLSFSVASAS CCCCCCEEEEECCCC	4.37	28857561
696	Phosphorylation	LLSFSVASASRPGRR CEEEEECCCCCCCCC	3.67	25627689
698	Phosphorylation	SFSVASASRPGRRNK EEEECCCCCCCCCCC	35.72	25627689
705	Ubiquitination	SRPGRRNKAAGADPG CCCCCCCCCCCCCCC	13.37	-
736	Ubiquitination	QALEELEKTGNFLAK HHHHHHHHHCCHHHH	35.41	-
743	Ubiquitination	KTGNFLAKGLGGLLE HHCCHHHHCCCCCCC	6.91	-
956	Ubiquitination	VAKALGPKNANKYLL HHHHHCCCCHHHHCH		-
964	Ubiquitination	NANKYLLKPLIGAYE CHHHHCHHHHHCCCC		-
1109	Phosphorylation	AVSLGRLSDKSSTSE EEECCCCCCCCCCCC		26329039
1112	Phosphorylation	LGRLSDKSSTSETSL CCCCCCCCCCCCCCC		29255136
1113	Phosphorylation	GRLSDKSSTSETSLG CCCCCCCCCCCCCCC		29255136
1114	Phosphorylation	RLSDKSSTSETSLGE CCCCCCCCCCCCCCC		29255136
1115	Phosphorylation	LSDKSSTSETSLGEE CCCCCCCCCCCCCCC		27732954
1117	Phosphorylation	DKSSTSETSLGEERA CCCCCCCCCCCCCCC		29255136
1118	Phosphorylation	KSSTSETSLGEERAP CCCCCCCCCCCCCCC		28192239
1134	Ubiquitination	EGGAPVDKSSLRSGD CCCCCCCHHHHCCCC		-
1135	Phosphorylation	GGAPVDKSSLRSGDS CCCCCCHHHHCCCCC		30266825
1136	Phosphorylation	GAPVDKSSLRSGDSS CCCCCHHHHCCCCCC		25849741
1139	Phosphorylation	VDKSSLRSGDSSQDL CCHHHHCCCCCCHHH		23403867
1142	Phosphorylation	SSLRSGDSSQDLKQS HHHCCCCCCHHHHHC		26657352
1219	Ubiquitination	QSEGKEQKILLDTAC CCCCHHHHHHHHHHH		-
1235	Ubiquitination	MVRWLSAKLGPTVAS HHHHHHHHHCHHHHH		-
1239	Phosphorylation	LSAKLGPTVASRHVA HHHHHCHHHHHHHHH		-
1242	Phosphorylation	KLGPTVASRHVARNL HHCHHHHHHHHHHHH		23532336
1254	Phosphorylation	RNLLRLLTSCYVGPT HHHHHHHHHCCCCCC		24719451
1266	Phosphorylation	GPTRQQFTVSSGESP CCCCCEEEECCCCCC		28450419
1268	Phosphorylation	TRQQFTVSSGESPPL CCCEEEECCCCCCCC		28450419
1269	Phosphorylation	RQQFTVSSGESPPLS CCEEEECCCCCCCCC		28450419
1272	Phosphorylation	FTVSSGESPPLSAGN EEECCCCCCCCCCCC		29507054
1276	Phosphorylation	SGESPPLSAGNIYQK CCCCCCCCCCCCCCC		28450419
1313	Phosphorylation	YGEPVLTYQYLPYIS HCCCEEEEEECCCEE		-
1318	Phosphorylation	LTYQYLPYISYLVAP EEEEECCCEEEEECC		-
1603	Ubiquitination	GSDDNALKQELPRSV CCCCHHHHHHCCCCC		-
1667	Phosphorylation	EDFFLSGSKDRTVRL CCCCCCCCCCCEEEE		24260401
1668	Ubiquitination	DFFLSGSKDRTVRLW CCCCCCCCCCEEEEE		-
1699	Phosphorylation	VYTQHRKSVFFVGQL EEECCCCEEEEEECC		27251275
1738	Phosphorylation	RTVEPLDSRVPLTAV CEECCCCCCCCEEEE		29759185
1844	Phosphorylation	VEGSVLVSSSSDHSL EECEEEEECCCCCCE		-
1860	Ubiquitination	VWKELEQKPTHHYKS HHHHHHCCCCCCCCC		-
1906	Ubiquitination	PPSQATTKLSSENFR CCCCCCCCCCCCCCC		-
1915	Phosphorylation	SSENFRGTLTSLALL CCCCCCCHHHHHHHC		-
1917	Phosphorylation	ENFRGTLTSLALLPT CCCCCHHHHHHHCCC		-
1918	Phosphorylation	NFRGTLTSLALLPTK CCCCHHHHHHHCCCC		-
1924	Phosphorylation	TSLALLPTKRHLLLG HHHHHCCCCCCEECC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR81_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR81_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR81_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SQSTM_HUMAN	SQSTM1	physical	28404643
MLP3C_HUMAN	MAP1LC3C	physical	28404643
UBC_HUMAN	UBC	physical	28404643
WDR91_HUMAN	WDR91	physical	28404643

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.