SYT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT4_HUMAN
• UniProt AC: Q9H2B2
• Protein Name: Synaptotagmin-4
• Gene Name: SYT4
• Organism: Homo sapiens (Human).
• Sequence Length: 425
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.
• Protein Description: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes. [PubMed: 23999003]
• Protein Sequence: MAPITTSREEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRKSSKSNKTPPYKFVHVLKGVDIYPENLNSKKKFGADDKNEVKNKPAVPKNSLHLDLEKRDLNGNFPKTNLKPGSPSDLENATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIELSEGKMLMNREIIKRNVRKSSGRGELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGGEHWKEICDYPRRQIAKWHVLCDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Ubiquitination	FAWICCQRKSSKSNK HHHHHHHCCCCCCCC	27.23	-
52	Ubiquitination	SNKTPPYKFVHVLKG CCCCCCCCEEEEEEC	46.84	23503661
58	Ubiquitination	YKFVHVLKGVDIYPE CCEEEEEECCCCCCC	56.66	23503661
63	Phosphorylation	VLKGVDIYPENLNSK EEECCCCCCCCCCCC	10.46	25884760
69	Phosphorylation	IYPENLNSKKKFGAD CCCCCCCCCCCCCCC	49.36	27499020
70	Ubiquitination	YPENLNSKKKFGADD CCCCCCCCCCCCCCC	59.93	32142685
78	Ubiquitination	KKFGADDKNEVKNKP CCCCCCCCCHHCCCC	56.40	-
93	Ubiquitination	AVPKNSLHLDLEKRD CCCCCCEECCCHHCC	19.67	-
107	Ubiquitination	DLNGNFPKTNLKPGS CCCCCCCCCCCCCCC	46.00	23503661
108	Phosphorylation	LNGNFPKTNLKPGSP CCCCCCCCCCCCCCH	46.12	24117733
111	Ubiquitination	NFPKTNLKPGSPSDL CCCCCCCCCCCHHHH	49.77	23503661
114	Phosphorylation	KTNLKPGSPSDLENA CCCCCCCCHHHHHCC	29.74	24117733
116	Phosphorylation	NLKPGSPSDLENATP CCCCCCHHHHHCCCC	57.43	24117733
122	Phosphorylation	PSDLENATPKLFLEG HHHHHCCCCCEEECC	32.32	24117733
133	Phosphorylation	FLEGEKESVSPESLK EECCCCCCCCHHHHH	38.67	24076635
135	Phosphorylation	EGEKESVSPESLKSS CCCCCCCCHHHHHCC	32.03	18046461
138	Phosphorylation	KESVSPESLKSSTSL CCCCCHHHHHCCCCC	44.47	26074081
156	Phosphorylation	EKQEKLGTLFFSLEY HHHHHHHHHEEEEEE	30.72	27050516
298	Ubiquitination	LLISLCYQSTTNTLT EEEEEEEECCCCEEE	33.05	-
310	Ubiquitination	TLTVVVLKARHLPKS EEEEEEEEECCCCHH	31.59	23503661
316	Ubiquitination	LKARHLPKSDVSGLS EEECCCCHHHCCCCC	66.69	23503661

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
135	S	Phosphorylation	Kinase	JNK1	P45983	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
135	S	Phosphorylation	Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNRPQ_HUMAN	SYNCRIP	physical	10734137

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.