dbPTM

HNRPQ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HNRPQ_HUMAN
UniProt AC	O60506
Protein Name	Heterogeneous nuclear ribonucleoprotein Q
Gene Name	SYNCRIP
Organism	Homo sapiens (Human).
Sequence Length	623
Subcellular Localization	Cytoplasm . Microsome . Endoplasmic reticulum. Nucleus . The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Isoform 1: Nucleus,
Protein Description	Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function..
Protein Sequence	MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENQEFYQDTFGQQWK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATEHVNGN ------CCCCCCCCC	22.99	19413330
13 (in isoform 5)	Ubiquitination	-	45.84	21890473
19 (in isoform 5)	Ubiquitination	-	23.72	21890473
42	Acetylation	LPQKVAEKLDEIYVA CCHHHHHHCCHHHHH	52.04	26051181
47	Phosphorylation	AEKLDEIYVAGLVAH HHHCCHHHHHHHHHC	5.12	-
55	Phosphorylation	VAGLVAHSDLDERAI HHHHHHCCCCCHHHH	30.08	28348404
66	Acetylation	ERAIEALKEFNEDGA HHHHHHHHHHCCCCH	68.27	26051181
66	Ubiquitination	ERAIEALKEFNEDGA HHHHHHHHHHCCCCH	68.27	-
70 (in isoform 5)	Ubiquitination	-	64.24	21890473
81	Acetylation	LAVLQQFKDSDLSHV HHHHHHHCCCCCHHH	52.57	25825284
81	Ubiquitination	LAVLQQFKDSDLSHV HHHHHHHCCCCCHHH	52.57	21906983
81 (in isoform 1)	Ubiquitination	-	52.57	21890473
81 (in isoform 2)	Ubiquitination	-	52.57	21906983
81 (in isoform 3)	Ubiquitination	-	52.57	21890473
81 (in isoform 4)	Ubiquitination	-	52.57	21906983
91	Ubiquitination	DLSHVQNKSAFLCGV CCHHHCCHHHHHHHH	26.52	-
92	Phosphorylation	LSHVQNKSAFLCGVM CHHHCCHHHHHHHHH	31.63	21712546
96	Glutathionylation	QNKSAFLCGVMKTYR CCHHHHHHHHHHHHH	2.89	22555962
100	Acetylation	AFLCGVMKTYRQREK HHHHHHHHHHHHHHH	39.74	19608861
100	Ubiquitination	AFLCGVMKTYRQREK HHHHHHHHHHHHHHH	39.74	19608861
107	Ubiquitination	KTYRQREKQGTKVAD HHHHHHHHHCCCCCC	57.10	-
110	Phosphorylation	RQREKQGTKVADSSK HHHHHHCCCCCCCCC	21.61	22817900
111	Ubiquitination	QREKQGTKVADSSKG HHHHHCCCCCCCCCC	42.10	21906983
111 (in isoform 1)	Ubiquitination	-	42.10	21890473
111 (in isoform 2)	Ubiquitination	-	42.10	21906983
111 (in isoform 3)	Ubiquitination	-	42.10	21890473
111 (in isoform 4)	Ubiquitination	-	42.10	21906983
115	Phosphorylation	QGTKVADSSKGPDEA HCCCCCCCCCCCCHH	24.98	29632367
116	Phosphorylation	GTKVADSSKGPDEAK CCCCCCCCCCCCHHH	42.02	29632367
117	Acetylation	TKVADSSKGPDEAKI CCCCCCCCCCCHHHH	77.68	26051181
117	Ubiquitination	TKVADSSKGPDEAKI CCCCCCCCCCCHHHH	77.68	21906983
117 (in isoform 1)	Ubiquitination	-	77.68	21890473
117 (in isoform 2)	Ubiquitination	-	77.68	21906983
117 (in isoform 3)	Ubiquitination	-	77.68	21890473
117 (in isoform 4)	Ubiquitination	-	77.68	21906983
123	Trimethylation	SKGPDEAKIKALLER CCCCCHHHHHHHHHH	42.57	-
123	Acetylation	SKGPDEAKIKALLER CCCCCHHHHHHHHHH	42.57	25953088
123	Methylation	SKGPDEAKIKALLER CCCCCHHHHHHHHHH	42.57	-
123	Ubiquitination	SKGPDEAKIKALLER CCCCCHHHHHHHHHH	42.57	17370265
123 (in isoform 5)	Ubiquitination	-	42.57	21890473
125	Trimethylation	GPDEAKIKALLERTG CCCHHHHHHHHHHHC	32.07	-
125	Methylation	GPDEAKIKALLERTG CCCHHHHHHHHHHHC	32.07	-
131	Phosphorylation	IKALLERTGYTLDVT HHHHHHHHCCEEEEC	25.76	21406692
133	Phosphorylation	ALLERTGYTLDVTTG HHHHHHCCEEEECCC	11.97	21406692
134	Phosphorylation	LLERTGYTLDVTTGQ HHHHHCCEEEECCCC	20.16	21406692
138	Phosphorylation	TGYTLDVTTGQRKYG HCCEEEECCCCCCCC	25.52	26074081
139	Phosphorylation	GYTLDVTTGQRKYGG CCEEEECCCCCCCCC	31.03	26074081
144	Phosphorylation	VTTGQRKYGGPPPDS ECCCCCCCCCCCCCC	29.51	28152594
151	Phosphorylation	YGGPPPDSVYSGQQP CCCCCCCCCCCCCCC	28.82	28152594
153	Phosphorylation	GPPPDSVYSGQQPSV CCCCCCCCCCCCCCC	15.84	28152594
154	Phosphorylation	PPPDSVYSGQQPSVG CCCCCCCCCCCCCCC	28.15	28152594
159	Phosphorylation	VYSGQQPSVGTEIFV CCCCCCCCCCCEEEE	28.92	23401153
162	Phosphorylation	GQQPSVGTEIFVGKI CCCCCCCCEEEEECC	24.61	28464451
168	Acetylation	GTEIFVGKIPRDLFE CCEEEEECCCHHHHC	44.21	25953088
168	Sumoylation	GTEIFVGKIPRDLFE CCEEEEECCCHHHHC	44.21	28112733
168	Ubiquitination	GTEIFVGKIPRDLFE CCEEEEECCCHHHHC	44.21	21906983
168 (in isoform 1)	Ubiquitination	-	44.21	21890473
168 (in isoform 2)	Ubiquitination	-	44.21	21906983
168 (in isoform 3)	Ubiquitination	-	44.21	21890473
168 (in isoform 4)	Ubiquitination	-	44.21	21906983
184	Ubiquitination	ELVPLFEKAGPIWDL CCHHHHHHHCCHHEH	51.84	-
184 (in isoform 3)	Ubiquitination	-	51.84	-
192	Methylation	AGPIWDLRLMMDPLT HCCHHEHHHHHCCCC	20.33	-
194	Sulfoxidation	PIWDLRLMMDPLTGL CHHEHHHHHCCCCCC	2.01	21406390
205	Phosphorylation	LTGLNRGYAFVTFCT CCCCCCCEEEEEEEC	8.14	28152594
211	S-palmitoylation	GYAFVTFCTKEAAQE CEEEEEEECHHHHHH	3.77	29575903
213	Acetylation	AFVTFCTKEAAQEAV EEEEEECHHHHHHHH	46.68	26051181
213	Methylation	AFVTFCTKEAAQEAV EEEEEECHHHHHHHH	46.68	23644510
221	Acetylation	EAAQEAVKLYNNHEI HHHHHHHHHHCCCCC	52.91	19608861
221	Malonylation	EAAQEAVKLYNNHEI HHHHHHHHHHCCCCC	52.91	26320211
221	Ubiquitination	EAAQEAVKLYNNHEI HHHHHHHHHHCCCCC	52.91	21890473
221 (in isoform 1)	Ubiquitination	-	52.91	21890473
221 (in isoform 2)	Ubiquitination	-	52.91	21906983
221 (in isoform 3)	Ubiquitination	-	52.91	21890473
221 (in isoform 4)	Ubiquitination	-	52.91	21906983
223	Phosphorylation	AQEAVKLYNNHEIRS HHHHHHHHCCCCCCC	14.27	28152594
232	Acetylation	NHEIRSGKHIGVCIS CCCCCCCCEEEEEEE	33.04	26051181
238 (in isoform 5)	Ubiquitination	-	3.27	21890473
240 (in isoform 5)	Ubiquitination	-	3.15	21890473
249	Phosphorylation	NNRLFVGSIPKSKTK CCEEEECCCCCCCCH	30.34	30266825
253	Phosphorylation	FVGSIPKSKTKEQIL EECCCCCCCCHHHHH	39.96	23312004
255	Phosphorylation	GSIPKSKTKEQILEE CCCCCCCCHHHHHHH	47.07	27134283
256	Acetylation	SIPKSKTKEQILEEF CCCCCCCHHHHHHHH	51.89	26822725
256	Ubiquitination	SIPKSKTKEQILEEF CCCCCCCHHHHHHHH	51.89	-
258 (in isoform 5)	Ubiquitination	-	47.31	21890473
265	Ubiquitination	QILEEFSKVTEGLTD HHHHHHHHHHCCCCE	59.50	-
265 (in isoform 5)	Ubiquitination	-	59.50	21890473
276	Phosphorylation	GLTDVILYHQPDDKK CCCEEEEEECCCCCC	6.31	28152594
282	Acetylation	LYHQPDDKKKNRGFC EEECCCCCCCCCCEE	73.38	25953088
282	Ubiquitination	LYHQPDDKKKNRGFC EEECCCCCCCCCCEE	73.38	-
283	Acetylation	YHQPDDKKKNRGFCF EECCCCCCCCCCEEE	63.37	25953088
283	Ubiquitination	YHQPDDKKKNRGFCF EECCCCCCCCCCEEE	63.37	-
284	Ubiquitination	HQPDDKKKNRGFCFL ECCCCCCCCCCEEEE	58.58	-
286	Methylation	PDDKKKNRGFCFLEY CCCCCCCCCEEEEEE	48.74	-
288 (in isoform 5)	Ubiquitination	-	2.10	21890473
289	Glutathionylation	KKKNRGFCFLEYEDH CCCCCCEEEEEECCH	4.19	22555962
289	S-palmitoylation	KKKNRGFCFLEYEDH CCCCCCEEEEEECCH	4.19	29575903
293	Phosphorylation	RGFCFLEYEDHKTAA CCEEEEEECCHHHHH	28.89	28152594
297	Acetylation	FLEYEDHKTAAQARR EEEECCHHHHHHHHH	52.78	25953088
297	Malonylation	FLEYEDHKTAAQARR EEEECCHHHHHHHHH	52.78	26320211
297	Sumoylation	FLEYEDHKTAAQARR EEEECCHHHHHHHHH	52.78	-
297	Ubiquitination	FLEYEDHKTAAQARR EEEECCHHHHHHHHH	52.78	-
308	Phosphorylation	QARRRLMSGKVKVWG HHHHHHHCCCEEEEE	39.80	24719451
310	Ubiquitination	RRRLMSGKVKVWGNV HHHHHCCCEEEEECE	31.41	-
312	Ubiquitination	RLMSGKVKVWGNVGT HHHCCCEEEEECEEE	35.44	-
321 (in isoform 2)	Ubiquitination	-	36.46	21906983
321 (in isoform 4)	Ubiquitination	-	36.46	21906983
328	Acetylation	EWADPIEDPDPEVMA EECCCCCCCCHHHHH	54.33	19608861
328	Ubiquitination	EWADPIEDPDPEVMA EECCCCCCCCHHHHH	54.33	19608861
328 (in isoform 2)	Ubiquitination	-	54.33	21906983
328 (in isoform 4)	Ubiquitination	-	54.33	21906983
336	Ubiquitination	PDPEVMAKVKVLFVR CCHHHHHHEEEHHHH	25.21	21906983
336 (in isoform 1)	Ubiquitination	-	25.21	21890473
336 (in isoform 3)	Ubiquitination	-	25.21	21890473
338	Acetylation	PEVMAKVKVLFVRNL HHHHHHEEEHHHHCH	32.30	24707635
338	Ubiquitination	PEVMAKVKVLFVRNL HHHHHHEEEHHHHCH	32.30	21890473
338 (in isoform 1)	Ubiquitination	-	32.30	21890473
338 (in isoform 3)	Ubiquitination	-	32.30	21890473
348	Phosphorylation	FVRNLANTVTEEILE HHHCHHHHCCHHHHH	24.17	23403867
350	Phosphorylation	RNLANTVTEEILEKA HCHHHHCCHHHHHHH	26.34	23403867
351 (in isoform 2)	Ubiquitination	-	38.41	21906983
351 (in isoform 4)	Ubiquitination	-	38.41	21906983
356	Acetylation	VTEEILEKAFSQFGK CCHHHHHHHHHHCCC	51.81	26051181
356	Ubiquitination	VTEEILEKAFSQFGK CCHHHHHHHHHHCCC	51.81	21906983
356 (in isoform 1)	Ubiquitination	-	51.81	21890473
356 (in isoform 3)	Ubiquitination	-	51.81	21890473
363	Acetylation	KAFSQFGKLERVKKL HHHHHCCCHHHHHHH	48.76	19608861
363	Malonylation	KAFSQFGKLERVKKL HHHHHCCCHHHHHHH	48.76	26320211
363	Methylation	KAFSQFGKLERVKKL HHHHHCCCHHHHHHH	48.76	22633583
363	Ubiquitination	KAFSQFGKLERVKKL HHHHHCCCHHHHHHH	48.76	21890473
363 (in isoform 1)	Ubiquitination	-	48.76	21890473
363 (in isoform 3)	Ubiquitination	-	48.76	21890473
371	Acetylation	LERVKKLKDYAFIHF HHHHHHHCCEEEEEE	58.53	26051181
371	Ubiquitination	LERVKKLKDYAFIHF HHHHHHHCCEEEEEE	58.53	21890473
373	Nitration	RVKKLKDYAFIHFDE HHHHHCCEEEEEEEC	11.21	-
373	Phosphorylation	RVKKLKDYAFIHFDE HHHHHCCEEEEEEEC	11.21	12601080
381	Methylation	AFIHFDERDGAVKAM EEEEEECCCCHHHHH	49.89	115485573
386	Ubiquitination	DERDGAVKAMEEMNG ECCCCHHHHHHHHCC	41.29	2190698
386 (in isoform 1)	Ubiquitination	-	41.29	21890473
386 (in isoform 3)	Ubiquitination	-	41.29	21890473
394	Ubiquitination	AMEEMNGKDLEGENI HHHHHCCCCCCCCCE	54.88	-
394 (in isoform 3)	Ubiquitination	-	54.88	-
407	Ubiquitination	NIEIVFAKPPDQKRK CEEEEEECCCCHHHH	45.69	-
407 (in isoform 3)	Ubiquitination	-	45.69	-
412	Acetylation	FAKPPDQKRKERKAQ EECCCCHHHHHHHHH	73.20	24431059
412	Ubiquitination	FAKPPDQKRKERKAQ EECCCCHHHHHHHHH	73.20	-
428	Phosphorylation	QAAKNQMYDDYYYYG HHHHHHCCCCCCCCC	8.90	26846344
431	Phosphorylation	KNQMYDDYYYYGPPH HHHCCCCCCCCCCCC	7.17	26846344
432	Phosphorylation	NQMYDDYYYYGPPHM HHCCCCCCCCCCCCC	9.37	26846344
433	Phosphorylation	QMYDDYYYYGPPHMP HCCCCCCCCCCCCCC	8.84	26846344
434	Phosphorylation	MYDDYYYYGPPHMPP CCCCCCCCCCCCCCC	13.67	26846344
443	Phosphorylation	PPHMPPPTRGRGRGG CCCCCCCCCCCCCCC	52.08	26846344
444	Asymmetric dimethylarginine	PHMPPPTRGRGRGGR CCCCCCCCCCCCCCC	38.29	-
444	Methylation	PHMPPPTRGRGRGGR CCCCCCCCCCCCCCC	38.29	23455924
446	Methylation	MPPPTRGRGRGGRGG CCCCCCCCCCCCCCC	28.48	24395445
448	Methylation	PPTRGRGRGGRGGYG CCCCCCCCCCCCCCC	42.93	24395453
472	Phosphorylation	DYYDYYGYDYHNYRG CCCCCCCCCCCCCCC	9.37	-
474	Phosphorylation	YDYYGYDYHNYRGGY CCCCCCCCCCCCCCC	5.40	-
478	Methylation	GYDYHNYRGGYEDPY CCCCCCCCCCCCCCC	37.06	-
485	Phosphorylation	RGGYEDPYYGYEDFQ CCCCCCCCCCCCCCC	23.11	22817900
488	Phosphorylation	YEDPYYGYEDFQVGA CCCCCCCCCCCCCCC	9.01	-
496	Dimethylation	EDFQVGARGRGGRGA CCCCCCCCCCCCCCC	29.43	-
496	Methylation	EDFQVGARGRGGRGA CCCCCCCCCCCCCCC	29.43	23455924
498	Dimethylation	FQVGARGRGGRGARG CCCCCCCCCCCCCCC	38.55	-
498	Methylation	FQVGARGRGGRGARG CCCCCCCCCCCCCCC	38.55	24396479
501	Methylation	GARGRGGRGARGAAP CCCCCCCCCCCCCCC	38.12	115485581
504	Methylation	GRGGRGARGAAPSRG CCCCCCCCCCCCCCC	37.80	115485589
509	Phosphorylation	GARGAAPSRGRGAAP CCCCCCCCCCCCCCC	42.51	22817900
510	Asymmetric dimethylarginine	ARGAAPSRGRGAAPP CCCCCCCCCCCCCCC	37.46	-
510	Methylation	ARGAAPSRGRGAAPP CCCCCCCCCCCCCCC	37.46	23455924
518	Asymmetric dimethylarginine	GRGAAPPRGRAGYSQ CCCCCCCCCCCCCCC	46.28	-
518	Methylation	GRGAAPPRGRAGYSQ CCCCCCCCCCCCCCC	46.28	23455924
520	Methylation	GAAPPRGRAGYSQRG CCCCCCCCCCCCCCC	26.56	115485597
524	Phosphorylation	PRGRAGYSQRGGPGS CCCCCCCCCCCCCCC	16.69	22817900
526	Asymmetric dimethylarginine	GRAGYSQRGGPGSAR CCCCCCCCCCCCCCC	46.20	-
526	Methylation	GRAGYSQRGGPGSAR CCCCCCCCCCCCCCC	46.20	23455924
531	Phosphorylation	SQRGGPGSARGVRGA CCCCCCCCCCCCCCC	20.23	22817900
533	Methylation	RGGPGSARGVRGARG CCCCCCCCCCCCCCC	45.92	24383427
536	Asymmetric dimethylarginine	PGSARGVRGARGGAQ CCCCCCCCCCCCCCH	35.56	-
536	Methylation	PGSARGVRGARGGAQ CCCCCCCCCCCCCCH	35.56	23455924
539	Asymmetric dimethylarginine	ARGVRGARGGAQQQR CCCCCCCCCCCHHCC	47.07	-
539	Methylation	ARGVRGARGGAQQQR CCCCCCCCCCCHHCC	47.07	23455924
565	Methylation	GGNVGGKRKADGYNQ CCCCCCCCCCCCCCC	42.54	-
566	Acetylation	GNVGGKRKADGYNQP CCCCCCCCCCCCCCC	55.08	19829793
566	Ubiquitination	GNVGGKRKADGYNQP CCCCCCCCCCCCCCC	55.08	-
570	Phosphorylation	GKRKADGYNQPDSKR CCCCCCCCCCCCHHH	15.92	28102081
575	Phosphorylation	DGYNQPDSKRRQTNN CCCCCCCHHHCCCCC	34.44	21815630
576	Acetylation	GYNQPDSKRRQTNNQ CCCCCCHHHCCCCCC	60.01	7495477
576	Ubiquitination	GYNQPDSKRRQTNNQ CCCCCCHHHCCCCCC	60.01	-
580	Phosphorylation	PDSKRRQTNNQNWGS CCHHHCCCCCCCCCC	34.03	24043423
587	Phosphorylation	TNNQNWGSQPIAQQP CCCCCCCCCCCCCCC	25.13	17525332
601	Phosphorylation	PLQGGDHSGNYGYKS CCCCCCCCCCCCCCC	33.21	21712546
607	Sumoylation	HSGNYGYKSENQEFY CCCCCCCCCCCCCHH	47.10	28112733
614	Phosphorylation	KSENQEFYQDTFGQQ CCCCCCHHHHCCCCC	12.53	21945579
617	Phosphorylation	NQEFYQDTFGQQWK- CCCHHHHCCCCCCC-	17.72	21945579
623	Acetylation	DTFGQQWK------- HCCCCCCC-------	46.23	91213

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
373	Y	Phosphorylation	Kinase	FGFR1	P11362	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HNRPQ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HNRPQ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN11_HUMAN	PTPN11	physical	9847309
ABEC1_HUMAN	APOBEC1	physical	11352648
A1CF_HUMAN	A1CF	physical	11352648
SYT7_HUMAN	SYT7	physical	10734137
SYT8_HUMAN	SYT8	physical	10734137
SYT9_HUMAN	SYT9	physical	10734137
HNRPD_HUMAN	HNRNPD	physical	12674497
A4_HUMAN	APP	physical	21832049
PABP1_HUMAN	PABPC1	physical	22939629
HNRPR_HUMAN	HNRNPR	physical	22939629
ROA1_HUMAN	HNRNPA1	physical	22939629
ROA3_HUMAN	HNRNPA3	physical	22939629
SRSF1_HUMAN	SRSF1	physical	22939629
SRSF3_HUMAN	SRSF3	physical	22939629
TADBP_HUMAN	TARDBP	physical	22939629
YBOX1_HUMAN	YBX1	physical	22939629
ILF3_HUMAN	ILF3	physical	22939629
ILF2_HUMAN	ILF2	physical	22939629
RU2A_HUMAN	SNRPA1	physical	22939629
RALY_HUMAN	RALY	physical	22939629
SRRM2_HUMAN	SRRM2	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
PP1A_HUMAN	PPP1CA	physical	22939629
U2AF2_HUMAN	U2AF2	physical	22939629
RU17_HUMAN	SNRNP70	physical	22939629
IF4H_HUMAN	EIF4H	physical	22939629
IF2B1_HUMAN	IGF2BP1	physical	22939629
PHB_HUMAN	PHB	physical	22939629
PTCD3_HUMAN	PTCD3	physical	22939629
RL10_HUMAN	RPL10	physical	22939629
RBMS2_HUMAN	RBMS2	physical	22939629
STT3B_HUMAN	STT3B	physical	22939629
RCC1L_HUMAN	WBSCR16	physical	22939629
TIM50_HUMAN	TIMM50	physical	22939629
ROA0_HUMAN	HNRNPA0	physical	22939629
NDUV2_HUMAN	NDUFV2	physical	22939629
LS14A_HUMAN	LSM14A	physical	22939629
IKIP_HUMAN	IKBIP	physical	22939629
ICT1_HUMAN	ICT1	physical	22939629
ML12A_HUMAN	MYL12A	physical	22939629
STML2_HUMAN	STOML2	physical	22939629
PLP2_HUMAN	PLP2	physical	22939629
LETM1_HUMAN	LETM1	physical	22939629
RUSD4_HUMAN	RPUSD4	physical	22939629
RPN1_HUMAN	RPN1	physical	22939629
SNP23_HUMAN	SNAP23	physical	22939629
ODP2_HUMAN	DLAT	physical	22939629
LYAG_HUMAN	GAA	physical	22939629
TM177_HUMAN	TMEM177	physical	22939629
LG3BP_HUMAN	LGALS3BP	physical	22939629
THIO_HUMAN	TXN	physical	22939629
RT28_HUMAN	MRPS28	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
HABP4_HUMAN	HABP4	physical	19523114
HNRPU_HUMAN	HNRNPU	physical	22365833
HNRPK_HUMAN	HNRNPK	physical	22365833
P63_HUMAN	TP63	physical	20085233
IL7RA_HUMAN	IL7R	physical	23151878
ANM8_HUMAN	PRMT8	physical	19060904
ANM1_HUMAN	PRMT1	physical	23455924
HMGA1_HUMAN	HMGA1	physical	18850631
HMGA2_HUMAN	HMGA2	physical	18850631
ANM8_HUMAN	PRMT8	physical	23455924
HNRPU_HUMAN	HNRNPU	physical	22863883
IQGA1_HUMAN	IQGAP1	physical	22863883
ANM8_HUMAN	PRMT8	physical	25416956
DDX17_HUMAN	DDX17	physical	26344197
DDX3X_HUMAN	DDX3X	physical	26344197
DDX5_HUMAN	DDX5	physical	26344197
HNRPU_HUMAN	HNRNPU	physical	26344197
MO4L1_HUMAN	MORF4L1	physical	26344197
MO4L2_HUMAN	MORF4L2	physical	26344197
NH2L1_HUMAN	NHP2L1	physical	26344197
ZN598_HUMAN	ZNF598	physical	26344197
APBB2_HUMAN	APBB2	physical	26496610
BAD_HUMAN	BAD	physical	26496610
BLMH_HUMAN	BLMH	physical	26496610
MCAT_HUMAN	SLC25A20	physical	26496610
CRY1_HUMAN	CRY1	physical	26496610
DKC1_HUMAN	DKC1	physical	26496610
DYHC1_HUMAN	DYNC1H1	physical	26496610
ECHM_HUMAN	ECHS1	physical	26496610
PHC2_HUMAN	PHC2	physical	26496610
EI2BA_HUMAN	EIF2B1	physical	26496610
SRC8_HUMAN	CTTN	physical	26496610
MTOR_HUMAN	MTOR	physical	26496610
GOGA3_HUMAN	GOLGA3	physical	26496610
HBA_HUMAN	HBA1	physical	26496610
HEXA_HUMAN	HEXA	physical	26496610
ROAA_HUMAN	HNRNPAB	physical	26496610
TAU_HUMAN	MAPT	physical	26496610
M3K4_HUMAN	MAP3K4	physical	26496610
KI67_HUMAN	MKI67	physical	26496610
MYH1_HUMAN	MYH1	physical	26496610
NDUB5_HUMAN	NDUFB5	physical	26496610
NHS_HUMAN	NHS	physical	26496610
NOP2_HUMAN	NOP2	physical	26496610
YBOX1_HUMAN	YBX1	physical	26496610
PHLP_HUMAN	PDCL	physical	26496610
PLCB3_HUMAN	PLCB3	physical	26496610
PSMD2_HUMAN	PSMD2	physical	26496610
PTMA_HUMAN	PTMA	physical	26496610
RECQ1_HUMAN	RECQL	physical	26496610
RET_HUMAN	RET	physical	26496610
SCO1_HUMAN	SCO1	physical	26496610
SDC2_HUMAN	SDC2	physical	26496610
SSXT_HUMAN	SS18	physical	26496610
TARB1_HUMAN	TARBP1	physical	26496610
ZEB1_HUMAN	ZEB1	physical	26496610
GCFC2_HUMAN	GCFC2	physical	26496610
TLN1_HUMAN	TLN1	physical	26496610
TNR1A_HUMAN	TNFRSF1A	physical	26496610
UBP1_HUMAN	USP1	physical	26496610
ZBT14_HUMAN	ZBTB14	physical	26496610
RBM10_HUMAN	RBM10	physical	26496610
UBP13_HUMAN	USP13	physical	26496610
MTA1_HUMAN	MTA1	physical	26496610
PTTG1_HUMAN	PTTG1	physical	26496610
COX5A_HUMAN	COX5A	physical	26496610
RM33_HUMAN	MRPL33	physical	26496610
GT2D1_HUMAN	GTF2IRD1	physical	26496610
RHG32_HUMAN	ARHGAP32	physical	26496610
C2CD5_HUMAN	C2CD5	physical	26496610
HMGX4_HUMAN	HMGXB4	physical	26496610
CEBPZ_HUMAN	CEBPZ	physical	26496610
VINEX_HUMAN	SORBS3	physical	26496610
VPP3_HUMAN	TCIRG1	physical	26496610
ABCA7_HUMAN	ABCA7	physical	26496610
TBB3_HUMAN	TUBB3	physical	26496610
TXN4A_HUMAN	TXNL4A	physical	26496610
EBP2_HUMAN	EBNA1BP2	physical	26496610
TARA_HUMAN	TRIOBP	physical	26496610
HNRL1_HUMAN	HNRNPUL1	physical	26496610
FND3A_HUMAN	FNDC3A	physical	26496610
SET1B_HUMAN	SETD1B	physical	26496610
F120A_HUMAN	FAM120A	physical	26496610
MD13L_HUMAN	MED13L	physical	26496610
DICER_HUMAN	DICER1	physical	26496610
MACF1_HUMAN	MACF1	physical	26496610
INT7_HUMAN	INTS7	physical	26496610
TB10B_HUMAN	TBC1D10B	physical	26496610
WDR91_HUMAN	WDR91	physical	26496610
ANR11_HUMAN	ANKRD11	physical	26496610
RGAP1_HUMAN	RACGAP1	physical	26496610
PLPL8_HUMAN	PNPLA8	physical	26496610
RRP15_HUMAN	RRP15	physical	26496610
TR112_HUMAN	TRMT112	physical	26496610
PPIL1_HUMAN	PPIL1	physical	26496610
PPIL3_HUMAN	PPIL3	physical	26496610
APTX_HUMAN	APTX	physical	26496610
URFB1_HUMAN	UHRF1BP1	physical	26496610
UACA_HUMAN	UACA	physical	26496610
CEP55_HUMAN	CEP55	physical	26496610
NAT10_HUMAN	NAT10	physical	26496610
UFSP2_HUMAN	UFSP2	physical	26496610
DNJA4_HUMAN	DNAJA4	physical	26496610
NOP10_HUMAN	NOP10	physical	26496610
PLXA3_HUMAN	PLXNA3	physical	26496610
PR40A_HUMAN	PRPF40A	physical	26496610
BIN3_HUMAN	BIN3	physical	26496610
DDX24_HUMAN	DDX24	physical	26496610
Z286A_HUMAN	ZNF286A	physical	26496610
UVSSA_HUMAN	UVSSA	physical	26496610
ICE2_HUMAN	ICE2	physical	26496610
IPO4_HUMAN	IPO4	physical	26496610
ELMO3_HUMAN	ELMO3	physical	26496610
MTMRD_HUMAN	SBF2	physical	26496610
TLN2_HUMAN	TLN2	physical	26496610
KLF16_HUMAN	KLF16	physical	26496610
UBP32_HUMAN	USP32	physical	26496610
FBH1_HUMAN	FBXO18	physical	26496610
SCMC2_HUMAN	SLC25A25	physical	26496610
PTGR2_HUMAN	PTGR2	physical	26496610
CENPV_HUMAN	CENPV	physical	26496610
LEMD2_HUMAN	LEMD2	physical	26496610
NSE2_HUMAN	NSMCE2	physical	26496610
RMXL1_HUMAN	RBMXL1	physical	28514442
ANGE2_HUMAN	ANGEL2	physical	28514442
RS27A_HUMAN	RPS27A	physical	28514442
RU17_HUMAN	SNRNP70	physical	28514442
YTHD1_HUMAN	YTHDF1	physical	28514442
VIGLN_HUMAN	HDLBP	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
HNRPR_HUMAN	HNRNPR	physical	28514442
ELAV4_HUMAN	ELAVL4	physical	28514442
F120A_HUMAN	FAM120A	physical	28514442
DUS11_HUMAN	DUSP11	physical	28514442
ZC3H8_HUMAN	ZC3H8	physical	28514442
KNOP1_HUMAN	KNOP1	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442
DDX21_HUMAN	DDX21	physical	28514442
ZRAB2_HUMAN	ZRANB2	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
NKAP_HUMAN	NKAP	physical	28514442
YPEL5_HUMAN	YPEL5	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HNRPQ_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-221 AND LYS-363, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-587, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Signaling initiated by overexpression of the fibroblast growth factorreceptor-1 investigated by mass spectrometry."; Hinsby A.M., Olsen J.V., Bennett K.L., Mann M.; Mol. Cell. Proteomics 2:29-36(2003). Cited for: PARTIAL PROTEIN SEQUENCE, MASS SPECTROMETRY, AND PHOSPHORYLATION ATTYR-373.	12601080 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-123, AND MASSSPECTROMETRY.	17370265 [Abstract]