PLPL8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPL8_HUMAN
• UniProt AC: Q9NP80
• Protein Name: Calcium-independent phospholipase A2-gamma
• Gene Name: PNPLA8
• Organism: Homo sapiens (Human).
• Sequence Length: 782
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Cytoplasm, perinuclear region.
• Protein Description: Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids..
• Protein Sequence: MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWTKSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQNEMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDKEEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSIDNRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENILKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQDGGLLLNNPSALAMHECKCLWPDVPLECIVSLGTGRYESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLDESRNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFSKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSINLTVDI ------CCCEEEEEE	21.86	24043423
4	N-linked_Glycosylation	----MSINLTVDIYI ----CCCEEEEEEHH	23.50	UniProtKB CARBOHYD
6	Phosphorylation	--MSINLTVDIYIYL --CCCEEEEEEHHHH	16.19	24043423
19	Phosphorylation	YLLSNARSVCGKQRS HHHHCCHHHHCCCCC	21.24	24043423
34	Phosphorylation	KQLYFLFSPKHYWRI CEEEEEECHHHEEEE	34.88	24719451
45	Phosphorylation	YWRISHISLQRGFHT EEEEEEEEECCCCCC	17.02	24719451
87	Phosphorylation	HIGILKLSTSAPKGL EEEEEEECCCCCCCC	20.80	27251275
88	Phosphorylation	IGILKLSTSAPKGLT EEEEEECCCCCCCCC	39.07	27251275
89	Phosphorylation	GILKLSTSAPKGLTK EEEEECCCCCCCCCH	38.92	27251275
102	Phosphorylation	TKVNICMSRIKSTLN CHHHHHHHHHHHHHH	26.83	29083192
106	Phosphorylation	ICMSRIKSTLNSVSK HHHHHHHHHHHHHHH	35.44	29083192
107	Phosphorylation	CMSRIKSTLNSVSKA HHHHHHHHHHHHHHH	25.59	29083192
110	Phosphorylation	RIKSTLNSVSKAVFG HHHHHHHHHHHHHHC	30.77	29083192
112	Phosphorylation	KSTLNSVSKAVFGNQ HHHHHHHHHHHHCCH	18.08	29083192
125	Dimethylation	NQNEMISRLAQFKPS CHHHHHHHHHCCCCH	24.10	-
125	Methylation	NQNEMISRLAQFKPS CHHHHHHHHHCCCCH	24.10	24410469
156	Phosphorylation	NIKQAIKSLKKYSDK CHHHHHHHHHHHCCC	39.03	24702127
168	Phosphorylation	SDKSAEKSPFPEEKS CCCCCCCCCCCHHHH	24.23	28348404
168	O-linked_Glycosylation	SDKSAEKSPFPEEKS CCCCCCCCCCCHHHH	24.23	31492838
188	Phosphorylation	EEDIGKRSLFHYTSS CHHCCCHHHHEEEEE	38.58	28450419
192	Phosphorylation	GKRSLFHYTSSITTK CCHHHHEEEEECEEC	10.86	28450419
193	Phosphorylation	KRSLFHYTSSITTKF CHHHHEEEEECEECC	13.87	28450419
194	Phosphorylation	RSLFHYTSSITTKFG HHHHEEEEECEECCC	16.75	28450419
195	Phosphorylation	SLFHYTSSITTKFGD HHHEEEEECEECCCC	19.02	28450419
197	Phosphorylation	FHYTSSITTKFGDSF HEEEEECEECCCCHH	26.36	28450419
198	Phosphorylation	HYTSSITTKFGDSFY EEEEECEECCCCHHH	23.78	28450419
233	Ubiquitination	ENEHFRDKSELEDKK HHHHCCCHHHHCCHH	41.39	-
239	Ubiquitination	DKSELEDKKVEEGKL CHHHHCCHHCCCCCC	49.71	-
245	Ubiquitination	DKKVEEGKLRSPDPG CHHCCCCCCCCCCCC	43.96	-
347	Phosphorylation	AEEKKRLSLQREKII HHHHHHHHHHHHHHH	26.87	24719451
358	Phosphorylation	EKIIARVSIDNRTRA HHHHHEEECCHHHHH	20.76	27251275
361	N-linked_Glycosylation	IARVSIDNRTRALVQ HHEEECCHHHHHHHH	45.62	UniProtKB CARBOHYD
381	Phosphorylation	TDPKLCITRVEELTF CCCCCEEEEHHHHEE	27.89	-
438	Ubiquitination	IGYVDPVKGRGIRIL HCCCCCCCCCCEEEE	48.56	-
511	Phosphorylation	ELYRKLGSDVFSQNV HHHHHHCCCHHHCCE	40.83	-
515	Phosphorylation	KLGSDVFSQNVIVGT HHCCCHHHCCEEEEE	22.24	-
558	Phosphorylation	IETARNPTCPKVAAV EECCCCCCCCCHHHH	45.01	28509920
561	Ubiquitination	ARNPTCPKVAAVSTI CCCCCCCCHHHHHHH	46.80	-
663	Phosphorylation	VSLGTGRYESDVRNT EEECCCCCCCCCCCC	22.56	-
664 (in isoform 2)	Ubiquitination	-	38.82	21906983
670	Phosphorylation	YESDVRNTVTYTSLK CCCCCCCCEEEECHH	12.03	-
672	Phosphorylation	SDVRNTVTYTSLKTK CCCCCCEEEECHHHH	21.02	21964256
673	Phosphorylation	DVRNTVTYTSLKTKL CCCCCEEEECHHHHH	7.04	26356563
674	Phosphorylation	VRNTVTYTSLKTKLS CCCCEEEECHHHHHH	20.44	26356563
677	Malonylation	TVTYTSLKTKLSNVI CEEEECHHHHHHHHH	43.30	26320211
726	Ubiquitination	LDESRNEKLDQLQLE CCCCCCCCCHHHHHH	62.00	2190698
726 (in isoform 1)	Ubiquitination	-	62.00	21906983
736	Succinylation	QLQLEGLKYIERNEQ HHHHHHHHHHHHCHH	55.85	-
736	Succinylation	QLQLEGLKYIERNEQ HHHHHHHHHHHHCHH	55.85	-
736	Ubiquitination	QLQLEGLKYIERNEQ HHHHHHHHHHHHCHH	55.85	-
736	Acetylation	QLQLEGLKYIERNEQ HHHHHHHHHHHHCHH	55.85	25038526
756	Ubiquitination	AKILSQEKTTLQKIN HHHHHCCCHHHHHHH	38.89	-
767	Ubiquitination	QKINDWIKLKTDMYE HHHHHHHHHCCCCCC	39.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
511	S	Phosphorylation	Kinase	MKNK1	Q9BUB5	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPL8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPL8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PLPL8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 251950: Mitochondrial myopathy with lactic acidosis (MMLA)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.