MTMRD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTMRD_HUMAN
• UniProt AC: Q86WG5
• Protein Name: Myotubularin-related protein 13
• Gene Name: SBF2
• Organism: Homo sapiens (Human).
• Sequence Length: 1849
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . Associated with membranes.
• Protein Description: Guanine nucleotide exchange factor (GEF) which may activate RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form..
• Protein Sequence: MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSERGPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNENPNPHMAFQKVPRPTEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPPATRIEKKCVVPAGPPVVSIMDKVTTVFNSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESGSNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQNQLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNEDDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTDRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQSCISDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
186	Phosphorylation	GDRQLIQTPLHDSLP CCCCEECCCCCCCCC	22.33	24043423
191	Phosphorylation	IQTPLHDSLPITGTS ECCCCCCCCCCCCHH	25.87	24043423
195	Phosphorylation	LHDSLPITGTSVALL CCCCCCCCCHHHHHH	32.25	24043423
197	Phosphorylation	DSLPITGTSVALLFQ CCCCCCCHHHHHHHH	16.04	24043423
198	Phosphorylation	SLPITGTSVALLFQQ CCCCCCHHHHHHHHH	13.51	24043423
213	Phosphorylation	LGIQNVLSLFCAVLT HCHHHHHHHHHHHHC	18.34	24043423
220	Phosphorylation	SLFCAVLTENKVLFH HHHHHHHCCCCEEEE	30.80	24043423
568	Phosphorylation	FENKILETEKTLPAA HHCCHHCCCCCHHHH	39.06	-
570	Ubiquitination	NKILETEKTLPAALR CCHHCCCCCHHHHHH	63.88	-
571	Phosphorylation	KILETEKTLPAALRA CHHCCCCCHHHHHHH	31.57	-
708	Phosphorylation	DKLPDDHYQEKTAMD CCCCCCCHHHHHHHH	25.92	27642862
712	Phosphorylation	DDHYQEKTAMDLAAE CCCHHHHHHHHHHHH	26.85	30576142
726	Phosphorylation	EQLRLWPTLSKSTQQ HHHHHHHHCCHHHHH	31.89	-
728	Phosphorylation	LRLWPTLSKSTQQEL HHHHHHCCHHHHHHH	27.34	-
940	Phosphorylation	DQLVGEQTVVRSFPI HHCCCCCEEEEECCC	19.37	24719451
957	Phosphorylation	ITKEKKITMQNQLQQ CCCCCCCCHHHHHHH	22.91	-
1035	Phosphorylation	KQKEKNTSFRTFSKT CCCCCCCCCCHHHHH	23.33	25159151
1085	Phosphorylation	WNEDDDVSVSDESEL CCCCCCCCCCCCCCC	23.93	25159151
1087	Phosphorylation	EDDDVSVSDESELPT CCCCCCCCCCCCCCC	28.31	25159151
1090	Phosphorylation	DVSVSDESELPTSTT CCCCCCCCCCCCCCC	49.80	22617229
1094	Phosphorylation	SDESELPTSTTLKAS CCCCCCCCCCCCCCC	51.86	23090842
1095	Phosphorylation	DESELPTSTTLKASE CCCCCCCCCCCCCCC	19.91	23090842
1096	Phosphorylation	ESELPTSTTLKASEK CCCCCCCCCCCCCCC	38.33	23090842
1097	Phosphorylation	SELPTSTTLKASEKS CCCCCCCCCCCCCCC	26.48	23090842
1101	Phosphorylation	TSTTLKASEKSTMEQ CCCCCCCCCCCHHHH	43.92	22210691
1104	Phosphorylation	TLKASEKSTMEQLVE CCCCCCCCHHHHHHH	29.00	29255136
1105	Phosphorylation	LKASEKSTMEQLVEK CCCCCCCHHHHHHHH	35.48	29255136
1118	Phosphorylation	EKACFRDYQRLGLGT HHHHHHCHHHHCCCC	7.41	22210691
1125	Phosphorylation	YQRLGLGTISGSSSR HHHHCCCCCCCCCCC	19.60	23403867
1127	Phosphorylation	RLGLGTISGSSSRSR HHCCCCCCCCCCCCC	32.24	23403867
1129	Phosphorylation	GLGTISGSSSRSRPE CCCCCCCCCCCCCCC	20.53	23403867
1130	Phosphorylation	LGTISGSSSRSRPEY CCCCCCCCCCCCCCE	33.04	23403867
1131	Phosphorylation	GTISGSSSRSRPEYF CCCCCCCCCCCCCEE	35.65	23403867
1137	Phosphorylation	SSRSRPEYFRITASN CCCCCCCEEEEEECH	10.80	25072903
1141	Phosphorylation	RPEYFRITASNRMYS CCCEEEEEECHHHHH	21.56	25072903
1143	Phosphorylation	EYFRITASNRMYSLC CEEEEEECHHHHHHH	19.13	25072903
1166	Phosphorylation	VPQAVQDSSLPRVAR ECHHHCCCCCCHHHH	19.38	25850435
1167	Phosphorylation	PQAVQDSSLPRVARC CHHHCCCCCCHHHHH	51.16	25850435
1210	Methylation	KGVVGLFKSQNSPQA CEEEEEEECCCCCCC	57.06	-
1211	Phosphorylation	GVVGLFKSQNSPQAA EEEEEEECCCCCCCC	27.53	22199227
1214	Phosphorylation	GLFKSQNSPQAAPTS EEEECCCCCCCCCCC	15.68	25159151
1220	Phosphorylation	NSPQAAPTSSLESSS CCCCCCCCCCCCCCC	26.65	23186163
1263	Phosphorylation	VRPAFALSPGVWASL EEEHHCCCCCHHHHH	19.04	-
1269	Phosphorylation	LSPGVWASLRSSTRL CCCCHHHHHHHCCCC	14.49	22210691
1273	Phosphorylation	VWASLRSSTRLISSP HHHHHHHCCCCCCCC	15.88	22210691
1274	Phosphorylation	WASLRSSTRLISSPT HHHHHHCCCCCCCCC	30.64	22210691
1278	Phosphorylation	RSSTRLISSPTSFID HHCCCCCCCCCCCCC	34.55	22199227
1279	Phosphorylation	SSTRLISSPTSFIDV HCCCCCCCCCCCCCC	25.79	22199227
1281	Phosphorylation	TRLISSPTSFIDVGA CCCCCCCCCCCCCCH	37.91	22199227
1282	Phosphorylation	RLISSPTSFIDVGAR CCCCCCCCCCCCCHH	24.48	29396449
1296	Phosphorylation	RLAGKDHSASFSNSS HHCCCCCCCCCCCHH	35.42	27251275
1298	Phosphorylation	AGKDHSASFSNSSYL CCCCCCCCCCCHHHH	32.02	26552605
1300	Phosphorylation	KDHSASFSNSSYLQN CCCCCCCCCHHHHHH	33.05	26552605
1302	Phosphorylation	HSASFSNSSYLQNQL CCCCCCCHHHHHHHH	21.11	26552605
1303	Phosphorylation	SASFSNSSYLQNQLL CCCCCCHHHHHHHHH	33.83	26552605
1304	Phosphorylation	ASFSNSSYLQNQLLK CCCCCHHHHHHHHHH	16.48	25159151
1352	Phosphorylation	EIRQVKASFKKLMRA HHHHHHHHHHHHHHH	31.70	24719451
1434	Phosphorylation	LSDPFYRTLEGFQML HCCHHHHHHHHHHHH	20.13	22210691
1516	Phosphorylation	FKTFLLDSDYERLEH HHHEEECCCHHHHHC	41.90	28152594
1518	Phosphorylation	TFLLDSDYERLEHGT HEEECCCHHHHHCCC	13.60	28152594
1552	Phosphorylation	IDRMHKRSPIFFNYL HHHHHHCCCCCHHHC	27.44	26126808
1558	Phosphorylation	RSPIFFNYLYSPLEI CCCCCHHHCCCCHHH	11.23	26126808
1560	Phosphorylation	PIFFNYLYSPLEIEA CCCHHHCCCCHHHHH	9.62	26126808
1561	Phosphorylation	IFFNYLYSPLEIEAL CCHHHCCCCHHHHHC	22.03	26126808
1575	Phosphorylation	LKPNVNVSSLKKWDY CCCCCCHHHHCCCCE	25.42	26126808
1576	Phosphorylation	KPNVNVSSLKKWDYY CCCCCHHHHCCCCEE	39.67	26126808
1685	Phosphorylation	DRSQRHLSRSPGIVS CHHHHHHHCCCCCEE	25.29	22617229
1687	Phosphorylation	SQRHLSRSPGIVSTN HHHHHHCCCCCEECC	24.89	21945579
1693	Phosphorylation	RSPGIVSTNLPSYQK CCCCCEECCCCHHCC	29.85	30576142
1697	Phosphorylation	IVSTNLPSYQKRSLL CEECCCCHHCCCHHC	43.28	21945579
1698	Phosphorylation	VSTNLPSYQKRSLLH EECCCCHHCCCHHCC	19.00	21945579
1702	Phosphorylation	LPSYQKRSLLHLPDS CCHHCCCHHCCCCCC	42.17	27251275
1720	Phosphorylation	EEQNSSISPSNGVER CCCCCCCCCCCHHHH	24.99	28555341
1731	Phosphorylation	GVERRAATLYSQYTS HHHHHHHHHHHHHCC	25.83	21945579
1733	Phosphorylation	ERRAATLYSQYTSKN HHHHHHHHHHHCCCC	6.86	21945579
1734	Phosphorylation	RRAATLYSQYTSKND HHHHHHHHHHCCCCC	21.59	21945579
1736	Phosphorylation	AATLYSQYTSKNDEN HHHHHHHHCCCCCCC	13.67	21945579
1737	Phosphorylation	ATLYSQYTSKNDENR HHHHHHHCCCCCCCC	26.11	21945579
1738	Phosphorylation	TLYSQYTSKNDENRS HHHHHHCCCCCCCCC	25.24	21945579
1739	Ubiquitination	LYSQYTSKNDENRSF HHHHHCCCCCCCCCE	61.69	-
1784	Phosphorylation	YDSGEDTSCKGHIDL ECCCCCCCCCCCEEE	26.59	-
1813	Ubiquitination	APKHTSDKAFFDLKT CCCCCCCCCCEECCC	47.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTMRD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTMRD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTMRD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTMR1_HUMAN	MTMR1	physical	27880917
MTMR2_HUMAN	MTMR2	physical	27880917
MTMR5_HUMAN	SBF1	physical	27880917
H2AW_HUMAN	H2AFY2	physical	27880917
BAG5_HUMAN	BAG5	physical	27880917
UBA1_HUMAN	UBA1	physical	27880917
FTO_HUMAN	FTO	physical	27880917
G6PD_HUMAN	G6PD	physical	27880917
KAD2_HUMAN	AK2	physical	27880917
MPPB_HUMAN	PMPCB	physical	27880917
TXD12_HUMAN	TXNDC12	physical	27880917
DCTP1_HUMAN	DCTPP1	physical	27880917

Drug and Disease Associations

• Kegg Disease
• H00264: Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atroph
• OMIM Disease
• 604563: Charcot-Marie-Tooth disease 4B2 (CMT4B2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.