TXD12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXD12_HUMAN
• UniProt AC: O95881
• Protein Name: Thioredoxin domain-containing protein 12
• Gene Name: TXNDC12
• Organism: Homo sapiens (Human).
• Sequence Length: 172
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Possesses significant protein thiol-disulfide oxidase activity..
• Protein Sequence: METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	2-Hydroxyisobutyrylation	RTLEDGKKEAAASGL EECCCCCHHHHHHCC	59.10	-
64	Phosphorylation	LMVIIHKSWCGACKA EEEEEEHHHHHHHHH	17.28	-
70	Acetylation	KSWCGACKALKPKFA HHHHHHHHHHCHHCC	57.11	26051181
121	Phosphorylation	RILFLDPSGKVHPEI EEEEECCCCCCCHHH	51.41	21712546
123	Ubiquitination	LFLDPSGKVHPEIIN EEECCCCCCCHHHCC	41.53	29967540
136	O-linked_Glycosylation	INENGNPSYKYFYVS CCCCCCCCCEEEEEE	37.95	21740066
165	Acetylation	LTGDAFRKKHLEDEL HHHHHHHHHHHHHCC	37.78	7683305
166	Ubiquitination	TGDAFRKKHLEDEL- HHHHHHHHHHHHCC-	49.52	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXD12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXD12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXD12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TXLNA_HUMAN	TXLNA	physical	22939629
SGTB_HUMAN	SGTB	physical	25416956
IQGA2_HUMAN	IQGAP2	physical	26344197
GCP4_HUMAN	TUBGCP4	physical	28514442
GCP5_HUMAN	TUBGCP5	physical	28514442
MZT2A_HUMAN	MZT2A	physical	28514442
GCP6_HUMAN	TUBGCP6	physical	28514442
MZT2B_HUMAN	MZT2B	physical	28514442
GCP3_HUMAN	TUBGCP3	physical	28514442
GCP2_HUMAN	TUBGCP2	physical	28514442
NDK7_HUMAN	NME7	physical	28514442
TBG1_HUMAN	TUBG1	physical	28514442
TM2D3_HUMAN	TM2D3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.