| UniProt ID | GCP4_HUMAN | |
|---|---|---|
| UniProt AC | Q9UGJ1 | |
| Protein Name | Gamma-tubulin complex component 4 | |
| Gene Name | TUBGCP4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 667 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. | |
| Protein Description | Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.. | |
| Protein Sequence | MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIEQYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLGDPHLSISHVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCHGVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQDLRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRKGSILKNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDFYLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEYHGKEHKADATQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFKYLLSVRRVQAELQHCWALQMQRKHLKSNQTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQFSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLVSQNLGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGGTLGSFGM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | Methylation | GSIFTWNKRSGLQVS CCEEEECCCCCCEEC | 39.23 | - | |
| 97 | Ubiquitination | CTGLDSVLQPYRQAL HCCHHHHHHHHHHHH | 5.00 | 21963094 | |
| 119 | Ubiquitination | LGDPHLSISHVNYFL HCCCCCCHHHHHHHH | 4.09 | 21963094 | |
| 147 | Ubiquitination | VEQIKSQKIHGCQIL HHHHHCCCCCCCCHH | 43.70 | 29967540 | |
| 179 | Ubiquitination | LEKILAVCHGVMYKQ HHHHHHHHHHHHHHH | 1.60 | 21963094 | |
| 219 | Ubiquitination | GNVSAQPEEDEEDLG CCCCCCCCCCCCCCC | 67.03 | 22817900 | |
| 222 | Ubiquitination | SAQPEEDEEDLGIGG CCCCCCCCCCCCCCC | 57.60 | 21890473 | |
| 233 (in isoform 2) | Ubiquitination | - | 40.71 | - | |
| 233 | Ubiquitination | GIGGLTGKQLRELQD CCCCCCHHHHHHHHH | 40.71 | 21906983 | |
| 249 | Sulfoxidation | RLIEEENMLAPSLKQ HHHHHHCCCCCHHHH | 3.69 | 21406390 | |
| 255 | Ubiquitination | NMLAPSLKQFSLRVE CCCCCHHHHHCEEEE | 54.34 | 21963094 | |
| 266 | Phosphorylation | LRVEILPSYIPVRVA EEEEECCCCCCHHHH | 32.05 | 23532336 | |
| 267 | Phosphorylation | RVEILPSYIPVRVAE EEEECCCCCCHHHHH | 13.80 | 23532336 | |
| 298 | Phosphorylation | VNLTRKGSILKNQED CCCCCCCHHHCCCHH | 27.99 | 24719451 | |
| 301 | Ubiquitination | TRKGSILKNQEDTFA CCCCHHHCCCHHCHH | 55.72 | 29967540 | |
| 306 | Phosphorylation | ILKNQEDTFAAELHR HHCCCHHCHHHHHHH | 17.89 | 28464451 | |
| 315 (in isoform 2) | Ubiquitination | - | 47.01 | - | |
| 315 | Ubiquitination | AAELHRLKQQPLFSL HHHHHHHHCCCCCCC | 47.01 | 21906983 | |
| 355 | Ubiquitination | SDLLGQLKIIKDFYL HHHHHHHHHHHHEEE | 34.20 | 22817900 | |
| 358 | Ubiquitination | LGQLKIIKDFYLLGR HHHHHHHHHEEEECC | 45.30 | 21906983 | |
| 375 | Phosphorylation | LFQAFIDTAQHMLKT HHHHHHHHHHHHHCC | 24.33 | - | |
| 385 | Phosphorylation | HMLKTPPTAVTEHDV HHHCCCCCCCCHHHH | 34.66 | - | |
| 441 | Phosphorylation | EGPSRETSPREAPAS CCCCCCCCCCCCCCC | 19.73 | 25159151 | |
| 456 | Phosphorylation | GWAALGLSYKVQWPL CCHHHCCCEEECCCE | 22.55 | 20860994 | |
| 505 | Ubiquitination | LQMQRKHLKSNQTDA HHHHHHHHHCCCHHH | 7.94 | 29967540 | |
| 506 | Ubiquitination | QMQRKHLKSNQTDAI HHHHHHHHCCCHHHH | 47.26 | 29967540 | |
| 507 | Phosphorylation | MQRKHLKSNQTDAIK HHHHHHHCCCHHHHH | 40.30 | 22210691 | |
| 556 | Phosphorylation | NSTRDFESIRLAHDH HCCCCHHHHHHHHHH | 17.01 | 24719451 | |
| 623 | Phosphorylation | VKGFSRQSSLLFKIL HHCCCCCHHHHHHHH | 23.11 | 23186163 | |
| 624 | Phosphorylation | KGFSRQSSLLFKILS HCCCCCHHHHHHHHH | 22.28 | 23312004 | |
| 631 | Phosphorylation | SLLFKILSSVRNHQI HHHHHHHHHHHHCCC | 30.20 | 24719451 | |
| 651 | Phosphorylation | QLLLRLDYNKYYTQA HHHHHCCCHHHHCCC | 20.39 | 27811184 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GCP4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GCP4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GCP4_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 616335 | Microcephaly and chorioretinopathy, autosomal recessive, 3 (MCCRP3) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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