MZT2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MZT2A_HUMAN
• UniProt AC: Q6P582
• Protein Name: Mitotic-spindle organizing protein 2A
• Gene Name: MZT2A
• Organism: Homo sapiens (Human).
• Sequence Length: 158
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
• Protein Sequence: MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGGIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSVPETRGRDKGSAALGGVLALAERSNHEGSSQRMPRQPSATRLPKGGGPGKSPTQGST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAQGVGPG ------CCCCCCCCC	14.43	-
12	Phosphorylation	GVGPGPGSAAPPGLE CCCCCCCCCCCCCHH	25.13	28122231
24	Ubiquitination	GLEAARQKLALRRKK CHHHHHHHHHHHHHC	30.12	-
31	Ubiquitination	KLALRRKKVLSTEEM HHHHHHHCCCCHHHH	46.74	29967540
34	Phosphorylation	LRRKKVLSTEEMELY HHHHCCCCHHHHHHH	36.44	20068231
35	Phosphorylation	RRKKVLSTEEMELYE HHHCCCCHHHHHHHH	31.63	27251275
41	Phosphorylation	STEEMELYELAQAAG CHHHHHHHHHHHHCC	8.80	27251275
77	Ubiquitination	LAVFQMLKSMCAGQR HHHHHHHHHHHHHCH	30.70	32015554
87	Phosphorylation	CAGQRLASEPQDPAA HHHCHHHCCCCCCCC	55.17	28555341
96	Phosphorylation	PQDPAAVSLPTSSVP CCCCCCCCCCCCCCC	24.73	20071362
99	Phosphorylation	PAAVSLPTSSVPETR CCCCCCCCCCCCCCC	38.64	20071362
100	Phosphorylation	AAVSLPTSSVPETRG CCCCCCCCCCCCCCC	27.65	20071362
101	Phosphorylation	AVSLPTSSVPETRGR CCCCCCCCCCCCCCC	44.14	20071362
105	Phosphorylation	PTSSVPETRGRDKGS CCCCCCCCCCCCHHH	32.14	20071362
110	Ubiquitination	PETRGRDKGSAALGG CCCCCCCHHHHHHHH	54.10	-
112	Phosphorylation	TRGRDKGSAALGGVL CCCCCHHHHHHHHHH	18.99	30001349
130	Phosphorylation	ERSNHEGSSQRMPRQ HHCCCCCCCCCCCCC	21.95	26074081
131	Phosphorylation	RSNHEGSSQRMPRQP HCCCCCCCCCCCCCC	32.44	26074081
133	Methylation	NHEGSSQRMPRQPSA CCCCCCCCCCCCCCC	38.73	24388017
136	Methylation	GSSQRMPRQPSATRL CCCCCCCCCCCCCCC	52.26	24388023
139	Phosphorylation	QRMPRQPSATRLPKG CCCCCCCCCCCCCCC	33.65	30266825
141	Phosphorylation	MPRQPSATRLPKGGG CCCCCCCCCCCCCCC	36.76	30266825
145	Ubiquitination	PSATRLPKGGGPGKS CCCCCCCCCCCCCCC	74.83	24816145
152	Phosphorylation	KGGGPGKSPTQGST- CCCCCCCCCCCCCC-	38.81	21955146
154	Phosphorylation	GGPGKSPTQGST--- CCCCCCCCCCCC---	53.29	27794612
157	Phosphorylation	GKSPTQGST------ CCCCCCCCC------	22.56	22199227
158	Phosphorylation	KSPTQGST------- CCCCCCCC-------	49.83	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MZT2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MZT2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MZT2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330