NDK7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDK7_HUMAN
• UniProt AC: Q9Y5B8
• Protein Name: Nucleoside diphosphate kinase 7
• Gene Name: NME7
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Protein Description: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate..
• Protein Sequence: MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKILDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Ubiquitination	VFIAEWYDPNASLLR EEEEEECCCCHHHHH	30.93	21890473
41	Ubiquitination	SVEMHDVKNHRTFLK CEEEEECCCCCHHHH	53.76	-
45	Phosphorylation	HDVKNHRTFLKRTKY EECCCCCHHHHHCCC	26.26	-
51	Ubiquitination	RTFLKRTKYDNLHLE CHHHHHCCCCCCCHH	55.42	21890473
51	Acetylation	RTFLKRTKYDNLHLE CHHHHHCCCCCCCHH	55.42	25038526
65	Ubiquitination	EDLFIGNKVNVFSRQ HHHCCCCEEEECCCE	29.94	-
78	Phosphorylation	RQLVLIDYGDQYTAR CEEEEEECCCHHHHH	18.66	-
82	Phosphorylation	LIDYGDQYTARQLGS EEECCCHHHHHHCCC	13.70	-
99	Ubiquitination	EKTLALIKPDAISKA CCEEEEECHHHHHHH	37.38	-
104	Phosphorylation	LIKPDAISKAGEIIE EECHHHHHHHHHHHH	20.41	-
105	Ubiquitination	IKPDAISKAGEIIEI ECHHHHHHHHHHHHH	55.06	-
119	Phosphorylation	IINKAGFTITKLKMM HHHHCCCCHHHHHHH	27.15	-
121	Phosphorylation	NKAGFTITKLKMMML HHCCCCHHHHHHHHH	27.54	-
173	Acetylation	DDAICEWKRLLGPAN CCHHHHHHHHHCCCC	15.75	25953088
174	Methylation	DAICEWKRLLGPANS CHHHHHHHHHCCCCC	35.90	24411799
174	Dimethylation	DAICEWKRLLGPANS CHHHHHHHHHCCCCC	35.90	-
181	Phosphorylation	RLLGPANSGVARTDA HHHCCCCCCCCCCCH	36.43	-
210	Phosphorylation	NAAHGPDSFASAARE CHHCCCCCHHHHHHH	26.33	27251275
245	Ubiquitination	NCTCCIVKPHAVSEG CCEEEEECHHHCCCC	15.92	-
285	Phosphorylation	RVNVEEFYEVYKGVV CCCHHHHHHHHHHCH	14.04	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDK7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDK7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDK7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCHP_HUMAN	TCHP	physical	16189514
TUFT1_HUMAN	TUFT1	physical	21988832
OFD1_HUMAN	OFD1	physical	21988832
TNIP1_HUMAN	TNIP1	physical	21988832
TBG1_HUMAN	TUBG1	physical	23443559
GCP2_HUMAN	TUBGCP2	physical	23443559
GCP3_HUMAN	TUBGCP3	physical	23443559
CCHCR_HUMAN	CCHCR1	physical	25416956
CEP72_HUMAN	CEP72	physical	25416956
SHOT1_HUMAN	KIAA1598	physical	25416956
TCHP_HUMAN	TCHP	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
SYCE1_HUMAN	SYCE1	physical	25416956
CA189_HUMAN	C1orf189	physical	25416956
FOSL1_HUMAN	FOSL1	physical	21516116
LNX1_HUMAN	LNX1	physical	21516116
GCP4_HUMAN	TUBGCP4	physical	27173435
TCHP_HUMAN	TCHP	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.