FOSL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOSL1_HUMAN
• UniProt AC: P15407
• Protein Name: Fos-related antigen 1
• Gene Name: FOSL1
• Organism: Homo sapiens (Human).
• Sequence Length: 271
• Subcellular Localization: Nucleus.
• Protein Sequence: MFRDFGEPGPSSGNGGGYGGPAQPPAAAQAAQQKFHLVPSINTMSGSQELQWMVQPHFLGPSSYPRPLTYPQYSPPQPRPGVIRALGPPPGVRRRPCEQISPEEEERRRVRRERNKLAAAKCRNRRKELTDFLQAETDKLEDEKSGLQREIEELQKQKERLELVLEAHRPICKIPEGAKEGDTGSTSGTSSPPAPCRPVPCISLSPGPVLEPEALHTPTLMTTPSLTPFTPSLVFTYPSTPEPCASAHRKSSSSSGDPSSDPLGSPTLLAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	DFGEPGPSSGNGGGY CCCCCCCCCCCCCCC	57.71	28555341
62	Phosphorylation	QPHFLGPSSYPRPLT CCHHCCCCCCCCCCC	40.48	28348404
63	Phosphorylation	PHFLGPSSYPRPLTY CHHCCCCCCCCCCCC	42.14	28348404
66	Methylation	LGPSSYPRPLTYPQY CCCCCCCCCCCCCCC	30.54	-
66	Dimethylation	LGPSSYPRPLTYPQY CCCCCCCCCCCCCCC	30.54	-
69	Phosphorylation	SSYPRPLTYPQYSPP CCCCCCCCCCCCCCC	35.52	23312004
70	Phosphorylation	SYPRPLTYPQYSPPQ CCCCCCCCCCCCCCC	8.95	30108239
73	Phosphorylation	RPLTYPQYSPPQPRP CCCCCCCCCCCCCCC	20.74	27642862
74	Phosphorylation	PLTYPQYSPPQPRPG CCCCCCCCCCCCCCC	25.51	26055452
79	Dimethylation	QYSPPQPRPGVIRAL CCCCCCCCCCCHHHC	35.04	-
84	Dimethylation	QPRPGVIRALGPPPG CCCCCCHHHCCCCCC	22.73	-
101	Phosphorylation	RRPCEQISPEEEERR CCCHHHCCHHHHHHH	26.42	30266825
144	Ubiquitination	TDKLEDEKSGLQREI HHHHHHHHHHHHHHH	63.24	-
183	Phosphorylation	EGAKEGDTGSTSGTS CCCCCCCCCCCCCCC	43.84	29632367
185	Phosphorylation	AKEGDTGSTSGTSSP CCCCCCCCCCCCCCC	22.84	29632367
186	Phosphorylation	KEGDTGSTSGTSSPP CCCCCCCCCCCCCCC	32.30	29632367
187	Phosphorylation	EGDTGSTSGTSSPPA CCCCCCCCCCCCCCC	41.59	25002506
189	Phosphorylation	DTGSTSGTSSPPAPC CCCCCCCCCCCCCCC	26.29	25002506
190	Phosphorylation	TGSTSGTSSPPAPCR CCCCCCCCCCCCCCE	44.35	25002506
191	Phosphorylation	GSTSGTSSPPAPCRP CCCCCCCCCCCCCEE	34.44	26657352
217	Phosphorylation	LEPEALHTPTLMTTP CCHHHHCCCCEECCC	20.86	22817900
223	Phosphorylation	HTPTLMTTPSLTPFT CCCCEECCCCCCCCC	9.27	22817900
227	Phosphorylation	LMTTPSLTPFTPSLV EECCCCCCCCCCCEE	22.24	-
230	Phosphorylation	TPSLTPFTPSLVFTY CCCCCCCCCCEEEEC	17.11	-
239	Phosphorylation	SLVFTYPSTPEPCAS CEEEECCCCCCCCHH	46.29	27273156
240	Phosphorylation	LVFTYPSTPEPCASA EEEECCCCCCCCHHH	27.45	27273156
246	Phosphorylation	STPEPCASAHRKSSS CCCCCCHHHCCCCCC	31.18	-
251	Phosphorylation	CASAHRKSSSSSGDP CHHHCCCCCCCCCCC	35.09	29255136
252	Phosphorylation	ASAHRKSSSSSGDPS HHHCCCCCCCCCCCC	36.96	29255136
253	Phosphorylation	SAHRKSSSSSGDPSS HHCCCCCCCCCCCCC	35.30	29255136
254	Phosphorylation	AHRKSSSSSGDPSSD HCCCCCCCCCCCCCC	40.04	29255136
255	Phosphorylation	HRKSSSSSGDPSSDP CCCCCCCCCCCCCCC	49.52	29255136
259	Phosphorylation	SSSSGDPSSDPLGSP CCCCCCCCCCCCCCC	52.71	23403867
260	Phosphorylation	SSSGDPSSDPLGSPT CCCCCCCCCCCCCCC	48.94	30266825
265	Phosphorylation	PSSDPLGSPTLLAL- CCCCCCCCCCEECC-	23.53	30266825
267	Phosphorylation	SDPLGSPTLLAL--- CCCCCCCCEECC---	35.78	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
217	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS
223	T	Phosphorylation	Kinase	PRKCQ	Q04759	GPS
227	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS
230	T	Phosphorylation	Kinase	PRKCQ	Q04759	GPS
265	S	Phosphorylation	Kinase	PRKCQ	Q04759	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOSL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOSL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LDOC1_HUMAN	LDOC1	physical	16189514
CACO1_HUMAN	CALCOCO1	physical	16189514
USF1_HUMAN	USF1	physical	9160889
JUN_HUMAN	JUN	physical	9160889
JUN_HUMAN	JUN	physical	11431474
TIF1A_HUMAN	TRIM24	physical	20211142
HDAC1_HUMAN	HDAC1	physical	15615716
EP300_HUMAN	EP300	physical	17882273
PRS6A_HUMAN	PSMC3	physical	21874050
LDOC1_HUMAN	LDOC1	physical	19060904
ATF4_HUMAN	ATF4	physical	23661758
JUN_HUMAN	JUN	physical	23661758
JUNB_HUMAN	JUNB	physical	23661758
PARVG_HUMAN	PARVG	physical	21988832
IMA5_HUMAN	KPNA1	physical	21988832
TAB2_HUMAN	TAB2	physical	21988832
WFDC1_HUMAN	WFDC1	physical	21988832
CREB5_HUMAN	CREB5	physical	25416956
NDK7_HUMAN	NME7	physical	25416956
TCAM1_HUMAN	TICAM1	physical	28049150
TRAF3_HUMAN	TRAF3	physical	28049150

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.