dbPTM

TCAM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TCAM1_HUMAN
UniProt AC	Q8IUC6
Protein Name	TIR domain-containing adapter molecule 1
Gene Name	TICAM1
Organism	Homo sapiens (Human).
Sequence Length	712
Subcellular Localization	Cytoplasmic vesicle, autophagosome . Colocalizes with UBQLN1 in the autophagosome.
Protein Description	Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively..
Protein Sequence	MACTGPSLPSAFDILGAAGQDKLLYLKHKLKTPRPGCQGQDLLHAMVLLKLGQETEARISLEALKADAVARLVARQWAGVDSTEDPEEPPDVSWAVARLYHLLAEEKLCPASLRDVAYQEAVRTLSSRDDHRLGELQDEARNRCGWDIAGDPGSIRTLQSNLGCLPPSSALPSGTRSLPRPIDGVSDWSQGCSLRSTGSPASLASNLEISQSPTMPFLSLHRSPHGPSKLCDDPQASLVPEPVPGGCQEPEEMSWPPSGEIASPPELPSSPPPGLPEVAPDATSTGLPDTPAAPETSTNYPVECTEGSAGPQSLPLPILEPVKNPCSVKDQTPLQLSVEDTTSPNTKPCPPTPTTPETSPPPPPPPPSSTPCSAHLTPSSLFPSSLESSSEQKFYNFVILHARADEHIALRVREKLEALGVPDGATFCEDFQVPGRGELSCLQDAIDHSAFIILLLTSNFDCRLSLHQVNQAMMSNLTRQGSPDCVIPFLPLESSPAQLSSDTASLLSGLVRLDEHSQIFARKVANTFKPHRLQARKAMWRKEQDTRALREQSQHLDGERMQAAALNAAYSAYLQSYLSYQAQMEQLQVAFGSHMSFGTGAPYGARMPFGGQVPLGAPPPFPTWPGCPQPPPLHAWQAGTPPPPSPQPAAFPQSLPFPQSPAFPTASPAPPQSPGLQPLIIHHAQMVQLGLNNHMWNQRGSQAPEDKTQEAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	QETEARISLEALKAD CCCHHHHCHHHHHHH	18.01	18669648
65	Ubiquitination	RISLEALKADAVARL HHCHHHHHHHHHHHH	51.79	-
82	O-linked_Glycosylation	RQWAGVDSTEDPEEP HHHCCCCCCCCCCCC	31.15	OGP
175	Phosphorylation	SSALPSGTRSLPRPI HHCCCCCCCCCCCCC	22.79	23403867
177	Phosphorylation	ALPSGTRSLPRPIDG CCCCCCCCCCCCCCC	42.43	23403867
196	Phosphorylation	SQGCSLRSTGSPASL CCCCCCCCCCCCHHH	42.27	20068231
197	Phosphorylation	QGCSLRSTGSPASLA CCCCCCCCCCCHHHH	34.93	24114839
199	Phosphorylation	CSLRSTGSPASLASN CCCCCCCCCHHHHHC	19.85	18669648
205	Phosphorylation	GSPASLASNLEISQS CCCHHHHHCCEECCC	47.44	21712546
210	Phosphorylation	LASNLEISQSPTMPF HHHCCEECCCCCCCE	18.41	25850435
212	Phosphorylation	SNLEISQSPTMPFLS HCCEECCCCCCCEEE	18.62	25850435
214	Phosphorylation	LEISQSPTMPFLSLH CEECCCCCCCEEEEC	42.60	25850435
219	Phosphorylation	SPTMPFLSLHRSPHG CCCCCEEEECCCCCC	23.62	25850435
223	Phosphorylation	PFLSLHRSPHGPSKL CEEEECCCCCCCCCC	15.53	24114839
263	Phosphorylation	PPSGEIASPPELPSS CCCCCCCCCCCCCCC	46.80	22468782
341	Phosphorylation	LQLSVEDTTSPNTKP CEEEEECCCCCCCCC	18.70	25627689
342	Phosphorylation	QLSVEDTTSPNTKPC EEEEECCCCCCCCCC	55.28	25627689
343	Phosphorylation	LSVEDTTSPNTKPCP EEEECCCCCCCCCCC	20.46	25627689
346	Phosphorylation	EDTTSPNTKPCPPTP ECCCCCCCCCCCCCC	39.48	25627689
388	Phosphorylation	LFPSSLESSSEQKFY HCCCCCCCCCHHHCE	44.45	-
389	Phosphorylation	FPSSLESSSEQKFYN CCCCCCCCCHHHCEE	28.63	-
390	Phosphorylation	PSSLESSSEQKFYNF CCCCCCCCHHHCEEE	54.01	-
500	Phosphorylation	ESSPAQLSSDTASLL CCCHHHCCHHHHHHH	17.68	-
570	Phosphorylation	AAALNAAYSAYLQSY HHHHHHHHHHHHHHH	7.45	-
573	Phosphorylation	LNAAYSAYLQSYLSY HHHHHHHHHHHHHHH	10.19	-
577	Phosphorylation	YSAYLQSYLSYQAQM HHHHHHHHHHHHHHH	6.16	-
707	Ubiquitination	GSQAPEDKTQEAE-- CCCCCCHHHCCCC--	50.90	2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
210	S	Phosphorylation	Kinase	TBK1	Q9UHD2	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	TANK	Q92844	PMID:20047764
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF2	Q12933	PMID:20047764
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF6	Q9Y4K3	PMID:20047764
-	K	Ubiquitination	E3 ubiquitin ligase	KCTD10	Q9H3F6	PMID:32484264
-	K	Ubiquitination	E3 ubiquitin ligase	WWP2	O00308	PMID:23479606

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
6	K	ubiquitylation	28747347
Polyubiquitinated with 'Lys-6'- and 'Lys-33'-linked chains in a TRIM8-dependent manner; ubiquitination disrupts the interaction with TBK1 and subsequent interferon production.
210	S	Phosphorylation	25636800
Following activation, phosphorylated by TBK1 at Ser-210 in the pLxIS motif.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TCAM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIPK1_HUMAN	RIPK1	physical	15064760
RN216_HUMAN	RNF216	physical	16968706
TRAF2_HUMAN	TRAF2	physical	20047764
TRAF6_HUMAN	TRAF6	physical	20047764
TANK_HUMAN	TANK	physical	21903422
TBK1_HUMAN	TBK1	physical	21903422
UBQL1_HUMAN	UBQLN1	physical	21695056
TLR4_HUMAN	TLR4	physical	19656901
TBK1_HUMAN	TBK1	physical	19656901
TRAF1_HUMAN	TRAF1	physical	14982987
TRAF2_HUMAN	TRAF2	physical	14982987
TRAF3_HUMAN	TRAF3	physical	14982987
TRAF5_HUMAN	TRAF5	physical	14982987
TRAF6_HUMAN	TRAF6	physical	14982987
TLR3_HUMAN	TLR3	physical	14982987
TNAP3_HUMAN	TNFAIP3	physical	15474016
TRAF6_HUMAN	TRAF6	physical	15474016
TRI56_HUMAN	TRIM56	physical	22948160
TRAF4_HUMAN	TRAF4	physical	16052631
TRAF1_HUMAN	TRAF1	physical	16323247
TRAF6_HUMAN	TRAF6	physical	14530355
TBK1_HUMAN	TBK1	physical	14530355
TCAM2_HUMAN	TICAM2	physical	12721283
MAVS_HUMAN	MAVS	physical	16153868
TRAF1_HUMAN	TRAF1	physical	19795416
TRAF2_HUMAN	TRAF2	physical	19795416
TRAF6_HUMAN	TRAF6	physical	19795416
TRI38_HUMAN	TRIM38	physical	23056470
KSYK_HUMAN	SYK	physical	23962979
TCAM1_HUMAN	TICAM1	physical	24577058
CARM1_HUMAN	CARM1	physical	26186194
TRAF6_HUMAN	TRAF6	physical	24812060
RIPK1_HUMAN	RIPK1	physical	25736436
TRAF6_HUMAN	TRAF6	physical	25736436
TBK1_HUMAN	TBK1	physical	25736436
TCAM2_HUMAN	TICAM2	physical	25736436
TBK1_HUMAN	TBK1	physical	28049150
CARM1_HUMAN	CARM1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614850	Herpes simplex encephalitis 4 (HSE4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TCAM1_HUMAN

Related Literatures of Post-Translational Modification

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