TRI38_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI38_HUMAN
• UniProt AC: O00635
• Protein Name: E3 ubiquitin-protein ligase TRIM38
• Gene Name: TRIM38
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Protein Description: E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling..
• Protein Sequence: MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETFCCPQCRAPFHMDSLRPNKQLGSLIEALKETDQEMSCEEHGEQFHLFCEDEGQLICWRCERAPQHKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKEKVQIQRQKIRSDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHILELEEKCQGSAQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNVSKLYFDVKKMLRSHQVSVTLDPDTAHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGFTSGRRYFEVDVGEGTGWDLGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLHEQPLLVGIFLDYEAGVVSFYNGNTGCHIFTFPKASFSDTLRPYFQVYQYSPLFLPPPGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASTTSTKKM -----CCCCHHHHHH	30.80	29759185
50	Ubiquitination	FFKNPSQKQLRQETF HHHCHHHHHHHHHEE	56.49	-
70	Phosphorylation	RAPFHMDSLRPNKQL CCCCCHHHCCCCHHH	20.78	30108239
75	Ubiquitination	MDSLRPNKQLGSLIE HHHCCCCHHHHHHHH	49.97	-
122	Ubiquitination	CERAPQHKGHTTALV EECCCCCCCCCHHHH	47.33	-
125	Phosphorylation	APQHKGHTTALVEDV CCCCCCCCHHHHHHH	23.56	25072903
126	Phosphorylation	PQHKGHTTALVEDVC CCCCCCCHHHHHHHH	16.60	25072903
136	Phosphorylation	VEDVCQGYKEKLQKA HHHHHHHHHHHHHHH	7.06	25072903
137	Ubiquitination	EDVCQGYKEKLQKAV HHHHHHHHHHHHHHH	56.02	-
139	Ubiquitination	VCQGYKEKLQKAVTK HHHHHHHHHHHHHHH	52.66	-
142	Ubiquitination	GYKEKLQKAVTKLKQ HHHHHHHHHHHHHHH	56.09	-
142	Acetylation	GYKEKLQKAVTKLKQ HHHHHHHHHHHHHHH	56.09	25953088
148	Ubiquitination	QKAVTKLKQLEDRCT HHHHHHHHHHHHHHH	55.16	-
155	O-linked_Glycosylation	KQLEDRCTEQKLSTA HHHHHHHHHHHHHHH	42.20	30379171
158	Ubiquitination	EDRCTEQKLSTAMRI HHHHHHHHHHHHHHH	37.87	-
158	Acetylation	EDRCTEQKLSTAMRI HHHHHHHHHHHHHHH	37.87	26051181
160	Phosphorylation	RCTEQKLSTAMRITK HHHHHHHHHHHHHHH	22.58	22210691
161	Phosphorylation	CTEQKLSTAMRITKW HHHHHHHHHHHHHHH	34.60	22210691
167	Acetylation	STAMRITKWKEKVQI HHHHHHHHHHHHHHH	54.63	20167786
171	Ubiquitination	RITKWKEKVQIQRQK HHHHHHHHHHHHHHH	35.39	-
184	Malonylation	QKIRSDFKNLQCFLH HHHHHHHHHCEEEEC	62.83	26320211
184	Acetylation	QKIRSDFKNLQCFLH HHHHHHHHHCEEEEC	62.83	25953088
184	Ubiquitination	QKIRSDFKNLQCFLH HHHHHHHHHCEEEEC	62.83	-
195	Ubiquitination	CFLHEEEKSYLWRLE EEECHHHHHHHHHCC	47.91	-
203	Ubiquitination	SYLWRLEKEEQQTLS HHHHHCCHHHHHHHH	71.75	-
215	Phosphorylation	TLSRLRDYEAGLGLK HHHHHHHHHHCCCCC	10.97	27642862
222	Ubiquitination	YEAGLGLKSNELKSH HHHCCCCCHHHHHHH	49.81	-
227	Ubiquitination	GLKSNELKSHILELE CCCHHHHHHHHHHHH	33.53	-
236	Ubiquitination	HILELEEKCQGSAQK HHHHHHHHHCHHHHH	23.60	-
243	Ubiquitination	KCQGSAQKLLQNVND HHCHHHHHHHHHHHH	51.38	-
251	Phosphorylation	LLQNVNDTLSRSWAV HHHHHHHHCHHHHEE	22.79	28857561
280	Phosphorylation	MCNVSKLYFDVKKML HHCHHHHHHHHHHHH	11.06	26307563
284	Ubiquitination	SKLYFDVKKMLRSHQ HHHHHHHHHHHHHCC	34.02	-
285	Ubiquitination	KLYFDVKKMLRSHQV HHHHHHHHHHHHCCC	42.91	-
319	Phosphorylation	RQVTRGYTQENQDTS CHHHCCCCCCCCCCC	32.03	-
343	Phosphorylation	VLGCEGFTSGRRYFE EEECCCCCCCCEEEE	40.92	22210691
344	Phosphorylation	LGCEGFTSGRRYFEV EECCCCCCCCEEEEE	28.21	22210691
375	Ubiquitination	VQRGTGMKQEPQSGF CCCCCCCCCCCCCCC	53.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM38	O00635	PMID:21306652

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI38_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI38_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UB2D1_HUMAN	UBE2D1	physical	21143188
UB2D2_HUMAN	UBE2D2	physical	21143188
UB2D3_HUMAN	UBE2D3	physical	21143188
UB2D4_HUMAN	UBE2D4	physical	21143188
UB2E1_HUMAN	UBE2E1	physical	21143188
UB2E2_HUMAN	UBE2E2	physical	21143188
UB2E3_HUMAN	UBE2E3	physical	21143188
TRAF6_HUMAN	TRAF6	physical	22323536
TAB2_HUMAN	TAB2	physical	24434549
TAB3_HUMAN	TAB3	physical	24434549
TRI38_HUMAN	TRIM38	physical	25416956
TSYL4_HUMAN	TSPYL4	physical	25416956
GORS2_HUMAN	GORASP2	physical	25416956
GMCL1_HUMAN	GMCL1	physical	25416956
AZI2_HUMAN	AZI2	physical	22539786

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.