EFL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFL1_HUMAN
• UniProt AC: Q7Z2Z2
• Protein Name: Elongation factor-like GTPase 1
• Gene Name: EFL1 {ECO:0000312|HGNC:HGNC:25789}
• Organism: Homo sapiens (Human).
• Sequence Length: 1120
• Protein Description: Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits..
• Protein Sequence: MVLNSLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQIRGITMKSSAISLHYATGNEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKIGIKKEVLMKTLWGDYYINMKAKKIMKGDQAKGKKPLFVQLILENIWSLYDAVLKKDKDKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCQKLPSPLDITAERVERLMCTGSQTFDSFPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAQRRERARQRHAEKLAAAQGQAPLEPTQDGSAIETCPKGEEPRGDEQQVESMTPKPVLQEENNQESFIAFARVFSGVARRGKKIFVLGPKYSPLEFLRRVPLGFSAPPDGLPQVPHMAYCALENLYLLMGRELEYLEEVPPGNVLGIGGLQDFVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQILIQETGEHVLVTAGEVHLQRCLDDLKERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQMKEDQSKIPEGIQVDSDGLITITTPNKLATLSVRAMPLPEEVTQILEENSDLIRSMEQLTSSLNEGENTHMIHQKTQEKIWEFKGKLEQHLTGRRWRNIVDQIWSFGPRKCGPNILVNKSEDFQNSVWTGPADKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQGASDLAKEGQEENETCSGGNENQELQDGCSEAFEKRTSQKGESPLTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATGDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Ubiquitination	DKMIQLQKNTANIRN HHHHHHHHHCCCCCE		-
47	Phosphorylation	ISSNGIISSRLAGKL HCCCCCCHHHHHHHC		24719451
48	Phosphorylation	SSNGIISSRLAGKLR CCCCCCHHHHHHHCC		24719451
53	Acetylation	ISSRLAGKLRYMDSR CHHHHHHHCCCCCCC		19815085
69	Phosphorylation	DEQIRGITMKSSAIS CHHHCCEEECCCEEE		29759185
182	Phosphorylation	ALTGTLFTSKVLEER HHHHHHHHHHHHHHH		24719451
252	Phosphorylation	IEHFARIYSQKIGIK HHHHHHHHHHCCCCC		25587033
253	Phosphorylation	EHFARIYSQKIGIKK HHHHHHHHHCCCCCH		25587033
255	Acetylation	FARIYSQKIGIKKEV HHHHHHHCCCCCHHH		25953088
271	Phosphorylation	MKTLWGDYYINMKAK HHHHHHHHHHHHEEH		25147952
272	Phosphorylation	KTLWGDYYINMKAKK HHHHHHHHHHHEEHH		25147952
278	Methylation	YYINMKAKKIMKGDQ HHHHHEEHHHHCCCH		-
365	Phosphorylation	MVCQKLPSPLDITAE HHHHCCCCCCCCCHH		27732954
370	Phosphorylation	LPSPLDITAERVERL CCCCCCCCHHHHHHH		20068231
372	Ubiquitination	SPLDITAERVERLMC CCCCCCHHHHHHHHC		32015554
378	Ubiquitination	AERVERLMCTGSQTF HHHHHHHHCCCCCCC		29967540
401	Ubiquitination	ALKAAFMKCGSEDTA HHHHHHHHCCCCCCC		29967540
423	Ubiquitination	KMFAVDAKALPQNKP CCCCCCHHHCCCCCC		29967540
429	Ubiquitination	AKALPQNKPRPLTQE HHHCCCCCCCCCCHH		29967540
452	Acetylation	ARQRHAEKLAAAQGQ HHHHHHHHHHHHCCC		26051181
452	Ubiquitination	ARQRHAEKLAAAQGQ HHHHHHHHHHHHCCC		29967540
469	Phosphorylation	LEPTQDGSAIETCPK CCCCCCCCCEEECCC		28555341
477	Acetylation	AIETCPKGEEPRGDE CEEECCCCCCCCCCH		19608861
528	Acetylation	KIFVLGPKYSPLEFL EEEEECCCCCCHHHH		19608861
584	Ubiquitination	VPPGNVLGIGGLQDF CCCCCEECCCCHHHH		32015554
591	Ubiquitination	GIGGLQDFVLKSATL CCCCHHHHHHHHCEE		33845483
625	Malonylation	VRVAVEPKHPSEMPQ EEEEECCCCHHHCHH		26320211
628	Phosphorylation	AVEPKHPSEMPQLVK EECCCCHHHCHHHHH		20068231
630	Sulfoxidation	EPKHPSEMPQLVKGM CCCCHHHCHHHHHHH		21406390
635	Ubiquitination	SEMPQLVKGMKLLNQ HHCHHHHHHHHHHHC		32015554
638	Ubiquitination	PQLVKGMKLLNQADP HHHHHHHHHHHCCCC		32015554
671	Ubiquitination	EVHLQRCLDDLKERF HHHHHHHHHHHHHHH		29967540
686	Phosphorylation	AKIHISVSEPIIPFR HEEEEEECCCCCCHH		27251275
701	Ubiquitination	ETITKPPKVDMVNEE HCCCCCCCCCCCCCC		-
714	Ubiquitination	EEIGKQQKVAVIHQM CCCCHHHHHHHEEEC		-
722	Ubiquitination	VAVIHQMKEDQSKIP HHHEEECCCCHHCCC		29967540
736	Phosphorylation	PEGIQVDSDGLITIT CCCEEECCCCEEEEE		20068231
741	Phosphorylation	VDSDGLITITTPNKL ECCCCEEEEECCCCE		20068231
743	Phosphorylation	SDGLITITTPNKLAT CCCEEEEECCCCEEE		20068231
744	Phosphorylation	DGLITITTPNKLATL CCEEEEECCCCEEEE		20068231
748	Ubiquitination	TITTPNKLATLSVRA EEECCCCEEEEEEEC		29967540
750	Phosphorylation	TTPNKLATLSVRAMP ECCCCEEEEEEECCC		21406692
752	Phosphorylation	PNKLATLSVRAMPLP CCCEEEEEEECCCCC		20068231
756	Sulfoxidation	ATLSVRAMPLPEEVT EEEEEECCCCCHHHH		21406390
775	Phosphorylation	ENSDLIRSMEQLTSS HCHHHHHHHHHHHHH		29978859
780	Phosphorylation	IRSMEQLTSSLNEGE HHHHHHHHHHHHCCC		29978859
781	Phosphorylation	RSMEQLTSSLNEGEN HHHHHHHHHHHCCCC		29978859
782	Phosphorylation	SMEQLTSSLNEGENT HHHHHHHHHHCCCCC		29978859
789	Phosphorylation	SLNEGENTHMIHQKT HHHCCCCCCCCCHHH		29978859
796	Phosphorylation	THMIHQKTQEKIWEF CCCCCHHHHHHHHHH		29978859
799	Ubiquitination	IHQKTQEKIWEFKGK CCHHHHHHHHHHHHH		29967540
803	Ubiquitination	TQEKIWEFKGKLEQH HHHHHHHHHHHHHHH		32015554
804	Methylation	QEKIWEFKGKLEQHL HHHHHHHHHHHHHHH		-
806	Acetylation	KIWEFKGKLEQHLTG HHHHHHHHHHHHHCC		25953088
825	Phosphorylation	NIVDQIWSFGPRKCG HHHHHHHHCCCCCCC		25159151
850	Ubiquitination	FQNSVWTGPADKASK HHHCCCCCCCHHHHH		32015554
854	Ubiquitination	VWTGPADKASKEASR CCCCCCHHHHHHHHH		32015554
901	Ubiquitination	LEKWDLSKFEEQGAS EEECCHHHHHHHCHH		32015554
908	Phosphorylation	KFEEQGASDLAKEGQ HHHHHCHHHHHHCCH		21815630
922	Phosphorylation	QEENETCSGGNENQE HHHCCCCCCCCCCHH		28985074
942	Phosphorylation	SEAFEKRTSQKGESP HHHHHHHHCCCCCCC		21712546
943	Phosphorylation	EAFEKRTSQKGESPL HHHHHHHCCCCCCCC		-
948	Phosphorylation	RTSQKGESPLTDCYG HHCCCCCCCCCCCCC		21815630
951	Phosphorylation	QKGESPLTDCYGPFS CCCCCCCCCCCCCCC		28102081
954	Phosphorylation	ESPLTDCYGPFSGQL CCCCCCCCCCCCCHH		-
1000	Phosphorylation	GDVLGRVYAVLSKRE CCHHHHHHHHHHHCC		27642862
1019	Phosphorylation	QEEMKEGTDMFIIKA HHHHHCCCCEEEEEH		28258704
1033	Phosphorylation	AVLPVAESFGFADEI HHHHHHHHCCCHHHH		28258704
1074	Phosphorylation	VPTTEEEYLHFGEKA CCCCHHHHHHCCCCC		-
1101	Phosphorylation	VRKRKGLYVEEKIVE HHHHCCCCCHHHHHH		27642862
1112	2-Hydroxyisobutyrylation	KIVEHAEKQRTLSKN HHHHHHHHHHHHCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARP2_HUMAN	ACTR2	physical	22863883
BAG1_HUMAN	BAG1	physical	22863883
KBP_HUMAN	KIAA1279	physical	22863883
LPP_HUMAN	LPP	physical	22863883
NSUN2_HUMAN	NSUN2	physical	22863883
PANK4_HUMAN	PANK4	physical	22863883
RAGP1_HUMAN	RANGAP1	physical	22863883
RPR1B_HUMAN	RPRD1B	physical	22863883
PRPK_HUMAN	TP53RK	physical	22863883
TPD54_HUMAN	TPD52L2	physical	22863883
UFM1_HUMAN	UFM1	physical	22863883
ABCF2_HUMAN	ABCF2	physical	26344197
DDX51_HUMAN	DDX51	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.