PANK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PANK4_HUMAN
• UniProt AC: Q9NVE7
• Protein Name: Pantothenate kinase 4
• Gene Name: PANK4
• Organism: Homo sapiens (Human).
• Sequence Length: 773
• Subcellular Localization: Cytoplasm .
• Protein Description: Plays a role in the physiological regulation of the intracellular CoA concentration..
• Protein Sequence: MAECGASGSGSSGDSLDKSITLPPDEIFRNLENAKRFAIDIGGSLTKLAYYSTVQHKVAKVRSFDHSGKDTEREHEPPYEISVQEEITARLHFIKFENTYIEACLDFIKDHLVNTETKVIQATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFVYQKDSDPEFRFQTNHPHIFPYLLVNIGSGVSIVKVETEDRFEWVGGSSIGGGTFWGLGALLTKTKKFDELLHLASRGQHSNVDMLVRDVYGGAHQTLGLSGNLIASSFGKSATADQEFSKEDMAKSLLHMISNDIGQLACLHARLHSLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQDNPNQYSWGENYAGSSGLMSASPELGPAQRARSGTFDLLEMDRLERPLVDLPLLLDPPSYVPDTVDLTDDALARKYWLTCFEEALDGVVKRAVASQPDSVDAAERAEKFRQKYWNKLQTLRQQPFAYGTLTVRSLLDTREHCLNEFNFPDPYSKVKQRENGVALRCFPGVVRSLDALGWEERQLALVKGLLAGNVFDWGAKAVSAVLESDPYFGFEEAKRKLQERPWLVDSYSEWLQRLKGPPHKCALIFADNSGIDIILGVFPFVRELLLRGTEVILACNSGPALNDVTHSESLIVAERIAGMDPVVHSALQEERLLLVQTGSSSPCLDLSRLDKGLAALVRERGADLVVIEGMGRAVHTNYHAALRCESLKLAVIKNAWLAERLGGRLFSVIFKYEVPAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAECGASGS ------CCCCCCCCC	22.31	19413330
19	Phosphorylation	SGDSLDKSITLPPDE CCCCCCCCCCCCHHH	22.07	22199227
21	Phosphorylation	DSLDKSITLPPDEIF CCCCCCCCCCHHHHH	40.06	22199227
27	Phosphorylation	ITLPPDEIFRNLENA CCCCHHHHHHCHHHH	5.25	-
43	Ubiquitination	RFAIDIGGSLTKLAY HHEEECCCHHHHHHH	21.59	-
51	Phosphorylation	SLTKLAYYSTVQHKV HHHHHHHHHHHHHHE	7.70	25159151
52	Phosphorylation	LTKLAYYSTVQHKVA HHHHHHHHHHHHHEE	14.93	28857561
63	Phosphorylation	HKVAKVRSFDHSGKD HHEEECCCCCCCCCC	37.70	28102081
67	Phosphorylation	KVRSFDHSGKDTERE ECCCCCCCCCCCCCC	49.75	28060719
71	Phosphorylation	FDHSGKDTEREHEPP CCCCCCCCCCCCCCC	40.19	24719451
77	Ubiquitination	DTEREHEPPYEISVQ CCCCCCCCCCEEEHH	38.39	-
79	Phosphorylation	EREHEPPYEISVQEE CCCCCCCCEEEHHHH	36.29	27642862
87	Ubiquitination	EISVQEEITARLHFI EEEHHHHHHHHEEEE	3.43	21890473
118	Ubiquitination	HLVNTETKVIQATGG HHCCCCCCEEECCCC	30.98	21890473
123	Phosphorylation	ETKVIQATGGGAYKF CCCEEECCCCCCCCH	21.71	21406692
126	Ubiquitination	VIQATGGGAYKFKDL EEECCCCCCCCHHHH	27.38	-
128	Phosphorylation	QATGGGAYKFKDLIE ECCCCCCCCHHHHHH	21.89	21406692
129	Ubiquitination	ATGGGAYKFKDLIEE CCCCCCCCHHHHHHH	45.46	21906983
131	Phosphorylation	GGGAYKFKDLIEEKL CCCCCCHHHHHHHHH	47.69	-
131	Ubiquitination	GGGAYKFKDLIEEKL CCCCCCHHHHHHHHH	47.69	21963094
137	Ubiquitination	FKDLIEEKLRLKVDK HHHHHHHHHCCCCCH	26.56	22817900
139	Ubiquitination	DLIEEKLRLKVDKED HHHHHHHCCCCCHHH	43.46	-
141	Ubiquitination	IEEKLRLKVDKEDVM HHHHHCCCCCHHHHH	41.79	22817900
144	Acetylation	KLRLKVDKEDVMTCL HHCCCCCHHHHHHHH	59.82	25953088
145	Ubiquitination	LRLKVDKEDVMTCLI HCCCCCHHHHHHHHH	51.91	21890473
149	Ubiquitination	VDKEDVMTCLIKGCN CCHHHHHHHHHCCCC	12.19	22817900
152	Ubiquitination	EDVMTCLIKGCNFVL HHHHHHHHCCCCEEE	3.81	-
161	Ubiquitination	GCNFVLKNIPHEAFV CCCEEEECCCCCCEE	49.19	-
168	Ubiquitination	NIPHEAFVYQKDSDP CCCCCCEEEECCCCC	6.79	-
169	Phosphorylation	IPHEAFVYQKDSDPE CCCCCEEEECCCCCC	11.91	27642862
171	Ubiquitination	HEAFVYQKDSDPEFR CCCEEEECCCCCCCC	41.32	21890473
179	Ubiquitination	DSDPEFRFQTNHPHI CCCCCCCCCCCCCCC	14.78	-
234	Ubiquitination	ALLTKTKKFDELLHL HHHHCCCCHHHHHHH	64.38	21890473
242	Ubiquitination	FDELLHLASRGQHSN HHHHHHHHHCCCCCC	6.09	21890473
278	Ubiquitination	LIASSFGKSATADQE EEHHHCCCCCCCCCC	34.60	21906983
279	Phosphorylation	IASSFGKSATADQEF EHHHCCCCCCCCCCC	31.09	-
286	Ubiquitination	SATADQEFSKEDMAK CCCCCCCCCHHHHHH	11.98	21963094
287	Phosphorylation	ATADQEFSKEDMAKS CCCCCCCCHHHHHHH	34.09	28985074
288	Ubiquitination	TADQEFSKEDMAKSL CCCCCCCHHHHHHHH	64.15	21890473
291	Sulfoxidation	QEFSKEDMAKSLLHM CCCCHHHHHHHHHHH	5.47	21406390
296	Ubiquitination	EDMAKSLLHMISNDI HHHHHHHHHHHHCHH	3.13	-
300	Phosphorylation	KSLLHMISNDIGQLA HHHHHHHHCHHHHHH	22.37	28188228
320	Nitrated tyrosine	LHSLDRVYFGGFFIR HHCCCEEEECCEEEC	9.44	-
320	Nitration	LHSLDRVYFGGFFIR HHCCCEEEECCEEEC	9.44	-
335	Phosphorylation	GHPVTMRTITYSINF CCCEEEEEEEEEEEC	13.57	24300666
337	Phosphorylation	PVTMRTITYSINFFS CEEEEEEEEEEECCC	15.59	24300666
338	Phosphorylation	VTMRTITYSINFFSK EEEEEEEEEEECCCH	12.05	24300666
339	Phosphorylation	TMRTITYSINFFSKG EEEEEEEEEECCCHH	11.47	24300666
340	Ubiquitination	MRTITYSINFFSKGE EEEEEEEEECCCHHH	3.52	21890473
344	Phosphorylation	TYSINFFSKGEVQAL EEEEECCCHHHHEEE	35.30	24300666
377	Phosphorylation	EQDNPNQYSWGENYA CCCCCCCCCCCCCCC	17.03	26074081
378	Phosphorylation	QDNPNQYSWGENYAG CCCCCCCCCCCCCCC	20.88	26074081
383	Phosphorylation	QYSWGENYAGSSGLM CCCCCCCCCCCCCCC	14.19	22199227
386	Phosphorylation	WGENYAGSSGLMSAS CCCCCCCCCCCCCCC	17.04	22199227
387	Phosphorylation	GENYAGSSGLMSASP CCCCCCCCCCCCCCC	34.72	28102081
391	Phosphorylation	AGSSGLMSASPELGP CCCCCCCCCCCCCCH	30.55	22199227
393	Phosphorylation	SSGLMSASPELGPAQ CCCCCCCCCCCCHHH	16.17	25159151
395	Phosphorylation	GLMSASPELGPAQRA CCCCCCCCCCHHHHH	64.96	18691976
401	Phosphorylation	PELGPAQRARSGTFD CCCCHHHHHHCCCCC	33.79	27251275
404	Phosphorylation	GPAQRARSGTFDLLE CHHHHHHCCCCCHHH	41.00	29255136
406	Phosphorylation	AQRARSGTFDLLEMD HHHHHCCCCCHHHCC	18.41	29255136
412	Phosphorylation	GTFDLLEMDRLERPL CCCCHHHCCCCCCCC	3.52	20068231
414	Phosphorylation	FDLLEMDRLERPLVD CCHHHCCCCCCCCCC	36.82	18669648
454	Ubiquitination	YWLTCFEEALDGVVK HHHHHHHHHHHHHHH	33.99	-
466	Phosphorylation	VVKRAVASQPDSVDA HHHHHHHCCCCCCCH	35.33	29978859
470	Phosphorylation	AVASQPDSVDAAERA HHHCCCCCCCHHHHH	28.69	29978859
487	Ubiquitination	FRQKYWNKLQTLRQQ HHHHHHHHHHHHHHC	28.03	21890473
495	Ubiquitination	LQTLRQQPFAYGTLT HHHHHHCCCCCCCEE	13.90	21890473
559	Ubiquitination	ERQLALVKGLLAGNV HHHHHHHHHHHHCCC	44.70	-
590	Ubiquitination	YFGFEEAKRKLQERP CCCHHHHHHHHHHCC	54.03	21890473
598	Ubiquitination	RKLQERPWLVDSYSE HHHHHCCCHHHHHHH	18.42	-
693	Phosphorylation	ERLLLVQTGSSSPCL CCEEEEECCCCCCCC	31.39	29449344
695	Phosphorylation	LLLVQTGSSSPCLDL EEEEECCCCCCCCCH	30.91	29449344
696	Phosphorylation	LLVQTGSSSPCLDLS EEEECCCCCCCCCHH	39.38	29449344
697	Phosphorylation	LVQTGSSSPCLDLSR EEECCCCCCCCCHHH	22.72	29449344
703	Phosphorylation	SSPCLDLSRLDKGLA CCCCCCHHHHCHHHH	30.39	29449344
707	Ubiquitination	LDLSRLDKGLAALVR CCHHHHCHHHHHHHH	61.49	-
715	Ubiquitination	GLAALVRERGADLVV HHHHHHHHCCCCEEE	48.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PANK4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PANK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PANK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN6_HUMAN	PTPN6	physical	22939629
KBP_HUMAN	KIAA1279	physical	22863883
NSUN2_HUMAN	NSUN2	physical	22863883
RAGP1_HUMAN	RANGAP1	physical	22863883
SAE1_HUMAN	SAE1	physical	22863883
TPD54_HUMAN	TPD52L2	physical	22863883
UBE3C_HUMAN	UBE3C	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330