GLCTK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLCTK_HUMAN
• UniProt AC: Q8IVS8
• Protein Name: Glycerate kinase
• Gene Name: GLYCTK
• Organism: Homo sapiens (Human).
• Sequence Length: 523
• Subcellular Localization: Isoform 1: Cytoplasm .; Isoform 2: Cytoplasm. Mitochondrion .
• Protein Sequence: MAAALQVLPRLARAPLHPLLWRGSVARLASSMALAEQARQLFESAVGAVLPGPMLHRALSLDPGGRQLKVRDRNFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMERAGKQEMLLKPHSRVQVFEGAEDNLPDRDALRAALAIQQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASSHNVQDCLHILNRYGLRAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNVLALAEAQRQAEALGYQAVVLSAAMQGDVKSMAQFYGLLAHVARTRLTPSMAGASVEEDAQLHELAAELQIPDLQLEEALETMAWGRGPVCLLAGGEPTVQLQGSGRGGRNQELALRVGAELRRWPLGPIDVLFLSGGTDGQDGPTEAAGAWVTPELASQAAAEGLDIATFLAHNDSHTFFCCLQGGAHLLHTGMTGTNVMDTHLLFLRPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7 (in isoform 5)	Phosphorylation	-	9.15	22210691
24	Phosphorylation	HPLLWRGSVARLASS CHHHCHHHHHHHHHH	12.20	24719451
30	Phosphorylation	GSVARLASSMALAEQ HHHHHHHHHHHHHHH	25.82	24719451
31	Phosphorylation	SVARLASSMALAEQA HHHHHHHHHHHHHHH	11.50	24719451
44	Phosphorylation	QARQLFESAVGAVLP HHHHHHHHHHHHHCC	22.41	-
60	Phosphorylation	PMLHRALSLDPGGRQ HHHHHHHCCCCCCCE	29.73	14702039
111	Phosphorylation	HLVQGVISVPKGIRA HHHHHHHHHCHHHHH	29.93	24719451
220	Phosphorylation	NTIRKALSQLKGGGL HHHHHHHHHCCCCCH	38.02	24719451
274	Phosphorylation	CLHILNRYGLRAALP HHHHHHHHCHHHHCC	21.31	20393185
285	Ubiquitination	AALPRSVKTVLSRAD HHCCCCHHHHHHCCC	33.88	-
343	Phosphorylation	AMQGDVKSMAQFYGL HHCCCHHHHHHHHHH	21.14	-
348	Phosphorylation	VKSMAQFYGLLAHVA HHHHHHHHHHHHHHH	8.52	-
357	Phosphorylation	LLAHVARTRLTPSMA HHHHHHHHCCCHHHC	21.94	24505115
360	Phosphorylation	HVARTRLTPSMAGAS HHHHHCCCHHHCCCC	15.27	24275569
362	Phosphorylation	ARTRLTPSMAGASVE HHHCCCHHHCCCCHH	18.94	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLCTK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLCTK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLCTK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCH2_HUMAN	TRIP13	physical	19060904
UBIP1_HUMAN	UBP1	physical	21988832
STK33_HUMAN	STK33	physical	21988832
SAXO1_HUMAN	FAM154A	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 220120: D-glyceric aciduria (D-GA)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.