UBIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBIP1_HUMAN
• UniProt AC: Q9NZI7
• Protein Name: Upstream-binding protein 1
• Gene Name: UBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 540
• Subcellular Localization: Nucleus .
• Protein Description: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box..
• Protein Sequence: MAWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETEHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAHEKEKYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTLPADYGDSLAKRGSCSPWPDAPTAYVNNSPSPAPTFTSPQQSTCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASENGSGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNFQDESCFLFSTVKAESSDGIHIILK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LVHDFDASLSGIGQE CCCCCCCHHCCCCHH	25.55	24275569
47	Sumoylation	VLALPIFKQEDSSLP HEECEEECCCCCCCC	54.20	-
51	Phosphorylation	PIFKQEDSSLPLDGE EEECCCCCCCCCCCC	32.78	30108239
52	Phosphorylation	IFKQEDSSLPLDGET EECCCCCCCCCCCCC	46.45	30108239
59	Phosphorylation	SLPLDGETEHPPFQY CCCCCCCCCCCCCEE	45.16	22199227
95	Methylation	QGQSYEIRMLDNRKM CCCCEEEEECCCCCC	13.99	-
128	Phosphorylation	FHDRRLQYTEHQQLE HCCCCCCCEECHHCC	20.77	27642862
190	Phosphorylation	FIQVHCISTEFTPRK EEEEEEEECCCCCCC	27.55	28348404
191	Phosphorylation	IQVHCISTEFTPRKH EEEEEEECCCCCCCC	18.40	28348404
194	Phosphorylation	HCISTEFTPRKHGGE EEEECCCCCCCCCCC	18.89	27422710
202	Ubiquitination	PRKHGGEKGVPFRIQ CCCCCCCCCCCEEEE	69.36	-
212	Phosphorylation	PFRIQVDTFKQNENG CEEEEEECEEECCCC	33.60	29083192
238	Ubiquitination	QIKVFKPKGADRKQK EEEEECCCCCCCCCC	68.28	-
262	Phosphorylation	TAHEKEKYQPSYDTT HHHHHHHCCCCCCCC	27.09	-
266	Phosphorylation	KEKYQPSYDTTILTE HHHCCCCCCCCCCEE	24.80	-
303	Phosphorylation	LPADYGDSLAKRGSC CCCCCCHHHHHCCCC	26.34	28555341
386	Phosphorylation	KNRFSSYTRLFSNFS HCCCHHHHHHHHCCC	23.89	25921289
390	Phosphorylation	SSYTRLFSNFSGADL HHHHHHHHCCCHHHH	41.37	20068231
393	Phosphorylation	TRLFSNFSGADLLKL HHHHHCCCHHHHHHC	37.00	25921289
401	Phosphorylation	GADLLKLTKEDLVQI HHHHHHCCHHHHHHH	30.70	20068231
402	Ubiquitination	ADLLKLTKEDLVQIC HHHHHCCHHHHHHHH	60.72	-
418	Phosphorylation	AADGIRLYNSLKSRS CCCHHHHHHHHHCCC	7.89	29978859
420	Phosphorylation	DGIRLYNSLKSRSVR CHHHHHHHHHCCCCC	24.50	29978859
423	Phosphorylation	RLYNSLKSRSVRPRL HHHHHHHCCCCCCCE	34.77	20068231
425	Phosphorylation	YNSLKSRSVRPRLTI HHHHHCCCCCCCEEE	29.57	20068231
531	Phosphorylation	FSTVKAESSDGIHII EEEEEEECCCCEEEE	38.29	23312004
532	Phosphorylation	STVKAESSDGIHIIL EEEEEECCCCEEEEE	31.21	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBIP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR4_HUMAN	WDR4	physical	22939629
UBP5_HUMAN	USP5	physical	22939629
ZN184_HUMAN	ZNF184	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.