SAXO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAXO1_HUMAN
• UniProt AC: Q8IYX7
• Protein Name: Stabilizer of axonemal microtubules 1 {ECO:0000303|PubMed:25673876}
• Gene Name: SAXO1
• Organism: Homo sapiens (Human).
• Sequence Length: 474
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskel
• Protein Description: May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature..
• Protein Sequence: MKTKCICELCSCGRHHCPHLPTKIYDKTEKPCLLSEYTENYPFYHSYLPRESFKPRREYQKGPIPMEGLTTSRRDFGPHKVAPVKVHQYDQFVPSEENMDLLTTYKKDYNPYPVCRVDPIKPRDSKYPCSDKMECLPTYKADYLPWNQPRREPLRLEHKYQPASVRFDNRTTHQDDYPIKGLVKTISCKPLAMPKLCNIPLEDVTNYKMSYVAHPVEKRFVHEAEKFRPCEIPFESLTTQKQSYRGLMGEPAKSLKPLARPPGLDMPFCNTTEFRDKYQAWPMPRMFSKAPITYVPPEDRMDLLTTVQAHYTCPKGAPAQSCRPALQIKKCGRFEGSSTTKDDYKQWSSMRTEPVKPVPQLDLPTEPLDCLTTTRAHYVPHLPINTKSCKPHWSGPRGNVPVESQTTYTISFTPKEMGRCLASYPEPPGYTFEEVDALGHRIYKPVSQAGSQQSSHLSVDDSENPNQRELEVLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Acetylation	LPTKIYDKTEKPCLL CCCCCCCCCCCCCCC		25038526
30	Acetylation	KIYDKTEKPCLLSEY CCCCCCCCCCCCCCC		25038526
85	Acetylation	PHKVAPVKVHQYDQF CCCCCCEEEEECCCC		25038526
106	Acetylation	MDLLTTYKKDYNPYP HCHHHHCCCCCCCCC		25038526
126	Acetylation	PIKPRDSKYPCSDKM CCCCCCCCCCCCCCC		25038526
132	Acetylation	SKYPCSDKMECLPTY CCCCCCCCCCCCCCC		25038526
164	Phosphorylation	EHKYQPASVRFDNRT CEECCCCEEEECCCC		30622161
208	Acetylation	LEDVTNYKMSYVAHP HHHHCCCCCEEECCC		25038526
243	Phosphorylation	SLTTQKQSYRGLMGE HHCCCCHHHHHHCCC		24719451
244	Phosphorylation	LTTQKQSYRGLMGEP HCCCCHHHHHHCCCC		24719451
254	Phosphorylation	LMGEPAKSLKPLARP HCCCCHHHCCCCCCC		30206219
271	Phosphorylation	LDMPFCNTTEFRDKY CCCCCCCCHHHHHHH		30206219
272	Phosphorylation	DMPFCNTTEFRDKYQ CCCCCCCHHHHHHHH		30206219
288	Phosphorylation	WPMPRMFSKAPITYV CCCCCCCCCCCCEEC		25693802
293	Phosphorylation	MFSKAPITYVPPEDR CCCCCCCEECCCHHH		25693802
337	Phosphorylation	KCGRFEGSSTTKDDY ECCCCCCCCCCHHHH		-
344	Phosphorylation	SSTTKDDYKQWSSMR CCCCHHHHHHHHHCC		29978859
345	Acetylation	STTKDDYKQWSSMRT CCCHHHHHHHHHCCC		25038526
348	Phosphorylation	KDDYKQWSSMRTEPV HHHHHHHHHCCCCCC		29978859
349	Phosphorylation	DDYKQWSSMRTEPVK HHHHHHHHCCCCCCC		29978859
352	Phosphorylation	KQWSSMRTEPVKPVP HHHHHCCCCCCCCCC		28348404
365	Phosphorylation	VPQLDLPTEPLDCLT CCCCCCCCCCCCCCC		28348404
404	Phosphorylation	RGNVPVESQTTYTIS CCCCCCCCCCEEEEE		25693802
406	Phosphorylation	NVPVESQTTYTISFT CCCCCCCCEEEEEEC		25693802
407	Phosphorylation	VPVESQTTYTISFTP CCCCCCCEEEEEECH		25693802
408	Phosphorylation	PVESQTTYTISFTPK CCCCCCEEEEEECHH		30622161
409	Phosphorylation	VESQTTYTISFTPKE CCCCCEEEEEECHHH		30622161
411	Phosphorylation	SQTTYTISFTPKEMG CCCEEEEEECHHHHH		30622161
413	Phosphorylation	TTYTISFTPKEMGRC CEEEEEECHHHHHCC		30622161
443	Phosphorylation	DALGHRIYKPVSQAG HCCCCEECCCHHHCC		25693802
447	Phosphorylation	HRIYKPVSQAGSQQS CEECCCHHHCCCCCC		30622161
451	Phosphorylation	KPVSQAGSQQSSHLS CCHHHCCCCCCCCCC		30622161
454	Phosphorylation	SQAGSQQSSHLSVDD HHCCCCCCCCCCCCC		30622161
455	Phosphorylation	QAGSQQSSHLSVDDS HCCCCCCCCCCCCCC		30622161
458	Phosphorylation	SQQSSHLSVDDSENP CCCCCCCCCCCCCCC		30622161
462	Phosphorylation	SHLSVDDSENPNQRE CCCCCCCCCCCCHHH		30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAXO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAXO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAXO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F124A_HUMAN	FAM124A	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.