dbPTM

STK33_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STK33_HUMAN
UniProt AC	Q9BYT3
Protein Name	Serine/threonine-protein kinase 33
Gene Name	STK33
Organism	Homo sapiens (Human).
Sequence Length	514
Subcellular Localization	Cytoplasm, perinuclear region.
Protein Description	Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines..
Protein Sequence	MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DSGLDKKSTKCPDCS CCCCCCCCCCCCCCC	38.55	26670566
11	Phosphorylation	SGLDKKSTKCPDCSS CCCCCCCCCCCCCCC	45.61	26670566
20	Phosphorylation	CPDCSSASQKDVLCV CCCCCCCCCCCEEEE	39.45	28961369
29	Phosphorylation	KDVLCVCSSKTRVPP CCEEEEECCCCCCCC	17.93	30622161
30	Phosphorylation	DVLCVCSSKTRVPPV CEEEEECCCCCCCCE	32.68	30622161
31	Ubiquitination	VLCVCSSKTRVPPVL EEEEECCCCCCCCEE	24.85	-
43	Phosphorylation	PVLVVEMSQTSSIGS CEEEEECCCCCCCCC	19.46	27732954
45	Phosphorylation	LVVEMSQTSSIGSAE EEEECCCCCCCCCHH	19.69	27732954
46	Phosphorylation	VVEMSQTSSIGSAES EEECCCCCCCCCHHH	16.60	27732954
47	Phosphorylation	VEMSQTSSIGSAESL EECCCCCCCCCHHHH	34.06	27732954
50	Phosphorylation	SQTSSIGSAESLISL CCCCCCCCHHHHHHH	27.48	22199227
53	Phosphorylation	SSIGSAESLISLERK CCCCCHHHHHHHHHH	30.62	27732954
56	Phosphorylation	GSAESLISLERKKEK CCHHHHHHHHHHHHH	29.48	29523821
73	Acetylation	NRDITSRKDLPSRTS CCCCCCCCCCCCCCC	64.48	7825429
79	Phosphorylation	RKDLPSRTSNVERKA CCCCCCCCCCHHHHH	29.05	28555341
85	Ubiquitination	RTSNVERKASQQQWG CCCCHHHHHHHHHHC	38.59	-
87	Phosphorylation	SNVERKASQQQWGRG CCHHHHHHHHHHCCC	31.40	-
100	Ubiquitination	RGNFTEGKVPHIRIE CCCCCCCCCCEEEEE	46.49	-
116	Phosphorylation	GAAIEEIYTFGRILG CCCEEEEEEHHHHHC	10.17	-
141	Ubiquitination	TDKETETKWAIKKVN CCCHHHHHHHHHHHC	28.53	-
154	Phosphorylation	VNKEKAGSSAVKLLE HCHHHCCHHHHHHHH	21.71	21406692
155	Phosphorylation	NKEKAGSSAVKLLER CHHHCCHHHHHHHHH	35.84	21406692
158	Ubiquitination	KAGSSAVKLLEREVN HCCHHHHHHHHHHHH	47.25	-
168	Ubiquitination	EREVNILKSVKHEHI HHHHHHHHHCCHHCE	49.78	-
240	Ubiquitination	DIVHRDLKLENIMVK CCCCCCCCHHCEEEE	59.03	-
271	Ubiquitination	TDFGLAVKKQSRSEA EECCEEEECCCCCHH	39.22	-
301	Phosphorylation	VISAHDYSQQCDIWS HHCCCCCHHHCCHHH	21.60	27251275
356	Phosphorylation	SISDCAKSVLKQLMK HHHHHHHHHHHHHHC	17.73	21406692
359	Ubiquitination	DCAKSVLKQLMKVDP HHHHHHHHHHHCCCH	38.95	-
373	Ubiquitination	PAHRITAKELLDNQW HHHCCCHHHHHHCCC	40.00	-
382	Phosphorylation	LLDNQWLTGNKLSSV HHHCCCCCCCCCCCC	35.43	-
385	Acetylation	NQWLTGNKLSSVRPT CCCCCCCCCCCCCCC	51.60	25953088
385	Ubiquitination	NQWLTGNKLSSVRPT CCCCCCCCCCCCCCC	51.60	-
387	Phosphorylation	WLTGNKLSSVRPTNV CCCCCCCCCCCCCCH	28.53	24719451
388	Phosphorylation	LTGNKLSSVRPTNVL CCCCCCCCCCCCCHH	32.36	28796482
392	Phosphorylation	KLSSVRPTNVLEMMK CCCCCCCCCHHHHHH	27.65	28796482
402	Ubiquitination	LEMMKEWKNNPESVE HHHHHHHHCCHHHHH	48.19	-
407	Phosphorylation	EWKNNPESVEENTTE HHHCCHHHHHHCCCC	35.77	-
420	Phosphorylation	TEEKNKPSTEEKLKS CCCCCCCCHHHHHHH	50.49	-
421	Phosphorylation	EEKNKPSTEEKLKSY CCCCCCCHHHHHHHC	57.60	-
427	Phosphorylation	STEEKLKSYQPWGNV CHHHHHHHCCCCCCC	39.16	26074081
428	Phosphorylation	TEEKLKSYQPWGNVP HHHHHHHCCCCCCCC	19.60	26074081
439	Phosphorylation	GNVPDANYTSDEEEE CCCCCCCCCCHHHHH	14.89	30576142
440	Phosphorylation	NVPDANYTSDEEEEK CCCCCCCCCHHHHHH	29.52	22617229
441	Phosphorylation	VPDANYTSDEEEEKQ CCCCCCCCHHHHHHH	32.44	22617229
449	Phosphorylation	DEEEEKQSTAYEKQF HHHHHHHCHHHHHHC	26.52	26852163
450	Phosphorylation	EEEEKQSTAYEKQFP HHHHHHCHHHHHHCC	30.66	26852163
452	Phosphorylation	EEKQSTAYEKQFPAT HHHHCHHHHHHCCCC	24.61	26852163
454	Ubiquitination	KQSTAYEKQFPATSK HHCHHHHHHCCCCCC	44.56	-
468	Phosphorylation	KDNFDMCSSSFTSSK CCCCCCCCCCCCCCC	23.52	18691976
469	Phosphorylation	DNFDMCSSSFTSSKL CCCCCCCCCCCCCCC	25.25	21712546
470	Phosphorylation	NFDMCSSSFTSSKLL CCCCCCCCCCCCCCC	19.09	21712546
472	Phosphorylation	DMCSSSFTSSKLLPA CCCCCCCCCCCCCCC	33.76	29116813
473	Phosphorylation	MCSSSFTSSKLLPAE CCCCCCCCCCCCCCC	24.38	29514088
474	Phosphorylation	CSSSFTSSKLLPAEI CCCCCCCCCCCCCCC	25.02	29514088
488	Phosphorylation	IKGEMEKTPVTPSQG CCCEEEECCCCCCCC	15.08	24505115
491	Phosphorylation	EMEKTPVTPSQGTAT EEEECCCCCCCCCCC	20.58	21815630
493	Phosphorylation	EKTPVTPSQGTATKY EECCCCCCCCCCCCC	31.69	22817900
496	Phosphorylation	PVTPSQGTATKYPAK CCCCCCCCCCCCCCC	24.42	22817900
498	Phosphorylation	TPSQGTATKYPAKSG CCCCCCCCCCCCCCC	30.83	24505115
500	Phosphorylation	SQGTATKYPAKSGAL CCCCCCCCCCCCCCC	12.22	-
504	Phosphorylation	ATKYPAKSGALSRTK CCCCCCCCCCCCCCC	31.25	-
508	Phosphorylation	PAKSGALSRTKKKL- CCCCCCCCCCCCCC-	37.05	24505115
510	Phosphorylation	KSGALSRTKKKL--- CCCCCCCCCCCC---	43.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
382	T	Phosphorylation	Kinase	STK33	Q9BYT3	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STK33_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STK33_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS90B_HUMAN	HSP90AB1	physical	22451720
HS90A_HUMAN	HSP90AA1	physical	22451720
CDC37_HUMAN	CDC37	physical	22451720
HERC2_HUMAN	HERC2	physical	22451720
BAG2_HUMAN	BAG2	physical	22451720
UBP5_HUMAN	USP5	physical	22451720
UBP15_HUMAN	USP15	physical	22451720
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STK33_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441 AND THR-491, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469 AND SER-470, ANDMASS SPECTROMETRY.	18691976 [Abstract]