STN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STN1_HUMAN
• UniProt AC: Q9H668
• Protein Name: CST complex subunit STN1
• Gene Name: STN1 {ECO:0000312|HGNC:HGNC:26200}
• Organism: Homo sapiens (Human).
• Sequence Length: 368
• Subcellular Localization: Nucleus . Chromosome, telomere .
• Protein Description: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. [PubMed: 19854130 However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha]
• Protein Sequence: MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQVDVLGTVIGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARELSLTSQLKKLQETIEQKTKIEIGDTIRVRGSIRTYREEREIHATTYYKVDDPVWNIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLMENRVQSFYQQELEMVESLLSLANQPVIHSASSDQVNFKKDTTSKAIHSIFKNAIQLLQEKGLVFQKDDGFDNLYYVTREDKDLHRKIHRIIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSDIVSTMEHYYTAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Ubiquitination	IRDILDMKESRQVPG HHHHHCCHHHCCCCC	52.81	29967540
55	Ubiquitination	LYNGHPIKQVDVLGT EECCEECCEEEEEEE	49.04	-
90	Ubiquitination	VINCICWKKLNTESV EEEEEEEEECCCCCC	42.86	22817900
91	Ubiquitination	INCICWKKLNTESVS EEEEEEEECCCCCCC	23.59	21906983
114	Ubiquitination	LSLTSQLKKLQETIE HHHHHHHHHHHHHHH	43.74	29967540
115	Ubiquitination	SLTSQLKKLQETIEQ HHHHHHHHHHHHHHH	65.09	-
119	Phosphorylation	QLKKLQETIEQKTKI HHHHHHHHHHHHHCC	19.49	-
123	Ubiquitination	LQETIEQKTKIEIGD HHHHHHHHHCCCCCC	38.71	21906983
125	Ubiquitination	ETIEQKTKIEIGDTI HHHHHHHCCCCCCEE	45.43	22817900
131	Phosphorylation	TKIEIGDTIRVRGSI HCCCCCCEEEECCEE	12.89	23403867
176	Ubiquitination	ELPTIYRKVYDQPFH CCCCCHHHHHCCCCC	28.33	21906983
178	Phosphorylation	PTIYRKVYDQPFHSS CCCHHHHHCCCCCCH	16.34	-
189	Ubiquitination	FHSSALEKEEALSNP CCCHHHHHHHHHCCC	62.80	21906983
194	Phosphorylation	LEKEEALSNPGALDL HHHHHHHCCCCCCCH	48.29	24719451
203	Phosphorylation	PGALDLPSLTSLLSE CCCCCHHHHHHHHHH	52.13	24719451
205	Phosphorylation	ALDLPSLTSLLSEKA CCCHHHHHHHHHHHH	22.97	26074081
206	Phosphorylation	LDLPSLTSLLSEKAK CCHHHHHHHHHHHHH	32.38	26074081
209	Phosphorylation	PSLTSLLSEKAKEFL HHHHHHHHHHHHHHH	42.20	26074081
211	Ubiquitination	LTSLLSEKAKEFLME HHHHHHHHHHHHHHH	62.47	21906983
213	Ubiquitination	SLLSEKAKEFLMENR HHHHHHHHHHHHHHH	61.13	21906983
261	Ubiquitination	FKKDTTSKAIHSIFK CCCCHHHHHHHHHHH	49.63	29967540
265	Phosphorylation	TTSKAIHSIFKNAIQ HHHHHHHHHHHHHHH	24.49	24719451
268	Ubiquitination	KAIHSIFKNAIQLLQ HHHHHHHHHHHHHHH	43.74	29967540
277	Ubiquitination	AIQLLQEKGLVFQKD HHHHHHHCCCEEECC	44.58	21906983
283	Ubiquitination	EKGLVFQKDDGFDNL HCCCEEECCCCCCCE	46.45	22817900
314	Ubiquitination	IIQQDCQKPNHMEKG HHHHHCCCCCHHHCC	54.86	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED12_HUMAN	MED12	physical	20133760
MED13_HUMAN	MED13	physical	20133760
MED25_HUMAN	MED25	physical	20133760
MED16_HUMAN	MED16	physical	20133760
MED17_HUMAN	MED17	physical	20133760
MED1_HUMAN	MED1	physical	20133760
MED24_HUMAN	MED24	physical	20133760
MED23_HUMAN	MED23	physical	20133760
MED4_HUMAN	MED4	physical	20133760
MED29_HUMAN	MED29	physical	20133760
MED8_HUMAN	MED8	physical	20133760
MED6_HUMAN	MED6	physical	20133760
MED14_HUMAN	MED14	physical	20133760
MED30_HUMAN	MED30	physical	20133760
RPB1_HUMAN	POLR2A	physical	20133760
MED9_HUMAN	MED9	physical	20133760
RCOR1_HUMAN	RCOR1	physical	20133760
MED27_HUMAN	MED27	physical	20133760
A4_HUMAN	APP	physical	21832049
TEN1L_HUMAN	TEN1	physical	26186194
UBP47_HUMAN	USP47	physical	26186194
UBP4_HUMAN	USP4	physical	26186194
UBP15_HUMAN	USP15	physical	26186194
CYTSA_HUMAN	SPECC1L	physical	26186194
GRN_HUMAN	GRN	physical	26186194
ARH_HUMAN	LDLRAP1	physical	26186194
CTC1_HUMAN	CTC1	physical	26186194
LRWD1_HUMAN	LRWD1	physical	26186194
PRI2_HUMAN	PRIM2	physical	26186194
DPOLA_HUMAN	POLA1	physical	26186194
OGA_HUMAN	MGEA5	physical	26186194
F136A_HUMAN	FAM136A	physical	26186194
ARP3C_HUMAN	ACTR3C	physical	26186194
NSE3_HUMAN	NDNL2	physical	26186194
SMC6_HUMAN	SMC6	physical	26186194
SMC5_HUMAN	SMC5	physical	26186194
ORC3_HUMAN	ORC3	physical	26186194
UBP33_HUMAN	USP33	physical	26186194
SMCO3_HUMAN	SMCO3	physical	26186194
KIF3A_HUMAN	KIF3A	physical	26186194
ORC2_HUMAN	ORC2	physical	26186194
NSE1_HUMAN	NSMCE1	physical	26186194
PRI1_HUMAN	PRIM1	physical	26186194
TEN1L_HUMAN	TEN1	physical	28514442
CTC1_HUMAN	CTC1	physical	28514442
ORC3_HUMAN	ORC3	physical	28514442
ORC2_HUMAN	ORC2	physical	28514442
ARP3C_HUMAN	ACTR3C	physical	28514442
SMC5_HUMAN	SMC5	physical	28514442
SMC6_HUMAN	SMC6	physical	28514442
UBP4_HUMAN	USP4	physical	28514442
F136A_HUMAN	FAM136A	physical	28514442
ARH_HUMAN	LDLRAP1	physical	28514442
KIF3A_HUMAN	KIF3A	physical	28514442
SMCO3_HUMAN	SMCO3	physical	28514442
NSE3_HUMAN	NDNL2	physical	28514442
UBP33_HUMAN	USP33	physical	28514442
UBP47_HUMAN	USP47	physical	28514442
CYTSA_HUMAN	SPECC1L	physical	28514442
OGA_HUMAN	MGEA5	physical	28514442
UBP15_HUMAN	USP15	physical	28514442
HNRPF_HUMAN	HNRNPF	physical	28514442
NSE1_HUMAN	NSMCE1	physical	28514442
GRN_HUMAN	GRN	physical	28514442
DPOA2_HUMAN	POLA2	physical	28514442
PRI1_HUMAN	PRIM1	physical	28514442
LRWD1_HUMAN	LRWD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.