NSE3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSE3_HUMAN
• UniProt AC: Q96MG7
• Protein Name: Non-structural maintenance of chromosomes element 3 homolog
• Gene Name: NSMCE3 {ECO:0000312|HGNC:HGNC:7677}
• Organism: Homo sapiens (Human).
• Sequence Length: 304
• Subcellular Localization: Cytoplasm. Nucleus . Chromosome, telomere .
• Protein Description: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. [PubMed: 20864041]
• Protein Sequence: MLQKPRNRGRSGGQAERDRDWSHSGNPGASRAGEDARVLRDGFAEEAPSTSRGPGGSQGSQGPSPQGARRAQAAPAVGPRSQKQLELKVSELVQFLLIKDQKKIPIKRADILKHVIGDYKDIFPDLFKRAAERLQYVFGYKLVELEPKSNTYILINTLEPVEEDAEMRGDQGTPTTGLLMIVLGLIFMKGNTIKETEAWDFLRRLGVYPTKKHLIFGDPKKLITEDFVRQRYLEYRRIPHTDPVDYEFQWGPRTNLETSKMKVLKFVAKVHNQDPKDWPAQYCEALADEENRARPQPSGPAPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	GFAEEAPSTSRGPGG CCCCCCCCCCCCCCC		23401153
50	Phosphorylation	FAEEAPSTSRGPGGS CCCCCCCCCCCCCCC		22199227
51	Phosphorylation	AEEAPSTSRGPGGSQ CCCCCCCCCCCCCCC		30576142
57	Phosphorylation	TSRGPGGSQGSQGPS CCCCCCCCCCCCCCC		17525332
60	Phosphorylation	GPGGSQGSQGPSPQG CCCCCCCCCCCCHHH		17525332
64	Phosphorylation	SQGSQGPSPQGARRA CCCCCCCCHHHHHHH		29255136
83	Ubiquitination	AVGPRSQKQLELKVS CCCCCCHHHHHHHHH		23000965
88	Ubiquitination	SQKQLELKVSELVQF CHHHHHHHHHHHHHH		23000965
113	Ubiquitination	IKRADILKHVIGDYK CCHHHHHHHHHCCHH		22817900
120	Ubiquitination	KHVIGDYKDIFPDLF HHHHCCHHHHCHHHH		32015554
128	Ubiquitination	DIFPDLFKRAAERLQ HHCHHHHHHHHHHHH		22817900
141	Ubiquitination	LQYVFGYKLVELEPK HHHHHCCEEEEEECC		22817900
194	Ubiquitination	FMKGNTIKETEAWDF HHCCCCCCHHHHHHH		29967540
211	Ubiquitination	RLGVYPTKKHLIFGD HHCCCCCCCEEECCC		33845483
212	Ubiquitination	LGVYPTKKHLIFGDP HCCCCCCCEEECCCH		29967540
220	Ubiquitination	HLIFGDPKKLITEDF EEECCCHHHHCCHHH		29967540
221	Ubiquitination	LIFGDPKKLITEDFV EECCCHHHHCCHHHH		29967540
246	Phosphorylation	PHTDPVDYEFQWGPR CCCCCCCCCCCCCCC		22817900
254	Phosphorylation	EFQWGPRTNLETSKM CCCCCCCCCCHHHHH		-
260	Acetylation	RTNLETSKMKVLKFV CCCCHHHHHHHHHHH		7710531
265	Ubiquitination	TSKMKVLKFVAKVHN HHHHHHHHHHHHHCC		29967540
269	Ubiquitination	KVLKFVAKVHNQDPK HHHHHHHHHCCCCCC		33845483
276	Ubiquitination	KVHNQDPKDWPAQYC HHCCCCCCCCCHHHH		29967540
282	Phosphorylation	PKDWPAQYCEALADE CCCCCHHHHHHHHCH		29759185
298	Phosphorylation	NRARPQPSGPAPSS- HHCCCCCCCCCCCC-		29396449
303	Phosphorylation	QPSGPAPSS------ CCCCCCCCC------		30266825
304	Phosphorylation	PSGPAPSS------- CCCCCCCC-------		30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSE3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSE3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSE3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2F1_HUMAN	E2F1	physical	14593116
TNR16_HUMAN	NGFR	physical	14593116
NSE1_HUMAN	NSMCE1	physical	20864041
PJA1_HUMAN	PJA1	physical	20864041
TIF1B_HUMAN	TRIM28	physical	20864041
NSE4A_HUMAN	NSMCE4A	physical	20864041
NSE1_HUMAN	NSMCE1	physical	18086888
SMC6_HUMAN	SMC6	physical	18086888
EID3_HUMAN	EID3	physical	21364888
NSE1_HUMAN	NSMCE1	physical	21364888
NSE4A_HUMAN	NSMCE4A	physical	21364888
SMC5_HUMAN	SMC5	physical	26344197
SMC6_HUMAN	SMC6	physical	26344197
NSE1_HUMAN	NSMCE1	physical	26910052

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.