NSE1_HUMAN - dbPTM
NSE1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NSE1_HUMAN
UniProt AC Q8WV22
Protein Name Non-structural maintenance of chromosomes element 1 homolog
Gene Name NSMCE1 {ECO:0000312|HGNC:HGNC:29897}
Organism Homo sapiens (Human).
Sequence Length 266
Subcellular Localization Nucleus . Chromosome, telomere .
Protein Description RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. [PubMed: 29225034]
Protein Sequence MQGSTRRMGVMTDVHRRFLQLLMTHGVLEEWDVKRLQTHCYKVHDRNATVDKLEDFINNINSVLESLYIEIKRGVTEDDGRPIYALVNLATTSISKMATDFAENELDLFRKALELIIDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQNKWLIEKEGEFTLHGRAILEMEQYIRETYPDAVKICNICHSLLIQGQSCETCGIRMHLPCVAKYFQSNAEPRCPHCNDYWPHEIPKVFDPEKERESGVLKSNKKSLRSRQH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationTRRMGVMTDVHRRFL
CHHCCCCHHHHHHHH		32.25-
42UbiquitinationRLQTHCYKVHDRNAT
HHHHHCEEECCCCCH		38.1933845483
56UbiquitinationTVDKLEDFINNINSV
HHHHHHHHHHHHHHH		4.7421890473
61UbiquitinationEDFINNINSVLESLY
HHHHHHHHHHHHHHH		28.3421890473
66UbiquitinationNINSVLESLYIEIKR
HHHHHHHHHHHHHHC		23.4722817900
72UbiquitinationESLYIEIKRGVTEDD
HHHHHHHHCCCCCCC		30.24-
76PhosphorylationIEIKRGVTEDDGRPI
HHHHCCCCCCCCCEE		36.2021406692
84PhosphorylationEDDGRPIYALVNLAT
CCCCCEEEEHHHHHH		9.1421406692
91PhosphorylationYALVNLATTSISKMA
EEHHHHHHHCHHHHH		25.0021406692
92PhosphorylationALVNLATTSISKMAT
EHHHHHHHCHHHHHH		20.6121406692
93PhosphorylationLVNLATTSISKMATD
HHHHHHHCHHHHHHH		22.1021406692
95PhosphorylationNLATTSISKMATDFA
HHHHHCHHHHHHHHH		19.0221406692
99PhosphorylationTSISKMATDFAENEL
HCHHHHHHHHHHHHH		28.3125690035
119PhosphorylationALELIIDSETGFASS
HHHHHHCCCCCCCCH		27.0122210691
121PhosphorylationELIIDSETGFASSTN
HHHHCCCCCCCCHHH		41.3622210691
122UbiquitinationLIIDSETGFASSTNI
HHHCCCCCCCCHHHH		16.4521890473
125PhosphorylationDSETGFASSTNILNL
CCCCCCCCHHHHHHH		35.1222210691
143UbiquitinationLKGKKMRKKEAEQVL
HCCCHHCHHHHHHHH		52.0129967540
144UbiquitinationKGKKMRKKEAEQVLQ
CCCHHCHHHHHHHHH		52.3633845483
145UbiquitinationGKKMRKKEAEQVLQK
CCHHCHHHHHHHHHH		61.5521890473
152UbiquitinationEAEQVLQKFVQNKWL
HHHHHHHHHHHCCCC		43.2622817900
157UbiquitinationLQKFVQNKWLIEKEG
HHHHHHCCCCEEECC		26.7022817900
159UbiquitinationKFVQNKWLIEKEGEF
HHHHCCCCEEECCEE		3.7524816145
162UbiquitinationQNKWLIEKEGEFTLH
HCCCCEEECCEEEEE		65.1222817900
189UbiquitinationETYPDAVKICNICHS
HHCCCHHHHHHHHHH		43.1721890473
194UbiquitinationAVKICNICHSLLIQG
HHHHHHHHHHHHHCC		0.8121890473
199UbiquitinationNICHSLLIQGQSCET
HHHHHHHHCCCCCCC		5.4022817900
218UbiquitinationMHLPCVAKYFQSNAE
EEHHHHHHHHHHCCC		26.6321890473
241UbiquitinationYWPHEIPKVFDPEKE
CCCCCCCCCCCHHHH		62.2822817900
247UbiquitinationPKVFDPEKERESGVL
CCCCCHHHHHHCCCC		68.41-
251PhosphorylationDPEKERESGVLKSNK
CHHHHHHCCCCCCCH		40.1823186163
255UbiquitinationERESGVLKSNKKSLR
HHHCCCCCCCHHHHH		49.9621890473
256PhosphorylationRESGVLKSNKKSLRS
HHCCCCCCCHHHHHH		50.12-
260PhosphorylationVLKSNKKSLRSRQH-
CCCCCHHHHHHCCC-		30.53-
278Ubiquitination-------------------
-------------------		21890473
292Ubiquitination---------------------------------
---------------------------------		24816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NSE1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NSE1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NSE1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NSE3_HUMANNDNL2physical
20864041
MAGF1_HUMANMAGEF1physical
20864041
SMC6_HUMANSMC6physical
18086888
NSE2_HUMANNSMCE2physical
18086888
SMC5_HUMANSMC5physical
18086888
NSE1_HUMANNSMCE1physical
18086888
NSE4A_HUMANNSMCE4Aphysical
18086888
NSE3_HUMANNDNL2physical
18086888
UBC_HUMANUBCphysical
22992278
UB2D2_HUMANUBE2D2physical
22992278
UBE2K_MOUSEUbe2kphysical
22992278
SMC6_HUMANSMC6physical
14701739
SMC6_HUMANSMC6physical
26186194
NSE2_HUMANNSMCE2physical
26186194
NSE3_HUMANNDNL2physical
26186194
SMC5_HUMANSMC5physical
26186194
PMF1_HUMANPMF1physical
26186194
SIMC1_HUMANSIMC1physical
26186194
SLF2_HUMANFAM178Aphysical
26186194
NSE4A_HUMANNSMCE4Aphysical
26186194
NSE3_HUMANNDNL2physical
26344197
SMC5_HUMANSMC5physical
26344197
SMC6_HUMANSMC6physical
26344197
NSE4A_HUMANNSMCE4Aphysical
28514442
SMC5_HUMANSMC5physical
28514442
SMC6_HUMANSMC6physical
28514442
NSE3_HUMANNDNL2physical
28514442
NSE2_HUMANNSMCE2physical
28514442
SLF2_HUMANFAM178Aphysical
28514442
SIMC1_HUMANSIMC1physical
28514442
PMF1_HUMANPMF1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NSE1_HUMAN

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Related Literatures of Post-Translational Modification

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